Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01090:Or7g18'

51897

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7g18

Ensembl Gene

ENSMUSG00000062868

Gene Name

olfactory receptor family 7 subfamily G member 18

Synonyms

GA_x6K02T2PVTD-12618399-12619337, Olfr830, MOR152-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

IGL01090

Quality Score

Status

Chromosome

Chromosomal Location

18786256-18787572 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18787538 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 305 (K305R)

Ref Sequence

ENSEMBL: ENSMUSP00000077903 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078861] [ENSMUST00000212723]

AlphaFold

Q8VFJ5

Predicted Effect

probably benign
Transcript: ENSMUST00000078861
AA Change: K305R

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000077903
Gene: ENSMUSG00000062868
AA Change: K305R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	1.8e-51	PFAM
Pfam:7tm_1	44	293	1.6e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000212723
AA Change: K302R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	T	C	6: 91,896,099 (GRCm39)	S316P	possibly damaging	Het
Actn1	A	T	12: 80,245,846 (GRCm39)		probably null	Het
Agbl3	T	C	6: 34,776,822 (GRCm39)	Y443H	probably benign	Het
Akap13	T	A	7: 75,316,279 (GRCm39)	D578E	probably benign	Het
Aldoa	A	T	7: 126,395,207 (GRCm39)	H292Q	probably benign	Het
Als2	T	C	1: 59,254,775 (GRCm39)	K194R	possibly damaging	Het
Bivm	C	A	1: 44,168,451 (GRCm39)	H244N	probably damaging	Het
Cabp5	G	A	7: 13,139,412 (GRCm39)	E146K	probably damaging	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cfap251	A	C	5: 123,418,052 (GRCm39)		probably benign	Het
Clcn4	A	G	7: 7,297,035 (GRCm39)	V129A	probably benign	Het
Clec4g	A	G	8: 3,769,482 (GRCm39)	S54P	probably damaging	Het
Crim1	G	T	17: 78,654,658 (GRCm39)	V645L	probably damaging	Het
Csta1	T	C	16: 35,945,421 (GRCm39)	T31A	probably damaging	Het
D930048N14Rik	T	C	11: 51,544,610 (GRCm39)		probably benign	Het
Dhx34	G	T	7: 15,950,181 (GRCm39)	P329Q	probably damaging	Het
Dusp16	T	C	6: 134,702,912 (GRCm39)	N193S	probably benign	Het
Fbn1	A	G	2: 125,236,696 (GRCm39)		probably benign	Het
Fbxo46	A	G	7: 18,870,728 (GRCm39)	Y449C	probably damaging	Het
Fmo4	C	A	1: 162,637,354 (GRCm39)		probably null	Het
Foxi3	C	A	6: 70,937,729 (GRCm39)	N320K	probably damaging	Het
Gm9964	A	G	11: 79,187,210 (GRCm39)	L79P	unknown	Het
Gpr161	T	C	1: 165,134,149 (GRCm39)	I137T	probably damaging	Het
Herc1	C	T	9: 66,376,457 (GRCm39)	Q3426*	probably null	Het
Hps5	C	T	7: 46,437,751 (GRCm39)	R108H	probably benign	Het
Itch	T	A	2: 155,048,256 (GRCm39)	V540E	probably damaging	Het
L3mbtl1	C	A	2: 162,807,925 (GRCm39)	P520H	probably damaging	Het
Mvp	A	G	7: 126,588,859 (GRCm39)	V636A	probably benign	Het
Odf4	A	G	11: 68,812,778 (GRCm39)		probably benign	Het
Pld1	T	C	3: 28,142,816 (GRCm39)	S675P	probably benign	Het
Plod3	A	G	5: 137,019,090 (GRCm39)	D325G	probably benign	Het
Prss12	T	C	3: 123,276,388 (GRCm39)	V339A	possibly damaging	Het
Ptpn13	T	A	5: 103,689,180 (GRCm39)	L991Q	probably null	Het
Ptpn3	T	A	4: 57,240,833 (GRCm39)	I261F	probably damaging	Het
Rab3gap1	T	C	1: 127,858,124 (GRCm39)		probably benign	Het
Rasa4	A	G	5: 136,130,847 (GRCm39)	R373G	possibly damaging	Het
Rmi1	T	C	13: 58,557,208 (GRCm39)	S486P	probably damaging	Het
Slc25a23	A	G	17: 57,354,233 (GRCm39)	I139T	probably benign	Het
Sspo	T	A	6: 48,467,059 (GRCm39)	S4017T	probably benign	Het
Tcaf1	C	A	6: 42,663,556 (GRCm39)	C108F	probably benign	Het
Tnc	T	C	4: 63,918,317 (GRCm39)	Q1198R	probably damaging	Het
Tnni3k	G	T	3: 154,645,320 (GRCm39)	Q522K	possibly damaging	Het
Trio	T	A	15: 27,773,093 (GRCm39)	E713V	probably damaging	Het
Ugt2b34	C	A	5: 87,041,679 (GRCm39)	V338F	probably damaging	Het
Usp40	T	A	1: 87,890,187 (GRCm39)	M892L	probably benign	Het
Usp54	A	T	14: 20,636,225 (GRCm39)		probably benign	Het
Vmn2r53	T	C	7: 12,334,835 (GRCm39)	E275G	possibly damaging	Het
Vmn2r87	A	G	10: 130,333,247 (GRCm39)	M1T	probably null	Het
Wdr83os	A	T	8: 85,808,476 (GRCm39)	D76V	probably damaging	Het

Other mutations in Or7g18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Or7g18	APN	9	18,787,310 (GRCm39)	nonsense	probably null
IGL00954:Or7g18	APN	9	18,787,369 (GRCm39)	missense	probably benign	0.15
IGL01613:Or7g18	APN	9	18,786,617 (GRCm39)	splice site	probably benign
IGL01987:Or7g18	APN	9	18,787,003 (GRCm39)	missense	probably benign	0.00
IGL03018:Or7g18	APN	9	18,787,523 (GRCm39)	missense	probably benign	0.15
IGL03037:Or7g18	APN	9	18,786,668 (GRCm39)	missense	probably damaging	0.98
R0284:Or7g18	UTSW	9	18,786,848 (GRCm39)	missense	probably benign
R1322:Or7g18	UTSW	9	18,786,817 (GRCm39)	missense	possibly damaging	0.90
R1715:Or7g18	UTSW	9	18,787,090 (GRCm39)	missense	probably benign	0.06
R1803:Or7g18	UTSW	9	18,787,376 (GRCm39)	missense	probably damaging	1.00
R4360:Or7g18	UTSW	9	18,787,013 (GRCm39)	missense	probably damaging	1.00
R4394:Or7g18	UTSW	9	18,786,907 (GRCm39)	missense	probably damaging	0.98
R4642:Or7g18	UTSW	9	18,787,463 (GRCm39)	missense	probably damaging	1.00
R4796:Or7g18	UTSW	9	18,787,475 (GRCm39)	missense	probably damaging	0.96
R4814:Or7g18	UTSW	9	18,787,213 (GRCm39)	missense	probably benign	0.30
R5210:Or7g18	UTSW	9	18,787,103 (GRCm39)	missense	probably damaging	1.00
R5375:Or7g18	UTSW	9	18,787,442 (GRCm39)	missense	probably benign	0.08
R6072:Or7g18	UTSW	9	18,786,718 (GRCm39)	missense	probably benign
R6361:Or7g18	UTSW	9	18,787,027 (GRCm39)	missense	probably damaging	1.00
R6602:Or7g18	UTSW	9	18,787,145 (GRCm39)	missense	possibly damaging	0.81
R6920:Or7g18	UTSW	9	18,786,821 (GRCm39)	missense	probably damaging	1.00
R7730:Or7g18	UTSW	9	18,786,709 (GRCm39)	missense	probably benign	0.00
R7780:Or7g18	UTSW	9	18,786,910 (GRCm39)	missense	possibly damaging	0.65
R8245:Or7g18	UTSW	9	18,787,126 (GRCm39)	missense	probably benign
R8274:Or7g18	UTSW	9	18,786,795 (GRCm39)	missense	probably benign	0.36
R8920:Or7g18	UTSW	9	18,787,394 (GRCm39)	missense	probably damaging	1.00
R9564:Or7g18	UTSW	9	18,786,640 (GRCm39)	missense	probably benign	0.00
X0026:Or7g18	UTSW	9	18,786,931 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21