Incidental Mutation 'IGL01100:Acad11'
ID 51918
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Acad11
Ensembl Gene ENSMUSG00000090150
Gene Name acyl-Coenzyme A dehydrogenase family, member 11
Synonyms 5730439E10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL01100
Quality Score
Status
Chromosome 9
Chromosomal Location 103940923-104004855 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 103953607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 32 (T32A)
Ref Sequence ENSEMBL: ENSMUSP00000112994 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047799] [ENSMUST00000120854] [ENSMUST00000189998]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000047799
AA Change: T150A

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000043424
Gene: ENSMUSG00000090150
AA Change: T150A

DomainStartEndE-ValueType
Pfam:APH 43 307 3.5e-45 PFAM
Pfam:Acyl-CoA_dh_N 376 498 1.5e-13 PFAM
Pfam:Acyl-CoA_dh_M 502 605 1.7e-21 PFAM
Pfam:Acyl-CoA_dh_1 617 768 2.7e-36 PFAM
Pfam:Acyl-CoA_dh_2 632 743 2e-12 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000120854
AA Change: T32A

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000112994
Gene: ENSMUSG00000090150
AA Change: T32A

DomainStartEndE-ValueType
Pfam:APH 1 188 1.1e-28 PFAM
Pfam:EcKinase 49 143 4.8e-9 PFAM
Pfam:Acyl-CoA_dh_N 257 380 8.7e-15 PFAM
Pfam:Acyl-CoA_dh_M 385 439 2.4e-19 PFAM
Pfam:Acyl-CoA_dh_1 499 650 1.3e-37 PFAM
Pfam:Acyl-CoA_dh_2 514 632 2.7e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000147249
SMART Domains Protein: ENSMUSP00000115381
Gene: ENSMUSG00000101152

DomainStartEndE-ValueType
Pfam:TPR_12 1 48 3e-14 PFAM
Pfam:TPR_12 12 75 2.1e-14 PFAM
Pfam:TPR_10 15 56 7.8e-13 PFAM
Pfam:TPR_1 16 49 4.4e-9 PFAM
Pfam:TPR_7 18 58 7e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189998
AA Change: T150A

PolyPhen 2 Score 0.102 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,224,673 (GRCm39) probably null Het
Abca8a C T 11: 109,949,249 (GRCm39) probably null Het
Ak7 T A 12: 105,679,833 (GRCm39) N122K probably benign Het
Arrb1 A T 7: 99,236,420 (GRCm39) probably null Het
Csde1 C A 3: 102,947,841 (GRCm39) R132S possibly damaging Het
Emilin1 A G 5: 31,075,748 (GRCm39) H663R probably benign Het
Etaa1 A G 11: 17,902,576 (GRCm39) probably null Het
Fat3 A T 9: 16,286,524 (GRCm39) F1000I probably damaging Het
Foxj2 T C 6: 122,805,350 (GRCm39) L74P probably damaging Het
Gas6 C T 8: 13,525,118 (GRCm39) V289M probably benign Het
Gm10801 A T 2: 98,494,328 (GRCm39) Y135F probably benign Het
Ihh C T 1: 74,985,601 (GRCm39) A295T probably damaging Het
Ip6k2 G T 9: 108,682,943 (GRCm39) S305I probably damaging Het
Kcnk2 A G 1: 189,072,133 (GRCm39) V65A probably damaging Het
Kif26b G A 1: 178,744,809 (GRCm39) C1635Y probably benign Het
Klhdc4 G A 8: 122,548,582 (GRCm39) Q44* probably null Het
Madd C A 2: 90,988,385 (GRCm39) R1216L probably damaging Het
Myo15a T A 11: 60,401,984 (GRCm39) C3076S probably damaging Het
Or1l4 A T 2: 37,091,652 (GRCm39) H133L possibly damaging Het
Or52e18 T A 7: 104,609,202 (GRCm39) I246F probably benign Het
Polq C A 16: 36,881,474 (GRCm39) P934T probably benign Het
Prkaa1 A T 15: 5,203,799 (GRCm39) K227M probably damaging Het
Psap G A 10: 60,135,708 (GRCm39) G388S probably benign Het
Repin1 A G 6: 48,573,839 (GRCm39) E200G probably damaging Het
Samd9l C A 6: 3,375,863 (GRCm39) S466I possibly damaging Het
Slc5a3 A G 16: 91,876,110 (GRCm39) probably benign Het
Smg9 G A 7: 24,116,376 (GRCm39) V314M probably damaging Het
Tktl1 G A X: 73,244,232 (GRCm39) R352H probably benign Het
Ube2z A G 11: 95,953,849 (GRCm39) V123A probably damaging Het
Vmn1r176 A T 7: 23,535,049 (GRCm39) F35I probably benign Het
Zdhhc18 A T 4: 133,340,269 (GRCm39) Y293N probably damaging Het
Other mutations in Acad11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00966:Acad11 APN 9 104,003,855 (GRCm39) missense probably damaging 1.00
IGL01920:Acad11 APN 9 103,941,104 (GRCm39) critical splice donor site probably null
IGL02019:Acad11 APN 9 103,992,544 (GRCm39) missense probably damaging 1.00
IGL02506:Acad11 APN 9 103,968,931 (GRCm39) critical splice donor site probably null
IGL02742:Acad11 APN 9 103,972,824 (GRCm39) missense probably damaging 1.00
IGL02830:Acad11 APN 9 103,953,118 (GRCm39) missense probably damaging 1.00
IGL02936:Acad11 APN 9 103,990,711 (GRCm39) missense probably benign 0.31
R0092:Acad11 UTSW 9 103,967,540 (GRCm39) splice site probably benign
R0277:Acad11 UTSW 9 104,001,224 (GRCm39) missense probably damaging 1.00
R0377:Acad11 UTSW 9 103,958,891 (GRCm39) splice site probably benign
R0411:Acad11 UTSW 9 103,993,495 (GRCm39) missense probably damaging 1.00
R0556:Acad11 UTSW 9 103,992,501 (GRCm39) missense probably damaging 1.00
R0594:Acad11 UTSW 9 103,972,762 (GRCm39) missense probably benign 0.09
R0688:Acad11 UTSW 9 104,001,299 (GRCm39) missense probably damaging 1.00
R1416:Acad11 UTSW 9 103,950,822 (GRCm39) missense probably damaging 0.96
R1551:Acad11 UTSW 9 104,003,785 (GRCm39) missense probably damaging 0.99
R1730:Acad11 UTSW 9 103,941,081 (GRCm39) missense probably benign 0.02
R1819:Acad11 UTSW 9 103,991,738 (GRCm39) critical splice donor site probably null
R1884:Acad11 UTSW 9 103,991,684 (GRCm39) missense probably benign 0.13
R2411:Acad11 UTSW 9 103,963,222 (GRCm39) intron probably benign
R3055:Acad11 UTSW 9 103,953,535 (GRCm39) missense probably damaging 0.98
R3683:Acad11 UTSW 9 103,992,543 (GRCm39) missense probably damaging 1.00
R3954:Acad11 UTSW 9 103,963,351 (GRCm39) intron probably benign
R3956:Acad11 UTSW 9 103,963,351 (GRCm39) intron probably benign
R4425:Acad11 UTSW 9 103,950,844 (GRCm39) missense probably damaging 1.00
R4557:Acad11 UTSW 9 103,960,038 (GRCm39) missense probably benign 0.00
R4701:Acad11 UTSW 9 103,972,764 (GRCm39) nonsense probably null
R4764:Acad11 UTSW 9 103,953,076 (GRCm39) missense probably damaging 0.99
R4872:Acad11 UTSW 9 103,963,465 (GRCm39) intron probably benign
R5132:Acad11 UTSW 9 104,003,791 (GRCm39) missense probably benign 0.03
R5161:Acad11 UTSW 9 104,001,227 (GRCm39) missense probably benign 0.19
R5222:Acad11 UTSW 9 103,974,576 (GRCm39) missense probably damaging 1.00
R5587:Acad11 UTSW 9 103,940,966 (GRCm39) missense probably benign
R5683:Acad11 UTSW 9 103,961,482 (GRCm39) missense probably damaging 1.00
R6512:Acad11 UTSW 9 103,972,758 (GRCm39) nonsense probably null
R6815:Acad11 UTSW 9 103,958,526 (GRCm39) missense probably benign 0.01
R7035:Acad11 UTSW 9 103,990,694 (GRCm39) missense probably damaging 1.00
R7318:Acad11 UTSW 9 103,958,466 (GRCm39) missense probably damaging 1.00
R7564:Acad11 UTSW 9 104,000,288 (GRCm39) missense possibly damaging 0.94
R7673:Acad11 UTSW 9 103,941,105 (GRCm39) splice site probably null
R7812:Acad11 UTSW 9 103,972,747 (GRCm39) missense probably benign 0.41
R7850:Acad11 UTSW 9 103,991,728 (GRCm39) missense probably damaging 1.00
R8037:Acad11 UTSW 9 103,953,035 (GRCm39) missense possibly damaging 0.93
R8251:Acad11 UTSW 9 103,968,906 (GRCm39) missense possibly damaging 0.88
R9021:Acad11 UTSW 9 104,003,864 (GRCm39) missense possibly damaging 0.88
R9657:Acad11 UTSW 9 103,953,035 (GRCm39) missense possibly damaging 0.93
Posted On 2013-06-21