Incidental Mutation 'R6446:Or14c45'
ID 519193
Institutional Source Beutler Lab
Gene Symbol Or14c45
Ensembl Gene ENSMUSG00000057067
Gene Name olfactory receptor family 14 subfamily C member 45
Synonyms Olfr297, GA_x6K02T2NHDJ-9587747-9586815, MOR220-3
MMRRC Submission 044583-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R6446 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 86175967-86176899 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86176310 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 115 (I115N)
Ref Sequence ENSEMBL: ENSMUSP00000134371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071112] [ENSMUST00000172965]
AlphaFold Q7TS07
Predicted Effect possibly damaging
Transcript: ENSMUST00000071112
AA Change: I115N

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000132942
Gene: ENSMUSG00000057067
AA Change: I115N

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.9e-45 PFAM
Pfam:7tm_1 39 288 1.4e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000172965
AA Change: I115N

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000134371
Gene: ENSMUSG00000057067
AA Change: I115N

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.2e-46 PFAM
Pfam:7tm_1 39 288 2e-20 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.9%
Validation Efficiency 97% (36/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp13a3 A G 16: 30,180,687 (GRCm39) L114P probably benign Het
Blm GCCTCCTCCTCCTCCTCCTCCTCCTCCTCC GCCTCCTCCTCCTCCTCCTCCTCCTCC 7: 80,162,652 (GRCm39) probably benign Het
Catsperg1 T C 7: 28,905,992 (GRCm39) I196V probably benign Het
Cbx2 T A 11: 118,918,752 (GRCm39) S106T probably benign Het
Ccar2 T A 14: 70,380,518 (GRCm39) E354V probably benign Het
Ccr1 A G 9: 123,764,143 (GRCm39) I129T probably damaging Het
Cdkl2 T A 5: 92,181,076 (GRCm39) I188F probably damaging Het
Cep350 T C 1: 155,737,900 (GRCm39) N2648D probably benign Het
Chtf18 A G 17: 25,940,218 (GRCm39) S658P probably benign Het
Csnka2ip G A 16: 64,299,744 (GRCm39) Q207* probably null Het
Dennd5a A G 7: 109,493,873 (GRCm39) L1253P probably damaging Het
Dennd6a T A 14: 26,350,689 (GRCm39) I374K probably damaging Het
Dut T C 2: 125,092,939 (GRCm39) probably null Het
Gcm1 T C 9: 77,967,065 (GRCm39) Y95H probably benign Het
Grid2 A T 6: 64,322,577 (GRCm39) I526F probably damaging Het
Hectd4 T A 5: 121,472,438 (GRCm39) Y2725N possibly damaging Het
Helq A T 5: 100,916,250 (GRCm39) N907K possibly damaging Het
Hpse G A 5: 100,843,435 (GRCm39) Q246* probably null Het
Iigp1c A G 18: 60,378,840 (GRCm39) D125G probably damaging Het
Kcnj15 C T 16: 95,097,118 (GRCm39) H247Y probably benign Het
Kif27 C A 13: 58,493,530 (GRCm39) V138F probably damaging Het
Map7 T G 10: 20,153,979 (GRCm39) D698E unknown Het
Mtmr11 A T 3: 96,078,504 (GRCm39) S687C probably benign Het
Ncbp2 CGTCTGGATG CG 16: 31,775,161 (GRCm39) probably null Het
Nup210l G A 3: 90,079,375 (GRCm39) G953E probably damaging Het
Piezo2 G T 18: 63,219,678 (GRCm39) P792T probably damaging Het
Pld3 T C 7: 27,237,156 (GRCm39) D241G probably damaging Het
Prss35 G T 9: 86,637,706 (GRCm39) V159F probably damaging Het
Rimbp3 A T 16: 17,030,793 (GRCm39) M1406L probably benign Het
Serpina3g T C 12: 104,205,341 (GRCm39) F27L probably damaging Het
Setd1b G A 5: 123,299,862 (GRCm39) probably benign Het
Sh3glb1 T C 3: 144,411,366 (GRCm39) K13E probably damaging Het
Slc29a1 A T 17: 45,900,171 (GRCm39) I217N possibly damaging Het
Spag17 A T 3: 100,010,448 (GRCm39) T1981S probably benign Het
Svil A C 18: 5,057,323 (GRCm39) E590D probably benign Het
Synm A G 7: 67,384,714 (GRCm39) S541P probably damaging Het
Vmn2r108 A T 17: 20,692,609 (GRCm39) Y82* probably null Het
Other mutations in Or14c45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01686:Or14c45 APN 7 86,175,986 (GRCm39) missense probably benign 0.10
IGL01823:Or14c45 APN 7 86,176,249 (GRCm39) missense probably damaging 1.00
PIT4378001:Or14c45 UTSW 7 86,176,306 (GRCm39) missense possibly damaging 0.50
R0304:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R0737:Or14c45 UTSW 7 86,176,195 (GRCm39) missense probably damaging 1.00
R2177:Or14c45 UTSW 7 86,176,870 (GRCm39) missense probably benign 0.01
R2436:Or14c45 UTSW 7 86,176,591 (GRCm39) missense probably damaging 0.99
R4289:Or14c45 UTSW 7 86,176,262 (GRCm39) missense probably damaging 1.00
R4639:Or14c45 UTSW 7 86,175,969 (GRCm39) start codon destroyed probably null 1.00
R5202:Or14c45 UTSW 7 86,176,324 (GRCm39) missense probably damaging 1.00
R5782:Or14c45 UTSW 7 86,176,421 (GRCm39) missense probably damaging 0.98
R6615:Or14c45 UTSW 7 86,176,120 (GRCm39) missense probably benign 0.06
R6920:Or14c45 UTSW 7 86,176,522 (GRCm39) missense probably benign 0.00
R7150:Or14c45 UTSW 7 86,176,322 (GRCm39) missense probably damaging 1.00
R7309:Or14c45 UTSW 7 86,176,349 (GRCm39) missense probably damaging 1.00
R7621:Or14c45 UTSW 7 86,176,280 (GRCm39) missense probably benign 0.37
R8257:Or14c45 UTSW 7 86,176,678 (GRCm39) missense possibly damaging 0.95
R9349:Or14c45 UTSW 7 86,176,373 (GRCm39) missense probably benign 0.01
R9466:Or14c45 UTSW 7 86,176,080 (GRCm39) missense probably benign
R9479:Or14c45 UTSW 7 86,176,285 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- GTTGACCAGACCCTGAACAC -3'
(R):5'- GTAAGCCTCAGCAAAGCAGG -3'

Sequencing Primer
(F):5'- GAACACACCCATGTACTTCTTCC -3'
(R):5'- GAACTGAGGAACTACATTTGAGTGAC -3'
Posted On 2018-05-24