Incidental Mutation 'R6447:Vmn1r205'
| ID |
519234 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r205
|
| Ensembl Gene |
ENSMUSG00000100296 |
| Gene Name |
vomeronasal 1 receptor 205 |
| Synonyms |
V1rh8 |
| MMRRC Submission |
044389-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.164)
|
| Stock # |
R6447 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
22776150-22777100 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 22776912 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 63
(N63K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139977
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000185475]
|
| AlphaFold |
Q8R276 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000185475
AA Change: N63K
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000139977
Gene: ENSMUSG00000100296
AA Change: N63K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
24 |
307 |
5.5e-36 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.0%
- 20x: 93.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2fm3 |
A |
G |
3: 59,772,819 (GRCm39) |
I108V |
probably damaging |
Het |
| Axl |
C |
A |
7: 25,469,708 (GRCm39) |
R476I |
probably damaging |
Het |
| Casr |
A |
G |
16: 36,315,907 (GRCm39) |
L721P |
probably damaging |
Het |
| Cntn6 |
A |
T |
6: 104,836,409 (GRCm39) |
H925L |
probably damaging |
Het |
| Csmd1 |
T |
C |
8: 15,960,527 (GRCm39) |
Y3296C |
probably damaging |
Het |
| Dnah3 |
G |
A |
7: 119,522,277 (GRCm39) |
T3972M |
probably benign |
Het |
| Ect2 |
A |
G |
3: 27,169,633 (GRCm39) |
F740S |
probably damaging |
Het |
| Eif1ad10 |
T |
C |
12: 88,216,494 (GRCm39) |
D126G |
unknown |
Het |
| Exoc1 |
T |
A |
5: 76,691,364 (GRCm39) |
D222E |
probably damaging |
Het |
| Hdac2 |
T |
C |
10: 36,869,812 (GRCm39) |
V258A |
possibly damaging |
Het |
| Lrrk1 |
A |
G |
7: 65,952,476 (GRCm39) |
S487P |
probably benign |
Het |
| Lyplal1 |
A |
T |
1: 185,821,639 (GRCm39) |
|
probably null |
Het |
| Nwd2 |
T |
A |
5: 63,964,898 (GRCm39) |
I1494N |
probably benign |
Het |
| Pcdhb22 |
A |
G |
18: 37,653,269 (GRCm39) |
E579G |
possibly damaging |
Het |
| Samd8 |
T |
C |
14: 21,842,624 (GRCm39) |
|
probably null |
Het |
| Sccpdh |
A |
G |
1: 179,506,453 (GRCm39) |
*131W |
probably null |
Het |
| Smarcal1 |
C |
T |
1: 72,625,033 (GRCm39) |
S60L |
probably damaging |
Het |
| Stau2 |
A |
T |
1: 16,460,049 (GRCm39) |
V264E |
possibly damaging |
Het |
| T |
T |
C |
17: 8,660,463 (GRCm39) |
I217T |
possibly damaging |
Het |
| Tbc1d1 |
C |
T |
5: 64,490,836 (GRCm39) |
L896F |
probably damaging |
Het |
| Thap1 |
CAGCATCTGCTCGGAGCA |
CAGCA |
8: 26,650,884 (GRCm39) |
|
probably null |
Het |
| Tmprss11f |
T |
C |
5: 86,676,086 (GRCm39) |
Y365C |
probably damaging |
Het |
| Trdv4 |
A |
G |
14: 54,312,931 (GRCm39) |
T102A |
probably damaging |
Het |
| Vps13b |
T |
C |
15: 35,572,272 (GRCm39) |
V963A |
probably benign |
Het |
| Zswim2 |
T |
C |
2: 83,745,457 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r205 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01329:Vmn1r205
|
APN |
13 |
22,776,273 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02148:Vmn1r205
|
APN |
13 |
22,776,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02608:Vmn1r205
|
APN |
13 |
22,776,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03140:Vmn1r205
|
APN |
13 |
22,776,746 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0831:Vmn1r205
|
UTSW |
13 |
22,776,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1418:Vmn1r205
|
UTSW |
13 |
22,777,049 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1873:Vmn1r205
|
UTSW |
13 |
22,776,223 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2358:Vmn1r205
|
UTSW |
13 |
22,776,566 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2434:Vmn1r205
|
UTSW |
13 |
22,776,524 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3105:Vmn1r205
|
UTSW |
13 |
22,777,109 (GRCm39) |
unclassified |
probably benign |
|
|
R3725:Vmn1r205
|
UTSW |
13 |
22,776,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Vmn1r205
|
UTSW |
13 |
22,777,016 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4851:Vmn1r205
|
UTSW |
13 |
22,777,074 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5642:Vmn1r205
|
UTSW |
13 |
22,776,206 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7453:Vmn1r205
|
UTSW |
13 |
22,776,931 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8177:Vmn1r205
|
UTSW |
13 |
22,776,415 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8813:Vmn1r205
|
UTSW |
13 |
22,776,424 (GRCm39) |
missense |
probably benign |
0.36 |
|
| Predicted Primers |
PCR Primer
(F):5'- GACTGATAATGATGGCCTGGACC -3'
(R):5'- GGATTGCAGAGGCTTCCTTC -3'
Sequencing Primer
(F):5'- TAATGATGGCCTGGACCACAGTG -3'
(R):5'- TTGCAGAGGCTTCCTTCAAAAAGC -3'
|
| Posted On |
2018-05-24 |
Incidental Mutation