Incidental Mutation 'R6447:Trdv4'
ID 519236
Institutional Source Beutler Lab
Gene Symbol Trdv4
Ensembl Gene ENSMUSG00000076867
Gene Name T cell receptor delta variable 4
Synonyms
MMRRC Submission 044389-MU
Accession Numbers
Essential gene? Not available question?
Stock # R6447 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 54312461-54312972 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 54312931 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 102 (T102A)
Ref Sequence ENSEMBL: ENSMUSP00000100456 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103679]
AlphaFold Q5R1A3
Predicted Effect probably damaging
Transcript: ENSMUST00000103679
AA Change: T102A

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000100456
Gene: ENSMUSG00000076867
AA Change: T102A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
IGv 37 113 1.16e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198124
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm3 A G 3: 59,772,819 (GRCm39) I108V probably damaging Het
Axl C A 7: 25,469,708 (GRCm39) R476I probably damaging Het
Casr A G 16: 36,315,907 (GRCm39) L721P probably damaging Het
Cntn6 A T 6: 104,836,409 (GRCm39) H925L probably damaging Het
Csmd1 T C 8: 15,960,527 (GRCm39) Y3296C probably damaging Het
Dnah3 G A 7: 119,522,277 (GRCm39) T3972M probably benign Het
Ect2 A G 3: 27,169,633 (GRCm39) F740S probably damaging Het
Eif1ad10 T C 12: 88,216,494 (GRCm39) D126G unknown Het
Exoc1 T A 5: 76,691,364 (GRCm39) D222E probably damaging Het
Hdac2 T C 10: 36,869,812 (GRCm39) V258A possibly damaging Het
Lrrk1 A G 7: 65,952,476 (GRCm39) S487P probably benign Het
Lyplal1 A T 1: 185,821,639 (GRCm39) probably null Het
Nwd2 T A 5: 63,964,898 (GRCm39) I1494N probably benign Het
Pcdhb22 A G 18: 37,653,269 (GRCm39) E579G possibly damaging Het
Samd8 T C 14: 21,842,624 (GRCm39) probably null Het
Sccpdh A G 1: 179,506,453 (GRCm39) *131W probably null Het
Smarcal1 C T 1: 72,625,033 (GRCm39) S60L probably damaging Het
Stau2 A T 1: 16,460,049 (GRCm39) V264E possibly damaging Het
T T C 17: 8,660,463 (GRCm39) I217T possibly damaging Het
Tbc1d1 C T 5: 64,490,836 (GRCm39) L896F probably damaging Het
Thap1 CAGCATCTGCTCGGAGCA CAGCA 8: 26,650,884 (GRCm39) probably null Het
Tmprss11f T C 5: 86,676,086 (GRCm39) Y365C probably damaging Het
Vmn1r205 G T 13: 22,776,912 (GRCm39) N63K probably damaging Het
Vps13b T C 15: 35,572,272 (GRCm39) V963A probably benign Het
Zswim2 T C 2: 83,745,457 (GRCm39) probably null Het
Other mutations in Trdv4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03261:Trdv4 APN 14 54,312,875 (GRCm39) missense possibly damaging 0.79
R8826:Trdv4 UTSW 14 54,312,946 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACTGCACTGTAACAGGAGGGG -3'
(R):5'- AACTTCAAAGGGTGGGCCTTG -3'

Sequencing Primer
(F):5'- GGGACATGAAGAATTATCATATGAGC -3'
(R):5'- AGCCTTTCTTATCAGAGGTGAC -3'
Posted On 2018-05-24