Incidental Mutation 'R6448:C2'
ID |
519269 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
C2
|
Ensembl Gene |
ENSMUSG00000024371 |
Gene Name |
complement C2 |
Synonyms |
classical-complement pathway C3/C5 convertase |
MMRRC Submission |
044584-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.147)
|
Stock # |
R6448 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
35081578-35101076 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 35082335 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Alanine
at position 298
(D298A)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025229]
[ENSMUST00000025230]
[ENSMUST00000128767]
[ENSMUST00000148431]
[ENSMUST00000152417]
[ENSMUST00000146299]
[ENSMUST00000176203]
[ENSMUST00000154526]
|
AlphaFold |
P21180 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000025229
|
SMART Domains |
Protein: ENSMUSP00000025229 Gene: ENSMUSG00000090231
Domain | Start | End | E-Value | Type |
low complexity region
|
8 |
23 |
N/A |
INTRINSIC |
CCP
|
36 |
88 |
5.15e-1 |
SMART |
CCP
|
102 |
157 |
4.62e-15 |
SMART |
CCP
|
164 |
217 |
2.06e-12 |
SMART |
VWA
|
267 |
472 |
1.07e-40 |
SMART |
Tryp_SPc
|
480 |
751 |
2.53e-30 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000025230
AA Change: D682A
PolyPhen 2
Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
|
SMART Domains |
Protein: ENSMUSP00000025230 Gene: ENSMUSG00000024371 AA Change: D682A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Blast:CCP
|
22 |
71 |
8e-24 |
BLAST |
low complexity region
|
72 |
83 |
N/A |
INTRINSIC |
CCP
|
94 |
149 |
1.34e-11 |
SMART |
CCP
|
156 |
210 |
1.89e-11 |
SMART |
Blast:VWA
|
219 |
245 |
1e-7 |
BLAST |
VWA
|
259 |
464 |
1.32e-31 |
SMART |
Tryp_SPc
|
468 |
747 |
4.43e-26 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127795
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000128767
|
SMART Domains |
Protein: ENSMUSP00000119977 Gene: ENSMUSG00000090231
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
21 |
N/A |
INTRINSIC |
CCP
|
34 |
86 |
5.15e-1 |
SMART |
CCP
|
100 |
155 |
4.62e-15 |
SMART |
CCP
|
162 |
215 |
2.06e-12 |
SMART |
VWA
|
265 |
470 |
1.07e-40 |
SMART |
Tryp_SPc
|
478 |
749 |
2.53e-30 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000129891
AA Change: D298A
PolyPhen 2
Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000120864 Gene: ENSMUSG00000092511 AA Change: D298A
Domain | Start | End | E-Value | Type |
Blast:VWA
|
2 |
77 |
8e-7 |
BLAST |
Tryp_SPc
|
85 |
365 |
5.69e-8 |
SMART |
CCP
|
310 |
365 |
4.62e-15 |
SMART |
CCP
|
372 |
425 |
2.06e-12 |
SMART |
VWA
|
475 |
680 |
1.07e-40 |
SMART |
Tryp_SPc
|
688 |
959 |
2.53e-30 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000133127
|
SMART Domains |
Protein: ENSMUSP00000118360 Gene: ENSMUSG00000090231
Domain | Start | End | E-Value | Type |
PDB:2WIN|L
|
2 |
43 |
2e-20 |
PDB |
Blast:VWA
|
13 |
44 |
9e-11 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000134300
|
SMART Domains |
Protein: ENSMUSP00000114241 Gene: ENSMUSG00000024371
Domain | Start | End | E-Value | Type |
Tryp_SPc
|
3 |
148 |
6.48e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000148431
AA Change: D405A
PolyPhen 2
Score 0.093 (Sensitivity: 0.93; Specificity: 0.85)
|
SMART Domains |
Protein: ENSMUSP00000120009 Gene: ENSMUSG00000024371 AA Change: D405A
Domain | Start | End | E-Value | Type |
VWA
|
33 |
187 |
2.33e0 |
SMART |
Tryp_SPc
|
191 |
470 |
4.43e-26 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000152417
AA Change: D545A
PolyPhen 2
Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
|
SMART Domains |
Protein: ENSMUSP00000123536 Gene: ENSMUSG00000024371 AA Change: D545A
Domain | Start | End | E-Value | Type |
low complexity region
|
4 |
13 |
N/A |
INTRINSIC |
CCP
|
19 |
73 |
1.89e-11 |
SMART |
Blast:VWA
|
82 |
108 |
2e-7 |
BLAST |
VWA
|
122 |
327 |
1.32e-31 |
SMART |
Tryp_SPc
|
331 |
610 |
4.43e-26 |
SMART |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000146299
AA Change: D529A
|
SMART Domains |
Protein: ENSMUSP00000117677 Gene: ENSMUSG00000092511 AA Change: D529A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
low complexity region
|
72 |
83 |
N/A |
INTRINSIC |
CCP
|
94 |
148 |
1.89e-11 |
SMART |
VWA
|
103 |
311 |
1.74e-1 |
SMART |
Tryp_SPc
|
315 |
547 |
1.49e-7 |
SMART |
CCP
|
549 |
601 |
5.15e-1 |
SMART |
CCP
|
615 |
670 |
4.62e-15 |
SMART |
CCP
|
677 |
730 |
2.06e-12 |
SMART |
VWA
|
780 |
985 |
1.07e-40 |
SMART |
Tryp_SPc
|
993 |
1264 |
2.53e-30 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176332
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000141295
|
SMART Domains |
Protein: ENSMUSP00000118945 Gene: ENSMUSG00000090231
Domain | Start | End | E-Value | Type |
Tryp_SPc
|
18 |
258 |
3.76e-7 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176203
|
SMART Domains |
Protein: ENSMUSP00000135660 Gene: ENSMUSG00000090231
Domain | Start | End | E-Value | Type |
low complexity region
|
8 |
23 |
N/A |
INTRINSIC |
CCP
|
36 |
88 |
5.15e-1 |
SMART |
CCP
|
102 |
157 |
4.62e-15 |
SMART |
CCP
|
164 |
217 |
2.06e-12 |
SMART |
VWA
|
267 |
472 |
1.07e-40 |
SMART |
Tryp_SPc
|
480 |
713 |
5.03e-5 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000154526
|
SMART Domains |
Protein: ENSMUSP00000120990 Gene: ENSMUSG00000090231
Domain | Start | End | E-Value | Type |
low complexity region
|
6 |
21 |
N/A |
INTRINSIC |
CCP
|
34 |
86 |
5.15e-1 |
SMART |
CCP
|
100 |
155 |
4.62e-15 |
SMART |
CCP
|
162 |
215 |
2.06e-12 |
SMART |
VWA
|
265 |
470 |
1.07e-40 |
SMART |
Tryp_SPc
|
478 |
711 |
5.03e-5 |
SMART |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.8%
- 20x: 93.3%
|
Validation Efficiency |
97% (32/33) |
MGI Phenotype |
FUNCTION: This gene encodes component C2 of the classical pathway of the complement system. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the complement system. Mice lacking the encoded protein are found to be more susceptible to bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 31 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arhgap5 |
A |
T |
12: 52,564,446 (GRCm39) |
K472N |
probably benign |
Het |
Col16a1 |
T |
G |
4: 129,952,781 (GRCm39) |
L409R |
probably damaging |
Het |
Dlgap1 |
A |
G |
17: 70,900,325 (GRCm39) |
E380G |
possibly damaging |
Het |
Fam111a |
C |
A |
19: 12,565,701 (GRCm39) |
H483Q |
probably benign |
Het |
Fancc |
C |
T |
13: 63,488,242 (GRCm39) |
R246Q |
probably damaging |
Het |
Glb1 |
A |
T |
9: 114,263,499 (GRCm39) |
Q256L |
probably damaging |
Het |
Gm9195 |
A |
T |
14: 72,671,451 (GRCm39) |
D2611E |
possibly damaging |
Het |
Gsto1 |
C |
T |
19: 47,846,420 (GRCm39) |
T89I |
probably benign |
Het |
Hmcn2 |
A |
G |
2: 31,310,832 (GRCm39) |
S3359G |
probably benign |
Het |
Hook3 |
T |
A |
8: 26,583,692 (GRCm39) |
N87I |
probably benign |
Het |
Htt |
T |
A |
5: 35,033,336 (GRCm39) |
M1868K |
probably benign |
Het |
Ighv1-19 |
T |
C |
12: 114,672,296 (GRCm39) |
E107G |
probably damaging |
Het |
Il20rb |
A |
T |
9: 100,356,986 (GRCm39) |
M48K |
probably benign |
Het |
Inpp5j |
T |
C |
11: 3,445,387 (GRCm39) |
H822R |
probably damaging |
Het |
Kif14 |
G |
T |
1: 136,431,085 (GRCm39) |
V1161F |
probably damaging |
Het |
Klhdc2 |
T |
A |
12: 69,350,694 (GRCm39) |
D169E |
probably benign |
Het |
Ly75 |
A |
G |
2: 60,129,389 (GRCm39) |
|
probably null |
Het |
Myh15 |
T |
G |
16: 48,992,295 (GRCm39) |
S1590A |
probably damaging |
Het |
Ncbp2 |
CGTCTGGATG |
CG |
16: 31,775,161 (GRCm39) |
|
probably null |
Het |
Neb |
T |
C |
2: 52,038,826 (GRCm39) |
D6748G |
probably damaging |
Het |
Nfrkb |
T |
C |
9: 31,306,085 (GRCm39) |
Y142H |
probably damaging |
Het |
Or6c208 |
A |
T |
10: 129,224,021 (GRCm39) |
D173V |
probably damaging |
Het |
Or7a39 |
G |
A |
10: 78,715,516 (GRCm39) |
C170Y |
possibly damaging |
Het |
Or8k20 |
T |
A |
2: 86,106,691 (GRCm39) |
I47F |
probably benign |
Het |
Prm2 |
G |
A |
16: 10,609,825 (GRCm39) |
|
probably benign |
Het |
Ralgapa1 |
T |
C |
12: 55,766,446 (GRCm39) |
T1283A |
probably benign |
Het |
Rest |
T |
C |
5: 77,429,318 (GRCm39) |
L579P |
possibly damaging |
Het |
Slc6a1 |
C |
T |
6: 114,279,047 (GRCm39) |
T46I |
possibly damaging |
Het |
Tcf20 |
A |
G |
15: 82,736,861 (GRCm39) |
I1530T |
probably benign |
Het |
Tox |
T |
G |
4: 6,822,975 (GRCm39) |
D114A |
probably benign |
Het |
Ulk4 |
C |
T |
9: 120,932,696 (GRCm39) |
G1048D |
probably damaging |
Het |
|
Other mutations in C2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02191:C2
|
APN |
17 |
35,085,539 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02249:C2
|
APN |
17 |
35,083,484 (GRCm39) |
unclassified |
probably benign |
|
IGL02568:C2
|
APN |
17 |
35,083,325 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL03013:C2
|
APN |
17 |
35,091,435 (GRCm39) |
missense |
probably damaging |
0.98 |
R0142:C2
|
UTSW |
17 |
35,092,504 (GRCm39) |
missense |
possibly damaging |
0.53 |
R0619:C2
|
UTSW |
17 |
35,091,479 (GRCm39) |
missense |
probably damaging |
1.00 |
R1401:C2
|
UTSW |
17 |
35,091,457 (GRCm39) |
missense |
possibly damaging |
0.71 |
R1639:C2
|
UTSW |
17 |
35,091,379 (GRCm39) |
missense |
probably benign |
0.02 |
R1808:C2
|
UTSW |
17 |
35,083,508 (GRCm39) |
missense |
probably damaging |
1.00 |
R2133:C2
|
UTSW |
17 |
35,098,878 (GRCm39) |
missense |
probably damaging |
1.00 |
R2860:C2
|
UTSW |
17 |
35,082,854 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2861:C2
|
UTSW |
17 |
35,082,854 (GRCm39) |
missense |
possibly damaging |
0.94 |
R3882:C2
|
UTSW |
17 |
35,092,465 (GRCm39) |
missense |
probably benign |
0.00 |
R4571:C2
|
UTSW |
17 |
35,082,635 (GRCm39) |
missense |
probably benign |
0.00 |
R4622:C2
|
UTSW |
17 |
35,082,650 (GRCm39) |
missense |
probably damaging |
0.99 |
R5611:C2
|
UTSW |
17 |
35,091,360 (GRCm39) |
missense |
probably damaging |
0.99 |
R5767:C2
|
UTSW |
17 |
35,095,432 (GRCm39) |
missense |
possibly damaging |
0.58 |
R6327:C2
|
UTSW |
17 |
35,083,079 (GRCm39) |
missense |
probably benign |
0.41 |
R6518:C2
|
UTSW |
17 |
35,083,094 (GRCm39) |
missense |
probably damaging |
1.00 |
R6929:C2
|
UTSW |
17 |
35,083,323 (GRCm39) |
missense |
possibly damaging |
0.68 |
R7324:C2
|
UTSW |
17 |
35,100,664 (GRCm39) |
missense |
probably benign |
0.13 |
R7446:C2
|
UTSW |
17 |
35,094,986 (GRCm39) |
missense |
probably damaging |
1.00 |
R7456:C2
|
UTSW |
17 |
35,083,558 (GRCm39) |
missense |
probably damaging |
1.00 |
R7479:C2
|
UTSW |
17 |
35,082,441 (GRCm39) |
missense |
probably damaging |
1.00 |
R7807:C2
|
UTSW |
17 |
35,095,347 (GRCm39) |
missense |
possibly damaging |
0.79 |
R7943:C2
|
UTSW |
17 |
35,091,354 (GRCm39) |
missense |
probably damaging |
1.00 |
R9235:C2
|
UTSW |
17 |
35,083,845 (GRCm39) |
missense |
probably damaging |
1.00 |
R9397:C2
|
UTSW |
17 |
35,094,965 (GRCm39) |
missense |
probably damaging |
1.00 |
R9452:C2
|
UTSW |
17 |
35,095,319 (GRCm39) |
missense |
probably benign |
0.01 |
R9605:C2
|
UTSW |
17 |
35,081,958 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Predicted Primers |
PCR Primer
(F):5'- AGAAGAACTTGTGCCCTGGC -3'
(R):5'- GCCTAATGTCTCCTGGAATGTC -3'
Sequencing Primer
(F):5'- CCTGGAAGAACCTGTATCTCCG -3'
(R):5'- AATGTCCTCATTCTTCTCTCCTATG -3'
|
Posted On |
2018-05-24 |