Incidental Mutation 'R6452:Vmn2r96'
ID 519441
Institutional Source Beutler Lab
Gene Symbol Vmn2r96
Ensembl Gene ENSMUSG00000091679
Gene Name vomeronasal 2, receptor 96
Synonyms EG433070
MMRRC Submission 044588-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R6452 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 18793282-18818419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 18804117 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 264 (T264P)
Ref Sequence ENSEMBL: ENSMUSP00000131564 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165692] [ENSMUST00000177244] [ENSMUST00000231261] [ENSMUST00000231286]
AlphaFold E9PZU5
Predicted Effect probably benign
Transcript: ENSMUST00000165692
AA Change: T264P

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000131564
Gene: ENSMUSG00000091679
AA Change: T264P

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 257 8.6e-20 PFAM
Pfam:NCD3G 317 370 3.7e-22 PFAM
Pfam:7tm_3 402 638 3.9e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177244
AA Change: T456P

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: T456P

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 245 4.2e-19 PFAM
Pfam:NCD3G 317 370 6.9e-21 PFAM
Pfam:7tm_3 400 639 3.4e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231261
Predicted Effect probably benign
Transcript: ENSMUST00000231286
AA Change: T456P

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110070M22Rik A G 13: 119,624,651 (GRCm39) probably benign Het
Alox12e A T 11: 70,210,831 (GRCm39) V296E probably damaging Het
Bmal2 G A 6: 146,724,705 (GRCm39) E400K probably benign Het
Ccdc171 A G 4: 83,782,527 (GRCm39) D1273G probably damaging Het
Cetn3 C T 13: 81,932,797 (GRCm39) R19* probably null Het
Chd6 G T 2: 160,807,418 (GRCm39) P1932H possibly damaging Het
Cimip1 C A 2: 173,369,700 (GRCm39) F71L probably benign Het
Cyp2d34 A T 15: 82,500,290 (GRCm39) I483N probably benign Het
Dglucy T C 12: 100,801,468 (GRCm39) V71A possibly damaging Het
Dhx35 A G 2: 158,673,607 (GRCm39) E346G probably damaging Het
Dnajc14 A G 10: 128,643,359 (GRCm39) E427G probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Fasn G T 11: 120,706,237 (GRCm39) Q1036K probably damaging Het
Fermt3 A T 19: 6,992,105 (GRCm39) F92I probably benign Het
Filip1l C A 16: 57,327,163 (GRCm39) D64E possibly damaging Het
Fnbp1l A G 3: 122,338,198 (GRCm39) F491S probably damaging Het
Fzd2 T G 11: 102,495,811 (GRCm39) V85G probably damaging Het
Gjd4 G A 18: 9,280,457 (GRCm39) T207M possibly damaging Het
Gm32742 T C 9: 51,057,490 (GRCm39) E1096G probably damaging Het
Itgb3 T A 11: 104,524,290 (GRCm39) L142* probably null Het
Kctd21 T A 7: 96,996,869 (GRCm39) I114N probably benign Het
Klra4 G T 6: 130,042,329 (GRCm39) probably null Het
Larp4b T C 13: 9,197,503 (GRCm39) V240A probably damaging Het
Lrriq4 T C 3: 30,709,882 (GRCm39) S409P probably damaging Het
Magel2 A G 7: 62,030,132 (GRCm39) E1012G unknown Het
Mmp24 A T 2: 155,657,673 (GRCm39) D521V possibly damaging Het
Mocos A G 18: 24,828,998 (GRCm39) I768V probably benign Het
Mprip A T 11: 59,643,609 (GRCm39) E553V probably damaging Het
Myh8 A T 11: 67,196,565 (GRCm39) I1762F possibly damaging Het
Myh8 A T 11: 67,183,275 (GRCm39) Y718F probably benign Het
Myo7a C T 7: 97,722,374 (GRCm39) V1184M probably benign Het
Neb A T 2: 52,069,495 (GRCm39) D5775E probably benign Het
Or10h5 T C 17: 33,434,919 (GRCm39) N133S probably benign Het
Or5p66 A G 7: 107,886,100 (GRCm39) S78P probably damaging Het
Pramel19 T C 4: 101,798,640 (GRCm39) Y204H probably benign Het
Prl8a2 T C 13: 27,536,780 (GRCm39) I134T probably benign Het
Qrich2 G A 11: 116,346,714 (GRCm39) T1370I probably benign Het
Rabgap1l A G 1: 160,281,331 (GRCm39) L630P probably damaging Het
Ranbp2 G T 10: 58,313,979 (GRCm39) L1566F probably benign Het
Rnf43 T A 11: 87,623,079 (GRCm39) W727R probably damaging Het
Rundc3b A T 5: 8,629,175 (GRCm39) probably null Het
Samm50 T G 15: 84,088,298 (GRCm39) probably benign Het
Sema4f G A 6: 82,894,643 (GRCm39) A476V probably benign Het
Slc4a4 A G 5: 89,376,839 (GRCm39) N1031S probably benign Het
Slc4a9 A G 18: 36,664,512 (GRCm39) Y390C probably damaging Het
Slco6d1 C A 1: 98,348,937 (GRCm39) Q3K probably benign Het
Smim1 T C 4: 154,108,071 (GRCm39) probably benign Het
Spg7 A G 8: 123,806,162 (GRCm39) K291E possibly damaging Het
Sppl2c A T 11: 104,079,017 (GRCm39) T606S probably benign Het
Tex15 A G 8: 34,062,844 (GRCm39) D758G probably damaging Het
Tigd5 A T 15: 75,783,287 (GRCm39) R550* probably null Het
Tlcd3a G T 11: 76,097,972 (GRCm39) G60* probably null Het
Tnrc18 A C 5: 142,712,767 (GRCm39) L2594R probably damaging Het
Vezf1 A G 11: 87,972,496 (GRCm39) T468A possibly damaging Het
Vmn1r210 T A 13: 23,011,840 (GRCm39) I149F probably damaging Het
Zfp217 C G 2: 169,961,214 (GRCm39) S371T probably benign Het
Zfp442 G A 2: 150,250,028 (GRCm39) H568Y probably damaging Het
Zfp53 A C 17: 21,729,875 (GRCm39) H636P probably damaging Het
Zscan4d C T 7: 10,895,999 (GRCm39) C457Y probably damaging Het
Other mutations in Vmn2r96
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Vmn2r96 APN 17 18,804,077 (GRCm39) missense probably benign 0.00
IGL00563:Vmn2r96 APN 17 18,804,077 (GRCm39) missense probably benign 0.00
IGL00769:Vmn2r96 APN 17 18,804,081 (GRCm39) missense probably benign 0.00
IGL01314:Vmn2r96 APN 17 18,803,226 (GRCm39) missense probably benign 0.00
IGL01983:Vmn2r96 APN 17 18,817,527 (GRCm39) missense probably damaging 0.99
IGL02314:Vmn2r96 APN 17 18,804,221 (GRCm39) missense probably benign 0.01
IGL02600:Vmn2r96 APN 17 18,817,829 (GRCm39) missense probably benign
IGL02672:Vmn2r96 APN 17 18,818,376 (GRCm39) missense probably benign 0.02
IGL02750:Vmn2r96 APN 17 18,802,851 (GRCm39) missense probably benign 0.01
IGL03068:Vmn2r96 APN 17 18,803,137 (GRCm39) missense probably benign 0.00
IGL03411:Vmn2r96 APN 17 18,806,634 (GRCm39) missense possibly damaging 0.88
R0316:Vmn2r96 UTSW 17 18,802,827 (GRCm39) missense probably damaging 1.00
R0502:Vmn2r96 UTSW 17 18,804,262 (GRCm39) missense probably benign
R0580:Vmn2r96 UTSW 17 18,802,900 (GRCm39) missense probably damaging 1.00
R0652:Vmn2r96 UTSW 17 18,817,830 (GRCm39) missense probably benign 0.05
R0789:Vmn2r96 UTSW 17 18,802,738 (GRCm39) missense possibly damaging 0.81
R1462:Vmn2r96 UTSW 17 18,817,660 (GRCm39) missense possibly damaging 0.94
R1462:Vmn2r96 UTSW 17 18,817,660 (GRCm39) missense possibly damaging 0.94
R1660:Vmn2r96 UTSW 17 18,817,988 (GRCm39) missense probably benign 0.00
R1755:Vmn2r96 UTSW 17 18,802,915 (GRCm39) missense possibly damaging 0.50
R1843:Vmn2r96 UTSW 17 18,818,183 (GRCm39) missense probably benign 0.14
R1943:Vmn2r96 UTSW 17 18,806,664 (GRCm39) missense probably benign 0.09
R1993:Vmn2r96 UTSW 17 18,804,138 (GRCm39) missense probably damaging 1.00
R2018:Vmn2r96 UTSW 17 18,804,263 (GRCm39) missense probably benign
R2405:Vmn2r96 UTSW 17 18,818,102 (GRCm39) missense probably damaging 0.96
R3977:Vmn2r96 UTSW 17 18,817,941 (GRCm39) missense probably damaging 1.00
R3979:Vmn2r96 UTSW 17 18,817,941 (GRCm39) missense probably damaging 1.00
R4059:Vmn2r96 UTSW 17 18,818,339 (GRCm39) missense probably benign 0.20
R4693:Vmn2r96 UTSW 17 18,803,270 (GRCm39) missense probably benign 0.03
R4709:Vmn2r96 UTSW 17 18,803,088 (GRCm39) missense probably benign 0.36
R4776:Vmn2r96 UTSW 17 18,817,770 (GRCm39) missense probably damaging 1.00
R4882:Vmn2r96 UTSW 17 18,817,866 (GRCm39) missense probably damaging 1.00
R4920:Vmn2r96 UTSW 17 18,802,918 (GRCm39) missense probably benign 0.07
R5143:Vmn2r96 UTSW 17 18,804,120 (GRCm39) missense possibly damaging 0.65
R5301:Vmn2r96 UTSW 17 18,817,950 (GRCm39) missense probably damaging 0.98
R5507:Vmn2r96 UTSW 17 18,818,091 (GRCm39) missense probably damaging 1.00
R6151:Vmn2r96 UTSW 17 18,804,221 (GRCm39) missense probably benign 0.01
R6181:Vmn2r96 UTSW 17 18,804,126 (GRCm39) missense probably benign
R6339:Vmn2r96 UTSW 17 18,804,124 (GRCm39) missense possibly damaging 0.84
R6404:Vmn2r96 UTSW 17 18,817,793 (GRCm39) missense probably damaging 1.00
R6749:Vmn2r96 UTSW 17 18,818,352 (GRCm39) missense probably damaging 0.99
R6813:Vmn2r96 UTSW 17 18,802,116 (GRCm39) missense probably benign 0.04
R6851:Vmn2r96 UTSW 17 18,802,800 (GRCm39) missense possibly damaging 0.95
R6944:Vmn2r96 UTSW 17 18,817,891 (GRCm39) missense probably benign 0.16
R6949:Vmn2r96 UTSW 17 18,818,100 (GRCm39) missense probably damaging 1.00
R6962:Vmn2r96 UTSW 17 18,818,283 (GRCm39) missense probably damaging 0.99
R6990:Vmn2r96 UTSW 17 18,804,082 (GRCm39) missense probably benign
R7149:Vmn2r96 UTSW 17 18,817,989 (GRCm39) missense possibly damaging 0.89
R7346:Vmn2r96 UTSW 17 18,803,029 (GRCm39) missense probably benign 0.15
R7385:Vmn2r96 UTSW 17 18,803,302 (GRCm39) missense probably damaging 1.00
R7442:Vmn2r96 UTSW 17 18,793,662 (GRCm39) missense probably benign 0.02
R7509:Vmn2r96 UTSW 17 18,802,995 (GRCm39) missense probably benign 0.02
R7652:Vmn2r96 UTSW 17 18,793,832 (GRCm39) missense probably benign
R7659:Vmn2r96 UTSW 17 18,793,749 (GRCm39) missense probably benign 0.00
R7753:Vmn2r96 UTSW 17 18,806,663 (GRCm39) missense possibly damaging 0.46
R7855:Vmn2r96 UTSW 17 18,818,130 (GRCm39) missense possibly damaging 0.59
R8166:Vmn2r96 UTSW 17 18,802,744 (GRCm39) missense probably damaging 1.00
R8260:Vmn2r96 UTSW 17 18,804,243 (GRCm39) missense probably benign 0.04
R8323:Vmn2r96 UTSW 17 18,803,023 (GRCm39) missense probably damaging 0.99
R8787:Vmn2r96 UTSW 17 18,818,250 (GRCm39) missense probably damaging 1.00
R8837:Vmn2r96 UTSW 17 18,802,888 (GRCm39) missense probably benign
R8933:Vmn2r96 UTSW 17 18,804,241 (GRCm39) missense probably benign 0.11
R9306:Vmn2r96 UTSW 17 18,803,226 (GRCm39) missense probably benign 0.00
R9481:Vmn2r96 UTSW 17 18,793,621 (GRCm39) start gained probably benign
R9626:Vmn2r96 UTSW 17 18,793,758 (GRCm39) missense probably benign 0.14
R9629:Vmn2r96 UTSW 17 18,803,257 (GRCm39) missense probably benign 0.15
Z1088:Vmn2r96 UTSW 17 18,817,628 (GRCm39) missense possibly damaging 0.86
Z1177:Vmn2r96 UTSW 17 18,818,376 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CAGTCAGGTTTTCACTAAGTCATC -3'
(R):5'- ACTCCAAGTGTAATGGAACTTGAGTC -3'

Sequencing Primer
(F):5'- GGTTTTCACTAAGTCATCATTAGTGG -3'
(R):5'- AAGCATTTAGGTAAAACATAACCCAC -3'
Posted On 2018-05-24