Incidental Mutation 'R6162:Adh4'
ID 519606
Institutional Source Beutler Lab
Gene Symbol Adh4
Ensembl Gene ENSMUSG00000037797
Gene Name alcohol dehydrogenase 4 (class II), pi polypeptide
Synonyms Adh2, mouse class II type ADH
MMRRC Submission 044309-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R6162 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 138121227-138136653 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 138121250 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000013458 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013458] [ENSMUST00000161312]
AlphaFold Q9QYY9
PDB Structure Mouse class II alcohol dehydrogenase complex with NADH [X-RAY DIFFRACTION]
Mouse class II alcohol dehydrogenase complex with NADH and inhibitor [X-RAY DIFFRACTION]
P47H MUTANT OF MOUSE CLASS II ALCOHOL DEHYDROGENASE COMPLEX WITH NADH [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000013458
SMART Domains Protein: ENSMUSP00000013458
Gene: ENSMUSG00000037797

DomainStartEndE-ValueType
Pfam:ADH_N 34 165 3.1e-23 PFAM
Pfam:ADH_zinc_N 207 337 8.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161312
SMART Domains Protein: ENSMUSP00000124163
Gene: ENSMUSG00000037797

DomainStartEndE-ValueType
Pfam:ADH_N 46 177 2.8e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162260
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,259,047 (GRCm39) C2924W probably damaging Het
Aox3 A T 1: 58,198,890 (GRCm39) D695V possibly damaging Het
Ccnj A G 19: 40,833,606 (GRCm39) Y221C probably damaging Het
Cct2 T A 10: 116,894,091 (GRCm39) D221V probably damaging Het
Cd5 G A 19: 10,703,244 (GRCm39) T138M probably damaging Het
Cep78 A T 19: 15,952,304 (GRCm39) M307K probably benign Het
Dclk1 C A 3: 55,163,575 (GRCm39) D222E probably benign Het
Dhrs11 C T 11: 84,719,605 (GRCm39) G40D probably damaging Het
Dnah10 A G 5: 124,900,382 (GRCm39) S3823G probably benign Het
Dnai3 T A 3: 145,750,617 (GRCm39) I821F probably damaging Het
Dock3 A T 9: 106,841,998 (GRCm39) Y944N possibly damaging Het
Dst A G 1: 34,045,318 (GRCm39) D17G probably damaging Het
Ehmt2 C T 17: 35,118,067 (GRCm39) R40* probably null Het
Fam20a G T 11: 109,573,696 (GRCm39) S229* probably null Het
Fbn1 T C 2: 125,202,147 (GRCm39) D1242G probably damaging Het
Ggt5 T A 10: 75,425,626 (GRCm39) V28D possibly damaging Het
Gimap4 A T 6: 48,667,655 (GRCm39) I137F probably damaging Het
Git2 T A 5: 114,899,717 (GRCm39) H212L probably damaging Het
Gprc6a T A 10: 51,491,008 (GRCm39) I739F probably benign Het
Il1rl2 A G 1: 40,391,038 (GRCm39) Y327C probably damaging Het
Lmf1 A G 17: 25,831,368 (GRCm39) I205V probably benign Het
Mipep C A 14: 61,024,853 (GRCm39) P98Q probably damaging Het
Mroh2b A G 15: 4,944,707 (GRCm39) D436G probably damaging Het
Mtcl2 T A 2: 156,881,784 (GRCm39) E756V possibly damaging Het
Myorg A G 4: 41,497,899 (GRCm39) V577A possibly damaging Het
Notch1 C T 2: 26,352,207 (GRCm39) V2035I probably benign Het
Or1e28-ps1 T A 11: 73,615,713 (GRCm39) I46F probably damaging Het
Or2ag16 A T 7: 106,352,227 (GRCm39) Y123N probably damaging Het
Or4c118 G T 2: 88,975,114 (GRCm39) F84L probably benign Het
Oxa1l A G 14: 54,605,789 (GRCm39) T395A probably damaging Het
Phospho2 T A 2: 69,626,375 (GRCm39) I177K probably damaging Het
Prpf40a T C 2: 53,049,317 (GRCm39) T224A probably benign Het
Reln T A 5: 22,116,048 (GRCm39) T2987S probably damaging Het
Scn5a T A 9: 119,351,621 (GRCm39) I787F probably damaging Het
Sgsm2 A T 11: 74,782,847 (GRCm39) D36E probably damaging Het
Slc12a3 A G 8: 95,072,401 (GRCm39) probably null Het
Tas2r134 T C 2: 51,517,571 (GRCm39) S17P probably damaging Het
Top3a T C 11: 60,636,763 (GRCm39) Y609C probably damaging Het
Trem2 A G 17: 48,655,694 (GRCm39) I84V probably damaging Het
Vmn2r12 A G 5: 109,234,430 (GRCm39) L594P probably damaging Het
Zdbf2 A T 1: 63,319,977 (GRCm39) probably benign Het
Zfr C T 15: 12,146,331 (GRCm39) A294V unknown Het
Other mutations in Adh4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Adh4 APN 3 138,126,397 (GRCm39) missense probably damaging 0.99
IGL01450:Adh4 APN 3 138,129,794 (GRCm39) missense probably benign 0.05
IGL01608:Adh4 APN 3 138,134,788 (GRCm39) unclassified probably benign
IGL01618:Adh4 APN 3 138,134,788 (GRCm39) unclassified probably benign
IGL01621:Adh4 APN 3 138,134,788 (GRCm39) unclassified probably benign
IGL01640:Adh4 APN 3 138,134,788 (GRCm39) unclassified probably benign
IGL01979:Adh4 APN 3 138,134,788 (GRCm39) unclassified probably benign
IGL01982:Adh4 APN 3 138,134,788 (GRCm39) unclassified probably benign
IGL01993:Adh4 APN 3 138,134,788 (GRCm39) unclassified probably benign
IGL02720:Adh4 APN 3 138,124,981 (GRCm39) missense possibly damaging 0.87
IGL03030:Adh4 APN 3 138,134,906 (GRCm39) missense probably benign 0.13
PIT4403001:Adh4 UTSW 3 138,129,939 (GRCm39) missense probably damaging 0.97
R0295:Adh4 UTSW 3 138,134,837 (GRCm39) missense probably damaging 1.00
R0308:Adh4 UTSW 3 138,129,863 (GRCm39) missense probably damaging 1.00
R0636:Adh4 UTSW 3 138,133,835 (GRCm39) missense probably damaging 1.00
R1450:Adh4 UTSW 3 138,129,935 (GRCm39) missense probably damaging 1.00
R4824:Adh4 UTSW 3 138,134,807 (GRCm39) missense possibly damaging 0.81
R5137:Adh4 UTSW 3 138,127,996 (GRCm39) missense probably benign 0.00
R5263:Adh4 UTSW 3 138,133,816 (GRCm39) missense probably benign 0.00
R5566:Adh4 UTSW 3 138,129,950 (GRCm39) missense probably damaging 1.00
R7297:Adh4 UTSW 3 138,134,901 (GRCm39) missense possibly damaging 0.88
R8430:Adh4 UTSW 3 138,128,145 (GRCm39) missense probably damaging 1.00
R9053:Adh4 UTSW 3 138,128,045 (GRCm39) missense probably damaging 0.99
R9253:Adh4 UTSW 3 138,129,860 (GRCm39) missense probably damaging 1.00
Z1187:Adh4 UTSW 3 138,125,091 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GATGGAGATGACCTTTGCTTAGTAAC -3'
(R):5'- ACTTCAGTCGCTGTGCCTTG -3'

Sequencing Primer
(F):5'- TGCACTTTGTCTAGTTGATACATTG -3'
(R):5'- TGCCTTGAGTGTAACCCGGAAG -3'
Posted On 2018-06-04