Incidental Mutation 'R6499:Or5p79'
ID 519628
Institutional Source Beutler Lab
Gene Symbol Or5p79
Ensembl Gene ENSMUSG00000061000
Gene Name olfactory receptor family 5 subfamily P member 79
Synonyms Olfr507, GA_x6K02T2PBJ9-10951546-10952496, MOR204-7
MMRRC Submission 044631-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R6499 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108221021-108221971 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 108221713 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 231 (M231I)
Ref Sequence ENSEMBL: ENSMUSP00000078926 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080014]
AlphaFold Q8VG13
Predicted Effect probably benign
Transcript: ENSMUST00000080014
AA Change: M231I

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000078926
Gene: ENSMUSG00000061000
AA Change: M231I

DomainStartEndE-ValueType
Pfam:7tm_4 34 313 6.1e-52 PFAM
Pfam:7tm_1 44 295 1e-20 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency 98% (43/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,774,561 (GRCm39) T1250M probably damaging Het
Actn1 C T 12: 80,215,191 (GRCm39) A857T possibly damaging Het
Adam2 C T 14: 66,296,239 (GRCm39) V207I probably damaging Het
Angpt2 T C 8: 18,744,533 (GRCm39) T404A probably benign Het
Ank3 T C 10: 69,827,574 (GRCm39) probably benign Het
Atosa C A 9: 74,930,930 (GRCm39) Q958K probably damaging Het
B4galt4 T A 16: 38,578,184 (GRCm39) D210E probably benign Het
Brinp3 A T 1: 146,777,431 (GRCm39) H626L possibly damaging Het
Ccna2 T G 3: 36,625,112 (GRCm39) D68A probably damaging Het
Cd163 G A 6: 124,281,703 (GRCm39) G2D probably benign Het
Chrm5 A T 2: 112,310,825 (GRCm39) V97D probably benign Het
Dctn5 G A 7: 121,734,320 (GRCm39) V55I probably benign Het
Dnm3 A T 1: 162,141,164 (GRCm39) I365N probably damaging Het
Esyt2 A G 12: 116,284,790 (GRCm39) D184G probably damaging Het
Ifi214 C A 1: 173,352,597 (GRCm39) K277N probably damaging Het
Il11ra1 C T 4: 41,765,412 (GRCm39) P169L probably benign Het
Inhbb C T 1: 119,345,069 (GRCm39) E407K probably damaging Het
Lama2 T A 10: 26,907,154 (GRCm39) T2336S probably damaging Het
Ldhb A T 6: 142,439,847 (GRCm39) V231E possibly damaging Het
Lrit2 T C 14: 36,790,767 (GRCm39) F149L probably damaging Het
Malrd1 T A 2: 15,936,500 (GRCm39) S1575T probably benign Het
Naip5 A G 13: 100,358,102 (GRCm39) C1045R probably benign Het
Nefl A G 14: 68,322,034 (GRCm39) E208G probably damaging Het
Oog4 A C 4: 143,164,548 (GRCm39) S328A probably damaging Het
Or1e1 T A 11: 73,245,011 (GRCm39) L144Q probably damaging Het
Or6c216 T C 10: 129,678,453 (GRCm39) I153V probably benign Het
Or7e168 A G 9: 19,719,847 (GRCm39) I78V probably benign Het
Pbrm1 A G 14: 30,783,466 (GRCm39) N528D probably damaging Het
Pls1 A G 9: 95,636,798 (GRCm39) I558T probably damaging Het
Polq T C 16: 36,881,189 (GRCm39) S839P probably benign Het
Psmg1 A G 16: 95,789,297 (GRCm39) F87L probably damaging Het
Ptprt A G 2: 161,376,507 (GRCm39) M1298T probably benign Het
Rbm27 T A 18: 42,470,076 (GRCm39) W958R probably damaging Het
Skint5 T G 4: 113,396,552 (GRCm39) D1207A unknown Het
Stx17 T A 4: 48,183,478 (GRCm39) probably null Het
Tas2r114 A T 6: 131,666,099 (GRCm39) *310R probably null Het
Tmem130 T A 5: 144,689,224 (GRCm39) N139I probably damaging Het
Trpc1 T C 9: 95,608,490 (GRCm39) E267G probably damaging Het
Trrap T A 5: 144,793,812 (GRCm39) M3398K probably damaging Het
Vrtn T G 12: 84,697,090 (GRCm39) D613E probably benign Het
Vsx1 G T 2: 150,530,441 (GRCm39) T147K probably benign Het
Wdr55 T C 18: 36,895,231 (GRCm39) V103A probably benign Het
Zfp712 A T 13: 67,200,400 (GRCm39) D28E probably benign Het
Other mutations in Or5p79
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01066:Or5p79 APN 7 108,221,064 (GRCm39) missense probably damaging 1.00
IGL01979:Or5p79 APN 7 108,221,648 (GRCm39) missense probably benign 0.09
IGL02373:Or5p79 APN 7 108,221,310 (GRCm39) missense probably benign 0.11
IGL02754:Or5p79 APN 7 108,221,880 (GRCm39) missense possibly damaging 0.94
IGL03008:Or5p79 APN 7 108,221,490 (GRCm39) missense probably damaging 0.99
R0305:Or5p79 UTSW 7 108,221,792 (GRCm39) missense probably benign 0.01
R0584:Or5p79 UTSW 7 108,221,622 (GRCm39) missense probably benign 0.00
R0611:Or5p79 UTSW 7 108,221,494 (GRCm39) missense possibly damaging 0.72
R0947:Or5p79 UTSW 7 108,221,879 (GRCm39) missense probably benign 0.02
R1488:Or5p79 UTSW 7 108,221,696 (GRCm39) missense probably damaging 1.00
R1808:Or5p79 UTSW 7 108,221,817 (GRCm39) missense possibly damaging 0.87
R3763:Or5p79 UTSW 7 108,221,924 (GRCm39) missense probably damaging 1.00
R4367:Or5p79 UTSW 7 108,221,096 (GRCm39) missense probably benign 0.27
R4369:Or5p79 UTSW 7 108,221,096 (GRCm39) missense probably benign 0.27
R4371:Or5p79 UTSW 7 108,221,096 (GRCm39) missense probably benign 0.27
R4609:Or5p79 UTSW 7 108,221,711 (GRCm39) missense probably benign 0.35
R5389:Or5p79 UTSW 7 108,221,924 (GRCm39) missense probably damaging 1.00
R6684:Or5p79 UTSW 7 108,221,141 (GRCm39) missense probably damaging 0.98
R7531:Or5p79 UTSW 7 108,221,269 (GRCm39) missense probably benign 0.06
R7555:Or5p79 UTSW 7 108,221,933 (GRCm39) missense probably damaging 1.00
R7893:Or5p79 UTSW 7 108,221,844 (GRCm39) missense probably damaging 1.00
R8415:Or5p79 UTSW 7 108,221,163 (GRCm39) missense probably damaging 1.00
R8444:Or5p79 UTSW 7 108,221,027 (GRCm39) missense probably benign 0.00
R8904:Or5p79 UTSW 7 108,221,919 (GRCm39) missense probably damaging 0.98
R9635:Or5p79 UTSW 7 108,221,654 (GRCm39) missense probably benign 0.00
R9795:Or5p79 UTSW 7 108,221,869 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- GTATCCAGTTGCTAGTGGGATC -3'
(R):5'- CATGGGGATTGCTATCGCTATC -3'

Sequencing Primer
(F):5'- CTCTTCTGTGGACCAAATAAAGTC -3'
(R):5'- GCTATCGCTATCATGTAAAACACAG -3'
Posted On 2018-06-06