Incidental Mutation 'R6499:Zfp712'
ID 519642
Institutional Source Beutler Lab
Gene Symbol Zfp712
Ensembl Gene ENSMUSG00000090641
Gene Name zinc finger protein 712
Synonyms 4921504N20Rik, mszf31, mszf89
MMRRC Submission 044631-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R6499 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 67186660-67209234 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 67200400 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 28 (D28E)
Ref Sequence ENSEMBL: ENSMUSP00000126665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167565]
AlphaFold E9PXJ4
Predicted Effect probably benign
Transcript: ENSMUST00000167565
AA Change: D28E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000126665
Gene: ENSMUSG00000090641
AA Change: D28E

DomainStartEndE-ValueType
KRAB 5 65 7.38e-36 SMART
ZnF_C2H2 109 131 1.28e-3 SMART
ZnF_C2H2 137 159 4.17e-3 SMART
ZnF_C2H2 165 186 1.73e0 SMART
ZnF_C2H2 192 214 3.39e-3 SMART
ZnF_C2H2 220 242 1.58e-3 SMART
ZnF_C2H2 248 270 8.34e-3 SMART
ZnF_C2H2 276 298 4.17e-3 SMART
ZnF_C2H2 304 326 4.87e-4 SMART
ZnF_C2H2 332 354 1.04e-3 SMART
ZnF_C2H2 360 382 5.5e-3 SMART
ZnF_C2H2 388 410 1.89e-1 SMART
ZnF_C2H2 416 438 7.15e-2 SMART
ZnF_C2H2 444 466 3.58e-2 SMART
ZnF_C2H2 472 494 5.99e-4 SMART
ZnF_C2H2 500 522 2.12e-4 SMART
ZnF_C2H2 528 550 3.83e-2 SMART
ZnF_C2H2 556 578 2.95e-3 SMART
ZnF_C2H2 584 606 6.32e-3 SMART
ZnF_C2H2 612 634 3.89e-3 SMART
ZnF_C2H2 640 662 3.49e-5 SMART
ZnF_C2H2 668 690 1.84e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223867
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency 98% (43/44)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,774,561 (GRCm39) T1250M probably damaging Het
Actn1 C T 12: 80,215,191 (GRCm39) A857T possibly damaging Het
Adam2 C T 14: 66,296,239 (GRCm39) V207I probably damaging Het
Angpt2 T C 8: 18,744,533 (GRCm39) T404A probably benign Het
Ank3 T C 10: 69,827,574 (GRCm39) probably benign Het
Atosa C A 9: 74,930,930 (GRCm39) Q958K probably damaging Het
B4galt4 T A 16: 38,578,184 (GRCm39) D210E probably benign Het
Brinp3 A T 1: 146,777,431 (GRCm39) H626L possibly damaging Het
Ccna2 T G 3: 36,625,112 (GRCm39) D68A probably damaging Het
Cd163 G A 6: 124,281,703 (GRCm39) G2D probably benign Het
Chrm5 A T 2: 112,310,825 (GRCm39) V97D probably benign Het
Dctn5 G A 7: 121,734,320 (GRCm39) V55I probably benign Het
Dnm3 A T 1: 162,141,164 (GRCm39) I365N probably damaging Het
Esyt2 A G 12: 116,284,790 (GRCm39) D184G probably damaging Het
Ifi214 C A 1: 173,352,597 (GRCm39) K277N probably damaging Het
Il11ra1 C T 4: 41,765,412 (GRCm39) P169L probably benign Het
Inhbb C T 1: 119,345,069 (GRCm39) E407K probably damaging Het
Lama2 T A 10: 26,907,154 (GRCm39) T2336S probably damaging Het
Ldhb A T 6: 142,439,847 (GRCm39) V231E possibly damaging Het
Lrit2 T C 14: 36,790,767 (GRCm39) F149L probably damaging Het
Malrd1 T A 2: 15,936,500 (GRCm39) S1575T probably benign Het
Naip5 A G 13: 100,358,102 (GRCm39) C1045R probably benign Het
Nefl A G 14: 68,322,034 (GRCm39) E208G probably damaging Het
Oog4 A C 4: 143,164,548 (GRCm39) S328A probably damaging Het
Or1e1 T A 11: 73,245,011 (GRCm39) L144Q probably damaging Het
Or5p79 G T 7: 108,221,713 (GRCm39) M231I probably benign Het
Or6c216 T C 10: 129,678,453 (GRCm39) I153V probably benign Het
Or7e168 A G 9: 19,719,847 (GRCm39) I78V probably benign Het
Pbrm1 A G 14: 30,783,466 (GRCm39) N528D probably damaging Het
Pls1 A G 9: 95,636,798 (GRCm39) I558T probably damaging Het
Polq T C 16: 36,881,189 (GRCm39) S839P probably benign Het
Psmg1 A G 16: 95,789,297 (GRCm39) F87L probably damaging Het
Ptprt A G 2: 161,376,507 (GRCm39) M1298T probably benign Het
Rbm27 T A 18: 42,470,076 (GRCm39) W958R probably damaging Het
Skint5 T G 4: 113,396,552 (GRCm39) D1207A unknown Het
Stx17 T A 4: 48,183,478 (GRCm39) probably null Het
Tas2r114 A T 6: 131,666,099 (GRCm39) *310R probably null Het
Tmem130 T A 5: 144,689,224 (GRCm39) N139I probably damaging Het
Trpc1 T C 9: 95,608,490 (GRCm39) E267G probably damaging Het
Trrap T A 5: 144,793,812 (GRCm39) M3398K probably damaging Het
Vrtn T G 12: 84,697,090 (GRCm39) D613E probably benign Het
Vsx1 G T 2: 150,530,441 (GRCm39) T147K probably benign Het
Wdr55 T C 18: 36,895,231 (GRCm39) V103A probably benign Het
Other mutations in Zfp712
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01407:Zfp712 APN 13 67,190,230 (GRCm39) missense possibly damaging 0.55
IGL02148:Zfp712 APN 13 67,190,222 (GRCm39) missense probably damaging 1.00
R0085:Zfp712 UTSW 13 67,189,256 (GRCm39) missense probably benign 0.00
R0332:Zfp712 UTSW 13 67,188,877 (GRCm39) missense probably damaging 1.00
R1676:Zfp712 UTSW 13 67,200,400 (GRCm39) missense probably benign 0.00
R1838:Zfp712 UTSW 13 67,190,111 (GRCm39) missense probably damaging 1.00
R1997:Zfp712 UTSW 13 67,190,114 (GRCm39) nonsense probably null
R2147:Zfp712 UTSW 13 67,189,960 (GRCm39) missense possibly damaging 0.94
R2203:Zfp712 UTSW 13 67,190,048 (GRCm39) missense probably benign 0.32
R3421:Zfp712 UTSW 13 67,200,456 (GRCm39) missense probably damaging 0.98
R3943:Zfp712 UTSW 13 67,189,396 (GRCm39) missense probably benign 0.06
R4722:Zfp712 UTSW 13 67,190,177 (GRCm39) missense probably benign 0.41
R4952:Zfp712 UTSW 13 67,188,905 (GRCm39) missense possibly damaging 0.63
R4964:Zfp712 UTSW 13 67,188,676 (GRCm39) missense probably damaging 1.00
R4966:Zfp712 UTSW 13 67,188,676 (GRCm39) missense probably damaging 1.00
R4967:Zfp712 UTSW 13 67,188,773 (GRCm39) nonsense probably null
R5114:Zfp712 UTSW 13 67,189,425 (GRCm39) missense probably damaging 1.00
R5361:Zfp712 UTSW 13 67,189,079 (GRCm39) missense possibly damaging 0.95
R5922:Zfp712 UTSW 13 67,189,668 (GRCm39) missense probably benign 0.01
R5950:Zfp712 UTSW 13 67,192,881 (GRCm39) missense probably damaging 0.99
R6004:Zfp712 UTSW 13 67,189,769 (GRCm39) missense probably damaging 1.00
R6236:Zfp712 UTSW 13 67,188,685 (GRCm39) missense probably damaging 1.00
R6298:Zfp712 UTSW 13 67,189,393 (GRCm39) missense probably damaging 1.00
R6774:Zfp712 UTSW 13 67,189,568 (GRCm39) missense probably benign 0.01
R6932:Zfp712 UTSW 13 67,188,891 (GRCm39) nonsense probably null
R7410:Zfp712 UTSW 13 67,189,400 (GRCm39) missense probably benign 0.00
R7831:Zfp712 UTSW 13 67,200,483 (GRCm39) splice site probably null
R7923:Zfp712 UTSW 13 67,190,249 (GRCm39) missense probably benign 0.01
R8144:Zfp712 UTSW 13 67,189,172 (GRCm39) missense probably benign
R8298:Zfp712 UTSW 13 67,188,976 (GRCm39) missense probably benign 0.06
R9115:Zfp712 UTSW 13 67,189,241 (GRCm39) missense probably damaging 0.96
R9138:Zfp712 UTSW 13 67,189,318 (GRCm39) missense probably damaging 1.00
R9187:Zfp712 UTSW 13 67,188,637 (GRCm39) missense probably damaging 1.00
R9256:Zfp712 UTSW 13 67,188,791 (GRCm39) missense probably benign 0.28
R9651:Zfp712 UTSW 13 67,188,824 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GTATGGAAGGCTTCTCCATTTG -3'
(R):5'- GTCTCGTCCCTTGAAGATGGATAG -3'

Sequencing Primer
(F):5'- GGAAGGCTTCTCCATTTGTAAGAATG -3'
(R):5'- GTGTAAAAGAATCTCATTCACTGCAC -3'
Posted On 2018-06-06