Incidental Mutation 'R6500:Vmn2r100'
ID 519701
Institutional Source Beutler Lab
Gene Symbol Vmn2r100
Ensembl Gene ENSMUSG00000091859
Gene Name vomeronasal 2, receptor 100
Synonyms EG627537
MMRRC Submission 044632-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R6500 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 19725073-19752322 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19742355 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 243 (I243N)
Ref Sequence ENSEMBL: ENSMUSP00000128350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166081] [ENSMUST00000231465]
AlphaFold E9QAZ9
Predicted Effect probably damaging
Transcript: ENSMUST00000166081
AA Change: I243N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000128350
Gene: ENSMUSG00000091859
AA Change: I243N

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 83 456 7.4e-41 PFAM
Pfam:NCD3G 510 563 1.9e-21 PFAM
Pfam:7tm_3 594 831 2.6e-51 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000231465
AA Change: I243N

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency 98% (53/54)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam21 A G 12: 81,606,380 (GRCm39) F461L probably benign Het
Adamtsl3 C A 7: 82,227,818 (GRCm39) H1334Q probably benign Het
Adgrf1 A G 17: 43,621,263 (GRCm39) N500S probably damaging Het
Afdn A G 17: 14,042,634 (GRCm39) D335G possibly damaging Het
Arhgap19 G A 19: 41,775,077 (GRCm39) T178M probably damaging Het
Chac2 T C 11: 30,927,625 (GRCm39) D86G probably damaging Het
Clhc1 T C 11: 29,510,542 (GRCm39) S209P possibly damaging Het
Col1a2 G A 6: 4,515,517 (GRCm39) G127S unknown Het
Coro2b A G 9: 62,396,606 (GRCm39) F51L probably benign Het
Cux2 A G 5: 122,002,789 (GRCm39) S1139P probably benign Het
Cyth3 A T 5: 143,693,595 (GRCm39) I379F probably damaging Het
Dock2 A T 11: 34,312,822 (GRCm39) L240H possibly damaging Het
Ercc6 A G 14: 32,248,780 (GRCm39) K444E probably damaging Het
Fam3b A G 16: 97,302,101 (GRCm39) L52P possibly damaging Het
Fat4 T G 3: 39,035,418 (GRCm39) Y3023* probably null Het
Gad1 A T 2: 70,423,780 (GRCm39) N396Y probably damaging Het
Gbp2b A G 3: 142,317,252 (GRCm39) E536G probably benign Het
Gm11564 G A 11: 99,706,061 (GRCm39) T123I unknown Het
Herc2 G T 7: 55,796,393 (GRCm39) E1922* probably null Het
Hrh4 G T 18: 13,155,525 (GRCm39) V355F probably damaging Het
Isyna1 A G 8: 71,047,339 (GRCm39) I21V probably damaging Het
Jak1 T C 4: 101,039,130 (GRCm39) D165G probably benign Het
Klhl38 C A 15: 58,185,809 (GRCm39) G307* probably null Het
Krt77 T C 15: 101,772,772 (GRCm39) N269S probably damaging Het
Lrp4 T A 2: 91,322,765 (GRCm39) I1118N possibly damaging Het
Ly6i T C 15: 74,853,833 (GRCm39) Y30C probably damaging Het
Magi2 A G 5: 20,807,345 (GRCm39) E620G possibly damaging Het
Mbl2 A G 19: 30,216,839 (GRCm39) D217G possibly damaging Het
Mogat2 T A 7: 98,871,553 (GRCm39) I253F probably benign Het
Mpped2 T C 2: 106,691,925 (GRCm39) L210P probably damaging Het
Nav3 C A 10: 109,600,617 (GRCm39) A1337S probably damaging Het
Ncaph2 T A 15: 89,248,407 (GRCm39) V206E probably benign Het
Nlgn1 T C 3: 25,488,094 (GRCm39) E747G possibly damaging Het
Nlrc3 C T 16: 3,770,308 (GRCm39) G237D possibly damaging Het
Nsun7 A G 5: 66,452,827 (GRCm39) D514G probably benign Het
Or10al5 C G 17: 38,063,577 (GRCm39) D277E probably damaging Het
Pals2 A G 6: 50,175,146 (GRCm39) K500E possibly damaging Het
Pcnx2 C A 8: 126,480,224 (GRCm39) V2028F probably damaging Het
Pdx1 G T 5: 147,207,440 (GRCm39) W131L probably damaging Het
Pkdrej C T 15: 85,703,747 (GRCm39) V730I probably damaging Het
Plcg1 T A 2: 160,596,487 (GRCm39) Y669N probably damaging Het
Plpp1 G T 13: 113,003,454 (GRCm39) W226L probably damaging Het
Sfxn1 G A 13: 54,242,918 (GRCm39) V59I probably benign Het
Shank1 T C 7: 43,976,645 (GRCm39) I581T unknown Het
Slc35f6 A C 5: 30,814,164 (GRCm39) K150N possibly damaging Het
Slc5a7 A T 17: 54,591,231 (GRCm39) S234T probably benign Het
Smg6 C T 11: 74,821,331 (GRCm39) T534I possibly damaging Het
Ush2a C T 1: 188,573,724 (GRCm39) T3649I probably benign Het
Vmn1r158 T C 7: 22,490,078 (GRCm39) T44A possibly damaging Het
Vmn1r217 A T 13: 23,298,073 (GRCm39) Y276* probably null Het
Vwde T C 6: 13,208,404 (GRCm39) probably null Het
Washc4 C A 10: 83,394,687 (GRCm39) P306T probably damaging Het
Wdhd1 C T 14: 47,488,217 (GRCm39) probably null Het
Xpo6 T C 7: 125,770,262 (GRCm39) probably benign Het
Other mutations in Vmn2r100
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00904:Vmn2r100 APN 17 19,746,262 (GRCm39) missense probably damaging 1.00
IGL00912:Vmn2r100 APN 17 19,751,654 (GRCm39) missense possibly damaging 0.95
IGL01107:Vmn2r100 APN 17 19,741,618 (GRCm39) missense probably damaging 1.00
IGL01517:Vmn2r100 APN 17 19,742,225 (GRCm39) missense probably benign 0.37
IGL01594:Vmn2r100 APN 17 19,751,495 (GRCm39) missense possibly damaging 0.52
IGL01657:Vmn2r100 APN 17 19,746,178 (GRCm39) missense possibly damaging 0.89
IGL01822:Vmn2r100 APN 17 19,725,100 (GRCm39) missense probably null 0.00
IGL02020:Vmn2r100 APN 17 19,725,200 (GRCm39) missense possibly damaging 0.78
IGL02060:Vmn2r100 APN 17 19,741,516 (GRCm39) missense possibly damaging 0.79
IGL02126:Vmn2r100 APN 17 19,741,504 (GRCm39) splice site probably benign
IGL02142:Vmn2r100 APN 17 19,742,583 (GRCm39) missense probably damaging 1.00
IGL02308:Vmn2r100 APN 17 19,741,597 (GRCm39) missense possibly damaging 0.90
IGL02407:Vmn2r100 APN 17 19,741,770 (GRCm39) missense probably damaging 0.98
IGL02469:Vmn2r100 APN 17 19,751,547 (GRCm39) nonsense probably null
IGL03088:Vmn2r100 APN 17 19,742,301 (GRCm39) missense probably benign 0.27
IGL03181:Vmn2r100 APN 17 19,752,207 (GRCm39) missense probably damaging 1.00
IGL03405:Vmn2r100 APN 17 19,752,186 (GRCm39) missense probably damaging 1.00
H8562:Vmn2r100 UTSW 17 19,741,752 (GRCm39) missense possibly damaging 0.87
R0012:Vmn2r100 UTSW 17 19,746,296 (GRCm39) missense probably damaging 0.99
R0012:Vmn2r100 UTSW 17 19,725,136 (GRCm39) missense probably benign
R0044:Vmn2r100 UTSW 17 19,742,441 (GRCm39) missense possibly damaging 0.46
R0109:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0111:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0112:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0149:Vmn2r100 UTSW 17 19,741,509 (GRCm39) critical splice acceptor site probably null
R0355:Vmn2r100 UTSW 17 19,751,582 (GRCm39) missense probably benign 0.00
R0395:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0396:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0453:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0465:Vmn2r100 UTSW 17 19,751,792 (GRCm39) missense probably damaging 0.98
R0477:Vmn2r100 UTSW 17 19,742,776 (GRCm39) missense probably benign 0.00
R0510:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0512:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0514:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0518:Vmn2r100 UTSW 17 19,742,178 (GRCm39) missense probably damaging 1.00
R0521:Vmn2r100 UTSW 17 19,742,178 (GRCm39) missense probably damaging 1.00
R0555:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0608:Vmn2r100 UTSW 17 19,742,382 (GRCm39) missense possibly damaging 0.80
R0959:Vmn2r100 UTSW 17 19,743,786 (GRCm39) missense possibly damaging 0.95
R1114:Vmn2r100 UTSW 17 19,752,261 (GRCm39) missense probably damaging 1.00
R2027:Vmn2r100 UTSW 17 19,742,334 (GRCm39) missense probably benign 0.02
R2049:Vmn2r100 UTSW 17 19,742,312 (GRCm39) missense probably benign 0.00
R2224:Vmn2r100 UTSW 17 19,742,634 (GRCm39) missense probably benign 0.03
R2226:Vmn2r100 UTSW 17 19,742,634 (GRCm39) missense probably benign 0.03
R3618:Vmn2r100 UTSW 17 19,743,692 (GRCm39) missense probably benign
R3715:Vmn2r100 UTSW 17 19,752,272 (GRCm39) missense probably damaging 0.99
R4120:Vmn2r100 UTSW 17 19,752,215 (GRCm39) missense probably damaging 1.00
R4152:Vmn2r100 UTSW 17 19,743,681 (GRCm39) frame shift probably null
R4153:Vmn2r100 UTSW 17 19,743,681 (GRCm39) frame shift probably null
R4154:Vmn2r100 UTSW 17 19,743,681 (GRCm39) frame shift probably null
R4200:Vmn2r100 UTSW 17 19,742,797 (GRCm39) missense probably benign 0.29
R4632:Vmn2r100 UTSW 17 19,752,216 (GRCm39) missense probably damaging 1.00
R4720:Vmn2r100 UTSW 17 19,742,788 (GRCm39) missense probably benign 0.02
R4761:Vmn2r100 UTSW 17 19,741,630 (GRCm39) missense possibly damaging 0.47
R4831:Vmn2r100 UTSW 17 19,741,672 (GRCm39) missense probably benign 0.28
R4951:Vmn2r100 UTSW 17 19,752,300 (GRCm39) missense probably benign 0.01
R5211:Vmn2r100 UTSW 17 19,746,257 (GRCm39) missense possibly damaging 0.67
R5553:Vmn2r100 UTSW 17 19,725,110 (GRCm39) missense possibly damaging 0.64
R5657:Vmn2r100 UTSW 17 19,725,178 (GRCm39) missense probably benign 0.31
R5883:Vmn2r100 UTSW 17 19,743,786 (GRCm39) missense probably benign
R5912:Vmn2r100 UTSW 17 19,752,071 (GRCm39) missense probably damaging 0.99
R6141:Vmn2r100 UTSW 17 19,742,576 (GRCm39) missense probably benign 0.07
R6146:Vmn2r100 UTSW 17 19,742,522 (GRCm39) missense probably benign 0.04
R6575:Vmn2r100 UTSW 17 19,741,671 (GRCm39) missense probably benign 0.12
R6647:Vmn2r100 UTSW 17 19,742,785 (GRCm39) missense probably benign 0.00
R7038:Vmn2r100 UTSW 17 19,725,263 (GRCm39) missense possibly damaging 0.76
R7052:Vmn2r100 UTSW 17 19,751,556 (GRCm39) missense possibly damaging 0.95
R7170:Vmn2r100 UTSW 17 19,752,233 (GRCm39) missense probably benign 0.00
R7209:Vmn2r100 UTSW 17 19,751,576 (GRCm39) missense not run
R7312:Vmn2r100 UTSW 17 19,742,296 (GRCm39) missense probably benign 0.01
R7734:Vmn2r100 UTSW 17 19,742,296 (GRCm39) missense probably benign 0.01
R7750:Vmn2r100 UTSW 17 19,742,726 (GRCm39) missense probably benign
R8103:Vmn2r100 UTSW 17 19,751,415 (GRCm39) splice site probably null
R8193:Vmn2r100 UTSW 17 19,725,102 (GRCm39) nonsense probably null
R8267:Vmn2r100 UTSW 17 19,742,752 (GRCm39) nonsense probably null
R8290:Vmn2r100 UTSW 17 19,751,612 (GRCm39) missense probably damaging 0.99
R8531:Vmn2r100 UTSW 17 19,742,459 (GRCm39) missense possibly damaging 0.66
R8786:Vmn2r100 UTSW 17 19,742,838 (GRCm39) missense probably damaging 1.00
R8920:Vmn2r100 UTSW 17 19,741,620 (GRCm39) missense probably damaging 1.00
R8938:Vmn2r100 UTSW 17 19,751,825 (GRCm39) missense probably benign 0.00
R9555:Vmn2r100 UTSW 17 19,743,857 (GRCm39) missense probably benign 0.00
R9572:Vmn2r100 UTSW 17 19,741,513 (GRCm39) missense probably benign 0.00
R9609:Vmn2r100 UTSW 17 19,743,732 (GRCm39) missense probably damaging 1.00
R9618:Vmn2r100 UTSW 17 19,742,583 (GRCm39) missense probably damaging 1.00
X0062:Vmn2r100 UTSW 17 19,751,652 (GRCm39) missense possibly damaging 0.89
Z1176:Vmn2r100 UTSW 17 19,741,792 (GRCm39) missense probably benign 0.00
Z1177:Vmn2r100 UTSW 17 19,725,251 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGTCAGTATTCTTCACTCTACCAG -3'
(R):5'- GGCTTCCATGAAATGAGTCTAAC -3'

Sequencing Primer
(F):5'- TCTACCAGATTGCCCCCAAGG -3'
(R):5'- TGTATTCAACGTTCATGACCCAAAC -3'
Posted On 2018-06-06