Incidental Mutation 'N/A - 293:Gm7634'
ID 52
Institutional Source Beutler Lab
Gene Symbol Gm7634
Ensembl Gene ENSMUSG00000100652
Gene Name predicted gene 7634
Synonyms
Accession Numbers
Essential gene? Not available question?
Stock # N/A - 293 of strain aoba
Quality Score
Status Validated
Chromosome 1
Chromosomal Location 16123559-16124111 bp(+) (GRCm39)
Type of Mutation exon
DNA Base Change (assembly) T to A at 16124084 bp (GRCm39)
Zygosity Homozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185778
Coding Region Coverage
  • 1x: 88.4%
  • 3x: 74.0%
Validation Efficiency 85% (165/193)
Allele List at MGI
Other mutations in this stock
Total: 8 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Exoc1l T C 5: 76,664,339 (GRCm39) S143P probably benign Homo
Kras T A 6: 145,177,940 (GRCm39) M111L probably benign Homo
Lrig1 T C 6: 94,586,068 (GRCm39) T707A probably benign Homo
Mycbp2 A G 14: 103,461,898 (GRCm39) probably benign Homo
Or2a7 C T 6: 43,151,493 (GRCm39) T191I probably benign Homo
Smarcad1 T A 6: 65,051,898 (GRCm39) F344I probably benign Homo
Sprr4 G A 3: 92,407,650 (GRCm39) Q51* probably null Homo
Zeb1 A T 18: 5,767,076 (GRCm39) H529L possibly damaging Homo
Nature of Mutation
DNA sequencing using the SOLiD technique identified a T to A transversion at position 454 of the Gm7634 transcript. The mutated nucleotide causes a leucine to glutamine substitution at amino acid 144. The mutation has been confirmed by DNA sequencing using the Sanger method. Figure 1 shows a BLAST search using DNA sequence containing the mutated nucleotide.
Protein Function and Prediction
Gm7634 is an uncharacterized gene that is predicted to encode a 158 amino acid protein.  Analysis using the SMART program predicted the protein to be similar to ribosomal protein L22, one of the proteins from the large ribosomal subunit.  The gene has been removed from the NCBI database.
 
The L144Q change is predicted to be benign by the PolyPhen program.
Posted On 2009-11-10