Incidental Mutation 'IGL01145:Layn'
ID |
52011 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Layn
|
Ensembl Gene |
ENSMUSG00000060594 |
Gene Name |
layilin |
Synonyms |
LOC244864, E030012M19Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.058)
|
Stock # |
IGL01145
|
Quality Score |
|
Status
|
|
Chromosome |
9 |
Chromosomal Location |
50966323-50988501 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 50985346 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Isoleucine
at position 62
(T62I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000149794
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098782]
[ENSMUST00000214452]
[ENSMUST00000214993]
[ENSMUST00000217212]
|
AlphaFold |
Q8C351 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000098782
AA Change: T70I
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
SMART Domains |
Protein: ENSMUSP00000096379 Gene: ENSMUSG00000060594 AA Change: T70I
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
CLECT
|
41 |
185 |
6.18e-25 |
SMART |
transmembrane domain
|
237 |
259 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000214090
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000214452
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000214993
AA Change: T62I
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216453
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000217212
AA Change: T70I
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acan |
A |
C |
7: 78,749,030 (GRCm39) |
D1267A |
probably damaging |
Het |
Ankrd44 |
A |
G |
1: 54,801,418 (GRCm39) |
|
probably null |
Het |
Arap3 |
T |
C |
18: 38,122,232 (GRCm39) |
M619V |
probably benign |
Het |
C8b |
A |
T |
4: 104,637,777 (GRCm39) |
Y83F |
probably benign |
Het |
Capn15 |
A |
G |
17: 26,182,024 (GRCm39) |
V595A |
probably damaging |
Het |
Cbx1 |
A |
T |
11: 96,692,392 (GRCm39) |
D93V |
probably benign |
Het |
Cyp2c66 |
G |
T |
19: 39,159,405 (GRCm39) |
E285D |
probably benign |
Het |
Dkk4 |
T |
A |
8: 23,115,402 (GRCm39) |
V84D |
probably damaging |
Het |
Dnah17 |
T |
A |
11: 117,937,999 (GRCm39) |
I3343F |
possibly damaging |
Het |
Dus3l |
T |
C |
17: 57,074,627 (GRCm39) |
|
probably benign |
Het |
Ecpas |
A |
C |
4: 58,811,501 (GRCm39) |
D1467E |
probably null |
Het |
Eif6 |
A |
G |
2: 155,668,355 (GRCm39) |
|
probably benign |
Het |
Eya3 |
A |
G |
4: 132,437,306 (GRCm39) |
I389V |
probably damaging |
Het |
Gm5916 |
A |
T |
9: 36,031,998 (GRCm39) |
D95E |
unknown |
Het |
Gucy2d |
T |
A |
7: 98,099,170 (GRCm39) |
S329T |
probably benign |
Het |
Hook3 |
C |
T |
8: 26,549,372 (GRCm39) |
M157I |
probably benign |
Het |
Iapp |
C |
A |
6: 142,249,090 (GRCm39) |
R48S |
probably damaging |
Het |
Ints11 |
A |
G |
4: 155,969,583 (GRCm39) |
Y153C |
probably damaging |
Het |
Llgl2 |
A |
G |
11: 115,744,631 (GRCm39) |
H876R |
probably benign |
Het |
Lrp4 |
T |
C |
2: 91,317,396 (GRCm39) |
I840T |
probably damaging |
Het |
Myo9a |
T |
A |
9: 59,762,658 (GRCm39) |
F796L |
probably benign |
Het |
Naip1 |
A |
G |
13: 100,545,629 (GRCm39) |
S1300P |
probably benign |
Het |
Nfat5 |
T |
A |
8: 108,093,847 (GRCm39) |
I602N |
probably damaging |
Het |
Omt2a |
T |
C |
9: 78,220,238 (GRCm39) |
M64V |
probably benign |
Het |
Pcnx1 |
T |
C |
12: 82,038,809 (GRCm39) |
S2025P |
probably damaging |
Het |
Pemt |
A |
G |
11: 59,874,293 (GRCm39) |
L62P |
probably damaging |
Het |
Polrmt |
A |
G |
10: 79,576,971 (GRCm39) |
V399A |
probably benign |
Het |
Rasgrp4 |
T |
C |
7: 28,850,898 (GRCm39) |
S77P |
possibly damaging |
Het |
Rrm2b |
G |
A |
15: 37,944,804 (GRCm39) |
P111L |
probably damaging |
Het |
Slc10a4-ps |
A |
T |
5: 72,743,547 (GRCm39) |
|
probably null |
Het |
Thap12 |
A |
G |
7: 98,362,110 (GRCm39) |
*121W |
probably null |
Het |
Tnik |
A |
G |
3: 28,658,316 (GRCm39) |
|
probably benign |
Het |
Trio |
G |
A |
15: 27,818,253 (GRCm39) |
|
probably benign |
Het |
Zfhx4 |
A |
G |
3: 5,310,407 (GRCm39) |
E930G |
probably damaging |
Het |
Zfp335 |
G |
T |
2: 164,749,422 (GRCm39) |
T299K |
probably benign |
Het |
|
Other mutations in Layn |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00921:Layn
|
APN |
9 |
50,968,708 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02006:Layn
|
APN |
9 |
50,968,591 (GRCm39) |
intron |
probably benign |
|
IGL02226:Layn
|
APN |
9 |
50,985,317 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4677001:Layn
|
UTSW |
9 |
50,968,711 (GRCm39) |
missense |
probably damaging |
0.98 |
R1464:Layn
|
UTSW |
9 |
50,968,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R1464:Layn
|
UTSW |
9 |
50,968,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R1775:Layn
|
UTSW |
9 |
50,970,833 (GRCm39) |
missense |
probably benign |
0.03 |
R2156:Layn
|
UTSW |
9 |
50,968,697 (GRCm39) |
missense |
probably benign |
|
R3732:Layn
|
UTSW |
9 |
50,970,844 (GRCm39) |
missense |
probably damaging |
1.00 |
R3732:Layn
|
UTSW |
9 |
50,970,844 (GRCm39) |
missense |
probably damaging |
1.00 |
R3733:Layn
|
UTSW |
9 |
50,970,844 (GRCm39) |
missense |
probably damaging |
1.00 |
R3757:Layn
|
UTSW |
9 |
50,970,856 (GRCm39) |
missense |
probably benign |
0.11 |
R4840:Layn
|
UTSW |
9 |
50,968,682 (GRCm39) |
missense |
probably damaging |
1.00 |
R5792:Layn
|
UTSW |
9 |
50,979,461 (GRCm39) |
missense |
probably damaging |
1.00 |
R7185:Layn
|
UTSW |
9 |
50,985,173 (GRCm39) |
missense |
possibly damaging |
0.58 |
R7216:Layn
|
UTSW |
9 |
50,988,352 (GRCm39) |
start gained |
probably benign |
|
R7404:Layn
|
UTSW |
9 |
50,968,670 (GRCm39) |
missense |
possibly damaging |
0.94 |
R8784:Layn
|
UTSW |
9 |
50,970,781 (GRCm39) |
missense |
possibly damaging |
0.60 |
R9228:Layn
|
UTSW |
9 |
50,968,837 (GRCm39) |
missense |
probably damaging |
1.00 |
R9248:Layn
|
UTSW |
9 |
50,968,760 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9725:Layn
|
UTSW |
9 |
50,968,775 (GRCm39) |
missense |
probably benign |
0.00 |
|
Posted On |
2013-06-21 |