Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01152:Or7d10'

52018

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7d10

Ensembl Gene

ENSMUSG00000051118

Gene Name

olfactory receptor family 7 subfamily D member 10

Synonyms

18A, Olfr77, GA_x6K02T2PVTD-13660026-13660964, MOR143-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL01152

Quality Score

Status

Chromosome

Chromosomal Location

19828525-19833806 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19832245 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 247 (V247M)

Ref Sequence

ENSEMBL: ENSMUSP00000149055 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057596] [ENSMUST00000217347]

AlphaFold

Q8VEY9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000057596
AA Change: V247M

PolyPhen 2 Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000058810
Gene: ENSMUSG00000051118
AA Change: V247M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3e-53	PFAM
Pfam:7tm_1	41	290	1.2e-24	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217347
AA Change: V247M

PolyPhen 2 Score 0.870 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A730013G03Rik	T	G	1: 192,515,947 (GRCm39)		noncoding transcript	Het
Abcb4	G	A	5: 9,000,678 (GRCm39)	V1031M	probably benign	Het
Abcc4	A	G	14: 118,836,797 (GRCm39)	S655P	probably damaging	Het
Actn1	T	C	12: 80,245,820 (GRCm39)	K121R	probably damaging	Het
Aldh1l2	T	A	10: 83,358,750 (GRCm39)	R82*	probably null	Het
Arhgap31	T	A	16: 38,422,601 (GRCm39)	H1155L	possibly damaging	Het
Atp8a1	G	T	5: 68,004,549 (GRCm39)	P2Q	probably damaging	Het
Bcs1l	A	G	1: 74,631,174 (GRCm39)	M401V	possibly damaging	Het
Brca2	A	T	5: 150,465,855 (GRCm39)	N1873I	probably damaging	Het
Cenpj	T	C	14: 56,789,757 (GRCm39)	N764S	probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Clk1	A	T	1: 58,452,611 (GRCm39)	C359S	possibly damaging	Het
Clk2	T	A	3: 89,083,818 (GRCm39)	F479I	probably damaging	Het
Cul4b	T	C	X: 37,632,247 (GRCm39)	M709V	probably damaging	Het
D130052B06Rik	G	T	11: 33,573,620 (GRCm39)		probably null	Het
Dgkb	T	A	12: 38,134,233 (GRCm39)	N46K	probably damaging	Het
Dnah9	C	T	11: 65,962,882 (GRCm39)	R1811H	probably damaging	Het
Dnajc18	T	C	18: 35,813,926 (GRCm39)	N281S	probably benign	Het
Galnt5	A	T	2: 57,915,405 (GRCm39)	I654L	probably benign	Het
Gm9989	T	G	3: 81,829,518 (GRCm39)		noncoding transcript	Het
Gpr179	T	C	11: 97,228,237 (GRCm39)	E1306G	probably benign	Het
Gsc	C	A	12: 104,437,864 (GRCm39)	K219N	probably damaging	Het
Gsx2	A	T	5: 75,236,452 (GRCm39)	I11F	probably damaging	Het
Igdcc4	A	C	9: 65,042,446 (GRCm39)	E121A	probably damaging	Het
Lama2	C	T	10: 27,084,425 (GRCm39)	R915H	probably benign	Het
Large2	A	G	2: 92,200,984 (GRCm39)	L64P	probably damaging	Het
Lztr1	C	A	16: 17,340,317 (GRCm39)	Q136K	probably damaging	Het
Mageb18	A	G	X: 91,163,430 (GRCm39)	W271R	possibly damaging	Het
Magoh	A	C	4: 107,742,203 (GRCm39)		probably benign	Het
Matcap2	A	T	9: 22,346,460 (GRCm39)	H356L	probably benign	Het
Mrgprx1	T	C	7: 47,671,234 (GRCm39)	H171R	probably benign	Het
Muc1	C	A	3: 89,138,061 (GRCm39)	T301K	probably benign	Het
Nbas	C	T	12: 13,410,959 (GRCm39)	L868F	probably damaging	Het
Nwd2	A	G	5: 63,963,872 (GRCm39)	D1152G	possibly damaging	Het
Or5p68	C	T	7: 107,946,156 (GRCm39)	A11T	probably benign	Het
Ovgp1	T	A	3: 105,893,488 (GRCm39)	D420E	possibly damaging	Het
Pacsin3	A	G	2: 91,094,121 (GRCm39)	D350G	probably benign	Het
Pcolce2	A	T	9: 95,574,976 (GRCm39)	N309Y	probably damaging	Het
Pim2	C	A	X: 7,744,661 (GRCm39)		probably benign	Het
Plcb1	A	G	2: 134,655,579 (GRCm39)	Y53C	probably damaging	Het
Pogk	T	C	1: 166,236,047 (GRCm39)	E18G	probably damaging	Het
Pxdn	T	A	12: 30,051,936 (GRCm39)	D704E	probably damaging	Het
Rb1	C	A	14: 73,443,310 (GRCm39)	S781I	probably damaging	Het
Rnpepl1	A	G	1: 92,843,621 (GRCm39)	H247R	possibly damaging	Het
Scube1	A	T	15: 83,497,771 (GRCm39)	F697I	probably damaging	Het
Sel1l3	G	T	5: 53,273,675 (GRCm39)	H1064N	probably damaging	Het
Serinc3	A	G	2: 163,478,831 (GRCm39)	Y99H	probably damaging	Het
Slc36a2	T	A	11: 55,060,673 (GRCm39)		probably benign	Het
Smarcc1	A	C	9: 109,968,693 (GRCm39)	E130A	possibly damaging	Het
Strc	A	G	2: 121,201,276 (GRCm39)	M1273T	probably benign	Het
Tmem116	A	G	5: 121,601,862 (GRCm39)	I21V	probably benign	Het
Tmem190	T	C	7: 4,787,025 (GRCm39)		probably benign	Het
Trim63	C	T	4: 134,052,987 (GRCm39)	A316V	probably benign	Het
Ugt2b34	T	C	5: 87,049,062 (GRCm39)	E321G	probably damaging	Het
Zfat	T	A	15: 67,982,353 (GRCm39)	R1053S	probably damaging	Het

Other mutations in Or7d10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01318:Or7d10	APN	9	19,832,054 (GRCm39)	missense	probably benign	0.44
IGL01547:Or7d10	APN	9	19,832,197 (GRCm39)	missense	probably benign	0.00
IGL01635:Or7d10	APN	9	19,831,780 (GRCm39)	missense	probably damaging	1.00
IGL02112:Or7d10	APN	9	19,831,821 (GRCm39)	missense	possibly damaging	0.48
IGL02858:Or7d10	APN	9	19,831,747 (GRCm39)	missense	probably damaging	0.99
IGL02904:Or7d10	APN	9	19,832,393 (GRCm39)	missense	probably damaging	1.00
IGL02956:Or7d10	APN	9	19,832,348 (GRCm39)	missense	possibly damaging	0.87
IGL03066:Or7d10	APN	9	19,831,667 (GRCm39)	missense	probably benign	0.12
R0662:Or7d10	UTSW	9	19,831,796 (GRCm39)	missense	probably damaging	1.00
R1222:Or7d10	UTSW	9	19,832,344 (GRCm39)	missense	possibly damaging	0.87
R1572:Or7d10	UTSW	9	19,832,208 (GRCm39)	missense	probably benign	0.35
R1761:Or7d10	UTSW	9	19,832,445 (GRCm39)	makesense	probably null
R2409:Or7d10	UTSW	9	19,832,077 (GRCm39)	missense	probably damaging	1.00
R2409:Or7d10	UTSW	9	19,832,072 (GRCm39)	missense	probably benign	0.31
R3621:Or7d10	UTSW	9	19,832,209 (GRCm39)	missense	probably damaging	0.99
R3849:Or7d10	UTSW	9	19,832,105 (GRCm39)	missense	probably damaging	1.00
R3850:Or7d10	UTSW	9	19,832,105 (GRCm39)	missense	probably damaging	1.00
R4277:Or7d10	UTSW	9	19,831,685 (GRCm39)	missense	possibly damaging	0.91
R4768:Or7d10	UTSW	9	19,831,841 (GRCm39)	missense	possibly damaging	0.56
R4979:Or7d10	UTSW	9	19,831,655 (GRCm39)	missense	probably benign	0.03
R5276:Or7d10	UTSW	9	19,831,917 (GRCm39)	missense	possibly damaging	0.87
R5503:Or7d10	UTSW	9	19,831,675 (GRCm39)	missense	probably benign	0.36
R5760:Or7d10	UTSW	9	19,832,050 (GRCm39)	missense	probably benign	0.00
R5778:Or7d10	UTSW	9	19,832,337 (GRCm39)	missense	probably benign	0.20
R5930:Or7d10	UTSW	9	19,832,206 (GRCm39)	missense	probably damaging	0.99
R6012:Or7d10	UTSW	9	19,832,237 (GRCm39)	missense	probably damaging	0.99
R7269:Or7d10	UTSW	9	19,831,631 (GRCm39)	missense	possibly damaging	0.95
R7977:Or7d10	UTSW	9	19,831,610 (GRCm39)	missense	possibly damaging	0.48
R7987:Or7d10	UTSW	9	19,831,610 (GRCm39)	missense	possibly damaging	0.48
R8174:Or7d10	UTSW	9	19,832,020 (GRCm39)	missense	probably damaging	1.00
Z1088:Or7d10	UTSW	9	19,832,008 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21