Mutagenetix > Incidental Mutation

Incidental Mutation 'R6515:Svep1'

520577

Institutional Source

Beutler Lab

Gene Symbol

Svep1

Ensembl Gene

ENSMUSG00000028369

Gene Name

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Synonyms

1110021D17Rik, Polydom, D430029O09Rik, 4833413O10Rik

MMRRC Submission

044642-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6515 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

58042796-58206596 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 58088280 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 1723 (G1723D)

Ref Sequence

ENSEMBL: ENSMUSP00000045856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042850]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000042850
AA Change: G1723D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000045856
Gene: ENSMUSG00000028369
AA Change: G1723D

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
low complexity region	51	60	N/A	INTRINSIC
VWA	82	261	2.18e-32	SMART
Pfam:GCC2_GCC3	311	361	3.4e-14	PFAM
CCP	379	434	3.62e-8	SMART
CCP	439	494	1.78e-16	SMART
CCP	499	559	2.13e-5	SMART
Pfam:HYR	560	642	1.7e-20	PFAM
Pfam:HYR	643	722	4.6e-15	PFAM
CCP	727	787	3.59e-1	SMART
low complexity region	862	873	N/A	INTRINSIC
Pfam:GCC2_GCC3	1004	1051	3.2e-16	PFAM
Pfam:GCC2_GCC3	1058	1105	5.4e-19	PFAM
Pfam:GCC2_GCC3	1112	1159	7.7e-19	PFAM
EGF	1195	1228	3.12e-7	SMART
EGF_CA	1230	1266	3.93e-13	SMART
EGF_CA	1268	1304	8.3e-12	SMART
EGF_CA	1306	1342	4.59e-14	SMART
EGF_CA	1344	1380	8.69e-15	SMART
EGF_CA	1382	1418	3.42e-13	SMART
Pfam:Pentaxin	1429	1622	1.8e-28	PFAM
Pfam:Laminin_G_3	1432	1589	1.1e-20	PFAM
CCP	1630	1684	1.71e-9	SMART
CCP	1689	1742	2.31e-15	SMART
EGF_CA	1744	1783	5.23e-9	SMART
CCP	1788	1841	4.62e-15	SMART
CCP	1846	1899	8.29e-17	SMART
CCP	1904	1957	1.1e-12	SMART
CCP	1962	2015	5.6e-14	SMART
CCP	2020	2077	4.15e-8	SMART
CCP	2082	2140	8.11e-11	SMART
CCP	2145	2198	4.38e-16	SMART
CCP	2203	2258	1.69e-8	SMART
CCP	2263	2317	1.42e-15	SMART
CCP	2322	2375	3.1e-7	SMART
CCP	2380	2434	4.55e-14	SMART
CCP	2439	2492	6.95e-10	SMART
CCP	2497	2550	8.88e-17	SMART
CCP	2555	2607	1.7e-13	SMART
CCP	2651	2709	1.02e-7	SMART
CCP	2714	2767	9.6e-13	SMART
CCP	2772	2825	3.64e-13	SMART
CCP	2830	2883	6.63e-16	SMART
CCP	2888	2941	2.76e-13	SMART
CCP	2946	2999	4.41e-12	SMART
CCP	3004	3055	4.25e-5	SMART
CCP	3060	3113	5.15e-13	SMART
CCP	3118	3172	2.11e-9	SMART
CCP	3177	3232	1.02e-7	SMART
CCP	3237	3290	6.19e-16	SMART
CCP	3295	3348	5.35e-11	SMART
CCP	3353	3407	8.43e-9	SMART
CCP	3412	3464	2.44e-14	SMART
EGF	3467	3496	1.28e-3	SMART
EGF	3499	3528	1.15e-5	SMART
EGF	3531	3560	2.85e-1	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.8%
20x: 93.1%

Validation Efficiency

100% (41/41)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete preweaning lethality, edema, abnormal skin coloration, thick epidermis, acanthosis, and tail/limb abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap1s3	T	C	1: 79,592,044 (GRCm39)	D102G	probably damaging	Het
Apcdd1	T	A	18: 63,084,910 (GRCm39)	M369K	probably damaging	Het
Atp4a	A	G	7: 30,411,903 (GRCm39)	K46R	possibly damaging	Het
Bcl9l	A	G	9: 44,419,171 (GRCm39)		probably null	Het
Cabyr	A	G	18: 12,887,340 (GRCm39)	S324G	possibly damaging	Het
Casp8ap2	A	G	4: 32,646,423 (GRCm39)	D1832G	possibly damaging	Het
Cdk4	C	T	10: 126,902,052 (GRCm39)	P256S	probably null	Het
Cnot6l	C	A	5: 96,309,537 (GRCm39)		probably benign	Het
Cox17	C	A	16: 38,167,557 (GRCm39)	A32E	probably damaging	Het
Cyp27b1	G	T	10: 126,884,119 (GRCm39)		probably benign	Het
Enpp2	T	A	15: 54,723,489 (GRCm39)	N628I	possibly damaging	Het
Ggcx	T	C	6: 72,402,815 (GRCm39)	C258R	probably benign	Het
Hbb-bh1	T	C	7: 103,491,974 (GRCm39)	D80G	probably damaging	Het
Hoxb5	A	T	11: 96,195,908 (GRCm39)	D252V	probably damaging	Het
Hspa4l	A	G	3: 40,736,014 (GRCm39)	D545G	possibly damaging	Het
Hspa5	T	A	2: 34,662,416 (GRCm39)	V28E	probably benign	Het
Ifit1bl1	T	C	19: 34,571,899 (GRCm39)	Y186C	probably damaging	Het
Itpr3	C	T	17: 27,310,344 (GRCm39)	A403V	probably benign	Het
Kif19b	T	C	5: 140,480,779 (GRCm39)	S970P	possibly damaging	Het
Klra17	A	T	6: 129,808,462 (GRCm39)	I257N	probably damaging	Het
Megf6	C	T	4: 154,343,376 (GRCm39)	H662Y	possibly damaging	Het
Mfsd6	T	C	1: 52,700,120 (GRCm39)	K676R	probably damaging	Het
Nutm1	A	C	2: 112,086,665 (GRCm39)	L22R	probably benign	Het
Oas1f	T	C	5: 120,986,497 (GRCm39)	V150A	probably damaging	Het
Or10ak13	T	C	4: 118,639,467 (GRCm39)	Y105C	probably benign	Het
Or4f62	T	C	2: 111,986,710 (GRCm39)	L138P	probably benign	Het
Pik3ap1	A	G	19: 41,364,585 (GRCm39)	Y45H	probably benign	Het
Pnlip	T	C	19: 58,661,547 (GRCm39)	S79P	probably damaging	Het
Ppfia3	T	C	7: 44,989,657 (GRCm39)	D1185G	possibly damaging	Het
Pphln1-ps1	G	A	16: 13,494,820 (GRCm39)		probably benign	Het
Rbm34	A	T	8: 127,688,682 (GRCm39)	S217T	possibly damaging	Het
Rbm44	T	C	1: 91,092,860 (GRCm39)	I820T	probably damaging	Het
Rnf151	A	T	17: 24,935,391 (GRCm39)	L180Q	probably benign	Het
Sec24d	G	A	3: 123,136,719 (GRCm39)	R484Q	possibly damaging	Het
Spop	C	A	11: 95,376,761 (GRCm39)	D271E	possibly damaging	Het
Tenm3	G	C	8: 48,870,257 (GRCm39)	Q179E	probably benign	Het
Thap12	A	G	7: 98,356,302 (GRCm39)	E63G	probably damaging	Het
Thsd7a	T	A	6: 12,501,085 (GRCm39)	T441S	possibly damaging	Het
Tle6	G	A	10: 81,427,810 (GRCm39)	H482Y	probably damaging	Het
Tmem184a	A	G	5: 139,794,193 (GRCm39)	F177L	probably benign	Het
Uggt2	A	T	14: 119,315,131 (GRCm39)	S313T	possibly damaging	Het
Unc13a	A	G	8: 72,100,584 (GRCm39)	I1068T	probably benign	Het
Xirp1	T	C	9: 119,845,983 (GRCm39)	R967G	probably benign	Het

Other mutations in Svep1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00475:Svep1	APN	4	58,176,077 (GRCm39)	missense	probably damaging	0.98
IGL00489:Svep1	APN	4	58,068,988 (GRCm39)	missense	possibly damaging	0.71
IGL00496:Svep1	APN	4	58,069,001 (GRCm39)	missense	possibly damaging	0.95
IGL00864:Svep1	APN	4	58,068,533 (GRCm39)	nonsense	probably null
IGL00904:Svep1	APN	4	58,097,398 (GRCm39)	missense	probably benign	0.00
IGL00935:Svep1	APN	4	58,090,664 (GRCm39)	missense	possibly damaging	0.71
IGL00963:Svep1	APN	4	58,072,791 (GRCm39)	nonsense	probably null
IGL01077:Svep1	APN	4	58,068,760 (GRCm39)	missense	possibly damaging	0.71
IGL01084:Svep1	APN	4	58,111,419 (GRCm39)	missense	possibly damaging	0.71
IGL01150:Svep1	APN	4	58,070,302 (GRCm39)	missense	probably benign	0.04
IGL01161:Svep1	APN	4	58,146,569 (GRCm39)	missense	probably damaging	0.96
IGL01360:Svep1	APN	4	58,116,554 (GRCm39)	missense	possibly damaging	0.73
IGL01365:Svep1	APN	4	58,100,878 (GRCm39)	critical splice acceptor site	probably null
IGL01396:Svep1	APN	4	58,068,552 (GRCm39)	missense	possibly damaging	0.85
IGL01601:Svep1	APN	4	58,084,872 (GRCm39)	missense	probably damaging	1.00
IGL01636:Svep1	APN	4	58,116,622 (GRCm39)	missense	possibly damaging	0.96
IGL01838:Svep1	APN	4	58,121,910 (GRCm39)	missense	possibly damaging	0.72
IGL01949:Svep1	APN	4	58,176,006 (GRCm39)	missense	probably damaging	1.00
IGL01984:Svep1	APN	4	58,068,877 (GRCm39)	missense	possibly damaging	0.93
IGL02005:Svep1	APN	4	58,069,056 (GRCm39)	missense	possibly damaging	0.93
IGL02036:Svep1	APN	4	58,088,245 (GRCm39)	missense	possibly damaging	0.85
IGL02039:Svep1	APN	4	58,123,980 (GRCm39)	critical splice donor site	probably null
IGL02043:Svep1	APN	4	58,068,556 (GRCm39)	missense	probably benign	0.19
IGL02073:Svep1	APN	4	58,070,104 (GRCm39)	missense	probably benign	0.06
IGL02188:Svep1	APN	4	58,068,382 (GRCm39)	missense	possibly damaging	0.71
IGL02256:Svep1	APN	4	58,070,311 (GRCm39)	missense	possibly damaging	0.71
IGL02284:Svep1	APN	4	58,072,819 (GRCm39)	missense	probably benign	0.32
IGL02323:Svep1	APN	4	58,070,236 (GRCm39)	nonsense	probably null
IGL02440:Svep1	APN	4	58,145,293 (GRCm39)	missense	probably benign	0.06
IGL02449:Svep1	APN	4	58,070,296 (GRCm39)	missense	possibly damaging	0.71
IGL02501:Svep1	APN	4	58,145,341 (GRCm39)	splice site	probably benign
IGL02568:Svep1	APN	4	58,135,441 (GRCm39)	missense	probably benign	0.42
IGL02625:Svep1	APN	4	58,115,807 (GRCm39)	missense	possibly damaging	0.53
IGL02795:Svep1	APN	4	58,123,223 (GRCm39)	missense	probably damaging	1.00
IGL02818:Svep1	APN	4	58,069,804 (GRCm39)	missense	possibly damaging	0.71
IGL02871:Svep1	APN	4	58,100,871 (GRCm39)	missense	probably benign
IGL02875:Svep1	APN	4	58,082,821 (GRCm39)	splice site	probably benign
IGL02887:Svep1	APN	4	58,145,301 (GRCm39)	missense	probably damaging	1.00
IGL03240:Svep1	APN	4	58,048,188 (GRCm39)	missense	possibly damaging	0.73
IGL03243:Svep1	APN	4	58,133,387 (GRCm39)	missense	probably benign	0.06
IGL03264:Svep1	APN	4	58,066,422 (GRCm39)	splice site	probably benign
IGL03288:Svep1	APN	4	58,116,532 (GRCm39)	missense	probably benign	0.01
IGL03340:Svep1	APN	4	58,111,451 (GRCm39)	missense	possibly damaging	0.96
IGL03341:Svep1	APN	4	58,070,308 (GRCm39)	nonsense	probably null
IGL03348:Svep1	APN	4	58,113,635 (GRCm39)	missense	probably damaging	1.00
R0001:Svep1	UTSW	4	58,066,460 (GRCm39)	missense	possibly damaging	0.93
R0042:Svep1	UTSW	4	58,123,192 (GRCm39)	missense	possibly damaging	0.92
R0042:Svep1	UTSW	4	58,123,192 (GRCm39)	missense	possibly damaging	0.92
R0125:Svep1	UTSW	4	58,099,937 (GRCm39)	splice site	probably benign
R0142:Svep1	UTSW	4	58,118,232 (GRCm39)	missense	probably benign	0.33
R0147:Svep1	UTSW	4	58,116,608 (GRCm39)	missense	possibly damaging	0.85
R0148:Svep1	UTSW	4	58,116,608 (GRCm39)	missense	possibly damaging	0.85
R0157:Svep1	UTSW	4	58,069,830 (GRCm39)	missense	possibly damaging	0.72
R0195:Svep1	UTSW	4	58,089,514 (GRCm39)	missense	possibly damaging	0.82
R0197:Svep1	UTSW	4	58,070,851 (GRCm39)	missense	possibly damaging	0.71
R0257:Svep1	UTSW	4	58,179,610 (GRCm39)	missense	possibly damaging	0.71
R0314:Svep1	UTSW	4	58,096,331 (GRCm39)	missense	possibly damaging	0.71
R0316:Svep1	UTSW	4	58,072,737 (GRCm39)	missense	probably damaging	0.98
R0322:Svep1	UTSW	4	58,057,996 (GRCm39)	splice site	probably benign
R0426:Svep1	UTSW	4	58,073,333 (GRCm39)	missense	possibly damaging	0.87
R0446:Svep1	UTSW	4	58,088,280 (GRCm39)	missense	probably damaging	1.00
R0457:Svep1	UTSW	4	58,118,136 (GRCm39)	missense	probably damaging	1.00
R0471:Svep1	UTSW	4	58,054,700 (GRCm39)	missense	possibly damaging	0.85
R0555:Svep1	UTSW	4	58,128,858 (GRCm39)	missense	possibly damaging	0.71
R0634:Svep1	UTSW	4	58,070,661 (GRCm39)	missense	possibly damaging	0.86
R0636:Svep1	UTSW	4	58,073,121 (GRCm39)	nonsense	probably null
R0827:Svep1	UTSW	4	58,053,113 (GRCm39)	splice site	probably benign
R1025:Svep1	UTSW	4	58,087,817 (GRCm39)	missense	possibly damaging	0.86
R1027:Svep1	UTSW	4	58,094,084 (GRCm39)	missense	possibly damaging	0.86
R1069:Svep1	UTSW	4	58,070,239 (GRCm39)	missense	probably damaging	1.00
R1161:Svep1	UTSW	4	58,069,416 (GRCm39)	missense	possibly damaging	0.71
R1245:Svep1	UTSW	4	58,066,427 (GRCm39)	critical splice donor site	probably null
R1282:Svep1	UTSW	4	58,100,032 (GRCm39)	missense	possibly damaging	0.93
R1310:Svep1	UTSW	4	58,069,416 (GRCm39)	missense	possibly damaging	0.71
R1444:Svep1	UTSW	4	58,115,754 (GRCm39)	missense	possibly damaging	0.53
R1460:Svep1	UTSW	4	58,068,740 (GRCm39)	missense	possibly damaging	0.85
R1500:Svep1	UTSW	4	58,070,239 (GRCm39)	missense	probably damaging	1.00
R1628:Svep1	UTSW	4	58,107,561 (GRCm39)	missense	probably benign	0.00
R1712:Svep1	UTSW	4	58,070,629 (GRCm39)	missense	probably benign	0.06
R1774:Svep1	UTSW	4	58,146,562 (GRCm39)	missense	possibly damaging	0.92
R1783:Svep1	UTSW	4	58,073,333 (GRCm39)	missense	probably benign
R1829:Svep1	UTSW	4	58,096,310 (GRCm39)	missense	possibly damaging	0.93
R1978:Svep1	UTSW	4	58,097,292 (GRCm39)	missense	possibly damaging	0.73
R1993:Svep1	UTSW	4	58,064,170 (GRCm39)	critical splice donor site	probably null
R2017:Svep1	UTSW	4	58,070,568 (GRCm39)	missense	probably benign	0.08
R2058:Svep1	UTSW	4	58,084,554 (GRCm39)	missense	possibly damaging	0.92
R2109:Svep1	UTSW	4	58,206,030 (GRCm39)	missense	possibly damaging	0.51
R2215:Svep1	UTSW	4	58,138,602 (GRCm39)	splice site	probably benign
R2281:Svep1	UTSW	4	58,082,677 (GRCm39)	missense	possibly damaging	0.85
R2504:Svep1	UTSW	4	58,135,628 (GRCm39)	splice site	probably null
R2763:Svep1	UTSW	4	58,084,061 (GRCm39)	missense	possibly damaging	0.86
R3122:Svep1	UTSW	4	58,087,845 (GRCm39)	missense	possibly damaging	0.51
R3605:Svep1	UTSW	4	58,066,542 (GRCm39)	missense	probably benign	0.32
R3763:Svep1	UTSW	4	58,084,833 (GRCm39)	missense	possibly damaging	0.89
R3827:Svep1	UTSW	4	58,096,177 (GRCm39)	missense	probably damaging	0.98
R3829:Svep1	UTSW	4	58,096,177 (GRCm39)	missense	probably damaging	0.98
R3830:Svep1	UTSW	4	58,096,177 (GRCm39)	missense	probably damaging	0.98
R3910:Svep1	UTSW	4	58,145,156 (GRCm39)	critical splice donor site	probably null
R3943:Svep1	UTSW	4	58,084,807 (GRCm39)	splice site	probably null
R3944:Svep1	UTSW	4	58,084,807 (GRCm39)	splice site	probably null
R4153:Svep1	UTSW	4	58,089,426 (GRCm39)	missense	possibly damaging	0.52
R4154:Svep1	UTSW	4	58,069,068 (GRCm39)	missense	possibly damaging	0.71
R4191:Svep1	UTSW	4	58,046,601 (GRCm39)	missense	possibly damaging	0.86
R4355:Svep1	UTSW	4	58,138,695 (GRCm39)	missense	possibly damaging	0.71
R4388:Svep1	UTSW	4	58,069,249 (GRCm39)	missense	possibly damaging	0.93
R4532:Svep1	UTSW	4	58,068,886 (GRCm39)	missense	possibly damaging	0.52
R4584:Svep1	UTSW	4	58,068,526 (GRCm39)	nonsense	probably null
R4592:Svep1	UTSW	4	58,084,028 (GRCm39)	missense	possibly damaging	0.93
R4593:Svep1	UTSW	4	58,091,944 (GRCm39)	missense	possibly damaging	0.71
R4625:Svep1	UTSW	4	58,072,698 (GRCm39)	missense	probably damaging	0.98
R4639:Svep1	UTSW	4	58,082,724 (GRCm39)	missense	probably benign
R4700:Svep1	UTSW	4	58,097,323 (GRCm39)	missense	possibly damaging	0.71
R4720:Svep1	UTSW	4	58,205,869 (GRCm39)	missense	possibly damaging	0.71
R4724:Svep1	UTSW	4	58,070,752 (GRCm39)	missense	possibly damaging	0.71
R4753:Svep1	UTSW	4	58,053,212 (GRCm39)	missense	probably benign	0.06
R4781:Svep1	UTSW	4	58,070,340 (GRCm39)	missense	probably damaging	0.98
R4820:Svep1	UTSW	4	58,082,664 (GRCm39)	missense	probably benign	0.27
R4896:Svep1	UTSW	4	58,087,751 (GRCm39)	missense	probably benign	0.08
R4905:Svep1	UTSW	4	58,069,308 (GRCm39)	missense	probably benign	0.00
R4910:Svep1	UTSW	4	58,096,276 (GRCm39)	missense	possibly damaging	0.71
R4972:Svep1	UTSW	4	58,087,778 (GRCm39)	missense	possibly damaging	0.71
R5004:Svep1	UTSW	4	58,087,751 (GRCm39)	missense	probably benign	0.08
R5088:Svep1	UTSW	4	58,120,648 (GRCm39)	missense	possibly damaging	0.73
R5112:Svep1	UTSW	4	58,068,610 (GRCm39)	nonsense	probably null
R5185:Svep1	UTSW	4	58,084,534 (GRCm39)	missense	probably damaging	0.99
R5302:Svep1	UTSW	4	58,096,183 (GRCm39)	missense	possibly damaging	0.71
R5307:Svep1	UTSW	4	58,072,677 (GRCm39)	missense	possibly damaging	0.71
R5339:Svep1	UTSW	4	58,121,892 (GRCm39)	missense	possibly damaging	0.96
R5379:Svep1	UTSW	4	58,072,991 (GRCm39)	missense	possibly damaging	0.51
R5384:Svep1	UTSW	4	58,104,545 (GRCm39)	missense	possibly damaging	0.71
R5414:Svep1	UTSW	4	58,206,322 (GRCm39)	missense	possibly damaging	0.53
R5514:Svep1	UTSW	4	58,044,054 (GRCm39)	missense	possibly damaging	0.53
R5538:Svep1	UTSW	4	58,049,282 (GRCm39)	critical splice acceptor site	probably null
R5549:Svep1	UTSW	4	58,057,954 (GRCm39)	missense	probably benign	0.32
R5618:Svep1	UTSW	4	58,070,537 (GRCm39)	missense	probably benign
R5623:Svep1	UTSW	4	58,091,964 (GRCm39)	missense	possibly damaging	0.92
R5686:Svep1	UTSW	4	58,072,826 (GRCm39)	missense	possibly damaging	0.71
R5743:Svep1	UTSW	4	58,096,223 (GRCm39)	missense	possibly damaging	0.71
R5773:Svep1	UTSW	4	58,099,985 (GRCm39)	missense	possibly damaging	0.86
R5809:Svep1	UTSW	4	58,116,524 (GRCm39)	missense	possibly damaging	0.73
R5896:Svep1	UTSW	4	58,084,906 (GRCm39)	missense	possibly damaging	0.71
R5918:Svep1	UTSW	4	58,069,345 (GRCm39)	missense	possibly damaging	0.71
R5969:Svep1	UTSW	4	58,070,977 (GRCm39)	nonsense	probably null
R6010:Svep1	UTSW	4	58,115,832 (GRCm39)	missense	possibly damaging	0.95
R6187:Svep1	UTSW	4	58,072,872 (GRCm39)	missense	probably damaging	1.00
R6192:Svep1	UTSW	4	58,104,536 (GRCm39)	missense	possibly damaging	0.92
R6209:Svep1	UTSW	4	58,128,869 (GRCm39)	missense	probably benign	0.32
R6234:Svep1	UTSW	4	58,113,458 (GRCm39)	splice site	probably null
R6326:Svep1	UTSW	4	58,073,045 (GRCm39)	missense	possibly damaging	0.51
R6400:Svep1	UTSW	4	58,049,169 (GRCm39)	missense	probably damaging	1.00
R6418:Svep1	UTSW	4	58,053,126 (GRCm39)	missense	probably benign	0.01
R6440:Svep1	UTSW	4	58,116,555 (GRCm39)	missense	possibly damaging	0.53
R6489:Svep1	UTSW	4	58,100,066 (GRCm39)	missense	probably damaging	1.00
R6738:Svep1	UTSW	4	58,123,180 (GRCm39)	missense	possibly damaging	0.71
R6773:Svep1	UTSW	4	58,049,146 (GRCm39)	missense	possibly damaging	0.71
R6796:Svep1	UTSW	4	58,064,275 (GRCm39)	missense	probably benign	0.01
R7055:Svep1	UTSW	4	58,120,642 (GRCm39)	missense	probably benign	0.33
R7055:Svep1	UTSW	4	58,064,275 (GRCm39)	missense	probably benign	0.19
R7111:Svep1	UTSW	4	58,118,207 (GRCm39)	missense	possibly damaging	0.70
R7161:Svep1	UTSW	4	58,128,859 (GRCm39)	missense	possibly damaging	0.93
R7162:Svep1	UTSW	4	58,070,262 (GRCm39)	missense	possibly damaging	0.71
R7182:Svep1	UTSW	4	58,043,991 (GRCm39)	missense	probably benign	0.18
R7292:Svep1	UTSW	4	58,111,395 (GRCm39)	missense	possibly damaging	0.71
R7299:Svep1	UTSW	4	58,046,587 (GRCm39)	nonsense	probably null
R7301:Svep1	UTSW	4	58,046,587 (GRCm39)	nonsense	probably null
R7316:Svep1	UTSW	4	58,068,763 (GRCm39)	missense	possibly damaging	0.71
R7337:Svep1	UTSW	4	58,108,323 (GRCm39)	missense	probably damaging	0.98
R7391:Svep1	UTSW	4	58,145,185 (GRCm39)	missense	probably damaging	0.98
R7402:Svep1	UTSW	4	58,069,699 (GRCm39)	missense	possibly damaging	0.71
R7445:Svep1	UTSW	4	58,094,122 (GRCm39)	missense	possibly damaging	0.85
R7450:Svep1	UTSW	4	58,064,248 (GRCm39)	missense	possibly damaging	0.71
R7492:Svep1	UTSW	4	58,066,468 (GRCm39)	missense	possibly damaging	0.51
R7505:Svep1	UTSW	4	58,115,862 (GRCm39)	missense	possibly damaging	0.53
R7509:Svep1	UTSW	4	58,090,683 (GRCm39)	missense	probably benign	0.40
R7538:Svep1	UTSW	4	58,053,260 (GRCm39)	missense	possibly damaging	0.71
R7555:Svep1	UTSW	4	58,069,422 (GRCm39)	missense	probably damaging	0.98
R7660:Svep1	UTSW	4	58,087,782 (GRCm39)	missense	probably benign	0.32
R7670:Svep1	UTSW	4	58,097,424 (GRCm39)	missense	probably damaging	1.00
R7719:Svep1	UTSW	4	58,068,523 (GRCm39)	missense	probably damaging	0.97
R7733:Svep1	UTSW	4	58,049,239 (GRCm39)	missense	probably benign	0.03
R7781:Svep1	UTSW	4	58,069,251 (GRCm39)	missense	possibly damaging	0.71
R7821:Svep1	UTSW	4	58,179,601 (GRCm39)	missense	probably damaging	0.99
R7832:Svep1	UTSW	4	58,054,539 (GRCm39)	missense	probably benign	0.44
R8017:Svep1	UTSW	4	58,146,637 (GRCm39)	missense	probably damaging	0.99
R8019:Svep1	UTSW	4	58,146,637 (GRCm39)	missense	probably damaging	0.99
R8066:Svep1	UTSW	4	58,113,650 (GRCm39)	missense	probably benign	0.33
R8159:Svep1	UTSW	4	58,087,815 (GRCm39)	missense	probably benign	0.01
R8159:Svep1	UTSW	4	58,069,396 (GRCm39)	missense	possibly damaging	0.71
R8170:Svep1	UTSW	4	58,069,378 (GRCm39)	missense	probably benign	0.00
R8246:Svep1	UTSW	4	58,091,889 (GRCm39)	missense	probably damaging	0.96
R8392:Svep1	UTSW	4	58,070,566 (GRCm39)	missense	possibly damaging	0.71
R8436:Svep1	UTSW	4	58,044,053 (GRCm39)	missense	possibly damaging	0.86
R8544:Svep1	UTSW	4	58,206,025 (GRCm39)	missense	probably benign	0.00
R8669:Svep1	UTSW	4	58,070,119 (GRCm39)	missense	possibly damaging	0.95
R8707:Svep1	UTSW	4	58,070,197 (GRCm39)	nonsense	probably null
R8790:Svep1	UTSW	4	58,118,145 (GRCm39)	missense	possibly damaging	0.53
R8804:Svep1	UTSW	4	58,206,043 (GRCm39)	missense	possibly damaging	0.86
R8868:Svep1	UTSW	4	58,135,578 (GRCm39)	missense	possibly damaging	0.77
R8880:Svep1	UTSW	4	58,064,204 (GRCm39)	missense	possibly damaging	0.51
R8949:Svep1	UTSW	4	58,054,604 (GRCm39)	missense	possibly damaging	0.85
R9007:Svep1	UTSW	4	58,091,915 (GRCm39)	missense	possibly damaging	0.86
R9028:Svep1	UTSW	4	58,145,199 (GRCm39)	missense	possibly damaging	0.92
R9131:Svep1	UTSW	4	58,087,778 (GRCm39)	missense	possibly damaging	0.71
R9285:Svep1	UTSW	4	58,084,809 (GRCm39)	critical splice donor site	probably null
R9302:Svep1	UTSW	4	58,120,565 (GRCm39)	missense	possibly damaging	0.53
R9314:Svep1	UTSW	4	58,070,347 (GRCm39)	missense	probably damaging	1.00
R9427:Svep1	UTSW	4	58,069,804 (GRCm39)	missense	possibly damaging	0.71
R9443:Svep1	UTSW	4	58,179,697 (GRCm39)	missense	possibly damaging	0.95
R9473:Svep1	UTSW	4	58,064,243 (GRCm39)	missense	probably benign	0.00
R9487:Svep1	UTSW	4	58,070,517 (GRCm39)	missense	probably benign
R9494:Svep1	UTSW	4	58,070,577 (GRCm39)	missense	possibly damaging	0.51
R9515:Svep1	UTSW	4	58,084,144 (GRCm39)	missense	possibly damaging	0.71
R9681:Svep1	UTSW	4	58,084,959 (GRCm39)	missense	probably damaging	0.98
X0063:Svep1	UTSW	4	58,070,468 (GRCm39)	nonsense	probably null
Z1176:Svep1	UTSW	4	58,133,415 (GRCm39)	missense	possibly damaging	0.51
Z1176:Svep1	UTSW	4	58,115,814 (GRCm39)	missense	possibly damaging	0.93
Z1176:Svep1	UTSW	4	58,111,386 (GRCm39)	missense	probably damaging	0.97
Z1177:Svep1	UTSW	4	58,206,300 (GRCm39)	missense	probably damaging	0.99
Z1177:Svep1	UTSW	4	58,115,841 (GRCm39)	missense	possibly damaging	0.91

Predicted Primers

PCR Primer
(F):5'- AATTGAGGAGCACTTTTAGCTCCC -3'
(R):5'- GGCAACTCCCATGGAACTAG -3'

Sequencing Primer
(F):5'- GAGCACTTTTAGCTCCCCTGGG -3'
(R):5'- TCCCATGGAACTAGGTTCATGCAAG -3'

Posted On

2018-06-06