Incidental Mutation 'R6515:Or10ak13'
ID 520579
Institutional Source Beutler Lab
Gene Symbol Or10ak13
Ensembl Gene ENSMUSG00000111159
Gene Name olfactory receptor family 10 subfamily AK member 13
Synonyms Olfr219-ps1, GA_x6K02SYWGW3-414-3, MOR259-10, GA_x6K02T2QD9B-18767132-18768073, Olfr1337
MMRRC Submission 044642-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.261) question?
Stock # R6515 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118638833-118639783 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118639467 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 105 (Y105C)
Ref Sequence ENSEMBL: ENSMUSP00000076483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077247]
AlphaFold A2ACY8
Predicted Effect probably benign
Transcript: ENSMUST00000077247
AA Change: Y105C

PolyPhen 2 Score 0.134 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000076483
Gene: ENSMUSG00000111159
AA Change: Y105C

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 7.8e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 8.5e-7 PFAM
Pfam:7tm_1 44 293 8.3e-23 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.1%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap1s3 T C 1: 79,592,044 (GRCm39) D102G probably damaging Het
Apcdd1 T A 18: 63,084,910 (GRCm39) M369K probably damaging Het
Atp4a A G 7: 30,411,903 (GRCm39) K46R possibly damaging Het
Bcl9l A G 9: 44,419,171 (GRCm39) probably null Het
Cabyr A G 18: 12,887,340 (GRCm39) S324G possibly damaging Het
Casp8ap2 A G 4: 32,646,423 (GRCm39) D1832G possibly damaging Het
Cdk4 C T 10: 126,902,052 (GRCm39) P256S probably null Het
Cnot6l C A 5: 96,309,537 (GRCm39) probably benign Het
Cox17 C A 16: 38,167,557 (GRCm39) A32E probably damaging Het
Cyp27b1 G T 10: 126,884,119 (GRCm39) probably benign Het
Enpp2 T A 15: 54,723,489 (GRCm39) N628I possibly damaging Het
Ggcx T C 6: 72,402,815 (GRCm39) C258R probably benign Het
Hbb-bh1 T C 7: 103,491,974 (GRCm39) D80G probably damaging Het
Hoxb5 A T 11: 96,195,908 (GRCm39) D252V probably damaging Het
Hspa4l A G 3: 40,736,014 (GRCm39) D545G possibly damaging Het
Hspa5 T A 2: 34,662,416 (GRCm39) V28E probably benign Het
Ifit1bl1 T C 19: 34,571,899 (GRCm39) Y186C probably damaging Het
Itpr3 C T 17: 27,310,344 (GRCm39) A403V probably benign Het
Kif19b T C 5: 140,480,779 (GRCm39) S970P possibly damaging Het
Klra17 A T 6: 129,808,462 (GRCm39) I257N probably damaging Het
Megf6 C T 4: 154,343,376 (GRCm39) H662Y possibly damaging Het
Mfsd6 T C 1: 52,700,120 (GRCm39) K676R probably damaging Het
Nutm1 A C 2: 112,086,665 (GRCm39) L22R probably benign Het
Oas1f T C 5: 120,986,497 (GRCm39) V150A probably damaging Het
Or4f62 T C 2: 111,986,710 (GRCm39) L138P probably benign Het
Pik3ap1 A G 19: 41,364,585 (GRCm39) Y45H probably benign Het
Pnlip T C 19: 58,661,547 (GRCm39) S79P probably damaging Het
Ppfia3 T C 7: 44,989,657 (GRCm39) D1185G possibly damaging Het
Pphln1-ps1 G A 16: 13,494,820 (GRCm39) probably benign Het
Rbm34 A T 8: 127,688,682 (GRCm39) S217T possibly damaging Het
Rbm44 T C 1: 91,092,860 (GRCm39) I820T probably damaging Het
Rnf151 A T 17: 24,935,391 (GRCm39) L180Q probably benign Het
Sec24d G A 3: 123,136,719 (GRCm39) R484Q possibly damaging Het
Spop C A 11: 95,376,761 (GRCm39) D271E possibly damaging Het
Svep1 C T 4: 58,088,280 (GRCm39) G1723D probably damaging Het
Tenm3 G C 8: 48,870,257 (GRCm39) Q179E probably benign Het
Thap12 A G 7: 98,356,302 (GRCm39) E63G probably damaging Het
Thsd7a T A 6: 12,501,085 (GRCm39) T441S possibly damaging Het
Tle6 G A 10: 81,427,810 (GRCm39) H482Y probably damaging Het
Tmem184a A G 5: 139,794,193 (GRCm39) F177L probably benign Het
Uggt2 A T 14: 119,315,131 (GRCm39) S313T possibly damaging Het
Unc13a A G 8: 72,100,584 (GRCm39) I1068T probably benign Het
Xirp1 T C 9: 119,845,983 (GRCm39) R967G probably benign Het
Other mutations in Or10ak13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02203:Or10ak13 APN 4 118,639,626 (GRCm39) missense possibly damaging 0.95
IGL02626:Or10ak13 APN 4 118,639,531 (GRCm39) missense probably damaging 0.98
IGL02699:Or10ak13 APN 4 118,639,349 (GRCm39) nonsense probably null
IGL02754:Or10ak13 APN 4 118,639,117 (GRCm39) missense possibly damaging 0.90
IGL03287:Or10ak13 APN 4 118,639,551 (GRCm39) missense possibly damaging 0.64
R1341:Or10ak13 UTSW 4 118,639,579 (GRCm39) missense probably benign 0.01
R4894:Or10ak13 UTSW 4 118,639,483 (GRCm39) missense probably damaging 1.00
R6124:Or10ak13 UTSW 4 118,639,392 (GRCm39) missense probably damaging 1.00
R6529:Or10ak13 UTSW 4 118,638,907 (GRCm39) missense probably benign 0.15
R7040:Or10ak13 UTSW 4 118,639,183 (GRCm39) missense probably benign 0.00
R7398:Or10ak13 UTSW 4 118,638,896 (GRCm39) missense possibly damaging 0.80
R7684:Or10ak13 UTSW 4 118,639,471 (GRCm39) missense probably benign 0.40
R8377:Or10ak13 UTSW 4 118,639,203 (GRCm39) missense probably benign 0.22
R8717:Or10ak13 UTSW 4 118,638,996 (GRCm39) missense probably damaging 1.00
R9369:Or10ak13 UTSW 4 118,639,077 (GRCm39) missense probably benign 0.31
R9594:Or10ak13 UTSW 4 118,638,952 (GRCm39) missense probably benign
Z1189:Or10ak13 UTSW 4 118,639,284 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- TGGCAGACTCATGGTGAAG -3'
(R):5'- ATGTACCTGAGCTCAGTCCTG -3'

Sequencing Primer
(F):5'- ACTCATGGTGAAGAAAGTATGTAAC -3'
(R):5'- GCAATGGGCTCATCATCATG -3'
Posted On 2018-06-06