Incidental Mutation 'R6515:Cnot6l'
ID 520583
Institutional Source Beutler Lab
Gene Symbol Cnot6l
Ensembl Gene ENSMUSG00000034724
Gene Name CCR4-NOT transcription complex, subunit 6-like
Synonyms 4932442K20Rik
MMRRC Submission 044642-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.549) question?
Stock # R6515 (G1)
Quality Score 221.009
Status Not validated
Chromosome 5
Chromosomal Location 96218192-96312030 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to A at 96309537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036646] [ENSMUST00000113005] [ENSMUST00000122003] [ENSMUST00000129646] [ENSMUST00000137207] [ENSMUST00000141383] [ENSMUST00000154500] [ENSMUST00000155901]
AlphaFold Q8VEG6
Predicted Effect probably benign
Transcript: ENSMUST00000036646
Predicted Effect probably benign
Transcript: ENSMUST00000113005
SMART Domains Protein: ENSMUSP00000108629
Gene: ENSMUSG00000034724

DomainStartEndE-ValueType
LRR 55 77 4.34e-1 SMART
LRR 78 100 1.01e-1 SMART
LRR 101 124 7.55e-1 SMART
Pfam:Exo_endo_phos 192 529 7.3e-22 PFAM
low complexity region 532 545 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000122003
SMART Domains Protein: ENSMUSP00000113821
Gene: ENSMUSG00000034724

DomainStartEndE-ValueType
LRR 50 72 4.34e-1 SMART
LRR 73 95 1.01e-1 SMART
LRR 96 119 7.55e-1 SMART
Pfam:Exo_endo_phos 187 433 1.3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129646
SMART Domains Protein: ENSMUSP00000123653
Gene: ENSMUSG00000034724

DomainStartEndE-ValueType
LRR 50 72 4.34e-1 SMART
LRR 73 95 1.01e-1 SMART
LRR 96 119 7.55e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000137207
SMART Domains Protein: ENSMUSP00000121627
Gene: ENSMUSG00000034724

DomainStartEndE-ValueType
LRR_TYP 50 73 6.67e-2 SMART
Pfam:LRR_1 75 87 6.9e-2 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000141383
SMART Domains Protein: ENSMUSP00000114436
Gene: ENSMUSG00000034724

DomainStartEndE-ValueType
LRR 50 72 4.34e-1 SMART
LRR_TYP 73 96 1.58e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154500
Predicted Effect probably benign
Transcript: ENSMUST00000155901
SMART Domains Protein: ENSMUSP00000119415
Gene: ENSMUSG00000034724

DomainStartEndE-ValueType
LRR 50 72 4.34e-1 SMART
LRR 73 95 1.01e-1 SMART
LRR 96 119 7.55e-1 SMART
Pfam:Exo_endo_phos 187 524 2.2e-23 PFAM
low complexity region 527 540 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.1%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap1s3 T C 1: 79,592,044 (GRCm39) D102G probably damaging Het
Apcdd1 T A 18: 63,084,910 (GRCm39) M369K probably damaging Het
Atp4a A G 7: 30,411,903 (GRCm39) K46R possibly damaging Het
Bcl9l A G 9: 44,419,171 (GRCm39) probably null Het
Cabyr A G 18: 12,887,340 (GRCm39) S324G possibly damaging Het
Casp8ap2 A G 4: 32,646,423 (GRCm39) D1832G possibly damaging Het
Cdk4 C T 10: 126,902,052 (GRCm39) P256S probably null Het
Cox17 C A 16: 38,167,557 (GRCm39) A32E probably damaging Het
Cyp27b1 G T 10: 126,884,119 (GRCm39) probably benign Het
Enpp2 T A 15: 54,723,489 (GRCm39) N628I possibly damaging Het
Ggcx T C 6: 72,402,815 (GRCm39) C258R probably benign Het
Hbb-bh1 T C 7: 103,491,974 (GRCm39) D80G probably damaging Het
Hoxb5 A T 11: 96,195,908 (GRCm39) D252V probably damaging Het
Hspa4l A G 3: 40,736,014 (GRCm39) D545G possibly damaging Het
Hspa5 T A 2: 34,662,416 (GRCm39) V28E probably benign Het
Ifit1bl1 T C 19: 34,571,899 (GRCm39) Y186C probably damaging Het
Itpr3 C T 17: 27,310,344 (GRCm39) A403V probably benign Het
Kif19b T C 5: 140,480,779 (GRCm39) S970P possibly damaging Het
Klra17 A T 6: 129,808,462 (GRCm39) I257N probably damaging Het
Megf6 C T 4: 154,343,376 (GRCm39) H662Y possibly damaging Het
Mfsd6 T C 1: 52,700,120 (GRCm39) K676R probably damaging Het
Nutm1 A C 2: 112,086,665 (GRCm39) L22R probably benign Het
Oas1f T C 5: 120,986,497 (GRCm39) V150A probably damaging Het
Or10ak13 T C 4: 118,639,467 (GRCm39) Y105C probably benign Het
Or4f62 T C 2: 111,986,710 (GRCm39) L138P probably benign Het
Pik3ap1 A G 19: 41,364,585 (GRCm39) Y45H probably benign Het
Pnlip T C 19: 58,661,547 (GRCm39) S79P probably damaging Het
Ppfia3 T C 7: 44,989,657 (GRCm39) D1185G possibly damaging Het
Pphln1-ps1 G A 16: 13,494,820 (GRCm39) probably benign Het
Rbm34 A T 8: 127,688,682 (GRCm39) S217T possibly damaging Het
Rbm44 T C 1: 91,092,860 (GRCm39) I820T probably damaging Het
Rnf151 A T 17: 24,935,391 (GRCm39) L180Q probably benign Het
Sec24d G A 3: 123,136,719 (GRCm39) R484Q possibly damaging Het
Spop C A 11: 95,376,761 (GRCm39) D271E possibly damaging Het
Svep1 C T 4: 58,088,280 (GRCm39) G1723D probably damaging Het
Tenm3 G C 8: 48,870,257 (GRCm39) Q179E probably benign Het
Thap12 A G 7: 98,356,302 (GRCm39) E63G probably damaging Het
Thsd7a T A 6: 12,501,085 (GRCm39) T441S possibly damaging Het
Tle6 G A 10: 81,427,810 (GRCm39) H482Y probably damaging Het
Tmem184a A G 5: 139,794,193 (GRCm39) F177L probably benign Het
Uggt2 A T 14: 119,315,131 (GRCm39) S313T possibly damaging Het
Unc13a A G 8: 72,100,584 (GRCm39) I1068T probably benign Het
Xirp1 T C 9: 119,845,983 (GRCm39) R967G probably benign Het
Other mutations in Cnot6l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01346:Cnot6l APN 5 96,234,105 (GRCm39) missense probably damaging 1.00
IGL02102:Cnot6l APN 5 96,239,518 (GRCm39) missense probably damaging 0.98
BB005:Cnot6l UTSW 5 96,278,927 (GRCm39) missense possibly damaging 0.95
BB015:Cnot6l UTSW 5 96,278,927 (GRCm39) missense possibly damaging 0.95
R0443:Cnot6l UTSW 5 96,239,604 (GRCm39) splice site probably benign
R0448:Cnot6l UTSW 5 96,227,905 (GRCm39) missense probably benign 0.00
R1436:Cnot6l UTSW 5 96,281,971 (GRCm39) missense probably damaging 1.00
R2198:Cnot6l UTSW 5 96,227,800 (GRCm39) missense possibly damaging 0.79
R4240:Cnot6l UTSW 5 96,225,221 (GRCm39) missense probably benign
R4506:Cnot6l UTSW 5 96,234,033 (GRCm39) missense possibly damaging 0.93
R4624:Cnot6l UTSW 5 96,225,070 (GRCm39) missense probably benign 0.05
R4627:Cnot6l UTSW 5 96,225,070 (GRCm39) missense probably benign 0.05
R4629:Cnot6l UTSW 5 96,225,070 (GRCm39) missense probably benign 0.05
R4868:Cnot6l UTSW 5 96,230,882 (GRCm39) missense probably damaging 1.00
R4936:Cnot6l UTSW 5 96,227,796 (GRCm39) missense probably damaging 1.00
R5597:Cnot6l UTSW 5 96,278,978 (GRCm39) missense probably damaging 1.00
R5781:Cnot6l UTSW 5 96,234,024 (GRCm39) missense probably benign 0.31
R6142:Cnot6l UTSW 5 96,230,837 (GRCm39) missense probably benign 0.00
R6166:Cnot6l UTSW 5 96,227,799 (GRCm39) missense possibly damaging 0.79
R6189:Cnot6l UTSW 5 96,246,136 (GRCm39) missense probably benign 0.18
R6382:Cnot6l UTSW 5 96,276,858 (GRCm39) missense probably damaging 0.99
R6773:Cnot6l UTSW 5 96,242,158 (GRCm39) missense probably damaging 1.00
R7326:Cnot6l UTSW 5 96,225,158 (GRCm39) missense probably benign 0.00
R7466:Cnot6l UTSW 5 96,278,987 (GRCm39) missense probably benign 0.01
R7832:Cnot6l UTSW 5 96,242,084 (GRCm39) missense possibly damaging 0.90
R7928:Cnot6l UTSW 5 96,278,927 (GRCm39) missense possibly damaging 0.95
R8310:Cnot6l UTSW 5 96,239,535 (GRCm39) missense probably benign
R8499:Cnot6l UTSW 5 96,225,176 (GRCm39) missense probably damaging 1.00
R8698:Cnot6l UTSW 5 96,225,149 (GRCm39) missense probably damaging 1.00
R9029:Cnot6l UTSW 5 96,246,136 (GRCm39) missense probably benign 0.18
R9100:Cnot6l UTSW 5 96,230,875 (GRCm39) missense probably damaging 1.00
R9377:Cnot6l UTSW 5 96,276,826 (GRCm39) missense probably benign 0.01
R9485:Cnot6l UTSW 5 96,230,858 (GRCm39) missense probably damaging 0.99
R9685:Cnot6l UTSW 5 96,230,749 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2018-06-06