Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01090:Vmn2r87'

52080

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r87

Ensembl Gene

ENSMUSG00000091511

Gene Name

vomeronasal 2, receptor 87

Synonyms

EG625131

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL01090

Quality Score

Status

Chromosome

Chromosomal Location

130307690-130333248 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

A to G at 130333247 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 1 (M1T)

Ref Sequence

ENSEMBL: ENSMUSP00000129215 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164227]

AlphaFold

E9PZX4

Predicted Effect

probably null
Transcript: ENSMUST00000164227
AA Change: M1T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129215
Gene: ENSMUSG00000091511
AA Change: M1T

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	77	422	1.8e-27	PFAM
Pfam:NCD3G	508	562	1.8e-19	PFAM
Pfam:7tm_3	595	829	8.8e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	T	C	6: 91,896,099 (GRCm39)	S316P	possibly damaging	Het
Actn1	A	T	12: 80,245,846 (GRCm39)		probably null	Het
Agbl3	T	C	6: 34,776,822 (GRCm39)	Y443H	probably benign	Het
Akap13	T	A	7: 75,316,279 (GRCm39)	D578E	probably benign	Het
Aldoa	A	T	7: 126,395,207 (GRCm39)	H292Q	probably benign	Het
Als2	T	C	1: 59,254,775 (GRCm39)	K194R	possibly damaging	Het
Bivm	C	A	1: 44,168,451 (GRCm39)	H244N	probably damaging	Het
Cabp5	G	A	7: 13,139,412 (GRCm39)	E146K	probably damaging	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cfap251	A	C	5: 123,418,052 (GRCm39)		probably benign	Het
Clcn4	A	G	7: 7,297,035 (GRCm39)	V129A	probably benign	Het
Clec4g	A	G	8: 3,769,482 (GRCm39)	S54P	probably damaging	Het
Crim1	G	T	17: 78,654,658 (GRCm39)	V645L	probably damaging	Het
Csta1	T	C	16: 35,945,421 (GRCm39)	T31A	probably damaging	Het
D930048N14Rik	T	C	11: 51,544,610 (GRCm39)		probably benign	Het
Dhx34	G	T	7: 15,950,181 (GRCm39)	P329Q	probably damaging	Het
Dusp16	T	C	6: 134,702,912 (GRCm39)	N193S	probably benign	Het
Fbn1	A	G	2: 125,236,696 (GRCm39)		probably benign	Het
Fbxo46	A	G	7: 18,870,728 (GRCm39)	Y449C	probably damaging	Het
Fmo4	C	A	1: 162,637,354 (GRCm39)		probably null	Het
Foxi3	C	A	6: 70,937,729 (GRCm39)	N320K	probably damaging	Het
Gm9964	A	G	11: 79,187,210 (GRCm39)	L79P	unknown	Het
Gpr161	T	C	1: 165,134,149 (GRCm39)	I137T	probably damaging	Het
Herc1	C	T	9: 66,376,457 (GRCm39)	Q3426*	probably null	Het
Hps5	C	T	7: 46,437,751 (GRCm39)	R108H	probably benign	Het
Itch	T	A	2: 155,048,256 (GRCm39)	V540E	probably damaging	Het
L3mbtl1	C	A	2: 162,807,925 (GRCm39)	P520H	probably damaging	Het
Mvp	A	G	7: 126,588,859 (GRCm39)	V636A	probably benign	Het
Odf4	A	G	11: 68,812,778 (GRCm39)		probably benign	Het
Or7g18	A	G	9: 18,787,538 (GRCm39)	K305R	probably benign	Het
Pld1	T	C	3: 28,142,816 (GRCm39)	S675P	probably benign	Het
Plod3	A	G	5: 137,019,090 (GRCm39)	D325G	probably benign	Het
Prss12	T	C	3: 123,276,388 (GRCm39)	V339A	possibly damaging	Het
Ptpn13	T	A	5: 103,689,180 (GRCm39)	L991Q	probably null	Het
Ptpn3	T	A	4: 57,240,833 (GRCm39)	I261F	probably damaging	Het
Rab3gap1	T	C	1: 127,858,124 (GRCm39)		probably benign	Het
Rasa4	A	G	5: 136,130,847 (GRCm39)	R373G	possibly damaging	Het
Rmi1	T	C	13: 58,557,208 (GRCm39)	S486P	probably damaging	Het
Slc25a23	A	G	17: 57,354,233 (GRCm39)	I139T	probably benign	Het
Sspo	T	A	6: 48,467,059 (GRCm39)	S4017T	probably benign	Het
Tcaf1	C	A	6: 42,663,556 (GRCm39)	C108F	probably benign	Het
Tnc	T	C	4: 63,918,317 (GRCm39)	Q1198R	probably damaging	Het
Tnni3k	G	T	3: 154,645,320 (GRCm39)	Q522K	possibly damaging	Het
Trio	T	A	15: 27,773,093 (GRCm39)	E713V	probably damaging	Het
Ugt2b34	C	A	5: 87,041,679 (GRCm39)	V338F	probably damaging	Het
Usp40	T	A	1: 87,890,187 (GRCm39)	M892L	probably benign	Het
Usp54	A	T	14: 20,636,225 (GRCm39)		probably benign	Het
Vmn2r53	T	C	7: 12,334,835 (GRCm39)	E275G	possibly damaging	Het
Wdr83os	A	T	8: 85,808,476 (GRCm39)	D76V	probably damaging	Het

Other mutations in Vmn2r87

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01295:Vmn2r87	APN	10	130,307,878 (GRCm39)	missense	probably damaging	1.00
IGL01411:Vmn2r87	APN	10	130,308,429 (GRCm39)	missense	probably benign	0.03
IGL01680:Vmn2r87	APN	10	130,315,586 (GRCm39)	nonsense	probably null
IGL01822:Vmn2r87	APN	10	130,307,991 (GRCm39)	missense	probably damaging	1.00
IGL01835:Vmn2r87	APN	10	130,314,978 (GRCm39)	missense	probably damaging	1.00
IGL01965:Vmn2r87	APN	10	130,314,924 (GRCm39)	missense	possibly damaging	0.49
IGL02562:Vmn2r87	APN	10	130,314,513 (GRCm39)	missense	probably damaging	1.00
IGL02665:Vmn2r87	APN	10	130,333,049 (GRCm39)	missense	probably benign	0.16
IGL03202:Vmn2r87	APN	10	130,333,091 (GRCm39)	missense	probably benign
FR4304:Vmn2r87	UTSW	10	130,314,583 (GRCm39)	missense	probably benign	0.01
FR4340:Vmn2r87	UTSW	10	130,314,583 (GRCm39)	missense	probably benign	0.01
FR4342:Vmn2r87	UTSW	10	130,314,583 (GRCm39)	missense	probably benign	0.01
FR4589:Vmn2r87	UTSW	10	130,314,583 (GRCm39)	missense	probably benign	0.01
LCD18:Vmn2r87	UTSW	10	130,314,583 (GRCm39)	missense	probably benign	0.01
R0344:Vmn2r87	UTSW	10	130,315,806 (GRCm39)	missense	probably damaging	1.00
R0374:Vmn2r87	UTSW	10	130,307,848 (GRCm39)	missense	probably damaging	1.00
R0384:Vmn2r87	UTSW	10	130,307,712 (GRCm39)	missense	probably benign
R1144:Vmn2r87	UTSW	10	130,312,098 (GRCm39)	splice site	probably benign
R1172:Vmn2r87	UTSW	10	130,313,453 (GRCm39)	missense	probably benign	0.03
R1860:Vmn2r87	UTSW	10	130,315,755 (GRCm39)	missense	probably benign	0.00
R1866:Vmn2r87	UTSW	10	130,308,441 (GRCm39)	missense	possibly damaging	0.88
R1897:Vmn2r87	UTSW	10	130,307,829 (GRCm39)	missense	probably damaging	1.00
R2360:Vmn2r87	UTSW	10	130,315,631 (GRCm39)	missense	probably damaging	0.99
R2909:Vmn2r87	UTSW	10	130,314,865 (GRCm39)	missense	probably damaging	0.99
R3874:Vmn2r87	UTSW	10	130,315,856 (GRCm39)	missense	possibly damaging	0.62
R4113:Vmn2r87	UTSW	10	130,315,691 (GRCm39)	missense	probably benign
R4190:Vmn2r87	UTSW	10	130,308,556 (GRCm39)	missense	probably damaging	1.00
R4197:Vmn2r87	UTSW	10	130,315,779 (GRCm39)	missense	possibly damaging	0.55
R4201:Vmn2r87	UTSW	10	130,308,448 (GRCm39)	missense	probably benign	0.03
R4202:Vmn2r87	UTSW	10	130,308,448 (GRCm39)	missense	probably benign	0.03
R4368:Vmn2r87	UTSW	10	130,315,676 (GRCm39)	missense	probably benign	0.44
R4485:Vmn2r87	UTSW	10	130,315,678 (GRCm39)	nonsense	probably null
R4537:Vmn2r87	UTSW	10	130,308,054 (GRCm39)	missense	probably benign	0.12
R4590:Vmn2r87	UTSW	10	130,315,014 (GRCm39)	missense	possibly damaging	0.69
R4752:Vmn2r87	UTSW	10	130,314,336 (GRCm39)	nonsense	probably null
R4873:Vmn2r87	UTSW	10	130,308,367 (GRCm39)	missense	probably damaging	1.00
R4875:Vmn2r87	UTSW	10	130,308,367 (GRCm39)	missense	probably damaging	1.00
R4923:Vmn2r87	UTSW	10	130,314,435 (GRCm39)	missense	probably damaging	0.99
R4970:Vmn2r87	UTSW	10	130,314,422 (GRCm39)	missense	probably damaging	1.00
R5049:Vmn2r87	UTSW	10	130,308,298 (GRCm39)	missense	probably damaging	0.96
R5112:Vmn2r87	UTSW	10	130,314,422 (GRCm39)	missense	probably damaging	1.00
R5187:Vmn2r87	UTSW	10	130,333,208 (GRCm39)	missense	probably null	0.99
R5618:Vmn2r87	UTSW	10	130,315,817 (GRCm39)	missense	probably damaging	1.00
R6057:Vmn2r87	UTSW	10	130,308,226 (GRCm39)	missense	probably benign	0.02
R6220:Vmn2r87	UTSW	10	130,315,807 (GRCm39)	missense	probably benign	0.01
R6287:Vmn2r87	UTSW	10	130,314,291 (GRCm39)	critical splice donor site	probably null
R6383:Vmn2r87	UTSW	10	130,314,869 (GRCm39)	missense	probably damaging	1.00
R6576:Vmn2r87	UTSW	10	130,314,654 (GRCm39)	missense	probably benign	0.05
R6742:Vmn2r87	UTSW	10	130,308,396 (GRCm39)	missense	probably damaging	1.00
R7086:Vmn2r87	UTSW	10	130,333,178 (GRCm39)	missense	probably benign	0.00
R7162:Vmn2r87	UTSW	10	130,313,416 (GRCm39)	missense	probably benign	0.08
R7419:Vmn2r87	UTSW	10	130,307,992 (GRCm39)	missense	probably damaging	1.00
R7425:Vmn2r87	UTSW	10	130,314,761 (GRCm39)	missense	probably damaging	1.00
R7443:Vmn2r87	UTSW	10	130,308,588 (GRCm39)	missense	probably damaging	1.00
R7571:Vmn2r87	UTSW	10	130,314,940 (GRCm39)	missense	probably damaging	0.99
R7663:Vmn2r87	UTSW	10	130,308,054 (GRCm39)	missense	probably damaging	0.97
R7716:Vmn2r87	UTSW	10	130,308,018 (GRCm39)	missense	probably benign	0.09
R7793:Vmn2r87	UTSW	10	130,313,413 (GRCm39)	missense	probably benign	0.05
R7806:Vmn2r87	UTSW	10	130,315,679 (GRCm39)	missense	probably benign
R7841:Vmn2r87	UTSW	10	130,333,095 (GRCm39)	missense	probably benign	0.31
R8326:Vmn2r87	UTSW	10	130,308,180 (GRCm39)	missense	possibly damaging	0.67
R8411:Vmn2r87	UTSW	10	130,308,126 (GRCm39)	missense	probably damaging	0.99
R8445:Vmn2r87	UTSW	10	130,313,335 (GRCm39)	missense	probably damaging	1.00
R8540:Vmn2r87	UTSW	10	130,314,762 (GRCm39)	missense	possibly damaging	0.74
R8892:Vmn2r87	UTSW	10	130,308,105 (GRCm39)	missense	probably damaging	0.99
R9093:Vmn2r87	UTSW	10	130,308,165 (GRCm39)	missense	probably benign	0.08
R9623:Vmn2r87	UTSW	10	130,315,794 (GRCm39)	missense	probably damaging	1.00
R9667:Vmn2r87	UTSW	10	130,314,776 (GRCm39)	missense	probably damaging	1.00
R9797:Vmn2r87	UTSW	10	130,312,064 (GRCm39)	missense	probably benign	0.44
R9797:Vmn2r87	UTSW	10	130,308,138 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r87	UTSW	10	130,308,183 (GRCm39)	missense	probably damaging	0.98
Z1176:Vmn2r87	UTSW	10	130,307,713 (GRCm39)	missense	probably benign	0.04

Posted On

2013-06-21