Incidental Mutation 'R6545:Or10ab5'
ID 521104
Institutional Source Beutler Lab
Gene Symbol Or10ab5
Ensembl Gene ENSMUSG00000049280
Gene Name olfactory receptor family 10 subfamily AB member 5
Synonyms GA_x6K02T2PBJ9-10976304-10975339, Olfr509, MOR267-14
MMRRC Submission 044671-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R6545 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108244816-108245781 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 108245662 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 40 (N40K)
Ref Sequence ENSEMBL: ENSMUSP00000150157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061690] [ENSMUST00000213756] [ENSMUST00000214861] [ENSMUST00000215075]
AlphaFold Q8VF20
Predicted Effect probably damaging
Transcript: ENSMUST00000061690
AA Change: N40K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000053819
Gene: ENSMUSG00000049280
AA Change: N40K

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.8e-42 PFAM
Pfam:7tm_1 39 288 1.5e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213756
AA Change: N40K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214861
AA Change: N40K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215075
AA Change: N40K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 95% (42/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago1 C T 4: 126,348,145 (GRCm39) A58T possibly damaging Het
Ago4 T A 4: 126,405,811 (GRCm39) Q366L probably benign Het
Card10 C A 15: 78,661,010 (GRCm39) G950V probably damaging Het
Ceacam1 A T 7: 25,173,279 (GRCm39) V303D probably damaging Het
Cfap54 C T 10: 92,672,319 (GRCm39) R2917H probably benign Het
Cit A G 5: 115,984,493 (GRCm39) S22G probably null Het
Cog4 A G 8: 111,607,577 (GRCm39) E666G probably damaging Het
Crocc2 A G 1: 93,140,659 (GRCm39) D1103G probably benign Het
Cttnbp2 A T 6: 18,405,278 (GRCm39) probably null Het
Dctn3 T C 4: 41,723,084 (GRCm39) E16G probably damaging Het
Dnah6 A G 6: 73,021,715 (GRCm39) S3536P probably damaging Het
Eef2 T A 10: 81,016,948 (GRCm39) I675N probably damaging Het
Gga3 A G 11: 115,477,995 (GRCm39) F531S possibly damaging Het
Gm19410 A G 8: 36,257,652 (GRCm39) R697G possibly damaging Het
Gm3173 T A 14: 15,728,395 (GRCm39) M18K possibly damaging Het
Gm5800 A T 14: 51,949,419 (GRCm39) S175R possibly damaging Het
Gria2 T C 3: 80,648,451 (GRCm39) K95R probably damaging Het
Gstm6 A G 3: 107,849,681 (GRCm39) I76T probably damaging Het
Harbi1 T G 2: 91,542,640 (GRCm39) Y34D probably damaging Het
Hectd2 C A 19: 36,564,778 (GRCm39) Q20K probably benign Het
Inpp5f C A 7: 128,296,280 (GRCm39) A250D possibly damaging Het
Irf9 T C 14: 55,842,684 (GRCm39) F59L probably damaging Het
Itgam T A 7: 127,707,044 (GRCm39) M625K probably damaging Het
Kcnh5 C T 12: 75,054,432 (GRCm39) R504Q probably damaging Het
Lama2 T C 10: 27,052,793 (GRCm39) T1389A probably benign Het
Lin54 T A 5: 100,632,996 (GRCm39) probably null Het
Mettl23 A G 11: 116,740,042 (GRCm39) D171G possibly damaging Het
Mgll A G 6: 88,802,685 (GRCm39) N296S probably benign Het
Mpv17 T A 5: 31,302,041 (GRCm39) probably benign Het
Myof A T 19: 37,930,745 (GRCm39) M1001K possibly damaging Het
Myom1 A T 17: 71,389,300 (GRCm39) Q850L probably benign Het
Pias2 A G 18: 77,217,781 (GRCm39) I328V possibly damaging Het
Polh G A 17: 46,493,685 (GRCm39) P311S possibly damaging Het
Prss34 A T 17: 25,517,809 (GRCm39) R61S probably benign Het
Rassf2 A T 2: 131,840,237 (GRCm39) M280K probably damaging Het
Rpsa A G 9: 119,959,323 (GRCm39) H47R probably benign Het
Rtp3 A G 9: 110,815,894 (GRCm39) V219A possibly damaging Het
Smarcc2 T C 10: 128,319,997 (GRCm39) I790T probably benign Het
Stag3 A G 5: 138,296,614 (GRCm39) T491A possibly damaging Het
Svil C T 18: 5,108,621 (GRCm39) H2007Y probably benign Het
Togaram1 T G 12: 65,024,981 (GRCm39) C750G possibly damaging Het
Vmn2r13 A T 5: 109,304,806 (GRCm39) probably null Het
Vmn2r4 A T 3: 64,313,777 (GRCm39) D401E possibly damaging Het
Wdr97 C T 15: 76,247,578 (GRCm39) R1585C probably damaging Het
Wsb1 A T 11: 79,141,881 (GRCm39) D45E probably damaging Het
Zfp808 T A 13: 62,319,709 (GRCm39) Y313N probably benign Het
Other mutations in Or10ab5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Or10ab5 APN 7 108,245,043 (GRCm39) missense possibly damaging 0.47
IGL02015:Or10ab5 APN 7 108,245,220 (GRCm39) missense probably damaging 0.99
IGL02721:Or10ab5 APN 7 108,245,582 (GRCm39) nonsense probably null
IGL03170:Or10ab5 APN 7 108,245,307 (GRCm39) missense probably benign 0.00
R0746:Or10ab5 UTSW 7 108,245,248 (GRCm39) missense probably damaging 1.00
R0863:Or10ab5 UTSW 7 108,244,865 (GRCm39) missense probably benign 0.00
R1791:Or10ab5 UTSW 7 108,245,571 (GRCm39) missense probably benign 0.30
R4128:Or10ab5 UTSW 7 108,245,633 (GRCm39) missense probably benign 0.03
R5290:Or10ab5 UTSW 7 108,245,755 (GRCm39) missense probably benign
R5878:Or10ab5 UTSW 7 108,244,946 (GRCm39) missense probably damaging 1.00
R6030:Or10ab5 UTSW 7 108,245,433 (GRCm39) missense possibly damaging 0.87
R6030:Or10ab5 UTSW 7 108,245,433 (GRCm39) missense possibly damaging 0.87
R7699:Or10ab5 UTSW 7 108,244,879 (GRCm39) missense probably damaging 1.00
R7700:Or10ab5 UTSW 7 108,244,879 (GRCm39) missense probably damaging 1.00
R8247:Or10ab5 UTSW 7 108,245,370 (GRCm39) missense probably damaging 0.97
R9021:Or10ab5 UTSW 7 108,245,428 (GRCm39) nonsense probably null
R9041:Or10ab5 UTSW 7 108,245,589 (GRCm39) missense probably damaging 1.00
Z1176:Or10ab5 UTSW 7 108,244,974 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TATTGCCTCCCAAGCCAAAG -3'
(R):5'- ACAAGCTCGTCACAGTCATC -3'

Sequencing Primer
(F):5'- AAGAAAAACATCTGAGTGGCAC -3'
(R):5'- AAGCTCGTCACAGTCATCTCTGAATC -3'
Posted On 2018-06-06