Incidental Mutation 'IGL01121:Or6c35'
ID 52122
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6c35
Ensembl Gene ENSMUSG00000095138
Gene Name olfactory receptor family 6 subfamily C member 35
Synonyms MOR114-6, Olfr781, GA_x6K02T2PULF-11013616-11014551
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # IGL01121
Quality Score
Status
Chromosome 10
Chromosomal Location 129168752-129169687 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129168804 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 18 (I18T)
Ref Sequence ENSEMBL: ENSMUSP00000145356 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075613] [ENSMUST00000204108]
AlphaFold Q8VFZ8
Predicted Effect probably benign
Transcript: ENSMUST00000075613
AA Change: I18T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000075041
Gene: ENSMUSG00000095138
AA Change: I18T

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.6e-44 PFAM
Pfam:7tm_1 38 287 5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204108
AA Change: I18T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000145356
Gene: ENSMUSG00000095138
AA Change: I18T

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.6e-44 PFAM
Pfam:7tm_1 38 287 5e-24 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700046A07Rik G A 18: 62,888,219 (GRCm39) noncoding transcript Het
4930432E11Rik A T 7: 29,273,426 (GRCm39) noncoding transcript Het
Alg3 T C 16: 20,429,397 (GRCm39) E31G probably damaging Het
Arhgap29 A G 3: 121,803,512 (GRCm39) E764G probably damaging Het
Atp5mf C A 5: 145,121,378 (GRCm39) V68L probably benign Het
Birc6 T A 17: 74,938,033 (GRCm39) I2645K probably benign Het
Capn11 A G 17: 45,950,058 (GRCm39) S369P probably benign Het
Car4 A T 11: 84,855,172 (GRCm39) probably null Het
Ccdc185 C T 1: 182,576,222 (GRCm39) V156I probably benign Het
Cpsf2 G T 12: 101,954,965 (GRCm39) E245D probably damaging Het
Dnah11 T C 12: 118,014,430 (GRCm39) D2019G probably benign Het
Dscc1 A G 15: 54,945,721 (GRCm39) probably benign Het
Dzip3 T C 16: 48,765,244 (GRCm39) D490G probably benign Het
E2f8 G A 7: 48,517,569 (GRCm39) Q745* probably null Het
Fat3 T A 9: 15,909,697 (GRCm39) T2102S probably benign Het
Fgf7 C T 2: 125,930,152 (GRCm39) probably benign Het
Fstl4 T C 11: 52,705,464 (GRCm39) F47L probably benign Het
Gm15097 A T X: 148,587,324 (GRCm39) R129S possibly damaging Het
Gm4297 C T X: 24,418,854 (GRCm39) D200N probably benign Het
Itgb5 G T 16: 33,740,359 (GRCm39) D490Y probably benign Het
Kansl1 A G 11: 104,226,422 (GRCm39) S912P probably benign Het
Kcnq3 A T 15: 65,877,826 (GRCm39) probably benign Het
Kctd6 A G 14: 8,222,656 (GRCm38) H166R possibly damaging Het
Kel T C 6: 41,679,343 (GRCm39) D140G probably benign Het
Lrif1 C A 3: 106,642,980 (GRCm39) S177* probably null Het
Lrp1 A T 10: 127,419,722 (GRCm39) C962* probably null Het
Lypd5 A T 7: 24,050,976 (GRCm39) Y29F probably benign Het
Mmrn1 A G 6: 60,952,928 (GRCm39) D403G possibly damaging Het
Nhsl1 T G 10: 18,387,458 (GRCm39) V244G probably damaging Het
Ptprd A T 4: 75,872,438 (GRCm39) probably benign Het
Rcan2 A T 17: 44,328,775 (GRCm39) I69L probably damaging Het
Rprd2 A G 3: 95,683,862 (GRCm39) L373P probably damaging Het
Slc10a4 T C 5: 73,164,929 (GRCm39) C174R probably damaging Het
Tas2r134 C T 2: 51,518,001 (GRCm39) T160I probably damaging Het
Tbc1d19 T A 5: 54,054,404 (GRCm39) L464* probably null Het
Tmem45a2 C T 16: 56,861,153 (GRCm39) D225N possibly damaging Het
Unc79 G A 12: 103,131,890 (GRCm39) C2139Y probably damaging Het
Vmn2r101 G T 17: 19,809,936 (GRCm39) G241C probably damaging Het
Vmn2r91 T C 17: 18,356,766 (GRCm39) V811A possibly damaging Het
Wdr11 T C 7: 129,229,746 (GRCm39) Y844H probably benign Het
Wdr70 T C 15: 7,902,655 (GRCm39) K656E possibly damaging Het
Zfp579 C A 7: 4,996,246 (GRCm39) C555F possibly damaging Het
Other mutations in Or6c35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01636:Or6c35 APN 10 129,168,752 (GRCm39) start codon destroyed probably damaging 0.96
IGL01744:Or6c35 APN 10 129,169,326 (GRCm39) missense probably benign 0.05
IGL01867:Or6c35 APN 10 129,169,232 (GRCm39) missense probably damaging 1.00
IGL02002:Or6c35 APN 10 129,168,996 (GRCm39) missense probably damaging 0.99
IGL02423:Or6c35 APN 10 129,169,397 (GRCm39) missense probably benign 0.00
R2036:Or6c35 UTSW 10 129,169,541 (GRCm39) missense probably benign 0.43
R2099:Or6c35 UTSW 10 129,169,152 (GRCm39) missense probably damaging 0.96
R2273:Or6c35 UTSW 10 129,169,326 (GRCm39) missense probably benign 0.05
R2274:Or6c35 UTSW 10 129,169,326 (GRCm39) missense probably benign 0.05
R3841:Or6c35 UTSW 10 129,169,202 (GRCm39) missense probably benign 0.00
R4585:Or6c35 UTSW 10 129,169,142 (GRCm39) missense probably benign 0.08
R4586:Or6c35 UTSW 10 129,169,142 (GRCm39) missense probably benign 0.08
R5522:Or6c35 UTSW 10 129,168,798 (GRCm39) missense probably damaging 0.98
R6052:Or6c35 UTSW 10 129,169,071 (GRCm39) missense possibly damaging 0.91
R6414:Or6c35 UTSW 10 129,169,578 (GRCm39) missense probably benign 0.23
R6468:Or6c35 UTSW 10 129,169,580 (GRCm39) missense possibly damaging 0.91
R6647:Or6c35 UTSW 10 129,169,033 (GRCm39) nonsense probably null
R8099:Or6c35 UTSW 10 129,168,996 (GRCm39) missense probably damaging 0.99
R9151:Or6c35 UTSW 10 129,169,623 (GRCm39) missense probably damaging 1.00
R9617:Or6c35 UTSW 10 129,168,794 (GRCm39) missense probably damaging 0.98
R9649:Or6c35 UTSW 10 129,169,368 (GRCm39) missense possibly damaging 0.68
T0975:Or6c35 UTSW 10 129,169,314 (GRCm39) missense probably benign 0.31
Posted On 2013-06-21