Incidental Mutation 'R6549:Vmn1r31'
ID 521435
Institutional Source Beutler Lab
Gene Symbol Vmn1r31
Ensembl Gene ENSMUSG00000115404
Gene Name vomeronasal 1 receptor 31
Synonyms Gm6709
MMRRC Submission 044674-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R6549 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 58448952-58449863 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58449648 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 72 (N72K)
Ref Sequence ENSEMBL: ENSMUSP00000153749 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176023] [ENSMUST00000176147] [ENSMUST00000176177] [ENSMUST00000177318] [ENSMUST00000226390] [ENSMUST00000228586]
AlphaFold H3BKW5
Predicted Effect possibly damaging
Transcript: ENSMUST00000176023
AA Change: N23K

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000135252
Gene: ENSMUSG00000115404
AA Change: N23K

DomainStartEndE-ValueType
Pfam:V1R 1 58 1.9e-14 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000176147
AA Change: N23K

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000135282
Gene: ENSMUSG00000115404
AA Change: N23K

DomainStartEndE-ValueType
Pfam:V1R 1 58 1.9e-14 PFAM
Predicted Effect
SMART Domains Protein: ENSMUSP00000135472
Gene: ENSMUSG00000093379
AA Change: N72K

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.7e-56 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000177318
AA Change: N72K

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000135555
Gene: ENSMUSG00000115404
AA Change: N72K

DomainStartEndE-ValueType
Pfam:V1R 28 107 1.9e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204999
Predicted Effect possibly damaging
Transcript: ENSMUST00000226390
AA Change: N72K

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228586
AA Change: N72K

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atm T C 9: 53,404,477 (GRCm39) D1288G probably benign Het
Atxn7 T C 14: 14,013,087 (GRCm38) S2P probably damaging Het
C1rl T A 6: 124,485,487 (GRCm39) I286N probably benign Het
Ccdc54 T C 16: 50,410,388 (GRCm39) R293G possibly damaging Het
Cndp1 A T 18: 84,654,309 (GRCm39) I85K probably benign Het
Col25a1 A G 3: 129,976,444 (GRCm39) T110A probably benign Het
Defb8 G T 8: 19,497,560 (GRCm39) P17Q probably damaging Het
Dnah1 A T 14: 30,991,340 (GRCm39) L3146Q probably damaging Het
Espn A T 4: 152,215,525 (GRCm39) M1K probably null Het
Gm9922 C A 14: 101,966,893 (GRCm39) probably benign Het
Hycc2 T C 1: 58,578,759 (GRCm39) I264V probably benign Het
Ldb3 A G 14: 34,263,854 (GRCm39) M545T probably damaging Het
Or8k30 A T 2: 86,339,726 (GRCm39) I308L probably benign Het
Piezo1 G A 8: 123,227,002 (GRCm39) H420Y Het
Primpol A T 8: 47,058,185 (GRCm39) L115I probably damaging Het
Pus10 G A 11: 23,679,075 (GRCm39) probably null Het
Rictor C G 15: 6,825,656 (GRCm39) A1689G probably damaging Het
Scn2a A G 2: 65,595,018 (GRCm39) N1956D probably benign Het
Scn4a T C 11: 106,234,791 (GRCm39) D384G probably damaging Het
Sell A G 1: 163,893,198 (GRCm39) D138G probably damaging Het
Slc4a7 T A 14: 14,748,564 (GRCm38) F327L probably damaging Het
Sox6 A G 7: 115,085,927 (GRCm39) I680T possibly damaging Het
Synj1 A G 16: 90,735,565 (GRCm39) S1463P probably benign Het
Vmn2r77 A G 7: 86,450,065 (GRCm39) I104V probably benign Het
Zfp988 G A 4: 147,416,310 (GRCm39) C248Y probably benign Het
Other mutations in Vmn1r31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01326:Vmn1r31 APN 6 58,449,784 (GRCm39) missense probably benign 0.06
IGL01386:Vmn1r31 APN 6 58,449,587 (GRCm39) missense probably benign 0.22
IGL01785:Vmn1r31 APN 6 58,449,709 (GRCm39) missense possibly damaging 0.95
IGL02527:Vmn1r31 APN 6 58,449,778 (GRCm39) missense probably benign 0.01
PIT4791001:Vmn1r31 UTSW 6 58,449,028 (GRCm39) missense probably damaging 0.97
R0107:Vmn1r31 UTSW 6 58,449,728 (GRCm39) missense probably benign 0.05
R1250:Vmn1r31 UTSW 6 58,449,643 (GRCm39) missense probably benign 0.01
R1616:Vmn1r31 UTSW 6 58,449,043 (GRCm39) missense probably damaging 0.97
R1883:Vmn1r31 UTSW 6 58,449,029 (GRCm39) missense probably damaging 0.97
R1884:Vmn1r31 UTSW 6 58,449,029 (GRCm39) missense probably damaging 0.97
R2942:Vmn1r31 UTSW 6 58,449,583 (GRCm39) missense possibly damaging 0.87
R4589:Vmn1r31 UTSW 6 58,449,596 (GRCm39) missense probably damaging 1.00
R4672:Vmn1r31 UTSW 6 58,449,056 (GRCm39) missense probably damaging 0.97
R4676:Vmn1r31 UTSW 6 58,448,998 (GRCm39) missense probably damaging 0.97
R4702:Vmn1r31 UTSW 6 58,448,953 (GRCm39) makesense probably null
R4703:Vmn1r31 UTSW 6 58,448,953 (GRCm39) makesense probably null
R4705:Vmn1r31 UTSW 6 58,448,953 (GRCm39) makesense probably null
R6341:Vmn1r31 UTSW 6 58,448,995 (GRCm39) missense probably benign 0.35
R7238:Vmn1r31 UTSW 6 58,449,858 (GRCm39) missense
R7609:Vmn1r31 UTSW 6 58,449,455 (GRCm39) missense probably damaging 0.97
R8438:Vmn1r31 UTSW 6 58,449,646 (GRCm39) missense
R8936:Vmn1r31 UTSW 6 58,449,083 (GRCm39) missense unknown
R9103:Vmn1r31 UTSW 6 58,449,073 (GRCm39) missense unknown
Z1176:Vmn1r31 UTSW 6 58,449,376 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TAGAAGAACCGGTTACTACTGTAGG -3'
(R):5'- AAGCTGGACTTGGAGCCTTAG -3'

Sequencing Primer
(F):5'- CCGGTTACTACTGTAGGACAAATTG -3'
(R):5'- GACTTGGAGCCTTAGCCAATATG -3'
Posted On 2018-06-06