Incidental Mutation 'IGL01141:Lingo3'
| ID |
52156 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lingo3
|
| Ensembl Gene |
ENSMUSG00000051067 |
| Gene Name |
leucine rich repeat and Ig domain containing 3 |
| Synonyms |
LERN2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.072)
|
| Stock # |
IGL01141
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
80668635-80679873 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 80671147 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Glutamine
at position 261
(P261Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054960
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053986]
[ENSMUST00000219924]
|
| AlphaFold |
Q6GQU6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000053986
AA Change: P261Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000054960
Gene: ENSMUSG00000051067
AA Change: P261Q
| Domain | Start | End | E-Value | Type |
|---|
|
LRRNT
|
23 |
57 |
1.54e-5 |
SMART |
|
LRR_TYP
|
76 |
99 |
1.38e-3 |
SMART |
|
LRR_TYP
|
100 |
123 |
4.94e-5 |
SMART |
|
LRR
|
124 |
147 |
3.86e0 |
SMART |
|
LRR
|
148 |
171 |
4.98e-1 |
SMART |
|
LRR
|
172 |
195 |
1.62e1 |
SMART |
|
LRR
|
246 |
267 |
3.46e2 |
SMART |
|
LRR
|
269 |
291 |
3.86e0 |
SMART |
|
LRR
|
292 |
315 |
3.24e0 |
SMART |
|
LRR
|
316 |
339 |
4.34e-1 |
SMART |
|
LRRCT
|
351 |
404 |
7.18e-3 |
SMART |
|
IGc2
|
419 |
486 |
3.12e-14 |
SMART |
|
transmembrane domain
|
526 |
548 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
581 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000219924
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
A |
T |
11: 109,828,556 (GRCm39) |
D1447E |
probably damaging |
Het |
| Atp2a3 |
T |
C |
11: 72,873,491 (GRCm39) |
I788T |
probably damaging |
Het |
| Axin1 |
G |
A |
17: 26,409,015 (GRCm39) |
E672K |
probably damaging |
Het |
| Ccno |
A |
G |
13: 113,125,561 (GRCm39) |
D175G |
probably damaging |
Het |
| Cep83 |
C |
A |
10: 94,624,619 (GRCm39) |
T632K |
probably benign |
Het |
| Ckmt1 |
A |
T |
2: 121,193,474 (GRCm39) |
I345F |
probably benign |
Het |
| Cntnap1 |
G |
A |
11: 101,069,633 (GRCm39) |
|
probably benign |
Het |
| Cstdc3 |
A |
G |
16: 36,128,426 (GRCm39) |
E7G |
probably benign |
Het |
| Edem2 |
A |
G |
2: 155,550,948 (GRCm39) |
Y340H |
probably benign |
Het |
| Erich3 |
A |
G |
3: 154,419,653 (GRCm39) |
K249R |
probably benign |
Het |
| Fndc9 |
T |
C |
11: 46,128,526 (GRCm39) |
I15T |
probably benign |
Het |
| Grip2 |
G |
T |
6: 91,759,878 (GRCm39) |
Q300K |
probably benign |
Het |
| Herc2 |
T |
C |
7: 55,862,589 (GRCm39) |
V4050A |
possibly damaging |
Het |
| Jup |
A |
T |
11: 100,277,075 (GRCm39) |
D44E |
probably benign |
Het |
| Lrrfip2 |
C |
T |
9: 111,048,783 (GRCm39) |
R311W |
probably damaging |
Het |
| Mansc1 |
C |
A |
6: 134,598,748 (GRCm39) |
L56F |
probably benign |
Het |
| Map1b |
A |
G |
13: 99,571,269 (GRCm39) |
I484T |
probably damaging |
Het |
| Mpeg1 |
T |
A |
19: 12,440,149 (GRCm39) |
F536I |
probably damaging |
Het |
| Mrgprb1 |
T |
G |
7: 48,097,775 (GRCm39) |
T46P |
probably benign |
Het |
| Mug1 |
A |
G |
6: 121,847,458 (GRCm39) |
N612S |
probably benign |
Het |
| Or5p56 |
T |
C |
7: 107,589,758 (GRCm39) |
F62S |
probably damaging |
Het |
| Or6c212 |
T |
A |
10: 129,558,814 (GRCm39) |
I200L |
probably benign |
Het |
| Pax8 |
A |
G |
2: 24,331,162 (GRCm39) |
S178P |
probably damaging |
Het |
| Peak1 |
A |
G |
9: 56,165,811 (GRCm39) |
F706L |
probably benign |
Het |
| Prkdc |
A |
G |
16: 15,544,568 (GRCm39) |
T1853A |
probably damaging |
Het |
| Reln |
A |
C |
5: 22,174,031 (GRCm39) |
F2024C |
probably damaging |
Het |
| Reln |
G |
T |
5: 22,124,067 (GRCm39) |
P2813Q |
probably damaging |
Het |
| Riox1 |
A |
G |
12: 83,998,568 (GRCm39) |
Q368R |
probably damaging |
Het |
| Rspry1 |
T |
C |
8: 95,376,483 (GRCm39) |
V335A |
probably benign |
Het |
| Scn3a |
T |
C |
2: 65,325,457 (GRCm39) |
N1020S |
possibly damaging |
Het |
| Scyl2 |
A |
G |
10: 89,476,497 (GRCm39) |
V876A |
probably benign |
Het |
| Sdhaf3 |
T |
A |
6: 6,956,141 (GRCm39) |
F39I |
probably damaging |
Het |
| Sfxn4 |
T |
C |
19: 60,839,452 (GRCm39) |
E202G |
possibly damaging |
Het |
| Slc1a4 |
A |
T |
11: 20,258,644 (GRCm39) |
|
probably benign |
Het |
| Sln |
A |
G |
9: 53,760,784 (GRCm39) |
I10V |
probably benign |
Het |
| Ssh2 |
A |
G |
11: 77,340,552 (GRCm39) |
E568G |
probably damaging |
Het |
| Supt7l |
G |
A |
5: 31,675,779 (GRCm39) |
P270S |
probably benign |
Het |
| Tanc2 |
A |
G |
11: 105,777,300 (GRCm39) |
|
probably benign |
Het |
| Tatdn1 |
A |
T |
15: 58,781,416 (GRCm39) |
|
probably benign |
Het |
| Tfip11 |
C |
T |
5: 112,477,369 (GRCm39) |
P117L |
possibly damaging |
Het |
| Vpreb1a |
T |
C |
16: 16,686,951 (GRCm39) |
M9V |
probably benign |
Het |
|
| Other mutations in Lingo3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02120:Lingo3
|
APN |
10 |
80,671,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02755:Lingo3
|
APN |
10 |
80,671,843 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02938:Lingo3
|
APN |
10 |
80,670,988 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02945:Lingo3
|
APN |
10 |
80,670,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03167:Lingo3
|
APN |
10 |
80,671,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Lingo3
|
UTSW |
10 |
80,671,618 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0645:Lingo3
|
UTSW |
10 |
80,671,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0673:Lingo3
|
UTSW |
10 |
80,671,618 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1250:Lingo3
|
UTSW |
10 |
80,670,605 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1521:Lingo3
|
UTSW |
10 |
80,671,555 (GRCm39) |
missense |
probably benign |
|
|
R1794:Lingo3
|
UTSW |
10 |
80,671,432 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4665:Lingo3
|
UTSW |
10 |
80,671,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Lingo3
|
UTSW |
10 |
80,671,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6458:Lingo3
|
UTSW |
10 |
80,671,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7082:Lingo3
|
UTSW |
10 |
80,671,625 (GRCm39) |
missense |
probably benign |
|
|
R7231:Lingo3
|
UTSW |
10 |
80,670,938 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7314:Lingo3
|
UTSW |
10 |
80,670,707 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7390:Lingo3
|
UTSW |
10 |
80,670,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Lingo3
|
UTSW |
10 |
80,670,671 (GRCm39) |
nonsense |
probably null |
|
|
R7650:Lingo3
|
UTSW |
10 |
80,671,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7894:Lingo3
|
UTSW |
10 |
80,670,610 (GRCm39) |
nonsense |
probably null |
|
|
R7920:Lingo3
|
UTSW |
10 |
80,670,382 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8070:Lingo3
|
UTSW |
10 |
80,671,955 (GRCm39) |
start gained |
probably benign |
|
|
R8095:Lingo3
|
UTSW |
10 |
80,671,255 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8171:Lingo3
|
UTSW |
10 |
80,670,595 (GRCm39) |
missense |
probably benign |
|
|
R8178:Lingo3
|
UTSW |
10 |
80,670,464 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8425:Lingo3
|
UTSW |
10 |
80,670,816 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9053:Lingo3
|
UTSW |
10 |
80,670,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9059:Lingo3
|
UTSW |
10 |
80,670,523 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9706:Lingo3
|
UTSW |
10 |
80,670,288 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9794:Lingo3
|
UTSW |
10 |
80,670,707 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Z1176:Lingo3
|
UTSW |
10 |
80,670,689 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Posted On |
2013-06-21 |
Incidental Mutation