Incidental Mutation 'R6551:Or10d1'
ID 521628
Institutional Source Beutler Lab
Gene Symbol Or10d1
Ensembl Gene ENSMUSG00000059366
Gene Name olfactory receptor family 10 subfamily D member 1
Synonyms MOR224-3, GA_x6K02T2PVTD-33270211-33269276, Olfr959
MMRRC Submission 044676-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R6551 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39483618-39484553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 39483856 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 233 (R233L)
Ref Sequence ENSEMBL: ENSMUSP00000150349 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079178] [ENSMUST00000215194] [ENSMUST00000216298]
AlphaFold Q9EQ86
Predicted Effect probably benign
Transcript: ENSMUST00000079178
AA Change: R233L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000078176
Gene: ENSMUSG00000059366
AA Change: R233L

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 4.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 33 251 1.2e-7 PFAM
Pfam:7tm_1 39 286 2.7e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215194
AA Change: R233L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000216298
AA Change: R233L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A130010J15Rik A T 1: 192,856,831 (GRCm39) Q61L probably damaging Het
Acss2 T C 2: 155,393,128 (GRCm39) S285P probably benign Het
Ager A G 17: 34,818,442 (GRCm39) probably null Het
Alkbh7 T A 17: 57,305,945 (GRCm39) Y115* probably null Het
Brwd1 T C 16: 95,795,162 (GRCm39) D2184G possibly damaging Het
Chp1 T A 2: 119,402,294 (GRCm39) H89Q possibly damaging Het
Clmp T C 9: 40,682,573 (GRCm39) V119A probably benign Het
Cryge A T 1: 65,087,796 (GRCm39) M171K probably benign Het
Cttnbp2nl A T 3: 104,912,433 (GRCm39) S484T possibly damaging Het
Dsg3 C A 18: 20,672,968 (GRCm39) P880T unknown Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Espn T C 4: 152,213,223 (GRCm39) Het
Fbxo31 A C 8: 122,291,443 (GRCm39) probably benign Het
Grin2b A G 6: 135,710,342 (GRCm39) V1068A probably damaging Het
Jak1 C A 4: 101,051,040 (GRCm39) probably benign Het
Klra10 A T 6: 130,252,718 (GRCm39) D185E probably benign Het
Lhx1 A C 11: 84,412,739 (GRCm39) D60E probably benign Het
Lyar C A 5: 38,390,616 (GRCm39) A326D probably damaging Het
Muc16 A C 9: 18,473,858 (GRCm39) S1280A possibly damaging Het
Nol9 G A 4: 152,136,325 (GRCm39) V466I possibly damaging Het
Or12e8 T C 2: 87,677,005 (GRCm39) V130A possibly damaging Het
Or1e17 T C 11: 73,831,129 (GRCm39) I19T probably benign Het
Or1o1 G A 17: 37,716,796 (GRCm39) R119H probably benign Het
Or2w3b A T 11: 58,623,583 (GRCm39) M136K probably damaging Het
Or2y10 G T 11: 49,454,816 (GRCm39) V23L probably benign Het
Pik3c2a A T 7: 116,016,731 (GRCm39) I342N probably damaging Het
Pnldc1 A G 17: 13,124,456 (GRCm39) M133T probably damaging Het
Rab11fip1 G A 8: 27,646,512 (GRCm39) S188L probably damaging Het
Rapgef2 A T 3: 79,122,342 (GRCm39) probably null Het
Rnf103 G A 6: 71,487,349 (GRCm39) C660Y probably damaging Het
Rph3al G A 11: 75,797,372 (GRCm39) S108F possibly damaging Het
Srsf7 A C 17: 80,511,648 (GRCm39) probably benign Het
Ssrp1 A G 2: 84,871,450 (GRCm39) probably null Het
Tamm41 T C 6: 114,989,142 (GRCm39) D284G possibly damaging Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tmem39b A G 4: 129,585,896 (GRCm39) V25A probably benign Het
Tmem88b G T 4: 155,870,149 (GRCm39) probably benign Het
Unk T C 11: 115,941,550 (GRCm39) W266R probably damaging Het
Usp8 T A 2: 126,575,102 (GRCm39) probably benign Het
Zbtb48 T G 4: 152,106,678 (GRCm39) Q142P probably benign Het
Zdhhc18 T C 4: 133,340,960 (GRCm39) T267A probably benign Het
Zfp335 G A 2: 164,751,285 (GRCm39) P94S probably benign Het
Other mutations in Or10d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02825:Or10d1 APN 9 39,483,877 (GRCm39) missense probably damaging 0.97
R0122:Or10d1 UTSW 9 39,484,020 (GRCm39) missense probably damaging 1.00
R0483:Or10d1 UTSW 9 39,484,139 (GRCm39) missense probably damaging 1.00
R1843:Or10d1 UTSW 9 39,484,031 (GRCm39) missense possibly damaging 0.74
R2038:Or10d1 UTSW 9 39,484,283 (GRCm39) missense probably damaging 1.00
R3838:Or10d1 UTSW 9 39,484,267 (GRCm39) missense probably benign
R4801:Or10d1 UTSW 9 39,484,154 (GRCm39) missense probably benign 0.00
R4802:Or10d1 UTSW 9 39,484,154 (GRCm39) missense probably benign 0.00
R4839:Or10d1 UTSW 9 39,484,441 (GRCm39) missense probably benign
R4967:Or10d1 UTSW 9 39,484,054 (GRCm39) missense probably damaging 1.00
R6128:Or10d1 UTSW 9 39,484,549 (GRCm39) missense probably benign 0.00
R6196:Or10d1 UTSW 9 39,483,776 (GRCm39) missense possibly damaging 0.75
R7757:Or10d1 UTSW 9 39,483,761 (GRCm39) missense probably benign 0.02
R7892:Or10d1 UTSW 9 39,483,845 (GRCm39) missense possibly damaging 0.96
R8674:Or10d1 UTSW 9 39,484,249 (GRCm39) missense probably damaging 1.00
R8693:Or10d1 UTSW 9 39,483,800 (GRCm39) missense probably damaging 1.00
R8958:Or10d1 UTSW 9 39,484,091 (GRCm39) missense probably benign 0.00
R9101:Or10d1 UTSW 9 39,483,805 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAGACCTTCCACAGTGATGC -3'
(R):5'- TGGTCCCAATGAGGTGGACTAC -3'

Sequencing Primer
(F):5'- CACCTCTTTATTCCTGAGACTGTAG -3'
(R):5'- CCAATGAGGTGGACTACTACTTCTG -3'
Posted On 2018-06-06