Incidental Mutation 'IGL01149:Slc26a10'
| ID |
52169 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Slc26a10
|
| Ensembl Gene |
ENSMUSG00000040441 |
| Gene Name |
solute carrier family 26, member 10 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01149
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
127007262-127016514 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
G to A
at 127010046 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152871
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006914]
[ENSMUST00000095270]
[ENSMUST00000217678]
[ENSMUST00000222911]
|
| AlphaFold |
Q5EBI0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000006914
|
| SMART Domains |
Protein: ENSMUSP00000006914
Gene: ENSMUSG00000006731
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
24 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
202 |
N/A |
INTRINSIC |
|
Pfam:Glycos_transf_2
|
280 |
450 |
7e-19 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095270
|
| SMART Domains |
Protein: ENSMUSP00000092904
Gene: ENSMUSG00000040441
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
51 |
78 |
N/A |
INTRINSIC |
|
low complexity region
|
82 |
97 |
N/A |
INTRINSIC |
|
Pfam:Sulfate_transp
|
105 |
497 |
5.5e-103 |
PFAM |
|
low complexity region
|
512 |
522 |
N/A |
INTRINSIC |
|
Pfam:STAS
|
549 |
664 |
3.3e-19 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000217678
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218658
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218977
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000220327
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221174
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222911
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4632415L05Rik |
A |
G |
3: 19,949,276 (GRCm39) |
|
noncoding transcript |
Het |
| Aadacl4fm4 |
T |
C |
4: 144,400,349 (GRCm39) |
D143G |
probably benign |
Het |
| Adcy1 |
A |
C |
11: 7,087,385 (GRCm39) |
N420H |
probably damaging |
Het |
| Avp |
T |
C |
2: 130,422,593 (GRCm39) |
|
probably benign |
Het |
| B3galnt2 |
A |
T |
13: 14,155,270 (GRCm39) |
I216F |
probably benign |
Het |
| Cdc42bpa |
T |
C |
1: 179,902,137 (GRCm39) |
S465P |
probably damaging |
Het |
| Cdc42bpg |
T |
A |
19: 6,362,235 (GRCm39) |
|
probably benign |
Het |
| Cdcp2 |
T |
C |
4: 106,964,308 (GRCm39) |
F386S |
probably benign |
Het |
| Cdh4 |
A |
G |
2: 179,515,937 (GRCm39) |
T372A |
probably damaging |
Het |
| Clspn |
T |
G |
4: 126,466,971 (GRCm39) |
M612R |
probably damaging |
Het |
| Dll4 |
T |
C |
2: 119,161,590 (GRCm39) |
C391R |
probably damaging |
Het |
| Dll4 |
T |
C |
2: 119,163,226 (GRCm39) |
Y616H |
probably damaging |
Het |
| Exoc1 |
A |
G |
5: 76,690,091 (GRCm39) |
|
probably benign |
Het |
| F830045P16Rik |
A |
G |
2: 129,302,232 (GRCm39) |
|
probably null |
Het |
| Fhod1 |
A |
G |
8: 106,074,439 (GRCm39) |
|
probably benign |
Het |
| Fign |
T |
C |
2: 63,810,104 (GRCm39) |
R389G |
possibly damaging |
Het |
| Gm13941 |
T |
A |
2: 110,931,482 (GRCm39) |
E50V |
unknown |
Het |
| Kit |
C |
T |
5: 75,771,536 (GRCm39) |
T231M |
probably damaging |
Het |
| Neu3 |
T |
C |
7: 99,463,087 (GRCm39) |
H212R |
probably benign |
Het |
| Nup214 |
G |
T |
2: 31,924,712 (GRCm39) |
S1747I |
probably damaging |
Het |
| Or4f4b |
T |
C |
2: 111,314,446 (GRCm39) |
S224P |
probably damaging |
Het |
| Or4q3 |
G |
T |
14: 50,583,071 (GRCm39) |
A276E |
probably damaging |
Het |
| Or8b12i |
G |
T |
9: 20,082,826 (GRCm39) |
L14I |
probably damaging |
Het |
| Secisbp2 |
T |
C |
13: 51,830,491 (GRCm39) |
|
probably null |
Het |
| Slc7a6 |
T |
C |
8: 106,906,232 (GRCm39) |
S155P |
probably damaging |
Het |
| Slf1 |
A |
T |
13: 77,260,767 (GRCm39) |
I173N |
probably damaging |
Het |
| Tedc1 |
C |
T |
12: 113,126,808 (GRCm39) |
R357* |
probably null |
Het |
| Tkfc |
A |
G |
19: 10,578,015 (GRCm39) |
L38P |
probably damaging |
Het |
| Tubgcp4 |
A |
G |
2: 121,015,264 (GRCm39) |
D324G |
probably null |
Het |
| Zfyve16 |
T |
C |
13: 92,644,791 (GRCm39) |
H1137R |
probably damaging |
Het |
|
| Other mutations in Slc26a10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01657:Slc26a10
|
APN |
10 |
127,010,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1202:Slc26a10
|
UTSW |
10 |
127,009,217 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1844:Slc26a10
|
UTSW |
10 |
127,014,279 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2423:Slc26a10
|
UTSW |
10 |
127,015,606 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4031:Slc26a10
|
UTSW |
10 |
127,013,871 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4779:Slc26a10
|
UTSW |
10 |
127,009,224 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5405:Slc26a10
|
UTSW |
10 |
127,010,864 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5478:Slc26a10
|
UTSW |
10 |
127,009,818 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5657:Slc26a10
|
UTSW |
10 |
127,010,833 (GRCm39) |
intron |
probably benign |
|
|
R5990:Slc26a10
|
UTSW |
10 |
127,014,627 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6681:Slc26a10
|
UTSW |
10 |
127,009,530 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7083:Slc26a10
|
UTSW |
10 |
127,013,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Slc26a10
|
UTSW |
10 |
127,012,716 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7997:Slc26a10
|
UTSW |
10 |
127,009,178 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8211:Slc26a10
|
UTSW |
10 |
127,009,834 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8268:Slc26a10
|
UTSW |
10 |
127,009,491 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8906:Slc26a10
|
UTSW |
10 |
127,016,459 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9390:Slc26a10
|
UTSW |
10 |
127,009,239 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Slc26a10
|
UTSW |
10 |
127,015,527 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Posted On |
2013-06-21 |
Incidental Mutation