Mutagenetix > Incidental Mutation

Incidental Mutation 'R6553:Tmem161b'

521796

Institutional Source

Beutler Lab

Gene Symbol

Tmem161b

Ensembl Gene

ENSMUSG00000035762

Gene Name

transmembrane protein 161B

Synonyms

2810446P07Rik

MMRRC Submission

044678-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6553 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

84370415-84444085 bp(+) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

C to A at 84370537 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000152891 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057495] [ENSMUST00000223827] [ENSMUST00000223862] [ENSMUST00000224525] [ENSMUST00000225069]

AlphaFold

Q8C2L6

Predicted Effect

probably benign
Transcript: ENSMUST00000057495
AA Change: -1

SMART Domains

Protein: ENSMUSP00000055208
Gene: ENSMUSG00000035762
AA Change: -1

Domain	Start	End	E-Value	Type
Pfam:Tmemb_161AB	2	485	1.3e-213	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180894

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185973

Predicted Effect

probably benign
Transcript: ENSMUST00000223827

Predicted Effect

probably benign
Transcript: ENSMUST00000223862

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224501

Predicted Effect

probably benign
Transcript: ENSMUST00000224525

Predicted Effect

probably benign
Transcript: ENSMUST00000225069

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225126

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225212

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.6%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice exhibit lethality before genotyping age. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam1b	G	T	5: 121,639,250 (GRCm39)	D598E	probably benign	Het
Ascc3	A	G	10: 50,718,273 (GRCm39)	K1989E	probably benign	Het
Asic5	A	T	3: 81,916,773 (GRCm39)	T288S	possibly damaging	Het
Chd1	A	G	17: 15,945,692 (GRCm39)	N72S	probably benign	Het
Ciita	T	A	16: 10,329,609 (GRCm39)	V628E	probably benign	Het
Cyp2c50	A	G	19: 40,079,046 (GRCm39)	T130A	probably benign	Het
Dapk1	T	A	13: 60,908,975 (GRCm39)	V1196E	probably damaging	Het
Dis3l2	T	A	1: 86,673,216 (GRCm39)	I69N	probably damaging	Het
Exph5	A	G	9: 53,213,012 (GRCm39)		probably benign	Het
Fcgbp	A	T	7: 27,813,404 (GRCm39)	Q2313L	possibly damaging	Het
Gm2888	A	G	14: 3,037,722 (GRCm38)	H238R	possibly damaging	Het
Gm5622	A	G	14: 51,895,200 (GRCm39)	K120E	probably damaging	Het
Gpr155	A	T	2: 73,179,989 (GRCm39)	I157N	probably damaging	Het
Hltf	T	C	3: 20,126,558 (GRCm39)	V245A	probably damaging	Het
Kmt2e	G	A	5: 23,668,024 (GRCm39)	V28I	probably damaging	Het
Lsm3	GATATATA	GATATATATA	6: 91,496,617 (GRCm39)		probably null	Het
Nprl3	C	T	11: 32,184,812 (GRCm39)	R399Q	probably benign	Het
Or6c6c	C	T	10: 129,540,932 (GRCm39)	R62C	probably benign	Het
Ptgs2	T	C	1: 149,979,738 (GRCm39)	V281A	possibly damaging	Het
Speer4f2	A	G	5: 17,579,420 (GRCm39)	E73G	probably damaging	Het
Trav13n-3	A	G	14: 53,574,618 (GRCm39)	T14A	probably benign	Het
Trav9d-4	A	T	14: 53,221,198 (GRCm39)	Q63L	probably benign	Het
Vmn2r75	T	A	7: 85,813,453 (GRCm39)	N450Y	probably benign	Het
Vmn2r97	G	A	17: 19,150,566 (GRCm39)	W471*	probably null	Het
Zfp27	G	A	7: 29,595,818 (GRCm39)	T49I	possibly damaging	Het
Zpld2	A	G	4: 133,929,367 (GRCm39)	S313P	probably damaging	Het

Other mutations in Tmem161b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00666:Tmem161b	APN	13	84,442,715 (GRCm39)	splice site	probably benign
IGL01086:Tmem161b	APN	13	84,370,541 (GRCm39)	utr 5 prime	probably benign
IGL01150:Tmem161b	APN	13	84,440,526 (GRCm39)	nonsense	probably null
IGL01566:Tmem161b	APN	13	84,442,881 (GRCm39)	missense	probably benign	0.35
IGL02183:Tmem161b	APN	13	84,420,373 (GRCm39)	missense	probably damaging	1.00
IGL02481:Tmem161b	APN	13	84,432,112 (GRCm39)	missense	probably damaging	0.99
IGL02519:Tmem161b	APN	13	84,442,863 (GRCm39)	missense	probably damaging	1.00
IGL03207:Tmem161b	APN	13	84,442,714 (GRCm39)	splice site	probably benign
R6836_Tmem161b_587	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R0015:Tmem161b	UTSW	13	84,370,533 (GRCm39)	splice site	probably null
R0376:Tmem161b	UTSW	13	84,440,502 (GRCm39)	missense	probably benign	0.43
R0613:Tmem161b	UTSW	13	84,399,439 (GRCm39)	missense	probably damaging	1.00
R1925:Tmem161b	UTSW	13	84,408,348 (GRCm39)	missense	probably benign	0.07
R1935:Tmem161b	UTSW	13	84,441,585 (GRCm39)	missense	probably damaging	1.00
R1936:Tmem161b	UTSW	13	84,441,585 (GRCm39)	missense	probably damaging	1.00
R2325:Tmem161b	UTSW	13	84,442,887 (GRCm39)	missense	possibly damaging	0.94
R2988:Tmem161b	UTSW	13	84,440,574 (GRCm39)	nonsense	probably null
R4327:Tmem161b	UTSW	13	84,399,359 (GRCm39)	missense	probably damaging	1.00
R4525:Tmem161b	UTSW	13	84,405,921 (GRCm39)	missense	probably benign	0.00
R4558:Tmem161b	UTSW	13	84,399,363 (GRCm39)	missense	possibly damaging	0.50
R5133:Tmem161b	UTSW	13	84,442,887 (GRCm39)	missense	possibly damaging	0.94
R5134:Tmem161b	UTSW	13	84,442,887 (GRCm39)	missense	possibly damaging	0.94
R5727:Tmem161b	UTSW	13	84,434,909 (GRCm39)	missense	possibly damaging	0.63
R5875:Tmem161b	UTSW	13	84,442,977 (GRCm39)	missense	probably damaging	1.00
R6217:Tmem161b	UTSW	13	84,399,363 (GRCm39)	missense	possibly damaging	0.50
R6527:Tmem161b	UTSW	13	84,420,383 (GRCm39)	missense	probably benign	0.06
R6550:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6551:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6554:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6640:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6641:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6685:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6836:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6837:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6838:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7077:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7078:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7386:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7388:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7429:Tmem161b	UTSW	13	84,430,866 (GRCm39)	critical splice acceptor site	probably null
R7430:Tmem161b	UTSW	13	84,430,866 (GRCm39)	critical splice acceptor site	probably null
R7547:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7548:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7634:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7636:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8094:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8095:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8255:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8257:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8669:Tmem161b	UTSW	13	84,420,288 (GRCm39)	critical splice acceptor site	probably null
R9049:Tmem161b	UTSW	13	84,442,754 (GRCm39)	missense	probably benign
R9092:Tmem161b	UTSW	13	84,440,503 (GRCm39)	missense	possibly damaging	0.69
R9316:Tmem161b	UTSW	13	84,430,855 (GRCm39)	missense	possibly damaging	0.84
R9326:Tmem161b	UTSW	13	84,440,602 (GRCm39)	nonsense	probably null

Predicted Primers

Posted On

2018-06-06