Incidental Mutation 'IGL01060:Trim16'
ID 52186
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim16
Ensembl Gene ENSMUSG00000047821
Gene Name tripartite motif-containing 16
Synonyms 9130006M08Rik, EBBP
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01060
Quality Score
Status
Chromosome 11
Chromosomal Location 62711034-62733774 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62711530 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 67 (I67T)
Ref Sequence ENSEMBL: ENSMUSP00000072432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055006] [ENSMUST00000072639] [ENSMUST00000108703]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000055006
AA Change: I67T

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000055542
Gene: ENSMUSG00000047821
AA Change: I67T

DomainStartEndE-ValueType
Blast:BBOX 64 113 6e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
SPRY 418 543 6.4e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000072639
AA Change: I67T

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000072432
Gene: ENSMUSG00000047821
AA Change: I67T

DomainStartEndE-ValueType
Blast:BBOX 64 113 5e-24 BLAST
BBOX 117 157 3.24e-4 SMART
coiled coil region 171 196 N/A INTRINSIC
coiled coil region 237 265 N/A INTRINSIC
PRY 364 417 1.41e-22 SMART
Pfam:SPRY 418 483 1.4e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108703
SMART Domains Protein: ENSMUSP00000104343
Gene: ENSMUSG00000047821

DomainStartEndE-ValueType
Blast:BBOX 1 26 9e-10 BLAST
BBOX 30 70 3.24e-4 SMART
coiled coil region 84 109 N/A INTRINSIC
coiled coil region 150 178 N/A INTRINSIC
PRY 277 330 1.41e-22 SMART
SPRY 331 456 6.4e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147942
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
Anks4b A G 7: 119,773,148 (GRCm39) T3A possibly damaging Het
Arhgef26 T A 3: 62,247,542 (GRCm39) S209T probably benign Het
Ccdc78 A G 17: 26,007,806 (GRCm39) D281G probably damaging Het
Ccnb3 A T X: 6,846,513 (GRCm39) N1362K probably benign Het
Dnah2 T C 11: 69,368,918 (GRCm39) N1662S possibly damaging Het
Elp1 C T 4: 56,784,537 (GRCm39) probably null Het
Ern2 T A 7: 121,769,315 (GRCm39) R904W probably damaging Het
Fam120c C T X: 150,252,583 (GRCm39) P1045S probably benign Het
Gm12887 C T 4: 121,473,610 (GRCm39) probably benign Het
Gpld1 G A 13: 25,166,549 (GRCm39) G627S probably damaging Het
Krt77 T A 15: 101,769,315 (GRCm39) probably benign Het
Ltf A T 9: 110,851,950 (GRCm39) probably null Het
Map3k6 G T 4: 132,974,613 (GRCm39) probably null Het
Nsd1 G A 13: 55,411,242 (GRCm39) G1431D probably damaging Het
Plekhm2 C T 4: 141,369,956 (GRCm39) probably null Het
Popdc2 T A 16: 38,194,327 (GRCm39) N249K probably damaging Het
Ppm1h A G 10: 122,743,476 (GRCm39) D400G possibly damaging Het
Rps6ka1 A T 4: 133,588,181 (GRCm39) S320T probably damaging Het
Rsph6a C T 7: 18,788,793 (GRCm39) R42* probably null Het
Sap130 T C 18: 31,848,496 (GRCm39) L967P probably damaging Het
Smyd2 T C 1: 189,629,667 (GRCm39) E121G possibly damaging Het
Sspo G A 6: 48,426,413 (GRCm39) W144* probably null Het
Taar6 A G 10: 23,860,970 (GRCm39) V192A probably benign Het
Tbc1d24 A T 17: 24,404,802 (GRCm39) V114E probably damaging Het
Ttll7 A G 3: 146,615,337 (GRCm39) D267G possibly damaging Het
Ttn T C 2: 76,720,073 (GRCm39) probably benign Het
Vmn2r56 T A 7: 12,447,016 (GRCm39) I379F probably damaging Het
Zfp14 T C 7: 29,737,510 (GRCm39) T492A probably damaging Het
Other mutations in Trim16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00661:Trim16 APN 11 62,728,058 (GRCm39) splice site probably benign
IGL01568:Trim16 APN 11 62,711,684 (GRCm39) missense probably benign 0.05
IGL01659:Trim16 APN 11 62,711,521 (GRCm39) missense probably benign 0.00
IGL02519:Trim16 APN 11 62,724,905 (GRCm39) missense possibly damaging 0.49
IGL02662:Trim16 APN 11 62,731,383 (GRCm39) missense possibly damaging 0.91
FR4589:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
FR4976:Trim16 UTSW 11 62,711,515 (GRCm39) intron probably benign
R0007:Trim16 UTSW 11 62,719,944 (GRCm39) missense probably benign 0.00
R0007:Trim16 UTSW 11 62,719,944 (GRCm39) missense probably benign 0.00
R0346:Trim16 UTSW 11 62,731,520 (GRCm39) missense probably benign 0.00
R0410:Trim16 UTSW 11 62,711,297 (GRCm39) start gained probably benign
R1725:Trim16 UTSW 11 62,711,331 (GRCm39) start codon destroyed possibly damaging 0.91
R3845:Trim16 UTSW 11 62,727,498 (GRCm39) splice site probably benign
R3879:Trim16 UTSW 11 62,731,433 (GRCm39) missense probably damaging 1.00
R5023:Trim16 UTSW 11 62,727,638 (GRCm39) missense probably benign 0.36
R5344:Trim16 UTSW 11 62,711,751 (GRCm39) missense probably damaging 1.00
R6919:Trim16 UTSW 11 62,731,695 (GRCm39) missense possibly damaging 0.86
R7490:Trim16 UTSW 11 62,724,949 (GRCm39) missense probably damaging 1.00
R7525:Trim16 UTSW 11 62,711,580 (GRCm39) missense probably damaging 1.00
R8354:Trim16 UTSW 11 62,727,587 (GRCm39) missense probably benign 0.01
R8439:Trim16 UTSW 11 62,741,414 (GRCm39) missense probably benign 0.10
R8754:Trim16 UTSW 11 62,731,763 (GRCm39) missense probably benign 0.01
R9581:Trim16 UTSW 11 62,727,557 (GRCm39) missense probably damaging 0.98
R9599:Trim16 UTSW 11 62,731,644 (GRCm39) missense probably damaging 0.97
R9789:Trim16 UTSW 11 62,720,026 (GRCm39) critical splice donor site probably null
X0026:Trim16 UTSW 11 62,719,963 (GRCm39) missense probably benign 0.02
Z1186:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1186:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1186:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1186:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1186:Trim16 UTSW 11 62,711,518 (GRCm39) intron probably benign
Z1186:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1186:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1187:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1187:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,520 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1187:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1187:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1188:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1188:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1188:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1188:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1188:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1189:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1189:Trim16 UTSW 11 62,711,520 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,517 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1189:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1189:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1190:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1190:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,519 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1190:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1190:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1191:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1191:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1191:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,428 (GRCm39) missense probably benign
Z1192:Trim16 UTSW 11 62,731,675 (GRCm39) missense probably benign 0.00
Z1192:Trim16 UTSW 11 62,731,572 (GRCm39) missense probably benign
Z1192:Trim16 UTSW 11 62,727,643 (GRCm39) missense probably benign 0.00
Z1192:Trim16 UTSW 11 62,711,521 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,516 (GRCm39) intron probably benign
Z1192:Trim16 UTSW 11 62,711,502 (GRCm39) missense probably benign
Posted On 2013-06-21