Incidental Mutation 'R6527:Or1n1b'
ID 521936
Institutional Source Beutler Lab
Gene Symbol Or1n1b
Ensembl Gene ENSMUSG00000075382
Gene Name olfactory receptor family 1 subfamily N member 1B
Synonyms GA_x6K02T2NLDC-33585366-33584431, Olfr353, MOR127-3
MMRRC Submission 044653-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.211) question?
Stock # R6527 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 36779923-36780858 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36780594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 89 (T89A)
Ref Sequence ENSEMBL: ENSMUSP00000149378 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100149] [ENSMUST00000215925] [ENSMUST00000217215]
AlphaFold Q8VGK0
Predicted Effect probably benign
Transcript: ENSMUST00000100149
AA Change: T89A

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000097726
Gene: ENSMUSG00000075382
AA Change: T89A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.3e-56 PFAM
Pfam:7tm_1 39 288 3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215925
AA Change: T89A

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000217215
AA Change: T89A

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,773,288 (GRCm39) T826A probably damaging Het
Abca16 T A 7: 120,076,995 (GRCm39) I686N possibly damaging Het
Abcb6 T C 1: 75,154,132 (GRCm39) probably null Het
Adgrl3 A C 5: 81,935,364 (GRCm39) E1299A probably damaging Het
Amd2 A C 10: 35,586,802 (GRCm39) Y252D probably damaging Het
Cfap74 A G 4: 155,506,722 (GRCm39) probably null Het
Dhx29 G T 13: 113,069,076 (GRCm39) K135N probably damaging Het
Dlg5 T A 14: 24,240,516 (GRCm39) D245V possibly damaging Het
Dscaml1 C T 9: 45,623,482 (GRCm39) Q83* probably null Het
Dsp T A 13: 38,379,849 (GRCm39) L1599Q probably damaging Het
Duox2 A G 2: 122,125,095 (GRCm39) V369A probably benign Het
Flacc1 T C 1: 58,731,572 (GRCm39) M1V probably null Het
Gbe1 T A 16: 70,230,560 (GRCm39) probably null Het
Gm7298 A G 6: 121,746,669 (GRCm39) K600R probably benign Het
Heatr4 C T 12: 84,026,537 (GRCm39) G240E probably damaging Het
Jakmip2 A G 18: 43,689,589 (GRCm39) V651A possibly damaging Het
Jam3 C T 9: 27,066,640 (GRCm39) R8Q unknown Het
Letm2 A G 8: 26,082,522 (GRCm39) probably benign Het
Lmod3 T C 6: 97,224,339 (GRCm39) D494G probably benign Het
Mast2 T C 4: 116,172,136 (GRCm39) D604G probably damaging Het
Mif4gd C T 11: 115,500,101 (GRCm39) probably null Het
Msr1 T C 8: 40,077,274 (GRCm39) E112G possibly damaging Het
Mtus2 A G 5: 148,214,408 (GRCm39) probably null Het
Muc4 A G 16: 32,753,433 (GRCm38) H1103R probably benign Het
Nudt14 T A 12: 112,898,507 (GRCm39) I198F possibly damaging Het
Or11j4 T A 14: 50,630,885 (GRCm39) L224* probably null Het
Or13p3 T A 4: 118,567,045 (GRCm39) F147Y possibly damaging Het
Osbpl8 T C 10: 111,129,066 (GRCm39) I884T probably benign Het
Podxl2 T C 6: 88,819,912 (GRCm39) N550S probably damaging Het
Ppp1r9a A G 6: 5,045,949 (GRCm39) Y151C probably damaging Het
Prss42 T C 9: 110,629,924 (GRCm39) V226A possibly damaging Het
Psmd12 A G 11: 107,379,794 (GRCm39) I116V probably damaging Het
Psme4 A C 11: 30,782,175 (GRCm39) I872L probably benign Het
Rab11fip1 A T 8: 27,664,420 (GRCm39) V65E probably damaging Het
Ros1 T C 10: 52,019,473 (GRCm39) N700S possibly damaging Het
Slc15a4 G A 5: 127,673,773 (GRCm39) T547M probably damaging Het
Slfn3 T A 11: 83,103,932 (GRCm39) C268S probably benign Het
Smc5 T C 19: 23,205,554 (GRCm39) Q794R probably benign Het
Sqor A G 2: 122,651,206 (GRCm39) Y434C probably damaging Het
Steap4 T A 5: 8,028,502 (GRCm39) L360H probably damaging Het
Sycp1 A G 3: 102,806,203 (GRCm39) V496A probably benign Het
Tmem161b T G 13: 84,420,383 (GRCm39) M128R probably benign Het
Tmem59l T C 8: 70,938,775 (GRCm39) E102G probably damaging Het
Tnks A T 8: 35,340,247 (GRCm39) V457D probably benign Het
Tomt A G 7: 101,549,599 (GRCm39) Y230H probably damaging Het
Trim37 A G 11: 87,080,910 (GRCm39) N561D probably damaging Het
V1ra8 T A 6: 90,180,295 (GRCm39) I166K probably damaging Het
Vmn1r56 A G 7: 5,199,575 (GRCm39) V14A probably benign Het
Vsig8 T C 1: 172,387,925 (GRCm39) V5A possibly damaging Het
Vwa8 A T 14: 79,184,653 (GRCm39) S384C possibly damaging Het
Wwc1 C T 11: 35,744,264 (GRCm39) E853K probably benign Het
Zfp984 T C 4: 147,840,381 (GRCm39) N157D probably benign Het
Zzef1 G A 11: 72,765,816 (GRCm39) D1448N probably benign Het
Other mutations in Or1n1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02706:Or1n1b APN 2 36,780,731 (GRCm39) missense probably damaging 1.00
IGL02944:Or1n1b APN 2 36,780,800 (GRCm39) missense possibly damaging 0.83
R0101:Or1n1b UTSW 2 36,780,138 (GRCm39) missense probably damaging 1.00
R0118:Or1n1b UTSW 2 36,780,035 (GRCm39) missense probably benign 0.07
R0276:Or1n1b UTSW 2 36,780,035 (GRCm39) missense probably benign 0.26
R0944:Or1n1b UTSW 2 36,780,698 (GRCm39) missense probably damaging 1.00
R0975:Or1n1b UTSW 2 36,780,562 (GRCm39) missense possibly damaging 0.52
R1895:Or1n1b UTSW 2 36,780,458 (GRCm39) missense possibly damaging 0.92
R1946:Or1n1b UTSW 2 36,780,458 (GRCm39) missense possibly damaging 0.92
R2847:Or1n1b UTSW 2 36,780,536 (GRCm39) missense probably damaging 1.00
R4573:Or1n1b UTSW 2 36,780,202 (GRCm39) missense probably damaging 1.00
R4631:Or1n1b UTSW 2 36,780,630 (GRCm39) missense probably benign 0.01
R4647:Or1n1b UTSW 2 36,780,663 (GRCm39) missense probably benign 0.00
R4918:Or1n1b UTSW 2 36,780,344 (GRCm39) missense probably damaging 0.98
R4967:Or1n1b UTSW 2 36,780,719 (GRCm39) missense probably damaging 1.00
R5102:Or1n1b UTSW 2 36,780,056 (GRCm39) missense possibly damaging 0.87
R5188:Or1n1b UTSW 2 36,780,405 (GRCm39) missense probably benign
R5392:Or1n1b UTSW 2 36,780,686 (GRCm39) missense probably benign 0.34
R5608:Or1n1b UTSW 2 36,780,527 (GRCm39) missense probably damaging 1.00
R8508:Or1n1b UTSW 2 36,780,366 (GRCm39) missense probably damaging 1.00
R8820:Or1n1b UTSW 2 36,780,622 (GRCm39) missense probably benign 0.01
R9052:Or1n1b UTSW 2 36,780,105 (GRCm39) missense probably damaging 1.00
X0017:Or1n1b UTSW 2 36,779,999 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGGTGAGAACCCAGCACAG -3'
(R):5'- TTTCCAGAGCAACAGCAGCTAC -3'

Sequencing Primer
(F):5'- GCACAGGGCAAGCATCAG -3'
(R):5'- GAGCAACAGCAGCTACTCTATGG -3'
Posted On 2018-06-06