Incidental Mutation 'R6556:Lpo'
ID 522189
Institutional Source Beutler Lab
Gene Symbol Lpo
Ensembl Gene ENSMUSG00000009356
Gene Name lactoperoxidase
Synonyms 5830499B15Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6556 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 87697254-87716750 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 87708589 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 136 (Y136*)
Ref Sequence ENSEMBL: ENSMUSP00000117763 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103177] [ENSMUST00000136446]
AlphaFold Q5SW46
Predicted Effect probably null
Transcript: ENSMUST00000103177
AA Change: Y136*
SMART Domains Protein: ENSMUSP00000099466
Gene: ENSMUSG00000009356
AA Change: Y136*

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:An_peroxidase 136 682 1.8e-180 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000136446
AA Change: Y136*
SMART Domains Protein: ENSMUSP00000117763
Gene: ENSMUSG00000009356
AA Change: Y136*

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
PDB:4OEK|A 116 145 4e-7 PDB
SCOP:g1cxp.1 130 145 1e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157004
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atosb C T 4: 43,033,896 (GRCm39) R460H probably damaging Het
Atp2a1 G T 7: 126,049,434 (GRCm39) P536Q probably benign Het
Bnip5 T A 17: 29,123,585 (GRCm39) D114V probably damaging Het
Cabyr T A 18: 12,884,073 (GRCm39) S187T probably benign Het
Camkk1 A T 11: 72,924,696 (GRCm39) N303I probably benign Het
Cdh13 C T 8: 119,694,926 (GRCm39) P259S probably damaging Het
Csnk1g3 A G 18: 54,063,354 (GRCm39) D255G possibly damaging Het
Dennd5b A C 6: 148,915,749 (GRCm39) probably null Het
Dnajc14 A G 10: 128,650,500 (GRCm39) D528G probably benign Het
Edem1 T C 6: 108,831,318 (GRCm39) F593S probably benign Het
Efcab3 A G 11: 104,899,077 (GRCm39) N4343S probably null Het
Erbb2 G A 11: 98,326,908 (GRCm39) D1106N possibly damaging Het
Ermp1 T C 19: 29,590,321 (GRCm39) M794V possibly damaging Het
Fip1l1 T A 5: 74,707,838 (GRCm39) probably null Het
Gm20730 C T 6: 43,058,476 (GRCm39) C112Y probably damaging Het
Gtf2h1 T A 7: 46,458,089 (GRCm39) C245S probably damaging Het
Hdhd5 T C 6: 120,500,515 (GRCm39) H61R probably benign Het
Ighv1-71 A T 12: 115,706,092 (GRCm39) V31E probably damaging Het
Igsf9b T C 9: 27,240,851 (GRCm39) F688S probably damaging Het
Iqcd T C 5: 120,740,443 (GRCm39) V258A probably damaging Het
Kcnc2 G C 10: 112,107,761 (GRCm39) G51R probably benign Het
Med30 A G 15: 52,593,779 (GRCm39) probably benign Het
Mertk T A 2: 128,618,341 (GRCm39) V524D probably benign Het
Ndufb11b A G 15: 81,864,939 (GRCm39) D60G probably damaging Het
Or4c126 T A 2: 89,824,517 (GRCm39) F260Y probably benign Het
Or4c52 T C 2: 89,845,438 (GRCm39) Y55H probably damaging Het
Or5l13 T C 2: 87,780,320 (GRCm39) I86V probably benign Het
Pde6b T A 5: 108,569,367 (GRCm39) M358K possibly damaging Het
Prep GA G 10: 45,034,410 (GRCm39) probably null Het
Prpf4b G A 13: 35,080,015 (GRCm39) R793Q probably damaging Het
Rela T A 19: 5,697,366 (GRCm39) N524K probably damaging Het
Relch T A 1: 105,654,165 (GRCm39) F845I probably damaging Het
Rnaset2a T C 17: 8,360,480 (GRCm39) D74G probably damaging Het
Semp2l2a G A 8: 13,887,690 (GRCm39) Q134* probably null Het
Serinc2 T A 4: 130,152,064 (GRCm39) I267F probably damaging Het
Sesn3 T C 9: 14,232,549 (GRCm39) F274S possibly damaging Het
Spag1 T C 15: 36,195,553 (GRCm39) Y249H probably damaging Het
Sstr1 A T 12: 58,260,478 (GRCm39) D367V possibly damaging Het
Tasor T G 14: 27,151,215 (GRCm39) Y64D probably benign Het
Tnnt1 T C 7: 4,512,576 (GRCm39) E110G probably damaging Het
Tpm1 T A 9: 66,935,451 (GRCm39) probably null Het
Unc93b1 T C 19: 3,994,105 (GRCm39) V412A probably benign Het
Uox G C 3: 146,330,403 (GRCm39) probably null Het
Usp44 T C 10: 93,681,870 (GRCm39) Y107H probably benign Het
Other mutations in Lpo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01483:Lpo APN 11 87,711,964 (GRCm39) missense probably benign 0.43
IGL01833:Lpo APN 11 87,698,159 (GRCm39) missense possibly damaging 0.81
IGL02413:Lpo APN 11 87,697,732 (GRCm39) missense possibly damaging 0.87
IGL02706:Lpo APN 11 87,708,599 (GRCm39) missense probably benign 0.02
IGL02865:Lpo APN 11 87,697,803 (GRCm39) missense possibly damaging 0.80
IGL02939:Lpo APN 11 87,706,004 (GRCm39) missense possibly damaging 0.85
R1072:Lpo UTSW 11 87,709,260 (GRCm39) missense probably damaging 1.00
R1169:Lpo UTSW 11 87,708,143 (GRCm39) missense possibly damaging 0.58
R1667:Lpo UTSW 11 87,698,067 (GRCm39) unclassified probably benign
R1719:Lpo UTSW 11 87,700,018 (GRCm39) splice site probably null
R2133:Lpo UTSW 11 87,711,956 (GRCm39) missense probably benign 0.17
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R4382:Lpo UTSW 11 87,713,027 (GRCm39) missense probably benign 0.14
R4657:Lpo UTSW 11 87,705,173 (GRCm39) missense probably damaging 1.00
R4936:Lpo UTSW 11 87,701,166 (GRCm39) missense probably benign 0.02
R4969:Lpo UTSW 11 87,697,751 (GRCm39) missense probably benign 0.09
R5368:Lpo UTSW 11 87,711,895 (GRCm39) missense possibly damaging 0.61
R5536:Lpo UTSW 11 87,707,389 (GRCm39) missense probably damaging 1.00
R6246:Lpo UTSW 11 87,713,058 (GRCm39) missense unknown
R6817:Lpo UTSW 11 87,700,067 (GRCm39) missense probably benign
R7024:Lpo UTSW 11 87,707,269 (GRCm39) missense probably damaging 1.00
R7203:Lpo UTSW 11 87,700,077 (GRCm39) missense possibly damaging 0.75
R7206:Lpo UTSW 11 87,698,249 (GRCm39) missense probably damaging 1.00
R8355:Lpo UTSW 11 87,705,114 (GRCm39) missense probably damaging 1.00
R8455:Lpo UTSW 11 87,705,114 (GRCm39) missense probably damaging 1.00
R8693:Lpo UTSW 11 87,700,066 (GRCm39) missense probably benign 0.04
R8848:Lpo UTSW 11 87,708,603 (GRCm39) missense probably benign 0.00
R8891:Lpo UTSW 11 87,697,848 (GRCm39) missense probably benign 0.08
R8989:Lpo UTSW 11 87,708,660 (GRCm39) missense probably benign 0.00
RF010:Lpo UTSW 11 87,711,928 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTCTGCACTGTGAGCTTCTG -3'
(R):5'- ATGAAACTTGCATTCTCTTCTGGG -3'

Sequencing Primer
(F):5'- AAAATCTAGGACTGTCTGTGTAGTG -3'
(R):5'- CTTCTGGGTTACACCGAGCTG -3'
Posted On 2018-06-06