Incidental Mutation 'R6562:Or6c211'
ID 522479
Institutional Source Beutler Lab
Gene Symbol Or6c211
Ensembl Gene ENSMUSG00000058513
Gene Name olfactory receptor family 6 subfamily C member 211
Synonyms Olfr801, GA_x6K02T2PULF-11349138-11348182, MOR110-10
MMRRC Submission 044686-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R6562 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129505430-129506386 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 129506008 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 127 (P127S)
Ref Sequence ENSEMBL: ENSMUSP00000149555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072063] [ENSMUST00000203424] [ENSMUST00000213294] [ENSMUST00000216067]
AlphaFold Q8VEU1
Predicted Effect probably damaging
Transcript: ENSMUST00000072063
AA Change: P127S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071941
Gene: ENSMUSG00000058513
AA Change: P127S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.2e-51 PFAM
Pfam:7tm_1 39 288 8.8e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203424
AA Change: P90S

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145011
Gene: ENSMUSG00000058513
AA Change: P90S

DomainStartEndE-ValueType
Pfam:7tm_4 1 96 5.9e-18 PFAM
Pfam:7tm_1 2 96 1.3e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213294
AA Change: P127S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216067
AA Change: P127S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.5121 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933434E20Rik A G 3: 89,970,543 (GRCm39) K26E probably benign Het
Abt1 T G 13: 23,607,758 (GRCm39) E82A probably damaging Het
Actr8 A G 14: 29,708,411 (GRCm39) probably null Het
Akap12 G T 10: 4,306,141 (GRCm39) E984* probably null Het
Ankrd13a C A 5: 114,942,453 (GRCm39) probably benign Het
Ankrd13c T A 3: 157,705,309 (GRCm39) S411T probably damaging Het
Arhgef28 A G 13: 98,124,647 (GRCm39) probably null Het
Arhgef3 A T 14: 26,874,953 (GRCm39) probably benign Het
Atad5 T C 11: 80,024,032 (GRCm39) S1712P probably benign Het
Bbs12 A G 3: 37,374,389 (GRCm39) E394G probably damaging Het
Ccdc158 T G 5: 92,810,581 (GRCm39) K102N probably damaging Het
Ccdc169 A G 3: 55,058,235 (GRCm39) N89S probably damaging Het
Cd200l1 C T 16: 45,264,442 (GRCm39) E39K probably benign Het
Cenpu T C 8: 47,025,858 (GRCm39) I132T possibly damaging Het
Cnrip1 G A 11: 17,028,539 (GRCm39) W157* probably null Het
Ctnnd1 A G 2: 84,454,652 (GRCm39) S53P probably benign Het
Dcpp3 AGGCCATGCTGGCC AGGCC 17: 24,136,572 (GRCm39) probably benign Het
Dock7 A T 4: 98,879,647 (GRCm39) V969D probably damaging Het
Ehd2 C A 7: 15,691,492 (GRCm39) R280L probably benign Het
Entpd5 T C 12: 84,432,974 (GRCm39) T218A probably damaging Het
Fcrl2 A C 3: 87,164,635 (GRCm39) I297S probably benign Het
Frmpd2 T A 14: 33,293,872 (GRCm39) L1346Q probably benign Het
Fry T C 5: 150,249,614 (GRCm39) S142P probably damaging Het
Gbgt1 A T 2: 28,394,898 (GRCm39) I179F probably damaging Het
Gm17067 A T 7: 42,358,153 (GRCm39) S116R probably damaging Het
Gm5565 G T 5: 146,094,964 (GRCm39) P261T probably damaging Het
Kat6a T C 8: 23,401,803 (GRCm39) F391L probably benign Het
Kcnmb4 A T 10: 116,309,089 (GRCm39) probably null Het
Krt6a T A 15: 101,600,094 (GRCm39) H386L probably benign Het
L3mbtl1 C T 2: 162,812,124 (GRCm39) T723I probably benign Het
Lamb2 A T 9: 108,364,207 (GRCm39) R1049W possibly damaging Het
Lrmda T C 14: 22,648,254 (GRCm39) probably benign Het
Lysmd2 C T 9: 75,542,691 (GRCm39) T95I unknown Het
Ndst3 A G 3: 123,346,181 (GRCm39) S698P probably damaging Het
Nin T C 12: 70,102,728 (GRCm39) D300G probably damaging Het
Nutf2 G T 8: 106,602,258 (GRCm39) D23Y probably benign Het
Ovgp1 A G 3: 105,887,589 (GRCm39) Y300C probably damaging Het
Pgghg A G 7: 140,526,506 (GRCm39) I633V probably benign Het
Pik3r3 C T 4: 116,157,006 (GRCm39) Q496* probably null Het
Pkn3 G T 2: 29,970,699 (GRCm39) probably null Het
Plin2 A T 4: 86,576,832 (GRCm39) S298T probably benign Het
Prdm8 T C 5: 98,331,202 (GRCm39) V18A possibly damaging Het
Rel C A 11: 23,707,026 (GRCm39) G59* probably null Het
Siglecg A G 7: 43,058,481 (GRCm39) R123G possibly damaging Het
Slc13a1 T A 6: 24,150,792 (GRCm39) I49F probably benign Het
Slc39a10 T A 1: 46,874,724 (GRCm39) T193S probably benign Het
Slc9a3 T A 13: 74,303,280 (GRCm39) V191E probably damaging Het
Spata31e2 T A 1: 26,721,443 (GRCm39) T1246S possibly damaging Het
Sult2b1 A C 7: 45,391,670 (GRCm39) S39A probably benign Het
Tead1 A G 7: 112,460,650 (GRCm39) T185A probably benign Het
Tmem67 A G 4: 12,053,445 (GRCm39) probably null Het
Trim12c A T 7: 103,994,341 (GRCm39) probably null Het
Trpm6 T A 19: 18,815,406 (GRCm39) F1164Y probably damaging Het
Ube2d1 C T 10: 71,098,071 (GRCm39) D16N probably benign Het
Vmn2r24 A T 6: 123,757,386 (GRCm39) I85F probably benign Het
Vwde T A 6: 13,193,122 (GRCm39) N406Y possibly damaging Het
Wdr54 A T 6: 83,132,050 (GRCm39) probably null Het
Zcchc14 A T 8: 122,330,842 (GRCm39) N840K probably damaging Het
Zfp451 C A 1: 33,801,260 (GRCm39) S1052I possibly damaging Het
Other mutations in Or6c211
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Or6c211 APN 10 129,505,756 (GRCm39) missense probably damaging 1.00
IGL02400:Or6c211 APN 10 129,505,752 (GRCm39) missense probably damaging 0.99
IGL02721:Or6c211 APN 10 129,505,992 (GRCm39) missense probably benign 0.08
IGL03107:Or6c211 APN 10 129,505,809 (GRCm39) missense probably benign 0.00
R0114:Or6c211 UTSW 10 129,505,467 (GRCm39) missense probably benign
R0140:Or6c211 UTSW 10 129,505,557 (GRCm39) missense probably damaging 1.00
R0652:Or6c211 UTSW 10 129,506,248 (GRCm39) missense probably benign 0.08
R1375:Or6c211 UTSW 10 129,506,241 (GRCm39) missense probably null 0.97
R1449:Or6c211 UTSW 10 129,506,238 (GRCm39) missense probably damaging 0.99
R2026:Or6c211 UTSW 10 129,506,334 (GRCm39) missense probably damaging 1.00
R2241:Or6c211 UTSW 10 129,505,764 (GRCm39) missense probably damaging 1.00
R2516:Or6c211 UTSW 10 129,506,155 (GRCm39) missense probably damaging 1.00
R2869:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2869:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2873:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R8362:Or6c211 UTSW 10 129,506,100 (GRCm39) missense possibly damaging 0.88
R8503:Or6c211 UTSW 10 129,505,512 (GRCm39) missense probably damaging 0.99
R8867:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R9251:Or6c211 UTSW 10 129,505,980 (GRCm39) missense possibly damaging 0.61
Z1177:Or6c211 UTSW 10 129,505,663 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- GAGAGCTATGACAAAAGCCATC -3'
(R):5'- ATTGCATTCACAACTGCCTG -3'

Sequencing Primer
(F):5'- GCCATCAATTCCATGAAATGTGTGTC -3'
(R):5'- ACAACTGCCTGTATTCCACGG -3'
Posted On 2018-06-06