Incidental Mutation 'R6566:Zfp944'
ID 522711
Institutional Source Beutler Lab
Gene Symbol Zfp944
Ensembl Gene ENSMUSG00000033972
Gene Name zinc finger protein 944
Synonyms 6330416L07Rik
MMRRC Submission 044690-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.223) question?
Stock # R6566 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 22556970-22580381 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 22558726 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamine at position 174 (K174Q)
Ref Sequence ENSEMBL: ENSMUSP00000111197 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115535]
AlphaFold E9PUS4
Predicted Effect possibly damaging
Transcript: ENSMUST00000115535
AA Change: K174Q

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000111197
Gene: ENSMUSG00000033972
AA Change: K174Q

DomainStartEndE-ValueType
KRAB 13 76 2.08e-21 SMART
ZnF_C2H2 183 205 1.01e-1 SMART
ZnF_C2H2 211 233 1.07e0 SMART
ZnF_C2H2 239 261 1.95e-3 SMART
ZnF_C2H2 267 289 1.22e-4 SMART
ZnF_C2H2 295 317 2.24e-3 SMART
ZnF_C2H2 323 345 1.82e-3 SMART
ZnF_C2H2 351 373 5.99e-4 SMART
ZnF_C2H2 379 401 4.79e-3 SMART
ZnF_C2H2 407 429 2.99e-4 SMART
ZnF_C2H2 435 457 4.17e-3 SMART
ZnF_C2H2 463 485 1.36e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 100% (36/36)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 A G 15: 91,075,321 (GRCm39) I164T probably damaging Het
Adad2 C T 8: 120,340,971 (GRCm39) P164S probably benign Het
Adcy3 T A 12: 4,244,324 (GRCm39) L278H probably damaging Het
Aldh16a1 A C 7: 44,792,651 (GRCm39) D670E probably benign Het
Bcat1 A G 6: 144,961,210 (GRCm39) M131T probably damaging Het
Dcstamp T C 15: 39,617,732 (GRCm39) F47S possibly damaging Het
Dsg1b T C 18: 20,530,499 (GRCm39) F385L probably damaging Het
Exoc8 A C 8: 125,622,783 (GRCm39) L528R probably damaging Het
Fat4 T C 3: 39,011,275 (GRCm39) V2125A possibly damaging Het
Gm57859 C T 11: 113,578,824 (GRCm39) P73L probably damaging Het
Hecw1 T C 13: 14,471,868 (GRCm39) D600G probably damaging Het
Ice2 G A 9: 69,323,511 (GRCm39) V669I probably benign Het
Khdc4 C T 3: 88,618,961 (GRCm39) T555M probably damaging Het
Lsr T A 7: 30,671,508 (GRCm39) Y75F possibly damaging Het
Mrps30 C A 13: 118,523,662 (GRCm39) V37L probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Or6c217 T A 10: 129,737,947 (GRCm39) I211L probably benign Het
Pign A G 1: 105,565,906 (GRCm39) probably null Het
Plcd3 A G 11: 102,964,626 (GRCm39) Y582H probably damaging Het
Rad9b A G 5: 122,490,630 (GRCm39) W29R probably damaging Het
Rb1cc1 T A 1: 6,319,316 (GRCm39) F912I probably benign Het
Rgs16 C T 1: 153,619,546 (GRCm39) S184L unknown Het
Runx2 A G 17: 45,125,375 (GRCm39) probably null Het
Serpina1f T A 12: 103,659,794 (GRCm39) I163F probably damaging Het
Serpina9 T C 12: 103,963,296 (GRCm39) E404G possibly damaging Het
Slc4a4 T C 5: 89,297,192 (GRCm39) S511P possibly damaging Het
Speg A T 1: 75,365,107 (GRCm39) E390V probably damaging Het
Syne3 A G 12: 104,912,966 (GRCm39) V614A probably benign Het
Tmc5 T C 7: 118,247,067 (GRCm39) S524P probably damaging Het
Tuba4a G A 1: 75,193,930 (GRCm39) T51I probably damaging Het
Tymp T A 15: 89,257,803 (GRCm39) T421S probably benign Het
Uvssa A G 5: 33,549,520 (GRCm39) R394G possibly damaging Het
Wdr7 T G 18: 63,888,126 (GRCm39) I533S possibly damaging Het
Zbtb5 G A 4: 44,994,508 (GRCm39) T292M probably damaging Het
Other mutations in Zfp944
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Zfp944 APN 17 22,558,186 (GRCm39) missense probably benign 0.10
IGL00917:Zfp944 APN 17 22,558,765 (GRCm39) missense probably benign 0.00
IGL01093:Zfp944 APN 17 22,562,615 (GRCm39) splice site probably benign
IGL02113:Zfp944 APN 17 22,558,047 (GRCm39) missense possibly damaging 0.88
IGL02694:Zfp944 APN 17 22,558,899 (GRCm39) missense probably benign 0.05
IGL03135:Zfp944 APN 17 22,558,737 (GRCm39) missense probably benign 0.00
IGL03172:Zfp944 APN 17 22,559,018 (GRCm39) missense probably damaging 0.98
R0121:Zfp944 UTSW 17 22,558,249 (GRCm39) missense possibly damaging 0.69
R0336:Zfp944 UTSW 17 22,558,009 (GRCm39) missense probably damaging 1.00
R0755:Zfp944 UTSW 17 22,558,889 (GRCm39) missense possibly damaging 0.63
R1536:Zfp944 UTSW 17 22,558,697 (GRCm39) nonsense probably null
R1708:Zfp944 UTSW 17 22,558,026 (GRCm39) missense probably damaging 0.98
R1886:Zfp944 UTSW 17 22,558,960 (GRCm39) missense probably benign 0.04
R1928:Zfp944 UTSW 17 22,560,065 (GRCm39) missense probably damaging 0.96
R1950:Zfp944 UTSW 17 22,558,681 (GRCm39) missense probably benign 0.16
R2075:Zfp944 UTSW 17 22,558,178 (GRCm39) nonsense probably null
R2101:Zfp944 UTSW 17 22,558,809 (GRCm39) missense probably benign 0.41
R2433:Zfp944 UTSW 17 22,558,193 (GRCm39) nonsense probably null
R4698:Zfp944 UTSW 17 22,558,180 (GRCm39) missense probably damaging 1.00
R4986:Zfp944 UTSW 17 22,558,211 (GRCm39) missense probably damaging 1.00
R6451:Zfp944 UTSW 17 22,557,846 (GRCm39) missense probably benign 0.40
R6752:Zfp944 UTSW 17 22,558,500 (GRCm39) missense probably benign 0.01
R7064:Zfp944 UTSW 17 22,558,560 (GRCm39) missense probably damaging 1.00
R8193:Zfp944 UTSW 17 22,558,861 (GRCm39) nonsense probably null
R8323:Zfp944 UTSW 17 22,558,235 (GRCm39) missense probably benign
R8328:Zfp944 UTSW 17 22,558,705 (GRCm39) nonsense probably null
R8902:Zfp944 UTSW 17 22,558,761 (GRCm39) missense probably benign 0.41
R8915:Zfp944 UTSW 17 22,558,507 (GRCm39) missense probably benign 0.05
R9130:Zfp944 UTSW 17 22,560,031 (GRCm39) missense probably damaging 1.00
R9248:Zfp944 UTSW 17 22,562,619 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CAGTACATTTGTAAGGTTTCTCTCCTG -3'
(R):5'- CAGGGATACACATGTTAAGTCATC -3'

Sequencing Primer
(F):5'- AAGGTTTCTCTCCTGTATGAATTTTC -3'
(R):5'- GGATACACATGTTAAGTCATCAGATG -3'
Posted On 2018-06-06