Incidental Mutation 'R6490:Agrn'
ID |
522738 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Agrn
|
Ensembl Gene |
ENSMUSG00000041936 |
Gene Name |
agrin |
Synonyms |
Agrin, NMF380, nmf380 |
MMRRC Submission |
044622-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.458)
|
Stock # |
R6490 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
4 |
Chromosomal Location |
156249747-156281945 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
A to T
at 156251819 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Stop codon
at position 1921
(Y1921*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000137931
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071248]
[ENSMUST00000105574]
[ENSMUST00000105575]
[ENSMUST00000180572]
|
AlphaFold |
A2ASQ1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000071248
|
SMART Domains |
Protein: ENSMUSP00000071229 Gene: ENSMUSG00000041936
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1139 |
5.57e-35 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000105574
AA Change: Y1814*
|
SMART Domains |
Protein: ENSMUSP00000101199 Gene: ENSMUSG00000041936 AA Change: Y1814*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1678 |
6.51e-36 |
SMART |
EGF
|
1699 |
1735 |
4.35e-6 |
SMART |
LamG
|
1771 |
1907 |
5.01e-37 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000105575
AA Change: Y1837*
|
SMART Domains |
Protein: ENSMUSP00000101200 Gene: ENSMUSG00000041936 AA Change: Y1837*
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1682 |
9.2e-36 |
SMART |
EGF
|
1703 |
1739 |
4.35e-6 |
SMART |
LamG
|
1794 |
1930 |
5.01e-37 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144749
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154494
|
Predicted Effect |
probably null
Transcript: ENSMUST00000180572
AA Change: Y1921*
|
SMART Domains |
Protein: ENSMUSP00000137931 Gene: ENSMUSG00000041936 AA Change: Y1921*
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
Pfam:NtA
|
32 |
159 |
5.1e-91 |
PFAM |
FOLN
|
173 |
198 |
8.25e-6 |
SMART |
KAZAL
|
198 |
244 |
1.22e-17 |
SMART |
FOLN
|
249 |
273 |
7.58e-5 |
SMART |
EGF_like
|
249 |
288 |
7.38e1 |
SMART |
KAZAL
|
273 |
319 |
1.51e-13 |
SMART |
KAZAL
|
348 |
391 |
1.8e-6 |
SMART |
KAZAL
|
417 |
463 |
1.55e-10 |
SMART |
FOLN
|
469 |
491 |
8.25e-6 |
SMART |
KAZAL
|
491 |
536 |
1.14e-17 |
SMART |
KAZAL
|
556 |
601 |
6.43e-17 |
SMART |
FOLN
|
603 |
626 |
2.94e-2 |
SMART |
KAZAL
|
614 |
666 |
8.96e-16 |
SMART |
low complexity region
|
672 |
679 |
N/A |
INTRINSIC |
KAZAL
|
706 |
752 |
1.12e-16 |
SMART |
EGF_Lam
|
795 |
846 |
3.29e-15 |
SMART |
EGF_Lam
|
849 |
893 |
6.7e-7 |
SMART |
FOLN
|
902 |
924 |
1.94e-2 |
SMART |
KAZAL
|
924 |
971 |
3.9e-16 |
SMART |
low complexity region
|
996 |
1013 |
N/A |
INTRINSIC |
low complexity region
|
1056 |
1085 |
N/A |
INTRINSIC |
SEA
|
1121 |
1243 |
2.26e-35 |
SMART |
low complexity region
|
1249 |
1276 |
N/A |
INTRINSIC |
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
EGF
|
1321 |
1356 |
1.49e-4 |
SMART |
LamG
|
1381 |
1517 |
4e-45 |
SMART |
EGF
|
1541 |
1575 |
2.23e-3 |
SMART |
EGF
|
1580 |
1614 |
7.13e-2 |
SMART |
LamG
|
1649 |
1785 |
6.51e-36 |
SMART |
EGF
|
1806 |
1842 |
4.35e-6 |
SMART |
LamG
|
1878 |
2014 |
5.01e-37 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181062
|
Meta Mutation Damage Score |
0.9755 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.6%
|
Validation Efficiency |
99% (69/70) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] PHENOTYPE: Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death. [provided by MGI curators]
|
Allele List at MGI |
All alleles(12) : Targeted, knock-out(4) Targeted, other(1) Gene trapped(7) |
Other mutations in this stock |
Total: 70 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700018B08Rik |
T |
G |
8: 122,267,293 (GRCm39) |
K38T |
probably benign |
Het |
Abca13 |
A |
G |
11: 9,248,661 (GRCm39) |
T2803A |
probably benign |
Het |
Adam23 |
A |
G |
1: 63,596,613 (GRCm39) |
D565G |
probably damaging |
Het |
Adcy3 |
A |
G |
12: 4,262,150 (GRCm39) |
T1067A |
probably damaging |
Het |
Apc2 |
A |
G |
10: 80,149,757 (GRCm39) |
N1604D |
probably benign |
Het |
Atxn7 |
A |
T |
14: 14,089,446 (GRCm38) |
R321* |
probably null |
Het |
Axin1 |
T |
A |
17: 26,361,968 (GRCm39) |
I104N |
probably damaging |
Het |
Bahd1 |
T |
C |
2: 118,747,619 (GRCm39) |
S413P |
probably benign |
Het |
Baz2b |
C |
T |
2: 59,732,073 (GRCm39) |
C2024Y |
probably damaging |
Het |
Cacna1i |
T |
A |
15: 80,262,448 (GRCm39) |
V1388E |
probably damaging |
Het |
Ces4a |
G |
A |
8: 105,876,090 (GRCm39) |
V544M |
probably benign |
Het |
Cntn3 |
G |
A |
6: 102,255,301 (GRCm39) |
T199I |
probably damaging |
Het |
Col6a4 |
A |
T |
9: 105,952,191 (GRCm39) |
L569* |
probably null |
Het |
Ctnna2 |
A |
G |
6: 77,120,892 (GRCm39) |
I12T |
probably benign |
Het |
Dhx37 |
A |
G |
5: 125,496,196 (GRCm39) |
M754T |
probably benign |
Het |
Dmrt1 |
T |
A |
19: 25,523,395 (GRCm39) |
S249T |
possibly damaging |
Het |
Ell |
G |
T |
8: 71,025,553 (GRCm39) |
S59I |
probably damaging |
Het |
Fam89a |
G |
A |
8: 125,467,982 (GRCm39) |
S110F |
probably damaging |
Het |
Fer1l4 |
A |
C |
2: 155,889,834 (GRCm39) |
F278V |
possibly damaging |
Het |
Fyn |
T |
C |
10: 39,427,398 (GRCm39) |
I427T |
probably damaging |
Het |
Galnt14 |
T |
C |
17: 73,832,365 (GRCm39) |
D250G |
probably damaging |
Het |
Glp1r |
T |
C |
17: 31,143,546 (GRCm39) |
V194A |
probably damaging |
Het |
Glt1d1 |
T |
A |
5: 127,721,360 (GRCm39) |
|
probably null |
Het |
Gm7995 |
A |
G |
14: 42,133,327 (GRCm39) |
K69R |
probably benign |
Het |
Grip1 |
A |
G |
10: 119,822,329 (GRCm39) |
T379A |
possibly damaging |
Het |
Gtpbp2 |
G |
T |
17: 46,479,147 (GRCm39) |
A570S |
probably benign |
Het |
Hmcn1 |
T |
C |
1: 150,459,029 (GRCm39) |
I5192V |
probably benign |
Het |
Igfl3 |
A |
T |
7: 17,913,844 (GRCm39) |
I65F |
possibly damaging |
Het |
Igsf10 |
G |
T |
3: 59,236,992 (GRCm39) |
T1063K |
probably benign |
Het |
Itfg1 |
A |
G |
8: 86,466,930 (GRCm39) |
V381A |
probably benign |
Het |
Itprid1 |
A |
G |
6: 55,953,405 (GRCm39) |
D907G |
probably damaging |
Het |
Jmjd8 |
T |
A |
17: 26,048,086 (GRCm39) |
V16E |
probably benign |
Het |
Kank1 |
A |
G |
19: 25,387,449 (GRCm39) |
Y374C |
probably damaging |
Het |
Kcnma1 |
C |
T |
14: 23,386,165 (GRCm39) |
V891I |
possibly damaging |
Het |
Kif20a |
C |
A |
18: 34,762,543 (GRCm39) |
T472K |
possibly damaging |
Het |
Klhl32 |
A |
T |
4: 24,711,578 (GRCm39) |
|
probably benign |
Het |
Lrrc37a |
A |
G |
11: 103,347,486 (GRCm39) |
S3070P |
unknown |
Het |
Mettl21e |
T |
G |
1: 44,249,425 (GRCm39) |
Y77S |
probably damaging |
Het |
Mlst8 |
G |
T |
17: 24,696,935 (GRCm39) |
D82E |
probably benign |
Het |
Mrgprx2 |
A |
T |
7: 48,132,617 (GRCm39) |
L67Q |
probably damaging |
Het |
Mylk |
T |
A |
16: 34,750,237 (GRCm39) |
L1192Q |
possibly damaging |
Het |
Myt1l |
A |
T |
12: 29,882,365 (GRCm39) |
Y520F |
unknown |
Het |
Naip2 |
A |
T |
13: 100,297,193 (GRCm39) |
W948R |
probably benign |
Het |
Nlrp9a |
A |
C |
7: 26,250,311 (GRCm39) |
K25N |
probably damaging |
Het |
Nsd3 |
T |
C |
8: 26,204,212 (GRCm39) |
C414R |
probably damaging |
Het |
Oit3 |
A |
T |
10: 59,274,374 (GRCm39) |
V142D |
possibly damaging |
Het |
Or2aj6 |
C |
T |
16: 19,443,194 (GRCm39) |
V219M |
probably benign |
Het |
P2ry6 |
T |
C |
7: 100,587,580 (GRCm39) |
T260A |
probably damaging |
Het |
Papola |
A |
G |
12: 105,771,196 (GRCm39) |
Q87R |
probably benign |
Het |
Pla2g4a |
T |
A |
1: 149,727,086 (GRCm39) |
R557* |
probably null |
Het |
Rgs13 |
G |
T |
1: 144,016,576 (GRCm39) |
H56N |
probably damaging |
Het |
Sbf1 |
T |
C |
15: 89,189,111 (GRCm39) |
S537G |
probably benign |
Het |
Sntg1 |
A |
C |
1: 8,653,508 (GRCm39) |
L243R |
possibly damaging |
Het |
Spata31h1 |
A |
T |
10: 82,125,138 (GRCm39) |
L2624Q |
possibly damaging |
Het |
Stam2 |
T |
C |
2: 52,610,954 (GRCm39) |
T23A |
probably benign |
Het |
Tbl1xr1 |
C |
A |
3: 22,258,141 (GRCm39) |
H467Q |
probably damaging |
Het |
Tmem131l |
A |
G |
3: 83,820,587 (GRCm39) |
S1222P |
possibly damaging |
Het |
Tmem43 |
G |
T |
6: 91,455,759 (GRCm39) |
Q123H |
probably damaging |
Het |
Tmem43 |
T |
A |
6: 91,463,862 (GRCm39) |
I379N |
possibly damaging |
Het |
Trim43c |
A |
T |
9: 88,727,003 (GRCm39) |
I277F |
possibly damaging |
Het |
Ttn |
A |
G |
2: 76,703,211 (GRCm39) |
|
probably benign |
Het |
Vmn1r75 |
T |
A |
7: 11,615,003 (GRCm39) |
V245D |
probably damaging |
Het |
Vmn2r111 |
T |
C |
17: 22,778,032 (GRCm39) |
N549S |
possibly damaging |
Het |
Vps53 |
A |
T |
11: 75,967,881 (GRCm39) |
M414K |
probably benign |
Het |
Wrn |
T |
G |
8: 33,809,248 (GRCm39) |
L249F |
probably benign |
Het |
Zc3h13 |
TGATGTCCGGGATGTCCGGGATGTCCGGGATGTCCGGGATGT |
TGATGTCCGGGATGTCCGGGATGTCCGGGATGT |
14: 75,560,998 (GRCm39) |
|
probably benign |
Het |
Zfp454 |
T |
C |
11: 50,764,950 (GRCm39) |
N161D |
probably benign |
Het |
Zfp619 |
G |
A |
7: 39,183,586 (GRCm39) |
G60R |
probably benign |
Het |
Zfp623 |
T |
A |
15: 75,820,308 (GRCm39) |
H421Q |
probably damaging |
Het |
Zfp827 |
A |
G |
8: 79,916,606 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Agrn |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00479:Agrn
|
APN |
4 |
156,255,029 (GRCm39) |
splice site |
probably benign |
|
IGL00811:Agrn
|
APN |
4 |
156,253,231 (GRCm39) |
missense |
possibly damaging |
0.70 |
IGL01066:Agrn
|
APN |
4 |
156,261,800 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01412:Agrn
|
APN |
4 |
156,255,491 (GRCm39) |
splice site |
probably benign |
|
IGL01414:Agrn
|
APN |
4 |
156,279,696 (GRCm39) |
splice site |
probably null |
|
IGL02075:Agrn
|
APN |
4 |
156,254,667 (GRCm39) |
missense |
probably benign |
0.40 |
IGL02609:Agrn
|
APN |
4 |
156,259,680 (GRCm39) |
splice site |
probably benign |
|
IGL02669:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02671:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02672:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02674:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02724:Agrn
|
APN |
4 |
156,257,264 (GRCm39) |
nonsense |
probably null |
|
IGL02804:Agrn
|
APN |
4 |
156,258,512 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02986:Agrn
|
APN |
4 |
156,263,311 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL03160:Agrn
|
APN |
4 |
156,254,820 (GRCm39) |
missense |
probably damaging |
0.98 |
BB004:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
BB014:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
F6893:Agrn
|
UTSW |
4 |
156,258,636 (GRCm39) |
missense |
probably benign |
|
R0092:Agrn
|
UTSW |
4 |
156,263,410 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0482:Agrn
|
UTSW |
4 |
156,258,012 (GRCm39) |
missense |
probably damaging |
0.98 |
R0531:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.38 |
R0536:Agrn
|
UTSW |
4 |
156,264,010 (GRCm39) |
missense |
probably benign |
0.01 |
R0690:Agrn
|
UTSW |
4 |
156,258,910 (GRCm39) |
missense |
probably damaging |
1.00 |
R0750:Agrn
|
UTSW |
4 |
156,251,394 (GRCm39) |
nonsense |
probably null |
|
R1079:Agrn
|
UTSW |
4 |
156,261,682 (GRCm39) |
missense |
probably damaging |
1.00 |
R1199:Agrn
|
UTSW |
4 |
156,256,756 (GRCm39) |
missense |
probably benign |
0.00 |
R1222:Agrn
|
UTSW |
4 |
156,261,842 (GRCm39) |
missense |
probably damaging |
0.99 |
R1534:Agrn
|
UTSW |
4 |
156,261,141 (GRCm39) |
missense |
probably damaging |
1.00 |
R1587:Agrn
|
UTSW |
4 |
156,263,897 (GRCm39) |
missense |
probably damaging |
0.99 |
R1625:Agrn
|
UTSW |
4 |
156,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
R1698:Agrn
|
UTSW |
4 |
156,251,015 (GRCm39) |
missense |
probably benign |
0.03 |
R1717:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1718:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1721:Agrn
|
UTSW |
4 |
156,259,630 (GRCm39) |
nonsense |
probably null |
|
R1765:Agrn
|
UTSW |
4 |
156,261,284 (GRCm39) |
nonsense |
probably null |
|
R1840:Agrn
|
UTSW |
4 |
156,251,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R1865:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R2105:Agrn
|
UTSW |
4 |
156,261,756 (GRCm39) |
nonsense |
probably null |
|
R2265:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2266:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2269:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2382:Agrn
|
UTSW |
4 |
156,260,973 (GRCm39) |
missense |
probably damaging |
0.97 |
R2497:Agrn
|
UTSW |
4 |
156,258,268 (GRCm39) |
missense |
probably benign |
0.28 |
R2509:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2510:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2511:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2994:Agrn
|
UTSW |
4 |
156,251,785 (GRCm39) |
missense |
possibly damaging |
0.79 |
R3824:Agrn
|
UTSW |
4 |
156,253,759 (GRCm39) |
missense |
probably damaging |
1.00 |
R4736:Agrn
|
UTSW |
4 |
156,256,858 (GRCm39) |
missense |
probably benign |
0.38 |
R4755:Agrn
|
UTSW |
4 |
156,257,979 (GRCm39) |
intron |
probably benign |
|
R4853:Agrn
|
UTSW |
4 |
156,270,007 (GRCm39) |
critical splice donor site |
probably null |
|
R4878:Agrn
|
UTSW |
4 |
156,255,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R5117:Agrn
|
UTSW |
4 |
156,270,010 (GRCm39) |
missense |
probably benign |
0.30 |
R5228:Agrn
|
UTSW |
4 |
156,251,403 (GRCm39) |
missense |
probably damaging |
1.00 |
R5236:Agrn
|
UTSW |
4 |
156,263,315 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5269:Agrn
|
UTSW |
4 |
156,253,447 (GRCm39) |
missense |
probably benign |
0.10 |
R5282:Agrn
|
UTSW |
4 |
156,257,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R5449:Agrn
|
UTSW |
4 |
156,251,737 (GRCm39) |
critical splice donor site |
probably null |
|
R5560:Agrn
|
UTSW |
4 |
156,262,954 (GRCm39) |
missense |
probably damaging |
0.99 |
R5668:Agrn
|
UTSW |
4 |
156,251,770 (GRCm39) |
missense |
probably damaging |
0.97 |
R5725:Agrn
|
UTSW |
4 |
156,258,332 (GRCm39) |
missense |
probably benign |
0.25 |
R5967:Agrn
|
UTSW |
4 |
156,259,560 (GRCm39) |
missense |
probably damaging |
1.00 |
R6226:Agrn
|
UTSW |
4 |
156,258,066 (GRCm39) |
missense |
probably damaging |
0.96 |
R6338:Agrn
|
UTSW |
4 |
156,255,042 (GRCm39) |
missense |
probably benign |
0.17 |
R6351:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.00 |
R6437:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably damaging |
0.96 |
R6909:Agrn
|
UTSW |
4 |
156,261,464 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7110:Agrn
|
UTSW |
4 |
156,263,332 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7123:Agrn
|
UTSW |
4 |
156,257,297 (GRCm39) |
missense |
probably benign |
|
R7163:Agrn
|
UTSW |
4 |
156,262,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R7180:Agrn
|
UTSW |
4 |
156,256,296 (GRCm39) |
missense |
probably benign |
0.00 |
R7251:Agrn
|
UTSW |
4 |
156,259,063 (GRCm39) |
missense |
probably damaging |
1.00 |
R7289:Agrn
|
UTSW |
4 |
156,263,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R7335:Agrn
|
UTSW |
4 |
156,260,989 (GRCm39) |
missense |
probably damaging |
1.00 |
R7336:Agrn
|
UTSW |
4 |
156,259,371 (GRCm39) |
nonsense |
probably null |
|
R7406:Agrn
|
UTSW |
4 |
156,256,758 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7460:Agrn
|
UTSW |
4 |
156,258,881 (GRCm39) |
missense |
probably damaging |
0.98 |
R7531:Agrn
|
UTSW |
4 |
156,254,261 (GRCm39) |
missense |
probably damaging |
1.00 |
R7585:Agrn
|
UTSW |
4 |
156,255,131 (GRCm39) |
missense |
probably benign |
0.08 |
R7646:Agrn
|
UTSW |
4 |
156,279,811 (GRCm39) |
missense |
probably damaging |
0.99 |
R7652:Agrn
|
UTSW |
4 |
156,253,675 (GRCm39) |
critical splice donor site |
probably null |
|
R7714:Agrn
|
UTSW |
4 |
156,279,854 (GRCm39) |
missense |
probably damaging |
1.00 |
R7751:Agrn
|
UTSW |
4 |
156,260,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R7852:Agrn
|
UTSW |
4 |
156,253,514 (GRCm39) |
missense |
probably benign |
0.01 |
R7927:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
R8039:Agrn
|
UTSW |
4 |
156,253,468 (GRCm39) |
missense |
probably benign |
0.12 |
R8056:Agrn
|
UTSW |
4 |
156,254,868 (GRCm39) |
missense |
probably benign |
|
R8061:Agrn
|
UTSW |
4 |
156,263,411 (GRCm39) |
missense |
probably damaging |
1.00 |
R8158:Agrn
|
UTSW |
4 |
156,258,346 (GRCm39) |
missense |
probably benign |
|
R8159:Agrn
|
UTSW |
4 |
156,256,825 (GRCm39) |
missense |
probably benign |
0.27 |
R8325:Agrn
|
UTSW |
4 |
156,258,119 (GRCm39) |
missense |
probably benign |
0.01 |
R8338:Agrn
|
UTSW |
4 |
156,253,018 (GRCm39) |
missense |
probably benign |
0.01 |
R8739:Agrn
|
UTSW |
4 |
156,257,045 (GRCm39) |
missense |
probably benign |
|
R8956:Agrn
|
UTSW |
4 |
156,250,995 (GRCm39) |
missense |
probably damaging |
0.99 |
R9094:Agrn
|
UTSW |
4 |
156,253,264 (GRCm39) |
missense |
probably benign |
0.01 |
R9112:Agrn
|
UTSW |
4 |
156,261,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R9384:Agrn
|
UTSW |
4 |
156,257,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R9472:Agrn
|
UTSW |
4 |
156,254,841 (GRCm39) |
missense |
|
|
R9619:Agrn
|
UTSW |
4 |
156,258,490 (GRCm39) |
missense |
probably benign |
0.00 |
R9629:Agrn
|
UTSW |
4 |
156,257,094 (GRCm39) |
nonsense |
probably null |
|
R9732:Agrn
|
UTSW |
4 |
156,258,446 (GRCm39) |
missense |
probably benign |
0.13 |
R9749:Agrn
|
UTSW |
4 |
156,258,114 (GRCm39) |
missense |
probably benign |
0.02 |
R9757:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably benign |
0.03 |
R9792:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
R9793:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
Z1177:Agrn
|
UTSW |
4 |
156,264,033 (GRCm39) |
missense |
possibly damaging |
0.95 |
Z1177:Agrn
|
UTSW |
4 |
156,256,001 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TATGTTATCCTGGCAGGCGG -3'
(R):5'- TGATAGTAGCGCTAACAGCAC -3'
Sequencing Primer
(F):5'- GGCTGGCTGCTTCTCCTG -3'
(R):5'- TTGCCTACCACCCTGGAAG -3'
|
Posted On |
2018-06-06 |