Mutagenetix > Incidental Mutation

Incidental Mutation 'R6491:Vmn2r11'

522861

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r11

Ensembl Gene

ENSMUSG00000091450

Gene Name

vomeronasal 2, receptor 11

Synonyms

EG384219

MMRRC Submission

044623-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R6491 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

109194739-109207318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109196800 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 557 (N557K)

Ref Sequence

ENSEMBL: ENSMUSP00000133218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164875]

AlphaFold

E9Q4X4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164875
AA Change: N557K

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: N557K

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	167	475	1.6e-29	PFAM
Pfam:NCD3G	520	574	9.1e-19	PFAM
Pfam:7tm_3	607	842	4.6e-55	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.5%

Validation Efficiency

100% (35/35)

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	C	13: 119,612,508 (GRCm39)	L431P	probably damaging	Het
Acad10	A	C	5: 121,768,220 (GRCm39)	W779G	probably damaging	Het
Acrbp	A	G	6: 125,028,442 (GRCm39)		probably benign	Het
Ank3	G	A	10: 69,827,459 (GRCm39)	A565T	probably benign	Het
Ap2a1	A	T	7: 44,565,588 (GRCm39)	I93K	probably damaging	Het
Arnt	T	A	3: 95,383,454 (GRCm39)	M240K	probably damaging	Het
Ceacam12	A	T	7: 17,803,185 (GRCm39)	K197M	probably damaging	Het
Cep41	T	C	6: 30,656,483 (GRCm39)	N323S	probably benign	Het
Dst	A	G	1: 34,232,093 (GRCm39)	T2904A	probably benign	Het
Eml1	G	A	12: 108,479,330 (GRCm39)		probably null	Het
Fbln2	A	G	6: 91,236,732 (GRCm39)	N749S	possibly damaging	Het
Irf2bpl	A	G	12: 86,930,238 (GRCm39)	V145A	probably benign	Het
Itga2b	T	C	11: 102,350,695 (GRCm39)		probably null	Het
Itga8	T	C	2: 12,209,587 (GRCm39)	D466G	probably damaging	Het
Kdm4c	G	T	4: 74,291,873 (GRCm39)	C830F	probably damaging	Het
Mrps27	T	C	13: 99,499,538 (GRCm39)	S73P	probably damaging	Het
Mtdh	T	G	15: 34,116,473 (GRCm39)	N17K	probably damaging	Het
Muc3a	A	G	5: 137,246,591 (GRCm39)	S9P	probably benign	Het
Or8b46	A	G	9: 38,558,751 (GRCm39)	L23P	probably damaging	Het
Oxgr1	T	A	14: 120,259,419 (GRCm39)	I263F	probably benign	Het
Phc1	A	G	6: 122,311,923 (GRCm39)			Het
Ppp2r5d	A	G	17: 46,996,509 (GRCm39)	F388S	probably damaging	Het
Pxmp4	A	G	2: 154,434,083 (GRCm39)		probably null	Het
Rnd2	C	T	11: 101,359,825 (GRCm39)	L57F	probably damaging	Het
Ror1	A	G	4: 100,267,109 (GRCm39)	N270S	possibly damaging	Het
Slc7a14	T	C	3: 31,278,093 (GRCm39)	Y504C	probably damaging	Het
Snx9	A	G	17: 5,970,437 (GRCm39)	D391G	probably benign	Het
St18	T	A	1: 6,898,209 (GRCm39)	Y670*	probably null	Het
Tjp1	A	T	7: 64,986,865 (GRCm39)	F207I	possibly damaging	Het
Trappc3	A	G	4: 126,169,022 (GRCm39)	I171V	probably benign	Het
Ugt2b5	A	T	5: 87,273,328 (GRCm39)	L446*	probably null	Het
Vmn2r105	A	T	17: 20,447,992 (GRCm39)	Y277*	probably null	Het
Yod1	G	A	1: 130,645,275 (GRCm39)	G19S	probably damaging	Het
Zfp938	A	G	10: 82,063,363 (GRCm39)	*65Q	probably null	Het

Other mutations in Vmn2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Vmn2r11	APN	5	109,194,885 (GRCm39)	missense	probably benign	0.00
IGL01677:Vmn2r11	APN	5	109,201,823 (GRCm39)	missense	possibly damaging	0.50
IGL02048:Vmn2r11	APN	5	109,202,658 (GRCm39)	missense	probably benign	0.00
IGL02559:Vmn2r11	APN	5	109,200,046 (GRCm39)	missense	probably damaging	0.98
IGL02879:Vmn2r11	APN	5	109,201,704 (GRCm39)	missense	possibly damaging	0.95
IGL03084:Vmn2r11	APN	5	109,207,209 (GRCm39)	missense	probably benign	0.00
IGL03163:Vmn2r11	APN	5	109,201,692 (GRCm39)	missense	probably benign	0.41
IGL03289:Vmn2r11	APN	5	109,196,788 (GRCm39)	splice site	probably benign
IGL03294:Vmn2r11	APN	5	109,201,935 (GRCm39)	missense	probably benign	0.22
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0421:Vmn2r11	UTSW	5	109,207,294 (GRCm39)	missense	probably benign	0.00
R0549:Vmn2r11	UTSW	5	109,199,963 (GRCm39)	missense	possibly damaging	0.80
R0628:Vmn2r11	UTSW	5	109,195,597 (GRCm39)	missense	possibly damaging	0.88
R1523:Vmn2r11	UTSW	5	109,201,707 (GRCm39)	missense	probably benign	0.25
R1660:Vmn2r11	UTSW	5	109,201,724 (GRCm39)	missense	possibly damaging	0.79
R1827:Vmn2r11	UTSW	5	109,199,938 (GRCm39)	missense	probably benign	0.01
R1913:Vmn2r11	UTSW	5	109,202,654 (GRCm39)	missense	probably benign
R2260:Vmn2r11	UTSW	5	109,201,657 (GRCm39)	nonsense	probably null
R2400:Vmn2r11	UTSW	5	109,199,928 (GRCm39)	missense	probably benign	0.03
R3933:Vmn2r11	UTSW	5	109,201,260 (GRCm39)	missense	probably damaging	0.97
R4091:Vmn2r11	UTSW	5	109,202,616 (GRCm39)	critical splice donor site	probably null
R4624:Vmn2r11	UTSW	5	109,200,101 (GRCm39)	missense	probably damaging	0.99
R4762:Vmn2r11	UTSW	5	109,195,436 (GRCm39)	missense	probably damaging	1.00
R5256:Vmn2r11	UTSW	5	109,202,658 (GRCm39)	missense	probably benign	0.26
R5370:Vmn2r11	UTSW	5	109,195,421 (GRCm39)	missense	probably damaging	1.00
R5419:Vmn2r11	UTSW	5	109,207,224 (GRCm39)	missense	possibly damaging	0.55
R5516:Vmn2r11	UTSW	5	109,195,032 (GRCm39)	missense	probably damaging	0.98
R5643:Vmn2r11	UTSW	5	109,194,869 (GRCm39)	missense	probably damaging	1.00
R5671:Vmn2r11	UTSW	5	109,202,772 (GRCm39)	missense	probably benign	0.03
R5679:Vmn2r11	UTSW	5	109,202,708 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r11	UTSW	5	109,207,114 (GRCm39)	critical splice donor site	probably null
R5746:Vmn2r11	UTSW	5	109,201,560 (GRCm39)	missense	probably benign	0.41
R5995:Vmn2r11	UTSW	5	109,194,921 (GRCm39)	missense	probably damaging	1.00
R6147:Vmn2r11	UTSW	5	109,202,700 (GRCm39)	missense	probably benign	0.04
R6220:Vmn2r11	UTSW	5	109,201,434 (GRCm39)	missense	probably benign	0.09
R6374:Vmn2r11	UTSW	5	109,201,679 (GRCm39)	missense	possibly damaging	0.65
R6804:Vmn2r11	UTSW	5	109,201,350 (GRCm39)	missense	probably damaging	1.00
R6814:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R6872:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R7014:Vmn2r11	UTSW	5	109,201,289 (GRCm39)	missense	probably damaging	1.00
R7041:Vmn2r11	UTSW	5	109,202,816 (GRCm39)	missense	probably damaging	1.00
R7043:Vmn2r11	UTSW	5	109,200,098 (GRCm39)	missense	probably benign	0.00
R7050:Vmn2r11	UTSW	5	109,202,657 (GRCm39)	missense	probably benign	0.05
R7184:Vmn2r11	UTSW	5	109,201,281 (GRCm39)	missense	probably damaging	1.00
R7388:Vmn2r11	UTSW	5	109,202,742 (GRCm39)	missense	probably benign	0.05
R7477:Vmn2r11	UTSW	5	109,207,214 (GRCm39)	missense	possibly damaging	0.67
R7524:Vmn2r11	UTSW	5	109,201,848 (GRCm39)	missense	probably benign	0.01
R7682:Vmn2r11	UTSW	5	109,195,481 (GRCm39)	missense	probably benign	0.02
R7715:Vmn2r11	UTSW	5	109,195,307 (GRCm39)	missense	probably damaging	0.99
R7869:Vmn2r11	UTSW	5	109,199,986 (GRCm39)	missense	probably damaging	1.00
R8094:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8277:Vmn2r11	UTSW	5	109,202,833 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r11	UTSW	5	109,207,270 (GRCm39)	missense	probably benign	0.00
R8676:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8701:Vmn2r11	UTSW	5	109,195,556 (GRCm39)	missense	probably damaging	1.00
R8749:Vmn2r11	UTSW	5	109,195,319 (GRCm39)	missense	probably damaging	0.97
R9046:Vmn2r11	UTSW	5	109,202,850 (GRCm39)	missense	probably benign	0.00
R9138:Vmn2r11	UTSW	5	109,201,904 (GRCm39)	missense	probably damaging	1.00
R9267:Vmn2r11	UTSW	5	109,199,929 (GRCm39)	missense	possibly damaging	0.93
R9306:Vmn2r11	UTSW	5	109,196,831 (GRCm39)	missense	probably damaging	1.00
R9384:Vmn2r11	UTSW	5	109,201,266 (GRCm39)	missense	probably damaging	1.00
R9443:Vmn2r11	UTSW	5	109,195,159 (GRCm39)	nonsense	probably null
R9520:Vmn2r11	UTSW	5	109,201,455 (GRCm39)	missense	probably benign	0.35
R9596:Vmn2r11	UTSW	5	109,201,563 (GRCm39)	missense	possibly damaging	0.67
R9677:Vmn2r11	UTSW	5	109,201,332 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- ACACATGCATGTTTCCCTAAAC -3'
(R):5'- CTGGTTATCATATCTGTTAAGGTCCC -3'

Sequencing Primer
(F):5'- ACATGCATGTTTCCCTAAACTTTTTC -3'
(R):5'- TGTATTGCCTCAGGTTCC -3'

Posted On

2018-06-06