Incidental Mutation 'R6498:Zfp268'
ID 523096
Institutional Source Beutler Lab
Gene Symbol Zfp268
Ensembl Gene ENSMUSG00000078502
Gene Name zinc finger protein 268
Synonyms Gm13212
MMRRC Submission 044630-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.401) question?
Stock # R6498 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 145311770-145351915 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145349459 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 299 (C299S)
Ref Sequence ENSEMBL: ENSMUSP00000095402 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097794] [ENSMUST00000105739] [ENSMUST00000119718]
AlphaFold B1ASQ7
Predicted Effect probably damaging
Transcript: ENSMUST00000097794
AA Change: C299S

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000095402
Gene: ENSMUSG00000078502
AA Change: C299S

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
ZnF_C2H2 294 316 1.3e-4 SMART
ZnF_C2H2 322 344 1.58e-3 SMART
ZnF_C2H2 350 372 4.24e-4 SMART
ZnF_C2H2 378 400 1.06e-4 SMART
Predicted Effect unknown
Transcript: ENSMUST00000105739
AA Change: C299S
SMART Domains Protein: ENSMUSP00000101365
Gene: ENSMUSG00000078502
AA Change: C299S

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
ZnF_C2H2 294 316 1.3e-4 SMART
ZnF_C2H2 322 344 1.58e-3 SMART
ZnF_C2H2 350 372 4.24e-4 SMART
ZnF_C2H2 378 400 1.06e-4 SMART
ZnF_C2H2 406 428 1.58e-3 SMART
ZnF_C2H2 434 456 3.39e-3 SMART
ZnF_C2H2 462 484 1.06e-4 SMART
ZnF_C2H2 490 512 1.58e-3 SMART
ZnF_C2H2 518 540 3.39e-3 SMART
ZnF_C2H2 546 568 3.39e-3 SMART
ZnF_C2H2 574 596 3.39e-3 SMART
ZnF_C2H2 602 624 3.39e-3 SMART
ZnF_C2H2 630 652 1.06e-4 SMART
ZnF_C2H2 658 680 1.58e-3 SMART
ZnF_C2H2 686 708 3.39e-3 SMART
ZnF_C2H2 714 736 1.3e-4 SMART
ZnF_C2H2 742 764 1.3e-4 SMART
ZnF_C2H2 770 792 4.79e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119718
SMART Domains Protein: ENSMUSP00000112918
Gene: ENSMUSG00000078502

DomainStartEndE-ValueType
KRAB 13 72 3.23e-18 SMART
internal_repeat_1 141 211 2.19e-13 PROSPERO
ZnF_C2H2 238 260 1.69e-3 SMART
ZnF_C2H2 266 288 1.18e-2 SMART
low complexity region 320 335 N/A INTRINSIC
low complexity region 350 357 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180968
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 96.9%
  • 20x: 89.8%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 T G 11: 110,182,928 (GRCm39) N1043T possibly damaging Het
Actn2 C T 13: 12,291,359 (GRCm39) E682K probably damaging Het
Agtpbp1 A G 13: 59,624,854 (GRCm39) V833A possibly damaging Het
Arrb2 G T 11: 70,330,375 (GRCm39) R333L probably benign Het
Atp9b C T 18: 80,820,230 (GRCm39) S135N probably benign Het
Cep112 T A 11: 108,331,357 (GRCm39) S135R probably benign Het
D630045J12Rik G A 6: 38,124,132 (GRCm39) R1607* probably null Het
Duox1 A T 2: 122,150,088 (GRCm39) S160C probably damaging Het
Eogt A T 6: 97,112,174 (GRCm39) Y160N probably damaging Het
Exosc10 T C 4: 148,657,795 (GRCm39) V647A probably benign Het
Fbxo44 C T 4: 148,238,882 (GRCm39) Het
Fen1 G T 19: 10,177,479 (GRCm39) R322S probably damaging Het
Gls A C 1: 52,259,198 (GRCm39) N134K probably benign Het
Hspg2 T C 4: 137,235,112 (GRCm39) V82A possibly damaging Het
Il33 G A 19: 29,927,137 (GRCm39) E23K probably benign Het
Macroh2a2 C A 10: 61,593,614 (GRCm39) V21F probably damaging Het
Map2k5 C A 9: 63,193,683 (GRCm39) A266S possibly damaging Het
Or13g1 T C 7: 85,956,226 (GRCm39) I32V probably benign Het
Or2t29 T A 11: 58,433,408 (GRCm39) N298I probably damaging Het
Or5p61 C T 7: 107,758,639 (GRCm39) C147Y probably benign Het
Pcdh1 G A 18: 38,330,490 (GRCm39) P838S probably benign Het
Pcdha5 A G 18: 37,095,768 (GRCm39) E759G possibly damaging Het
Pclo T C 5: 14,719,505 (GRCm39) I1214T unknown Het
Per3 T C 4: 151,113,662 (GRCm39) I299V probably benign Het
Pls1 A G 9: 95,636,798 (GRCm39) I558T probably damaging Het
Synpo2 A T 3: 122,873,881 (GRCm39) probably null Het
Sys1 G A 2: 164,306,438 (GRCm39) A131T probably benign Het
Tekt2 A G 4: 126,218,098 (GRCm39) L138P probably benign Het
Tmprss12 T A 15: 100,183,133 (GRCm39) N158K probably damaging Het
Tnrc18 A T 5: 142,717,923 (GRCm39) M2177K unknown Het
Trim43a T A 9: 88,464,395 (GRCm39) I102N probably damaging Het
Ugt1a10 C A 1: 88,143,862 (GRCm39) H361N probably damaging Het
Utrn C T 10: 12,317,837 (GRCm39) C498Y probably benign Het
Vmn1r39 A T 6: 66,781,841 (GRCm39) V159D probably damaging Het
Vmn1r44 A G 6: 89,870,562 (GRCm39) T103A probably benign Het
Wsb1 A T 11: 79,139,315 (GRCm39) V127D probably damaging Het
Other mutations in Zfp268
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01797:Zfp268 APN 4 145,347,241 (GRCm39) missense probably damaging 0.98
IGL02678:Zfp268 APN 4 145,349,067 (GRCm39) missense probably damaging 1.00
IGL03035:Zfp268 APN 4 145,348,802 (GRCm39) missense possibly damaging 0.77
BB008:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
BB018:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
R0090:Zfp268 UTSW 4 145,349,195 (GRCm39) nonsense probably null
R0904:Zfp268 UTSW 4 145,348,745 (GRCm39) missense possibly damaging 0.95
R1617:Zfp268 UTSW 4 145,350,877 (GRCm39) utr 3 prime probably benign
R1851:Zfp268 UTSW 4 145,350,820 (GRCm39) unclassified probably benign
R1864:Zfp268 UTSW 4 145,348,998 (GRCm39) missense possibly damaging 0.92
R2093:Zfp268 UTSW 4 145,349,139 (GRCm39) missense probably benign 0.02
R2132:Zfp268 UTSW 4 145,350,803 (GRCm39) unclassified probably benign
R2240:Zfp268 UTSW 4 145,311,891 (GRCm39) start gained probably benign
R4177:Zfp268 UTSW 4 145,347,225 (GRCm39) missense probably damaging 1.00
R4584:Zfp268 UTSW 4 145,343,747 (GRCm39) critical splice donor site probably null
R4991:Zfp268 UTSW 4 145,348,904 (GRCm39) missense probably benign 0.31
R5164:Zfp268 UTSW 4 145,348,775 (GRCm39) missense probably damaging 1.00
R6175:Zfp268 UTSW 4 145,350,811 (GRCm39) unclassified probably benign
R6176:Zfp268 UTSW 4 145,350,628 (GRCm39) nonsense probably null
R6984:Zfp268 UTSW 4 145,347,186 (GRCm39) missense probably damaging 1.00
R7134:Zfp268 UTSW 4 145,349,375 (GRCm39) missense possibly damaging 0.93
R7931:Zfp268 UTSW 4 145,349,126 (GRCm39) missense possibly damaging 0.49
R8017:Zfp268 UTSW 4 145,349,138 (GRCm39) missense probably benign 0.28
R8282:Zfp268 UTSW 4 145,349,547 (GRCm39) missense possibly damaging 0.94
R9320:Zfp268 UTSW 4 145,349,156 (GRCm39) missense possibly damaging 0.77
R9358:Zfp268 UTSW 4 145,349,613 (GRCm39) missense possibly damaging 0.79
R9435:Zfp268 UTSW 4 145,349,045 (GRCm39) missense
V5622:Zfp268 UTSW 4 145,311,891 (GRCm39) start gained probably benign
Z1176:Zfp268 UTSW 4 145,349,538 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- CACAACCGAAATGCAGAATTTG -3'
(R):5'- TGATGAATTCTCAGACTGCCG -3'

Sequencing Primer
(F):5'- TCCATCAGGGAATTCATGCAG -3'
(R):5'- CTCAGACTGCCGTTTTTAGTAAAGC -3'
Posted On 2018-06-06