Incidental Mutation 'R6224:Mphosph8'
ID 523287
Institutional Source Beutler Lab
Gene Symbol Mphosph8
Ensembl Gene ENSMUSG00000079184
Gene Name M-phase phosphoprotein 8
Synonyms 1500035L22Rik, 4930548G07Rik
MMRRC Submission 044355-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.664) question?
Stock # R6224 (G1)
Quality Score 64.0073
Status Validated
Chromosome 14
Chromosomal Location 56905705-56934887 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to C at 56905810 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000112170 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000116468]
AlphaFold Q3TYA6
Predicted Effect probably null
Transcript: ENSMUST00000116468
AA Change: M1T
SMART Domains Protein: ENSMUSP00000112170
Gene: ENSMUSG00000079184
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 1 13 N/A INTRINSIC
CHROMO 58 111 6.2e-13 SMART
low complexity region 152 160 N/A INTRINSIC
coiled coil region 226 256 N/A INTRINSIC
low complexity region 325 336 N/A INTRINSIC
low complexity region 405 417 N/A INTRINSIC
Blast:ANK 563 592 1e-7 BLAST
ANK 598 627 4.43e-2 SMART
ANK 631 660 5.45e-2 SMART
ANK 664 693 1.08e-5 SMART
Blast:ANK 697 726 5e-11 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130246
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210886
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210920
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211600
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 100% (55/55)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300003K06Rik A C 11: 99,728,840 (GRCm39) M1R probably null Het
4930505A04Rik A C 11: 30,404,815 (GRCm39) N29K probably benign Het
Adamtsl4 T C 3: 95,589,039 (GRCm39) Y464C probably damaging Het
Asgr2 T C 11: 69,989,072 (GRCm39) V172A probably damaging Het
Atad1 T C 19: 32,676,028 (GRCm39) Y132C probably damaging Het
Bpifa6 G A 2: 153,829,073 (GRCm39) R200H probably damaging Het
Brd1 A T 15: 88,572,558 (GRCm39) M1171K possibly damaging Het
Cadm2 A T 16: 66,461,281 (GRCm39) L392Q probably damaging Het
Ccdc183 C T 2: 25,500,594 (GRCm39) E333K possibly damaging Het
Cenpe T C 3: 134,949,536 (GRCm39) I1335T possibly damaging Het
Cpxm2 T C 7: 131,745,460 (GRCm39) N122D probably benign Het
Crls1 T A 2: 132,691,770 (GRCm39) probably null Het
Cyp46a1 T C 12: 108,327,819 (GRCm39) F460S probably damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dcps T A 9: 35,047,777 (GRCm39) T128S probably benign Het
Dcun1d3 A T 7: 119,458,714 (GRCm39) L107* probably null Het
Eml1 T C 12: 108,480,767 (GRCm39) F397S probably damaging Het
Fanca T A 8: 124,032,020 (GRCm39) H348L possibly damaging Het
Foxo1 T A 3: 52,253,093 (GRCm39) S419T probably benign Het
Gli3 T C 13: 15,899,730 (GRCm39) V1039A probably benign Het
Gng14 A T 8: 85,794,220 (GRCm39) *73R probably null Het
Gp6 A T 7: 4,397,211 (GRCm39) F75I probably benign Het
Gpha2 T A 19: 6,277,142 (GRCm39) I81N possibly damaging Het
Gspt1 C A 16: 11,042,406 (GRCm39) V493L probably benign Het
Igsf10 C A 3: 59,232,931 (GRCm39) C1934F probably damaging Het
Irgm1 T C 11: 48,757,713 (GRCm39) T49A probably benign Het
Klc4 A G 17: 46,950,988 (GRCm39) I207T possibly damaging Het
Krt1 A T 15: 101,758,702 (GRCm39) V154D possibly damaging Het
Lama1 T C 17: 68,109,982 (GRCm39) V2201A possibly damaging Het
Lilrb4a T A 10: 51,367,745 (GRCm39) Y96N probably damaging Het
Lrfn2 A G 17: 49,403,379 (GRCm39) T501A probably damaging Het
Lrriq1 A G 10: 103,051,618 (GRCm39) I378T probably damaging Het
Nsd1 T C 13: 55,460,945 (GRCm39) S2391P possibly damaging Het
Ogdhl G A 14: 32,064,018 (GRCm39) G647D probably benign Het
Or5p57 T C 7: 107,665,949 (GRCm39) I19V probably benign Het
Or6c76b A G 10: 129,693,061 (GRCm39) K225E probably benign Het
Pbrm1 T A 14: 30,772,068 (GRCm39) H387Q probably benign Het
Pdgfrb C A 18: 61,215,011 (GRCm39) Y1013* probably null Het
Pitrm1 T C 13: 6,615,090 (GRCm39) V562A probably damaging Het
Pnpla8 T C 12: 44,329,811 (GRCm39) V121A possibly damaging Het
Psd4 T C 2: 24,291,569 (GRCm39) L639P probably damaging Het
Psmc3 G T 2: 90,884,975 (GRCm39) R47L probably damaging Het
Rptn C G 3: 93,305,437 (GRCm39) H923Q possibly damaging Het
Sesn2 A G 4: 132,229,881 (GRCm39) V50A probably benign Het
Skic3 C T 13: 76,266,410 (GRCm39) T219M probably benign Het
Slc6a16 G A 7: 44,910,572 (GRCm39) G377S probably damaging Het
Slitrk1 A G 14: 109,149,454 (GRCm39) F419S probably damaging Het
Slitrk5 GACTAC GACTACTAC 14: 111,917,248 (GRCm39) probably benign Het
Spata31d1a T A 13: 59,854,134 (GRCm39) probably benign Homo
Tgoln1 A T 6: 72,592,984 (GRCm39) D165E possibly damaging Het
Tmprss15 T A 16: 78,821,266 (GRCm39) T492S probably benign Het
Zc3h13 T A 14: 75,574,849 (GRCm39) M1565K probably damaging Het
Zcwpw1 T C 5: 137,810,298 (GRCm39) V358A possibly damaging Het
Zfp607a A G 7: 27,578,007 (GRCm39) H359R probably damaging Het
Zzef1 T A 11: 72,746,209 (GRCm39) V837E probably damaging Het
Other mutations in Mphosph8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00778:Mphosph8 APN 14 56,911,900 (GRCm39) missense probably benign 0.00
IGL00786:Mphosph8 APN 14 56,910,001 (GRCm39) missense probably benign 0.00
IGL01635:Mphosph8 APN 14 56,910,003 (GRCm39) missense probably damaging 0.99
IGL02104:Mphosph8 APN 14 56,912,036 (GRCm39) missense probably benign 0.02
IGL02387:Mphosph8 APN 14 56,933,178 (GRCm39) missense probably damaging 1.00
IGL02486:Mphosph8 APN 14 56,925,844 (GRCm39) missense possibly damaging 0.80
IGL02547:Mphosph8 APN 14 56,909,941 (GRCm39) missense probably damaging 1.00
IGL02578:Mphosph8 APN 14 56,911,667 (GRCm39) missense probably benign
IGL03247:Mphosph8 APN 14 56,916,277 (GRCm39) critical splice donor site probably null
IGL03377:Mphosph8 APN 14 56,930,943 (GRCm39) missense probably damaging 1.00
R0412:Mphosph8 UTSW 14 56,911,870 (GRCm39) missense probably damaging 0.97
R0647:Mphosph8 UTSW 14 56,911,862 (GRCm39) missense probably benign
R1079:Mphosph8 UTSW 14 56,911,716 (GRCm39) missense probably damaging 1.00
R1451:Mphosph8 UTSW 14 56,905,878 (GRCm39) missense possibly damaging 0.62
R1486:Mphosph8 UTSW 14 56,926,496 (GRCm39) missense probably damaging 1.00
R1687:Mphosph8 UTSW 14 56,909,935 (GRCm39) missense probably damaging 1.00
R1733:Mphosph8 UTSW 14 56,930,916 (GRCm39) missense probably damaging 1.00
R1809:Mphosph8 UTSW 14 56,909,909 (GRCm39) missense probably damaging 1.00
R1844:Mphosph8 UTSW 14 56,934,616 (GRCm39) missense probably damaging 1.00
R2132:Mphosph8 UTSW 14 56,916,161 (GRCm39) missense probably benign 0.04
R4242:Mphosph8 UTSW 14 56,911,771 (GRCm39) missense probably benign 0.00
R4261:Mphosph8 UTSW 14 56,911,922 (GRCm39) missense probably benign 0.00
R4563:Mphosph8 UTSW 14 56,928,457 (GRCm39) missense probably benign 0.00
R4962:Mphosph8 UTSW 14 56,916,046 (GRCm39) missense probably benign 0.27
R5121:Mphosph8 UTSW 14 56,914,003 (GRCm39) nonsense probably null
R6082:Mphosph8 UTSW 14 56,905,998 (GRCm39) missense probably damaging 1.00
R6455:Mphosph8 UTSW 14 56,925,943 (GRCm39) missense probably damaging 1.00
R7086:Mphosph8 UTSW 14 56,905,980 (GRCm39) missense possibly damaging 0.94
R7236:Mphosph8 UTSW 14 56,911,754 (GRCm39) missense possibly damaging 0.63
R7266:Mphosph8 UTSW 14 56,922,497 (GRCm39) missense possibly damaging 0.89
R7564:Mphosph8 UTSW 14 56,911,495 (GRCm39) missense probably benign
R8313:Mphosph8 UTSW 14 56,916,062 (GRCm39) frame shift probably null
R8508:Mphosph8 UTSW 14 56,914,003 (GRCm39) nonsense probably null
R9428:Mphosph8 UTSW 14 56,934,114 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- CAGCGTTCTTCCTCAGAGTC -3'
(R):5'- GCACTTCATGTCCAGGATCCTC -3'

Sequencing Primer
(F):5'- TCCTCAGAGTCCGTCGAC -3'
(R):5'- GGATCCTCTCCACCTCGAAAACG -3'
Posted On 2018-06-18