Incidental Mutation 'R6574:Sucnr1'
ID 523340
Institutional Source Beutler Lab
Gene Symbol Sucnr1
Ensembl Gene ENSMUSG00000027762
Gene Name succinate receptor 1
Synonyms Gpr91
MMRRC Submission 044698-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R6574 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 59989290-59994987 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59994020 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 183 (Y183H)
Ref Sequence ENSEMBL: ENSMUSP00000029326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029326]
AlphaFold Q99MT6
Predicted Effect probably damaging
Transcript: ENSMUST00000029326
AA Change: Y183H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000029326
Gene: ENSMUSG00000027762
AA Change: Y183H

DomainStartEndE-ValueType
Pfam:7tm_1 36 290 9.3e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195544
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a knockout allele exhibit decreased renin plasma and kidney levels upon high-glucose stimulation in a diabetic or non-diabetic model. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503B20Rik A C 3: 146,356,613 (GRCm39) D98E probably benign Het
Ackr3 T C 1: 90,141,790 (GRCm39) I83T probably damaging Het
Ahnak A T 19: 8,994,411 (GRCm39) M5232L probably benign Het
Ano1 A C 7: 144,161,653 (GRCm39) probably null Het
Arap1 T A 7: 101,053,208 (GRCm39) I532N probably damaging Het
Bsn A G 9: 107,991,153 (GRCm39) V1533A possibly damaging Het
Ccdc83 T C 7: 89,875,885 (GRCm39) S329G possibly damaging Het
Ccno T A 13: 113,124,719 (GRCm39) D96E probably benign Het
Cpsf1 CCCCTGCATGAGGCAGGTCCC CCCC 15: 76,481,655 (GRCm39) probably null Het
Degs1 T C 1: 182,106,638 (GRCm39) Y207C probably damaging Het
Dnah7a A T 1: 53,495,693 (GRCm39) probably null Het
Dnah9 C T 11: 66,059,107 (GRCm39) A63T probably benign Het
Eif4e1b T C 13: 54,932,711 (GRCm39) F100S probably damaging Het
Eps8 A T 6: 137,460,596 (GRCm39) Y722* probably null Het
Etfa A T 9: 55,402,910 (GRCm39) I96N probably damaging Het
Flt4 A G 11: 49,516,199 (GRCm39) T101A probably benign Het
Gabra4 A G 5: 71,781,268 (GRCm39) I381T probably benign Het
Gria2 A G 3: 80,596,603 (GRCm39) V821A probably damaging Het
Gss G T 2: 155,423,931 (GRCm39) T51K probably damaging Het
Igkv13-84 C A 6: 68,916,977 (GRCm39) Y91* probably null Het
Iqcb1 A T 16: 36,691,863 (GRCm39) Q487H probably damaging Het
Itga8 G A 2: 12,234,972 (GRCm39) H429Y probably benign Het
Myo1c T G 11: 75,547,124 (GRCm39) probably benign Het
Odad2 C A 18: 7,129,394 (GRCm39) probably null Het
Pcdhga5 T C 18: 37,828,434 (GRCm39) L294P probably damaging Het
Pkd2l2 T C 18: 34,558,134 (GRCm39) L271P probably damaging Het
Plcb2 T C 2: 118,549,654 (GRCm39) D290G probably damaging Het
Pmp22 C T 11: 63,049,099 (GRCm39) A114V probably damaging Het
Ppp1r15a T C 7: 45,173,533 (GRCm39) D425G probably benign Het
Ppp2r3d G A 9: 101,071,584 (GRCm39) P678L probably benign Het
Ptbp2 T G 3: 119,541,596 (GRCm39) Q147P probably damaging Het
Sez6l A G 5: 112,724,692 (GRCm39) S15P possibly damaging Het
Slc25a10 T C 11: 120,387,903 (GRCm39) F199L probably benign Het
Slc4a8 A G 15: 100,705,197 (GRCm39) N801S probably damaging Het
Tmem67 T C 4: 12,063,086 (GRCm39) D520G possibly damaging Het
Trgc3 G T 13: 19,445,293 (GRCm39) R80S probably benign Het
Trrap G T 5: 144,752,360 (GRCm39) probably null Het
Tubgcp5 C T 7: 55,473,331 (GRCm39) P803L probably benign Het
Ubash3a A T 17: 31,451,370 (GRCm39) Q423L probably damaging Het
Ucp1 G A 8: 84,020,718 (GRCm39) probably null Het
Vmn2r94 G T 17: 18,476,421 (GRCm39) N425K probably damaging Het
Vps52 A G 17: 34,181,452 (GRCm39) M418V probably null Het
Other mutations in Sucnr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Sucnr1 APN 3 59,994,053 (GRCm39) missense probably benign 0.03
IGL01656:Sucnr1 APN 3 59,993,832 (GRCm39) missense possibly damaging 0.67
IGL02096:Sucnr1 APN 3 59,994,371 (GRCm39) missense possibly damaging 0.56
R0727:Sucnr1 UTSW 3 59,994,081 (GRCm39) missense probably benign 0.14
R4110:Sucnr1 UTSW 3 59,994,215 (GRCm39) missense probably damaging 1.00
R4112:Sucnr1 UTSW 3 59,994,215 (GRCm39) missense probably damaging 1.00
R4620:Sucnr1 UTSW 3 59,994,190 (GRCm39) missense possibly damaging 0.68
R4831:Sucnr1 UTSW 3 59,994,069 (GRCm39) missense probably damaging 1.00
R5068:Sucnr1 UTSW 3 59,994,288 (GRCm39) missense probably damaging 1.00
R5263:Sucnr1 UTSW 3 59,994,190 (GRCm39) missense possibly damaging 0.68
R6258:Sucnr1 UTSW 3 59,993,778 (GRCm39) missense probably damaging 1.00
R6505:Sucnr1 UTSW 3 59,994,144 (GRCm39) missense probably benign 0.23
R7022:Sucnr1 UTSW 3 59,993,699 (GRCm39) missense probably benign 0.03
R7072:Sucnr1 UTSW 3 59,993,604 (GRCm39) missense probably damaging 1.00
R7439:Sucnr1 UTSW 3 59,994,117 (GRCm39) missense probably benign
R7918:Sucnr1 UTSW 3 59,993,790 (GRCm39) missense probably damaging 1.00
R8098:Sucnr1 UTSW 3 59,994,162 (GRCm39) missense probably damaging 1.00
R8342:Sucnr1 UTSW 3 59,994,155 (GRCm39) missense probably damaging 0.96
R8891:Sucnr1 UTSW 3 59,994,263 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATGAAGTACCCTTTCCGAGAACAC -3'
(R):5'- GCGATCCTCAAATTGCGCATG -3'

Sequencing Primer
(F):5'- CGAGAACACTTTCTACAAAAGAAGG -3'
(R):5'- CGATCCTCAAATTGCGCATGATATG -3'
Posted On 2018-06-22