Incidental Mutation 'R6581:Vmn1r158'
| ID |
523435 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r158
|
| Ensembl Gene |
ENSMUSG00000094700 |
| Gene Name |
vomeronasal 1 receptor 158 |
| Synonyms |
Gm16455 |
| MMRRC Submission |
044705-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.653)
|
| Stock # |
R6581 (G1)
|
| Quality Score |
125.008 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
22489284-22490207 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 22489465 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 248
(T248I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133990
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000174643]
|
| AlphaFold |
G3UY92 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000174643
AA Change: T248I
PolyPhen 2
Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000133990
Gene: ENSMUSG00000094700
AA Change: T248I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
298 |
2.9e-15 |
PFAM |
|
Pfam:7tm_1
|
39 |
290 |
5.5e-9 |
PFAM |
|
Pfam:V1R
|
41 |
298 |
3.2e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.0%
- 20x: 94.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh8a1 |
G |
A |
10: 21,256,741 (GRCm39) |
V51M |
probably damaging |
Het |
| Cdh17 |
A |
T |
4: 11,799,615 (GRCm39) |
I471F |
probably damaging |
Het |
| Dnajb7 |
T |
A |
15: 81,292,226 (GRCm39) |
E37V |
probably damaging |
Het |
| Dpy19l1 |
T |
A |
9: 24,359,160 (GRCm39) |
I337F |
possibly damaging |
Het |
| Etv5 |
C |
T |
16: 22,258,449 (GRCm39) |
|
probably benign |
Het |
| Gbp2b |
T |
A |
3: 142,313,999 (GRCm39) |
Y426* |
probably null |
Het |
| Gm21103 |
A |
T |
14: 17,484,809 (GRCm39) |
N78K |
probably damaging |
Het |
| Helz2 |
A |
G |
2: 180,871,172 (GRCm39) |
V2755A |
probably damaging |
Het |
| Itga9 |
A |
T |
9: 118,487,632 (GRCm39) |
E238D |
probably benign |
Het |
| Itgb8 |
A |
T |
12: 119,126,950 (GRCm39) |
C736S |
probably benign |
Het |
| Luzp1 |
A |
G |
4: 136,267,942 (GRCm39) |
E55G |
probably damaging |
Het |
| Mrtfa |
A |
G |
15: 80,900,574 (GRCm39) |
L589P |
probably damaging |
Het |
| Ms4a4d |
G |
A |
19: 11,532,204 (GRCm39) |
V117M |
probably damaging |
Het |
| Odad2 |
C |
T |
18: 7,129,560 (GRCm39) |
V873I |
possibly damaging |
Het |
| Or2f1 |
T |
C |
6: 42,721,013 (GRCm39) |
L14P |
probably damaging |
Het |
| Or3a1d |
A |
G |
11: 74,238,032 (GRCm39) |
F126S |
probably damaging |
Het |
| Or52a5b |
T |
C |
7: 103,417,428 (GRCm39) |
I59V |
probably benign |
Het |
| Prl7a1 |
A |
T |
13: 27,817,612 (GRCm39) |
D217E |
probably damaging |
Het |
| Slc12a5 |
T |
C |
2: 164,829,035 (GRCm39) |
F525S |
probably damaging |
Het |
| Smyd5 |
G |
A |
6: 85,409,005 (GRCm39) |
D7N |
probably damaging |
Het |
| Spata18 |
G |
T |
5: 73,826,859 (GRCm39) |
R152L |
probably benign |
Het |
| Thbd |
A |
G |
2: 148,248,192 (GRCm39) |
S559P |
probably benign |
Het |
| Tiam2 |
CGGG |
CGGGG |
17: 3,464,897 (GRCm39) |
|
probably null |
Het |
| Tnpo2 |
C |
A |
8: 85,782,033 (GRCm39) |
P874Q |
probably damaging |
Het |
| Uchl4 |
A |
T |
9: 64,143,075 (GRCm39) |
E185D |
possibly damaging |
Het |
| Vmn1r5 |
T |
C |
6: 56,962,366 (GRCm39) |
F14L |
probably benign |
Het |
| Yaf2 |
T |
C |
15: 93,184,295 (GRCm39) |
T101A |
probably benign |
Het |
|
| Other mutations in Vmn1r158 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01147:Vmn1r158
|
APN |
7 |
22,490,204 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1173:Vmn1r158
|
UTSW |
7 |
22,489,870 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1574:Vmn1r158
|
UTSW |
7 |
22,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1574:Vmn1r158
|
UTSW |
7 |
22,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn1r158
|
UTSW |
7 |
22,490,072 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1777:Vmn1r158
|
UTSW |
7 |
22,489,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1813:Vmn1r158
|
UTSW |
7 |
22,490,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Vmn1r158
|
UTSW |
7 |
22,490,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Vmn1r158
|
UTSW |
7 |
22,489,815 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3749:Vmn1r158
|
UTSW |
7 |
22,489,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4872:Vmn1r158
|
UTSW |
7 |
22,490,179 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5238:Vmn1r158
|
UTSW |
7 |
22,489,799 (GRCm39) |
missense |
probably benign |
|
|
R6500:Vmn1r158
|
UTSW |
7 |
22,490,078 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6511:Vmn1r158
|
UTSW |
7 |
22,490,116 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6751:Vmn1r158
|
UTSW |
7 |
22,489,306 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7168:Vmn1r158
|
UTSW |
7 |
22,490,101 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7337:Vmn1r158
|
UTSW |
7 |
22,489,649 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7747:Vmn1r158
|
UTSW |
7 |
22,489,725 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7902:Vmn1r158
|
UTSW |
7 |
22,489,433 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8328:Vmn1r158
|
UTSW |
7 |
22,489,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8400:Vmn1r158
|
UTSW |
7 |
22,489,305 (GRCm39) |
nonsense |
probably null |
|
|
R8809:Vmn1r158
|
UTSW |
7 |
22,489,775 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9227:Vmn1r158
|
UTSW |
7 |
22,489,469 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9468:Vmn1r158
|
UTSW |
7 |
22,489,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vmn1r158
|
UTSW |
7 |
22,490,065 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9719:Vmn1r158
|
UTSW |
7 |
22,489,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1177:Vmn1r158
|
UTSW |
7 |
22,489,883 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAGCGACTCTGATTTTCAACAGTTG -3'
(R):5'- CTTCTGGATTCAGTGTAGGCAC -3'
Sequencing Primer
(F):5'- TCAACAGTTGAAGAGCACAGAAC -3'
(R):5'- GTAGGCACTGTCCTCTTGCAG -3'
|
| Posted On |
2018-06-22 |
Incidental Mutation