Incidental Mutation 'R6593:Gpr88'
Institutional Source Beutler Lab
Gene Symbol Gpr88
Ensembl Gene ENSMUSG00000068696
Gene NameG-protein coupled receptor 88
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.109) question?
Stock #R6593 (G1)
Quality Score204.009
Status Validated
Chromosomal Location116249654-116253503 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 116252624 bp
Amino Acid Change Threonine to Alanine at position 13 (T13A)
Ref Sequence ENSEMBL: ENSMUSP00000143586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090473] [ENSMUST00000197759]
Predicted Effect unknown
Transcript: ENSMUST00000090473
AA Change: T13A
SMART Domains Protein: ENSMUSP00000087959
Gene: ENSMUSG00000068696
AA Change: T13A

low complexity region 4 26 N/A INTRINSIC
Pfam:7tm_1 48 336 5.2e-16 PFAM
low complexity region 357 373 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000197759
AA Change: T13A
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199128
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.2%
  • 10x: 96.6%
  • 20x: 89.6%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b C A 5: 8,853,491 N1047K probably benign Het
AI597479 C A 1: 43,111,248 Q173K probably damaging Het
Arhgef10 T C 8: 14,962,522 L282P probably damaging Het
Arhgef10 T C 8: 14,962,564 I296T possibly damaging Het
Atg2b A G 12: 105,644,848 S1275P probably damaging Het
Ccdc114 T A 7: 45,947,384 D378E probably damaging Het
Cep290 T C 10: 100,508,776 M485T probably benign Het
Clca3a2 A G 3: 144,808,577 probably null Het
Clcn6 C T 4: 148,010,769 S731N probably benign Het
Clic6 A G 16: 92,528,117 I388V possibly damaging Het
Cpsf4l G T 11: 113,709,366 probably benign Het
Ddx58 T C 4: 40,226,651 I169V probably benign Het
Dlg5 G A 14: 24,150,652 H1350Y probably benign Het
Dnase2b T C 3: 146,586,911 Y169C probably damaging Het
Elavl3 C T 9: 22,018,547 V354M possibly damaging Het
Farp2 A C 1: 93,569,940 I231L possibly damaging Het
Gcc2 T A 10: 58,271,507 M755K probably damaging Het
Gstm3 T A 3: 107,968,195 N40Y probably benign Het
Krtap5-2 A T 7: 142,174,960 C328S unknown Het
Lpar1 A T 4: 58,486,605 V222E probably damaging Het
Neto2 A G 8: 85,669,546 S192P probably damaging Het
Olfr665 C T 7: 104,881,433 T242I probably damaging Het
Pcdhgb1 G T 18: 37,682,081 D542Y probably damaging Het
Phldb2 G A 16: 45,825,427 Q264* probably null Het
Ptgs2 G A 1: 150,101,033 D6N possibly damaging Het
Rasef G T 4: 73,745,090 H167N probably damaging Het
Rbbp4 A G 4: 129,322,375 L193S probably damaging Het
Sec24d T C 3: 123,353,412 F673S probably damaging Het
Slc9b1 T C 3: 135,357,458 M1T probably null Het
Stra6 A G 9: 58,151,979 T542A probably benign Het
Stt3b T C 9: 115,252,511 Y569C probably damaging Het
Traf3ip1 A G 1: 91,527,695 K626R possibly damaging Het
Washc2 T A 6: 116,259,249 I1227N probably damaging Het
Xpo7 G A 14: 70,682,362 A671V probably damaging Het
Zfp799 A G 17: 32,819,790 Y501H probably damaging Het
Other mutations in Gpr88
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4498001:Gpr88 UTSW 3 116252615 missense unknown
R1914:Gpr88 UTSW 3 116252424 missense possibly damaging 0.86
R1915:Gpr88 UTSW 3 116252424 missense possibly damaging 0.86
R5934:Gpr88 UTSW 3 116252309 missense probably damaging 1.00
R7184:Gpr88 UTSW 3 116251994 missense possibly damaging 0.51
Predicted Primers PCR Primer

Sequencing Primer
Posted On2018-06-22