Incidental Mutation 'R6612:Zbtb10'
ID 523639
Institutional Source Beutler Lab
Gene Symbol Zbtb10
Ensembl Gene ENSMUSG00000069114
Gene Name zinc finger and BTB domain containing 10
Synonyms
MMRRC Submission 044735-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.442) question?
Stock # R6612 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 9315662-9350393 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 9317125 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 312 (H312Q)
Ref Sequence ENSEMBL: ENSMUSP00000119386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000155203]
AlphaFold E9Q8X5
Predicted Effect possibly damaging
Transcript: ENSMUST00000155203
AA Change: H312Q

PolyPhen 2 Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000119386
Gene: ENSMUSG00000069114
AA Change: H312Q

DomainStartEndE-ValueType
low complexity region 15 32 N/A INTRINSIC
low complexity region 38 54 N/A INTRINSIC
low complexity region 75 82 N/A INTRINSIC
low complexity region 96 111 N/A INTRINSIC
low complexity region 121 137 N/A INTRINSIC
low complexity region 180 222 N/A INTRINSIC
ZnF_TTF 239 321 7.92e-2 SMART
BTB 357 456 4.02e-20 SMART
internal_repeat_1 648 671 2.82e-12 PROSPERO
internal_repeat_1 672 695 2.82e-12 PROSPERO
ZnF_C2H2 714 736 6.78e-3 SMART
ZnF_C2H2 742 764 2.09e-3 SMART
low complexity region 765 777 N/A INTRINSIC
low complexity region 823 842 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.4%
Validation Efficiency 95% (59/62)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930523C07Rik A C 1: 159,902,804 (GRCm39) N25H probably damaging Het
Akr1c14 A T 13: 4,115,331 (GRCm39) S87C probably benign Het
Arhgef37 T C 18: 61,627,952 (GRCm39) T664A probably benign Het
Arsi A G 18: 61,045,528 (GRCm39) T73A probably benign Het
Cacnb2 A T 2: 14,979,960 (GRCm39) T274S probably benign Het
Cd244a A G 1: 171,401,672 (GRCm39) T133A probably benign Het
Cep20 TTGTG TTG 16: 14,118,009 (GRCm39) probably null Het
Ciz1 T A 2: 32,267,323 (GRCm39) S720T possibly damaging Het
Cxcr6 T A 9: 123,639,785 (GRCm39) I262N probably damaging Het
Cyp2a4 T A 7: 26,008,072 (GRCm39) F160I probably benign Het
Esrra T C 19: 6,889,220 (GRCm39) T390A probably benign Het
Gm17079 T A 14: 51,931,833 (GRCm39) Q91L possibly damaging Het
Gm17079 C A 14: 51,931,832 (GRCm39) Q91H probably damaging Het
Got1 A G 19: 43,493,242 (GRCm39) S256P probably damaging Het
Gria4 C T 9: 4,472,206 (GRCm39) V428I possibly damaging Het
Grin2b A G 6: 135,717,996 (GRCm39) Y699H probably damaging Het
Hipk2 T C 6: 38,795,808 (GRCm39) I154V probably benign Het
Hkdc1 T C 10: 62,231,220 (GRCm39) E628G possibly damaging Het
Hmcn1 C G 1: 150,470,869 (GRCm39) probably null Het
Hspbap1 T G 16: 35,621,961 (GRCm39) L102W probably damaging Het
Iqcb1 G A 16: 36,692,023 (GRCm39) probably benign Het
Itga7 A G 10: 128,784,862 (GRCm39) Y763C possibly damaging Het
Itgb4 A T 11: 115,874,897 (GRCm39) D418V probably benign Het
Jakmip2 T C 18: 43,690,432 (GRCm39) D631G probably damaging Het
Kcnc2 G C 10: 112,107,761 (GRCm39) G51R probably benign Het
Kcnu1 A G 8: 26,408,344 (GRCm39) I52V probably benign Het
Kdm5a T C 6: 120,407,189 (GRCm39) I1468T probably damaging Het
Kmt2d A G 15: 98,743,739 (GRCm39) probably benign Het
Mab21l3 A G 3: 101,725,961 (GRCm39) V345A possibly damaging Het
Marchf10 A T 11: 105,287,904 (GRCm39) S133T probably damaging Het
Mccc1 T C 3: 36,048,079 (GRCm39) S115G probably benign Het
Mchr1 G A 15: 81,122,071 (GRCm39) V274M probably damaging Het
Mrgpra3 T A 7: 47,239,783 (GRCm39) I48F probably benign Het
Myo9a T A 9: 59,734,479 (GRCm39) F687Y probably damaging Het
Nfrkb T A 9: 31,308,302 (GRCm39) L216* probably null Het
Nrxn3 A T 12: 89,780,102 (GRCm39) probably benign Het
Olig2 T A 16: 91,023,769 (GRCm39) M161K probably damaging Het
Or11h7 A T 14: 50,891,090 (GRCm39) Y132F probably damaging Het
Pcdh15 T A 10: 74,021,210 (GRCm39) N141K probably damaging Het
Pcdha4 T C 18: 37,088,031 (GRCm39) V738A probably benign Het
Pdgfra T C 5: 75,328,503 (GRCm39) S212P probably benign Het
Plk3 G A 4: 116,989,934 (GRCm39) Q194* probably null Het
Ppp1r36 T C 12: 76,484,378 (GRCm39) I216T possibly damaging Het
Ptprz1 T A 6: 23,052,081 (GRCm39) N2303K probably damaging Het
Rab25 G A 3: 88,450,710 (GRCm39) T117M probably damaging Het
Relch T A 1: 105,619,732 (GRCm39) D320E possibly damaging Het
Slc25a47 T C 12: 108,821,904 (GRCm39) V231A probably benign Het
Slx4 G A 16: 3,803,140 (GRCm39) H1225Y probably damaging Het
Snx13 C T 12: 35,156,758 (GRCm39) A470V probably benign Het
Spa17 A G 9: 37,517,090 (GRCm39) F101S probably benign Het
Ssh1 C T 5: 114,096,791 (GRCm39) A217T probably benign Het
Stimate T A 14: 30,593,521 (GRCm39) probably null Het
Synm G C 7: 67,383,264 (GRCm39) T1466S probably damaging Het
Tbc1d19 A G 5: 53,967,187 (GRCm39) E29G possibly damaging Het
Teddm2 T A 1: 153,726,191 (GRCm39) T175S probably benign Het
Tet2 T A 3: 133,193,096 (GRCm39) H446L possibly damaging Het
Tpm3-rs7 G T 14: 113,552,268 (GRCm39) R54L probably benign Het
Ttc5 T A 14: 51,022,926 (GRCm39) probably null Het
Tyk2 G T 9: 21,019,312 (GRCm39) Q1014K probably benign Het
Ush2a T C 1: 188,643,594 (GRCm39) S4319P possibly damaging Het
Zfp462 A T 4: 55,012,324 (GRCm39) probably null Het
Other mutations in Zbtb10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02174:Zbtb10 APN 3 9,316,872 (GRCm39) missense probably damaging 0.96
IGL02207:Zbtb10 APN 3 9,345,525 (GRCm39) critical splice donor site probably null
IGL02499:Zbtb10 APN 3 9,316,800 (GRCm39) missense probably damaging 1.00
IGL02506:Zbtb10 APN 3 9,330,297 (GRCm39) missense probably damaging 0.99
IGL03294:Zbtb10 APN 3 9,346,047 (GRCm39) missense probably benign 0.18
R0510:Zbtb10 UTSW 3 9,329,728 (GRCm39) missense probably damaging 1.00
R1859:Zbtb10 UTSW 3 9,345,446 (GRCm39) missense possibly damaging 0.47
R2342:Zbtb10 UTSW 3 9,330,255 (GRCm39) missense possibly damaging 0.60
R3407:Zbtb10 UTSW 3 9,329,926 (GRCm39) missense probably damaging 1.00
R4161:Zbtb10 UTSW 3 9,345,356 (GRCm39) missense probably damaging 1.00
R4301:Zbtb10 UTSW 3 9,330,220 (GRCm39) missense probably damaging 0.96
R4698:Zbtb10 UTSW 3 9,329,610 (GRCm39) missense possibly damaging 0.87
R5184:Zbtb10 UTSW 3 9,329,731 (GRCm39) missense probably damaging 0.99
R5443:Zbtb10 UTSW 3 9,345,108 (GRCm39) missense probably benign
R5665:Zbtb10 UTSW 3 9,330,252 (GRCm39) missense probably damaging 0.99
R5744:Zbtb10 UTSW 3 9,329,623 (GRCm39) missense probably damaging 1.00
R5862:Zbtb10 UTSW 3 9,330,276 (GRCm39) missense probably damaging 0.98
R5909:Zbtb10 UTSW 3 9,345,109 (GRCm39) missense probably benign 0.14
R6547:Zbtb10 UTSW 3 9,316,763 (GRCm39) missense probably benign 0.38
R7457:Zbtb10 UTSW 3 9,316,538 (GRCm39) missense possibly damaging 0.77
R8985:Zbtb10 UTSW 3 9,345,807 (GRCm39) missense probably damaging 1.00
R9191:Zbtb10 UTSW 3 9,330,295 (GRCm39) missense probably damaging 0.98
R9472:Zbtb10 UTSW 3 9,343,355 (GRCm39) missense probably benign 0.25
R9616:Zbtb10 UTSW 3 9,316,473 (GRCm39) missense probably benign 0.01
Z1177:Zbtb10 UTSW 3 9,343,391 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCCAGACCTCTTGGCTCAAG -3'
(R):5'- CAGGCTTTCTAAACCCCTACG -3'

Sequencing Primer
(F):5'- AGACCTCTTGGCTCAAGGACTTC -3'
(R):5'- TACGCATAAGCTCTCGCG -3'
Posted On 2018-06-22