Incidental Mutation 'R6615:Tars3'
ID 523942
Institutional Source Beutler Lab
Gene Symbol Tars3
Ensembl Gene ENSMUSG00000030515
Gene Name threonyl-tRNA synthetase 3
Synonyms A530046H20Rik, Tarsl2
MMRRC Submission 044738-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # R6615 (G1)
Quality Score 202.009
Status Validated
Chromosome 7
Chromosomal Location 65294646-65341839 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 65327890 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 533 (F533S)
Ref Sequence ENSEMBL: ENSMUSP00000032728 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032728]
AlphaFold Q8BLY2
Predicted Effect probably damaging
Transcript: ENSMUST00000032728
AA Change: F533S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515
AA Change: F533S

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
coiled coil region 44 68 N/A INTRINSIC
Pfam:TGS 151 210 8.8e-14 PFAM
tRNA_SAD 316 365 1.26e-16 SMART
Pfam:tRNA-synt_2b 464 675 2.2e-35 PFAM
Pfam:HGTP_anticodon 687 778 1.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126941
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127354
Meta Mutation Damage Score 0.9591 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.4%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Avl9 T C 6: 56,730,870 (GRCm39) V598A probably benign Het
Bcar3 T A 3: 122,220,282 (GRCm39) S60T probably benign Het
Bean1 CT C 8: 104,908,664 (GRCm39) probably null Homo
Calm3 A G 7: 16,651,508 (GRCm39) probably null Het
Ccdc113 A C 8: 96,272,620 (GRCm39) E242D probably benign Het
Celsr1 C T 15: 85,786,315 (GRCm39) probably null Het
Clhc1 T A 11: 29,528,149 (GRCm39) M559K possibly damaging Het
Dhx36 T A 3: 62,396,338 (GRCm39) I440L probably benign Het
Dnah7c A T 1: 46,554,599 (GRCm39) T445S probably benign Het
Dnah7c A G 1: 46,688,511 (GRCm39) S1894G probably benign Het
Dnah7c C A 1: 46,688,500 (GRCm39) T1890K probably benign Het
Dsc2 T A 18: 20,165,576 (GRCm39) H843L possibly damaging Het
F11 T C 8: 45,701,811 (GRCm39) Y333C probably benign Het
Fbxo41 T C 6: 85,455,505 (GRCm39) T560A possibly damaging Het
Fbxo7 A T 10: 85,880,398 (GRCm39) H282L possibly damaging Het
Gmnc T G 16: 26,779,278 (GRCm39) D243A probably benign Het
Hdac5 C A 11: 102,087,882 (GRCm39) probably null Het
Krt87 A G 15: 101,334,443 (GRCm39) V188A probably benign Het
Lpxn G A 19: 12,802,163 (GRCm39) V163M probably benign Het
Lrrk1 A T 7: 65,931,396 (GRCm39) L55Q probably damaging Het
Ltbp2 C T 12: 84,860,091 (GRCm39) C621Y probably damaging Het
Marchf8 A G 6: 116,382,624 (GRCm39) E147G probably damaging Het
Muc16 T G 9: 18,558,484 (GRCm39) H2603P unknown Het
Nipa1 T A 7: 55,629,571 (GRCm39) N181Y probably damaging Het
Nt5el T A 13: 105,248,993 (GRCm39) N402K probably damaging Het
Or14c45 A G 7: 86,176,120 (GRCm39) T52A probably benign Het
Or2h2c G A 17: 37,422,494 (GRCm39) P127S probably damaging Het
Or4k37 A G 2: 111,159,457 (GRCm39) D231G probably benign Het
Or51f23c-ps1 T C 7: 102,430,994 (GRCm39) F104L probably damaging Het
Or7g35 A G 9: 19,496,285 (GRCm39) I151V probably benign Het
Pcf11 T A 7: 92,307,090 (GRCm39) Q1026L probably damaging Het
Ptch1 T G 13: 63,687,644 (GRCm39) K378T possibly damaging Het
Ptprm C T 17: 67,660,951 (GRCm39) probably null Het
Pxmp2 C A 5: 110,425,573 (GRCm39) W154L possibly damaging Het
Rdh7 T G 10: 127,720,491 (GRCm39) S294R probably damaging Het
Rexo1 C T 10: 80,379,848 (GRCm39) R994Q possibly damaging Het
Sacs A G 14: 61,446,383 (GRCm39) T2810A probably benign Het
Serpina3c A T 12: 104,117,980 (GRCm39) H119Q possibly damaging Het
Slc12a2 T G 18: 58,031,200 (GRCm39) I335R probably damaging Het
Slc25a13 C T 6: 6,073,454 (GRCm39) R468Q probably damaging Het
Slc5a6 C T 5: 31,194,174 (GRCm39) V628I probably benign Het
Srsf2 T C 11: 116,743,905 (GRCm39) probably null Het
Sugp2 A G 8: 70,695,420 (GRCm39) Q131R possibly damaging Het
Syne1 T C 10: 5,251,340 (GRCm39) R2525G probably damaging Het
Tmem8b G T 4: 43,682,249 (GRCm39) G82W probably damaging Het
Unc13c A G 9: 73,837,890 (GRCm39) I987T possibly damaging Het
Usp44 T C 10: 93,682,351 (GRCm39) V267A possibly damaging Het
Wac C A 18: 7,868,884 (GRCm39) probably null Het
Xkr5 T C 8: 18,983,569 (GRCm39) I658V probably benign Het
Zbtb38 A T 9: 96,568,707 (GRCm39) Y792* probably null Het
Other mutations in Tars3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Tars3 APN 7 65,302,007 (GRCm39) critical splice acceptor site probably null
IGL00470:Tars3 APN 7 65,338,656 (GRCm39) missense probably benign 0.03
IGL00594:Tars3 APN 7 65,325,880 (GRCm39) critical splice donor site probably null
IGL01352:Tars3 APN 7 65,308,658 (GRCm39) missense possibly damaging 0.80
IGL01519:Tars3 APN 7 65,313,634 (GRCm39) missense probably damaging 1.00
IGL01726:Tars3 APN 7 65,332,566 (GRCm39) missense possibly damaging 0.46
IGL02370:Tars3 APN 7 65,310,913 (GRCm39) missense probably benign 0.17
IGL02729:Tars3 APN 7 65,332,567 (GRCm39) missense probably damaging 0.97
IGL03234:Tars3 APN 7 65,302,026 (GRCm39) missense probably benign 0.06
gary UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R8254_tarsl2_650 UTSW 7 65,325,809 (GRCm39) missense probably benign
smart_money UTSW 7 65,327,890 (GRCm39) missense probably damaging 1.00
R0127:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R0153:Tars3 UTSW 7 65,333,829 (GRCm39) missense probably damaging 1.00
R0605:Tars3 UTSW 7 65,327,819 (GRCm39) missense probably damaging 1.00
R1070:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1450:Tars3 UTSW 7 65,297,244 (GRCm39) missense probably benign 0.01
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R2142:Tars3 UTSW 7 65,308,645 (GRCm39) missense probably benign
R2143:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2144:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2145:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2208:Tars3 UTSW 7 65,332,596 (GRCm39) missense probably damaging 1.00
R3713:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3715:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3914:Tars3 UTSW 7 65,333,556 (GRCm39) missense probably benign 0.05
R3929:Tars3 UTSW 7 65,333,791 (GRCm39) splice site probably null
R4008:Tars3 UTSW 7 65,327,876 (GRCm39) missense probably damaging 1.00
R4064:Tars3 UTSW 7 65,302,018 (GRCm39) missense possibly damaging 0.90
R4367:Tars3 UTSW 7 65,332,567 (GRCm39) missense probably damaging 0.97
R4652:Tars3 UTSW 7 65,339,717 (GRCm39) missense probably damaging 1.00
R4825:Tars3 UTSW 7 65,297,302 (GRCm39) missense probably benign 0.38
R4901:Tars3 UTSW 7 65,341,042 (GRCm39) missense probably benign 0.05
R4999:Tars3 UTSW 7 65,308,683 (GRCm39) missense probably damaging 0.99
R5423:Tars3 UTSW 7 65,333,567 (GRCm39) missense probably benign 0.00
R5756:Tars3 UTSW 7 65,325,724 (GRCm39) missense probably benign 0.22
R5772:Tars3 UTSW 7 65,333,873 (GRCm39) missense probably damaging 1.00
R6160:Tars3 UTSW 7 65,332,527 (GRCm39) missense probably benign 0.32
R6230:Tars3 UTSW 7 65,336,184 (GRCm39) splice site probably null
R6424:Tars3 UTSW 7 65,305,487 (GRCm39) missense probably damaging 1.00
R6792:Tars3 UTSW 7 65,312,051 (GRCm39) missense probably damaging 1.00
R7350:Tars3 UTSW 7 65,308,672 (GRCm39) missense probably damaging 1.00
R7549:Tars3 UTSW 7 65,297,341 (GRCm39) missense probably damaging 0.96
R7592:Tars3 UTSW 7 65,308,619 (GRCm39) missense probably benign 0.01
R7634:Tars3 UTSW 7 65,325,760 (GRCm39) missense probably damaging 0.99
R7710:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R7808:Tars3 UTSW 7 65,302,009 (GRCm39) missense probably benign 0.01
R7875:Tars3 UTSW 7 65,327,899 (GRCm39) missense probably benign 0.05
R8254:Tars3 UTSW 7 65,325,809 (GRCm39) missense probably benign
R8793:Tars3 UTSW 7 65,294,673 (GRCm39) start gained probably benign
R9162:Tars3 UTSW 7 65,332,518 (GRCm39) missense probably benign 0.01
R9200:Tars3 UTSW 7 65,302,013 (GRCm39) missense probably benign
R9461:Tars3 UTSW 7 65,339,719 (GRCm39) missense possibly damaging 0.68
R9533:Tars3 UTSW 7 65,333,808 (GRCm39) critical splice acceptor site probably null
Z1177:Tars3 UTSW 7 65,302,012 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCATCGGTAAAGTCTGTCCC -3'
(R):5'- ATCTCACAGGTGAAGCTTGAG -3'

Sequencing Primer
(F):5'- GGTAAAGTCTGTCCCCCTGTC -3'
(R):5'- CACAGGTGAAGCTTGAGTCTATAAAG -3'
Posted On 2018-06-22