Incidental Mutation 'R6618:Zfy2'
ID 524248
Institutional Source Beutler Lab
Gene Symbol Zfy2
Ensembl Gene ENSMUSG00000000103
Gene Name zinc finger protein 2, Y-linked
Synonyms Zfy-2
MMRRC Submission 044741-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R6618 (G1)
Quality Score 221.999
Status Validated
Chromosome Y
Chromosomal Location 2106175-2170409 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 2121477 bp (GRCm39)
Zygosity Homozygous
Amino Acid Change Serine to Proline at position 139 (S139P)
Ref Sequence ENSEMBL: ENSMUSP00000139591 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115891] [ENSMUST00000187148]
AlphaFold P20662
Predicted Effect probably benign
Transcript: ENSMUST00000115891
AA Change: S139P

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000111557
Gene: ENSMUSG00000000103
AA Change: S139P

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
Pfam:Zfx_Zfy_act 68 388 1.1e-115 PFAM
ZnF_C2H2 403 425 3.69e-4 SMART
ZnF_C2H2 434 456 1.26e-2 SMART
ZnF_C2H2 491 514 1.41e0 SMART
ZnF_C2H2 520 542 3.69e-4 SMART
ZnF_C2H2 548 571 3.63e-3 SMART
ZnF_C2H2 577 599 1.02e1 SMART
ZnF_C2H2 605 628 3.58e-2 SMART
ZnF_C2H2 634 656 2.95e-3 SMART
ZnF_C2H2 662 685 1.23e0 SMART
ZnF_C2H2 691 713 1.45e-2 SMART
ZnF_C2H2 719 742 1.2e-3 SMART
ZnF_C2H2 748 770 3.34e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187148
AA Change: S139P

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000139591
Gene: ENSMUSG00000000103
AA Change: S139P

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
Pfam:Zfx_Zfy_act 67 388 2.6e-149 PFAM
ZnF_C2H2 403 425 3.69e-4 SMART
ZnF_C2H2 434 456 1.26e-2 SMART
ZnF_C2H2 491 514 1.41e0 SMART
ZnF_C2H2 520 542 3.69e-4 SMART
ZnF_C2H2 548 571 3.63e-3 SMART
ZnF_C2H2 577 599 1.02e1 SMART
ZnF_C2H2 605 628 3.58e-2 SMART
ZnF_C2H2 634 656 2.95e-3 SMART
ZnF_C2H2 662 685 1.23e0 SMART
ZnF_C2H2 691 713 1.45e-2 SMART
ZnF_C2H2 719 742 1.2e-3 SMART
ZnF_C2H2 748 770 3.34e-2 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.4%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp1b2 T C 11: 69,494,289 (GRCm39) D68G probably damaging Het
Barx2 G A 9: 31,758,168 (GRCm39) L257F probably benign Het
Bbx C G 16: 50,086,626 (GRCm39) W90S probably damaging Het
Bmp1 T A 14: 70,728,808 (GRCm39) D588V probably damaging Het
Caskin2 C T 11: 115,690,855 (GRCm39) M1188I possibly damaging Het
Ccdc180 T A 4: 45,950,708 (GRCm39) I1651N probably damaging Het
Cimip2a C A 2: 25,110,635 (GRCm39) L148M probably benign Het
Cr2 T C 1: 194,839,687 (GRCm39) D580G probably damaging Het
Crebbp C T 16: 3,937,670 (GRCm39) A698T possibly damaging Het
Fam204a T C 19: 60,209,069 (GRCm39) probably null Het
Fam83h T C 15: 75,875,360 (GRCm39) D659G probably damaging Het
Garin3 A G 11: 46,298,126 (GRCm39) T477A probably damaging Het
Hells G T 19: 38,945,528 (GRCm39) R589L probably benign Het
Helz A G 11: 107,489,976 (GRCm39) T144A probably benign Het
Il1r1 T A 1: 40,339,971 (GRCm39) V258D probably damaging Het
Isoc2a A T 7: 4,898,325 (GRCm39) I183F probably benign Het
Kat2a G T 11: 100,603,196 (GRCm39) probably benign Het
Klf9 A G 19: 23,142,235 (GRCm39) M232V probably benign Het
Lars1 G T 18: 42,377,973 (GRCm39) S147R possibly damaging Het
Mkrn3 A G 7: 62,068,781 (GRCm39) F337L probably benign Het
Mrc2 A T 11: 105,240,708 (GRCm39) N1466I probably damaging Het
Myo5c G A 9: 75,182,919 (GRCm39) probably null Het
Pigs T C 11: 78,232,056 (GRCm39) L396P probably damaging Het
Prkcb G A 7: 122,226,886 (GRCm39) R624Q probably benign Het
R3hdm1 T C 1: 128,121,302 (GRCm39) S269P probably benign Het
Racgap1 A T 15: 99,521,875 (GRCm39) I505K probably damaging Het
Ralgds T A 2: 28,440,523 (GRCm39) D777E probably benign Het
Rdh14 A G 12: 10,445,123 (GRCm39) I325V probably benign Het
Rpn2 T A 2: 157,163,781 (GRCm39) H624Q probably benign Het
Scarb1 C T 5: 125,381,394 (GRCm39) S50N probably damaging Het
Shmt1 T C 11: 60,683,772 (GRCm39) probably null Het
Slc49a3 G T 5: 108,590,964 (GRCm39) T400K probably benign Het
Smim24 A G 10: 81,229,966 (GRCm39) N27S possibly damaging Het
Snx13 A G 12: 35,162,444 (GRCm39) D550G probably damaging Het
Tnfsf18 T A 1: 161,322,349 (GRCm39) L23* probably null Het
Trpc3 T A 3: 36,694,844 (GRCm39) K703N possibly damaging Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Other mutations in Zfy2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02850:Zfy2 APN Y 2,117,188 (GRCm39) missense probably benign 0.00
IGL02850:Zfy2 APN Y 2,106,894 (GRCm39) missense probably benign 0.01
IGL02851:Zfy2 APN Y 2,117,188 (GRCm39) missense probably benign 0.00
IGL02851:Zfy2 APN Y 2,106,894 (GRCm39) missense probably benign 0.01
IGL02852:Zfy2 APN Y 2,117,188 (GRCm39) missense probably benign 0.00
IGL02852:Zfy2 APN Y 2,106,894 (GRCm39) missense probably benign 0.01
PIT4515001:Zfy2 UTSW Y 2,117,096 (GRCm39) missense probably benign 0.09
R0426:Zfy2 UTSW Y 2,107,348 (GRCm39) missense possibly damaging 0.61
R0490:Zfy2 UTSW Y 2,106,620 (GRCm39) missense possibly damaging 0.89
R1080:Zfy2 UTSW Y 2,121,645 (GRCm39) missense probably benign 0.00
R1513:Zfy2 UTSW Y 2,116,185 (GRCm39) missense probably benign 0.00
R1935:Zfy2 UTSW Y 2,121,496 (GRCm39) missense probably benign 0.02
R1936:Zfy2 UTSW Y 2,121,496 (GRCm39) missense probably benign 0.02
R2358:Zfy2 UTSW Y 2,107,272 (GRCm39) missense possibly damaging 0.61
R4484:Zfy2 UTSW Y 2,107,351 (GRCm39) missense possibly damaging 0.86
R4754:Zfy2 UTSW Y 2,121,477 (GRCm39) missense probably benign 0.02
R4777:Zfy2 UTSW Y 2,116,194 (GRCm39) missense probably benign 0.00
R4812:Zfy2 UTSW Y 2,106,334 (GRCm39) missense probably benign 0.08
R5045:Zfy2 UTSW Y 2,107,159 (GRCm39) missense possibly damaging 0.77
R5363:Zfy2 UTSW Y 2,106,555 (GRCm39) missense possibly damaging 0.95
R6256:Zfy2 UTSW Y 2,116,267 (GRCm39) missense probably benign 0.02
R6941:Zfy2 UTSW Y 2,121,491 (GRCm39) missense probably benign 0.02
R7011:Zfy2 UTSW Y 2,107,127 (GRCm39) missense possibly damaging 0.59
R7712:Zfy2 UTSW Y 2,121,420 (GRCm39) missense probably benign 0.05
R7759:Zfy2 UTSW Y 2,117,083 (GRCm39) missense probably benign 0.02
R7985:Zfy2 UTSW Y 2,116,263 (GRCm39) missense probably benign 0.00
R8051:Zfy2 UTSW Y 2,117,380 (GRCm39) intron probably benign
R8218:Zfy2 UTSW Y 2,133,421 (GRCm39) missense unknown
R8345:Zfy2 UTSW Y 2,107,096 (GRCm39) missense possibly damaging 0.95
R8371:Zfy2 UTSW Y 2,117,168 (GRCm39) missense probably benign 0.00
R8830:Zfy2 UTSW Y 2,106,600 (GRCm39) missense possibly damaging 0.60
R9448:Zfy2 UTSW Y 2,109,904 (GRCm39) missense probably damaging 0.98
R9537:Zfy2 UTSW Y 2,108,596 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- GATTCTGGCATCATCTTGCTGC -3'
(R):5'- TTTTGTTCCTGATGATCCAGACTCAG -3'

Sequencing Primer
(F):5'- ATCATCTTGCTGCTCCAGAGG -3'
(R):5'- TCTTATTGAAGATGTTCACTGTTCAC -3'
Posted On 2018-06-22