Incidental Mutation 'R6584:Or1o1'
ID 524309
Institutional Source Beutler Lab
Gene Symbol Or1o1
Ensembl Gene ENSMUSG00000063188
Gene Name olfactory receptor family 1 subfamily O member 1
Synonyms MOR156-3, GA_x6K02T2PSCP-1867165-1868094, Olfr107
MMRRC Submission 044708-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R6584 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37716368-37717400 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 37716796 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 119 (R119H)
Ref Sequence ENSEMBL: ENSMUSP00000148879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077008] [ENSMUST00000215894] [ENSMUST00000215947] [ENSMUST00000215974] [ENSMUST00000216844]
AlphaFold Q7TRK4
Predicted Effect probably benign
Transcript: ENSMUST00000077008
AA Change: R119H

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000076267
Gene: ENSMUSG00000063188
AA Change: R119H

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.3e-54 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.3e-5 PFAM
Pfam:7tm_1 38 287 3.7e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174238
Predicted Effect probably benign
Transcript: ENSMUST00000215894
AA Change: R119H

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000215947
AA Change: R119H

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000215974
AA Change: R119H

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000216844
AA Change: R119H

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agr2 G A 12: 36,045,625 (GRCm39) R37Q probably benign Het
Amfr T C 8: 94,700,783 (GRCm39) D559G probably benign Het
Atg2b T C 12: 105,624,254 (GRCm39) Y711C probably damaging Het
Brd10 T C 19: 29,696,128 (GRCm39) N1122D possibly damaging Het
Clgn T C 8: 84,126,665 (GRCm39) I122T probably benign Het
Ets1 T A 9: 32,645,293 (GRCm39) F180Y probably damaging Het
Fbxw14 C G 9: 109,115,611 (GRCm39) C53S possibly damaging Het
Ifna9 A G 4: 88,510,375 (GRCm39) L83P probably damaging Het
Igf2r A G 17: 12,920,137 (GRCm39) C1401R probably damaging Het
Il22 A T 10: 118,040,932 (GRCm39) M13L probably benign Het
Il9r A G 11: 32,141,782 (GRCm39) Y319H probably benign Het
Itgb5 T C 16: 33,705,400 (GRCm39) F230S probably damaging Het
Klk1b27 T A 7: 43,703,935 (GRCm39) I26N possibly damaging Het
Lrba C T 3: 86,571,883 (GRCm39) R300C probably damaging Het
Map3k4 A C 17: 12,479,378 (GRCm39) Y730D probably damaging Het
Ogfrl1 T G 1: 23,408,944 (GRCm39) K427N probably benign Het
Paxip1 G A 5: 27,963,450 (GRCm39) H792Y probably damaging Het
Phf20 T C 2: 156,136,043 (GRCm39) S621P probably damaging Het
Pramel22 T A 4: 143,382,040 (GRCm39) T219S possibly damaging Het
Slitrk3 C A 3: 72,956,558 (GRCm39) G738V probably damaging Het
Smurf1 T C 5: 144,819,333 (GRCm39) D598G probably damaging Het
St6galnac2 A G 11: 116,585,330 (GRCm39) S19P probably benign Het
Stra6l G A 4: 45,869,635 (GRCm39) probably null Het
Tbc1d9 C A 8: 83,987,629 (GRCm39) Q863K probably damaging Het
Traf1 T A 2: 34,848,070 (GRCm39) D8V probably damaging Het
Vmn2r24 T G 6: 123,792,764 (GRCm39) M697R possibly damaging Het
Wdr27 T A 17: 15,122,031 (GRCm39) Y625F probably damaging Het
Wdr49 T C 3: 75,245,065 (GRCm39) M339V probably benign Het
Other mutations in Or1o1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Or1o1 APN 17 37,717,031 (GRCm39) missense probably benign 0.00
IGL01614:Or1o1 APN 17 37,716,529 (GRCm39) missense probably benign 0.00
IGL02390:Or1o1 APN 17 37,716,986 (GRCm39) missense probably benign 0.04
R1051:Or1o1 UTSW 17 37,717,341 (GRCm39) missense possibly damaging 0.74
R4767:Or1o1 UTSW 17 37,717,091 (GRCm39) nonsense probably null
R4849:Or1o1 UTSW 17 37,716,589 (GRCm39) missense probably benign 0.16
R6182:Or1o1 UTSW 17 37,716,883 (GRCm39) missense possibly damaging 0.65
R6550:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6551:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6552:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6555:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6586:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6588:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6688:Or1o1 UTSW 17 37,716,796 (GRCm39) missense probably benign 0.30
R6758:Or1o1 UTSW 17 37,716,586 (GRCm39) missense probably damaging 0.97
R7024:Or1o1 UTSW 17 37,717,095 (GRCm39) missense probably benign 0.04
R7083:Or1o1 UTSW 17 37,717,063 (GRCm39) missense probably benign 0.00
R8350:Or1o1 UTSW 17 37,717,260 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCTCAGTCAGCTCTCACTAGTG -3'
(R):5'- ACTGAGGTGAGTGTCTGAGC -3'

Sequencing Primer
(F):5'- AGTCAGCTCTCACTAGTGGATCTTTG -3'
(R):5'- CAGTAAGAGAGGCCTAGAATCAC -3'
Posted On 2018-06-22