Incidental Mutation 'R6586:Trim60'
ID 524411
Institutional Source Beutler Lab
Gene Symbol Trim60
Ensembl Gene ENSMUSG00000053490
Gene Name tripartite motif-containing 60
Synonyms Rnf33, 2czf45
MMRRC Submission 044710-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R6586 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 65451959-65471236 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 65453248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Isoleucine at position 334 (L334I)
Ref Sequence ENSEMBL: ENSMUSP00000040299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048565]
AlphaFold Q8VI40
Predicted Effect possibly damaging
Transcript: ENSMUST00000048565
AA Change: L334I

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000040299
Gene: ENSMUSG00000053490
AA Change: L334I

DomainStartEndE-ValueType
RING 15 55 1.48e-7 SMART
low complexity region 81 90 N/A INTRINSIC
BBOX 91 132 3.12e-6 SMART
PRY 289 341 4.11e-15 SMART
Pfam:SPRY 344 459 2e-14 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.5%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik T C 4: 137,182,639 (GRCm39) F265L possibly damaging Het
9930022D16Rik A G 11: 109,308,786 (GRCm39) T51A unknown Het
Acaa1a A G 9: 119,178,604 (GRCm39) probably null Het
Clasp2 T C 9: 113,642,332 (GRCm39) S280P probably damaging Het
Cnga3 T C 1: 37,300,359 (GRCm39) S398P probably damaging Het
Cngb3 T G 4: 19,280,946 (GRCm39) L5R probably damaging Het
Cyp2c65 T C 19: 39,070,662 (GRCm39) F282L possibly damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Dnm2 T C 9: 21,416,942 (GRCm39) F825S probably benign Het
Egfem1 T A 3: 29,716,560 (GRCm39) C343* probably null Het
Fah T A 7: 84,242,468 (GRCm39) D280V probably benign Het
Fiz1 C T 7: 5,011,400 (GRCm39) A373T possibly damaging Het
Flg A T 3: 93,200,290 (GRCm39) probably benign Het
Flnb A G 14: 7,929,138 (GRCm38) R1956G possibly damaging Het
Mterf2 A G 10: 84,955,970 (GRCm39) F218S probably damaging Het
Nlrp1a A G 11: 70,996,899 (GRCm39) V868A probably benign Het
Nrip2 T A 6: 128,381,911 (GRCm39) C85* probably null Het
Ogfrl1 T G 1: 23,408,944 (GRCm39) K427N probably benign Het
Or1o1 G A 17: 37,716,796 (GRCm39) R119H probably benign Het
Or51v14 T A 7: 103,261,183 (GRCm39) I126F possibly damaging Het
Palm A C 10: 79,645,365 (GRCm39) N111H probably benign Het
Pipox T C 11: 77,772,005 (GRCm39) D373G possibly damaging Het
Plec C T 15: 76,059,287 (GRCm39) G3540D probably damaging Het
Psd3 T C 8: 68,416,197 (GRCm39) T567A probably damaging Het
Psg28 T C 7: 18,164,469 (GRCm39) Y81C probably damaging Het
Rarres1 A T 3: 67,398,366 (GRCm39) N131K probably damaging Het
Rbbp8nl G A 2: 179,922,752 (GRCm39) H214Y probably damaging Het
Styxl2 T C 1: 165,928,454 (GRCm39) E386G possibly damaging Het
Tas2r135 A G 6: 42,382,952 (GRCm39) T164A probably benign Het
Tmco3 G T 8: 13,370,894 (GRCm39) probably benign Het
Tnpo2 T A 8: 85,771,831 (GRCm39) M259K possibly damaging Het
Tns4 T C 11: 98,971,093 (GRCm39) R206G probably benign Het
Ttn T C 2: 76,560,754 (GRCm39) T29216A probably damaging Het
Urb2 G T 8: 124,757,864 (GRCm39) E1190D probably damaging Het
Vmn1r60 T A 7: 5,547,446 (GRCm39) N218I probably benign Het
Vps25 T G 11: 101,149,835 (GRCm39) V125G probably damaging Het
Ythdc2 A G 18: 44,978,855 (GRCm39) D455G probably benign Het
Ythdf2 A T 4: 131,932,911 (GRCm39) M83K probably benign Het
Other mutations in Trim60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00467:Trim60 APN 8 65,453,371 (GRCm39) missense possibly damaging 0.61
IGL03145:Trim60 APN 8 65,453,224 (GRCm39) missense probably damaging 0.99
R0054:Trim60 UTSW 8 65,453,973 (GRCm39) missense probably benign 0.05
R0054:Trim60 UTSW 8 65,453,973 (GRCm39) missense probably benign 0.05
R0080:Trim60 UTSW 8 65,453,251 (GRCm39) missense probably damaging 1.00
R0244:Trim60 UTSW 8 65,453,700 (GRCm39) missense probably benign 0.07
R0348:Trim60 UTSW 8 65,453,868 (GRCm39) missense probably damaging 1.00
R1104:Trim60 UTSW 8 65,454,071 (GRCm39) missense probably benign 0.04
R1615:Trim60 UTSW 8 65,453,162 (GRCm39) nonsense probably null
R1667:Trim60 UTSW 8 65,454,116 (GRCm39) missense probably benign 0.00
R1944:Trim60 UTSW 8 65,453,964 (GRCm39) missense possibly damaging 0.95
R2009:Trim60 UTSW 8 65,453,975 (GRCm39) missense probably damaging 0.99
R4093:Trim60 UTSW 8 65,454,030 (GRCm39) missense probably benign 0.05
R4400:Trim60 UTSW 8 65,453,864 (GRCm39) nonsense probably null
R5171:Trim60 UTSW 8 65,453,176 (GRCm39) missense probably benign 0.05
R5898:Trim60 UTSW 8 65,453,016 (GRCm39) nonsense probably null
R7012:Trim60 UTSW 8 65,453,043 (GRCm39) missense possibly damaging 0.93
R7092:Trim60 UTSW 8 65,453,700 (GRCm39) missense probably benign 0.07
R7274:Trim60 UTSW 8 65,453,133 (GRCm39) missense possibly damaging 0.76
R7567:Trim60 UTSW 8 65,454,177 (GRCm39) missense probably damaging 0.97
R7761:Trim60 UTSW 8 65,453,964 (GRCm39) missense possibly damaging 0.95
R9063:Trim60 UTSW 8 65,453,465 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- AATATGCCGACCTTGCTGGG -3'
(R):5'- AGTATTCTGGCTTGAGCAGAATC -3'

Sequencing Primer
(F):5'- GCAGAAACTCCGTTCTTAGAGGTC -3'
(R):5'- TCTGGCTTGAGCAGAATCATCAAG -3'
Posted On 2018-06-22