Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01142:Lin52'

52505

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lin52

Ensembl Gene

ENSMUSG00000085793

Gene Name

lin-52 DREAM MuvB core complex component

Synonyms

5830457H20Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.942) question?

Stock #

IGL01142

Quality Score

Status

Chromosome

Chromosomal Location

84498196-84592919 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 84503009 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000137170]

AlphaFold

Q8CD94

Predicted Effect

probably benign
Transcript: ENSMUST00000137170

SMART Domains

Protein: ENSMUSP00000133045
Gene: ENSMUSG00000085793

Domain	Start	End	E-Value	Type
Pfam:LIN52	18	112	1.1e-42	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000221033

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221172

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Armc3	C	T	2: 19,302,709 (GRCm39)		probably benign	Het
Cacnb3	T	A	15: 98,539,883 (GRCm39)	L269*	probably null	Het
Calu	T	C	6: 29,366,207 (GRCm39)		probably null	Het
Cep97	A	G	16: 55,742,561 (GRCm39)	S129P	probably damaging	Het
Cpt1b	T	C	15: 89,303,196 (GRCm39)	M620V	probably benign	Het
Dnah7b	T	C	1: 46,234,538 (GRCm39)		probably null	Het
Evi5	T	C	5: 107,963,477 (GRCm39)	K410R	probably benign	Het
Gad2	T	C	2: 22,571,297 (GRCm39)		probably benign	Het
Helb	A	T	10: 119,947,049 (GRCm39)	V88D	probably damaging	Het
Hexim2	A	G	11: 103,024,960 (GRCm39)	E19G	probably benign	Het
Klhl25	T	C	7: 75,516,344 (GRCm39)	Y112H	probably damaging	Het
Ms4a4c	A	G	19: 11,403,614 (GRCm39)	T157A	probably benign	Het
Or12e8	T	C	2: 87,187,889 (GRCm39)	F34L	possibly damaging	Het
Or7g17	A	G	9: 18,768,830 (GRCm39)	N303S	probably damaging	Het
Plxnb1	A	G	9: 108,931,765 (GRCm39)	T472A	probably benign	Het
Sez6	T	G	11: 77,864,642 (GRCm39)	V534G	probably damaging	Het
Sim1	C	A	10: 50,786,767 (GRCm39)	T333K	probably damaging	Het
Tedc1	C	T	12: 113,126,808 (GRCm39)	R357*	probably null	Het
Tmem115	A	G	9: 107,411,844 (GRCm39)	N56S	possibly damaging	Het
Ubac1	T	C	2: 25,896,580 (GRCm39)	I150V	probably damaging	Het
Vps13a	T	C	19: 16,664,479 (GRCm39)	K1455E	possibly damaging	Het
Yrdc	T	C	4: 124,747,787 (GRCm39)	F97L	probably damaging	Het

Other mutations in Lin52

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03190:Lin52	APN	12	84,504,732 (GRCm39)	missense	probably damaging	1.00
R0038:Lin52	UTSW	12	84,576,499 (GRCm39)	missense	probably damaging	1.00
R7326:Lin52	UTSW	12	84,504,728 (GRCm39)	missense	probably damaging	0.96
R9030:Lin52	UTSW	12	84,592,681 (GRCm39)	missense
R9311:Lin52	UTSW	12	84,576,470 (GRCm39)	missense	probably damaging	0.98

Posted On

2013-06-21