Incidental Mutation 'R6610:Zfp426'
ID 525898
Institutional Source Beutler Lab
Gene Symbol Zfp426
Ensembl Gene ENSMUSG00000059475
Gene Name zinc finger protein 426
Synonyms Zfp68-rs1, KRAB1, Zfo61, 2900057C04Rik
MMRRC Submission 044733-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R6610 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 20379845-20404042 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20384389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 98 (K98R)
Ref Sequence ENSEMBL: ENSMUSP00000127045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080386] [ENSMUST00000115562] [ENSMUST00000163348] [ENSMUST00000163427] [ENSMUST00000164250] [ENSMUST00000169558] [ENSMUST00000164825] [ENSMUST00000166005] [ENSMUST00000167457] [ENSMUST00000168095] [ENSMUST00000164799] [ENSMUST00000169269]
AlphaFold Q8R1D1
Predicted Effect probably damaging
Transcript: ENSMUST00000080386
AA Change: K84R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000079250
Gene: ENSMUSG00000059475
AA Change: K84R

DomainStartEndE-ValueType
KRAB 39 99 5.56e-31 SMART
ZnF_C2H2 219 241 2.12e-4 SMART
ZnF_C2H2 274 296 1.69e-3 SMART
ZnF_C2H2 302 324 8.81e-2 SMART
ZnF_C2H2 330 352 5.59e-4 SMART
ZnF_C2H2 358 380 3.16e-3 SMART
ZnF_C2H2 386 408 1.43e-1 SMART
ZnF_C2H2 414 436 1.79e-2 SMART
ZnF_C2H2 442 464 1.22e-4 SMART
ZnF_C2H2 470 492 1.38e-3 SMART
ZnF_C2H2 498 520 3.58e-2 SMART
ZnF_C2H2 528 550 3.44e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000115562
AA Change: K84R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000111224
Gene: ENSMUSG00000059475
AA Change: K84R

DomainStartEndE-ValueType
KRAB 39 99 5.56e-31 SMART
ZnF_C2H2 219 241 2.12e-4 SMART
ZnF_C2H2 274 296 1.69e-3 SMART
ZnF_C2H2 302 324 8.81e-2 SMART
ZnF_C2H2 330 352 5.59e-4 SMART
ZnF_C2H2 358 380 3.16e-3 SMART
ZnF_C2H2 386 408 1.43e-1 SMART
ZnF_C2H2 414 436 1.79e-2 SMART
ZnF_C2H2 442 464 1.22e-4 SMART
ZnF_C2H2 470 492 1.38e-3 SMART
ZnF_C2H2 498 520 3.58e-2 SMART
ZnF_C2H2 528 550 3.44e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157997
Predicted Effect probably benign
Transcript: ENSMUST00000163348
AA Change: K84R

PolyPhen 2 Score 0.361 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000126446
Gene: ENSMUSG00000059475
AA Change: K84R

DomainStartEndE-ValueType
KRAB 39 99 5.56e-31 SMART
ZnF_C2H2 218 240 2.12e-4 SMART
ZnF_C2H2 273 295 1.69e-3 SMART
ZnF_C2H2 301 323 8.81e-2 SMART
ZnF_C2H2 329 351 5.59e-4 SMART
ZnF_C2H2 357 379 3.16e-3 SMART
ZnF_C2H2 385 407 1.43e-1 SMART
ZnF_C2H2 413 435 1.79e-2 SMART
ZnF_C2H2 441 463 1.22e-4 SMART
ZnF_C2H2 469 491 1.38e-3 SMART
ZnF_C2H2 497 519 3.58e-2 SMART
ZnF_C2H2 527 549 3.44e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163427
AA Change: N42D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000164250
Predicted Effect probably damaging
Transcript: ENSMUST00000169558
AA Change: K98R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000127045
Gene: ENSMUSG00000059475
AA Change: K98R

DomainStartEndE-ValueType
KRAB 53 113 5.56e-31 SMART
ZnF_C2H2 233 255 2.12e-4 SMART
ZnF_C2H2 288 310 1.69e-3 SMART
ZnF_C2H2 316 338 8.81e-2 SMART
ZnF_C2H2 344 366 5.59e-4 SMART
ZnF_C2H2 372 394 3.16e-3 SMART
ZnF_C2H2 400 422 1.43e-1 SMART
ZnF_C2H2 428 450 1.79e-2 SMART
ZnF_C2H2 456 478 1.22e-4 SMART
ZnF_C2H2 484 506 1.38e-3 SMART
ZnF_C2H2 512 534 3.58e-2 SMART
ZnF_C2H2 542 564 3.44e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000164825
AA Change: K84R

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000127914
Gene: ENSMUSG00000059475
AA Change: K84R

DomainStartEndE-ValueType
KRAB 39 99 5.56e-31 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000166005
AA Change: K84R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000129727
Gene: ENSMUSG00000059475
AA Change: K84R

DomainStartEndE-ValueType
KRAB 39 99 5.56e-31 SMART
ZnF_C2H2 219 241 2.12e-4 SMART
ZnF_C2H2 274 296 1.69e-3 SMART
ZnF_C2H2 302 324 8.81e-2 SMART
ZnF_C2H2 330 352 5.59e-4 SMART
ZnF_C2H2 358 380 3.16e-3 SMART
ZnF_C2H2 386 408 1.43e-1 SMART
ZnF_C2H2 414 436 1.79e-2 SMART
ZnF_C2H2 442 464 1.22e-4 SMART
ZnF_C2H2 470 492 1.38e-3 SMART
ZnF_C2H2 498 520 3.58e-2 SMART
ZnF_C2H2 528 550 3.44e-4 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000167457
AA Change: K17R

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000130945
Gene: ENSMUSG00000059475
AA Change: K17R

DomainStartEndE-ValueType
KRAB 1 32 1.46e0 SMART
ZnF_C2H2 152 174 2.12e-4 SMART
ZnF_C2H2 207 229 1.69e-3 SMART
ZnF_C2H2 235 257 8.81e-2 SMART
ZnF_C2H2 263 285 5.59e-4 SMART
ZnF_C2H2 291 313 3.16e-3 SMART
ZnF_C2H2 319 341 1.43e-1 SMART
ZnF_C2H2 347 369 1.79e-2 SMART
ZnF_C2H2 375 397 1.22e-4 SMART
ZnF_C2H2 403 425 1.38e-3 SMART
ZnF_C2H2 431 453 3.58e-2 SMART
ZnF_C2H2 461 483 3.44e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168095
AA Change: N83D

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000130309
Gene: ENSMUSG00000059475
AA Change: N83D

DomainStartEndE-ValueType
KRAB 39 83 1.37e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000164799
SMART Domains Protein: ENSMUSP00000130120
Gene: ENSMUSG00000059475

DomainStartEndE-ValueType
KRAB 53 93 1.2e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169269
SMART Domains Protein: ENSMUSP00000128843
Gene: ENSMUSG00000059475

DomainStartEndE-ValueType
KRAB 39 69 7.16e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180846
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166465
Meta Mutation Damage Score 0.1367 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.8%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 A T 9: 21,437,561 (GRCm39) M1L probably benign Het
Adam26b T C 8: 43,974,190 (GRCm39) K271E probably damaging Het
Ankrd44 A G 1: 54,694,246 (GRCm39) I914T probably benign Het
Atp12a A G 14: 56,612,013 (GRCm39) R396G probably damaging Het
C2cd3 A G 7: 100,104,505 (GRCm39) K2173E probably benign Het
Cbx2 A G 11: 118,915,036 (GRCm39) D51G probably damaging Het
Ccdc33 T A 9: 57,976,419 (GRCm39) T532S possibly damaging Het
Ccnt1 T C 15: 98,462,982 (GRCm39) I63M probably damaging Het
Cdc20b C T 13: 113,200,796 (GRCm39) T172I probably benign Het
Cep20 TTGTG TTG 16: 14,118,009 (GRCm39) probably null Het
Ces2f T G 8: 105,676,738 (GRCm39) probably null Het
Cfh A T 1: 140,029,486 (GRCm39) C597* probably null Het
Cntnap2 A T 6: 45,992,191 (GRCm39) T373S probably benign Het
Cyb5r4 T G 9: 86,941,470 (GRCm39) C64G probably benign Het
Cyp2c23 A G 19: 43,995,520 (GRCm39) F416L probably damaging Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Eif4e1b A G 13: 54,932,128 (GRCm39) probably benign Het
Elp1 A G 4: 56,758,236 (GRCm39) V1227A probably benign Het
Etl4 G A 2: 20,718,180 (GRCm39) R256K probably damaging Het
Fhad1 A G 4: 141,643,707 (GRCm39) L1054P possibly damaging Het
Grik1 A G 16: 87,831,200 (GRCm39) I190T probably damaging Het
Gsdmc2 T C 15: 63,696,857 (GRCm39) N438S probably benign Het
Igkv15-103 A T 6: 68,414,617 (GRCm39) R19* probably null Het
Kcnc2 G C 10: 112,107,761 (GRCm39) G51R probably benign Het
Lhcgr A T 17: 89,077,307 (GRCm39) I93K possibly damaging Het
Muc6 G C 7: 141,226,700 (GRCm39) probably benign Het
Mymk G T 2: 26,957,405 (GRCm39) S29R possibly damaging Het
Nab2 A T 10: 127,500,207 (GRCm39) I295N probably damaging Het
Neu2 A T 1: 87,524,407 (GRCm39) T131S probably benign Het
Pdcd7 T A 9: 65,261,965 (GRCm39) M129K possibly damaging Het
Ptar1 A G 19: 23,695,208 (GRCm39) H225R probably benign Het
Pygb T A 2: 150,665,886 (GRCm39) probably null Het
Rpap3 T C 15: 97,586,049 (GRCm39) D314G probably benign Het
Scara3 A G 14: 66,168,670 (GRCm39) S316P probably damaging Het
Sec24a C T 11: 51,587,483 (GRCm39) V1051I probably benign Het
Setdb1 G T 3: 95,235,888 (GRCm39) A841D probably damaging Het
Stk32b G A 5: 37,606,022 (GRCm39) T407I probably benign Het
Tcte2 G A 17: 13,948,250 (GRCm39) Q10* probably null Het
Tgm2 C A 2: 157,985,020 (GRCm39) E29* probably null Het
Trim32 G A 4: 65,533,308 (GRCm39) V622M probably damaging Het
Ttn G A 2: 76,579,673 (GRCm39) T23740M probably damaging Het
Tyk2 G T 9: 21,019,312 (GRCm39) Q1014K probably benign Het
Vmn1r123 A G 7: 20,896,515 (GRCm39) N136D probably benign Het
Vmn2r31 A T 7: 7,387,588 (GRCm39) V661E probably damaging Het
Vmn2r85 A T 10: 130,261,838 (GRCm39) F166L probably damaging Het
Zfp534 C T 4: 147,758,947 (GRCm39) R574K probably benign Het
Other mutations in Zfp426
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:Zfp426 APN 9 20,389,453 (GRCm39) start codon destroyed possibly damaging 0.93
IGL02499:Zfp426 APN 9 20,384,414 (GRCm39) splice site probably benign
R0157:Zfp426 UTSW 9 20,382,432 (GRCm39) missense probably benign 0.00
R0356:Zfp426 UTSW 9 20,382,541 (GRCm39) missense probably benign 0.15
R0456:Zfp426 UTSW 9 20,381,593 (GRCm39) missense probably damaging 1.00
R0504:Zfp426 UTSW 9 20,381,327 (GRCm39) missense probably damaging 0.96
R2352:Zfp426 UTSW 9 20,381,401 (GRCm39) missense probably benign 0.08
R2507:Zfp426 UTSW 9 20,381,727 (GRCm39) missense probably benign 0.00
R2509:Zfp426 UTSW 9 20,381,977 (GRCm39) missense possibly damaging 0.68
R3771:Zfp426 UTSW 9 20,384,413 (GRCm39) splice site probably null
R3772:Zfp426 UTSW 9 20,384,413 (GRCm39) splice site probably null
R3773:Zfp426 UTSW 9 20,384,413 (GRCm39) splice site probably null
R3864:Zfp426 UTSW 9 20,381,382 (GRCm39) missense possibly damaging 0.88
R4649:Zfp426 UTSW 9 20,381,923 (GRCm39) missense possibly damaging 0.66
R4798:Zfp426 UTSW 9 20,382,310 (GRCm39) missense probably benign 0.17
R4863:Zfp426 UTSW 9 20,381,334 (GRCm39) missense probably damaging 1.00
R4894:Zfp426 UTSW 9 20,386,369 (GRCm39) intron probably benign
R5421:Zfp426 UTSW 9 20,382,015 (GRCm39) missense probably damaging 0.99
R6084:Zfp426 UTSW 9 20,381,923 (GRCm39) missense possibly damaging 0.66
R7239:Zfp426 UTSW 9 20,381,887 (GRCm39) missense probably benign 0.00
R7441:Zfp426 UTSW 9 20,382,147 (GRCm39) missense possibly damaging 0.95
R7646:Zfp426 UTSW 9 20,381,320 (GRCm39) missense probably damaging 0.98
R7827:Zfp426 UTSW 9 20,381,446 (GRCm39) missense probably damaging 1.00
R8987:Zfp426 UTSW 9 20,387,744 (GRCm39) missense probably damaging 1.00
R8993:Zfp426 UTSW 9 20,386,296 (GRCm39) missense probably damaging 1.00
R9043:Zfp426 UTSW 9 20,386,308 (GRCm39) missense probably damaging 1.00
R9450:Zfp426 UTSW 9 20,381,577 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CATTCATCAATCCATTCACTTACTGAG -3'
(R):5'- TGGGACTTGCATTACCAATCC -3'

Sequencing Primer
(F):5'- GGCTTGGTCGAAAACGCCTTTAC -3'
(R):5'- CACTTCTGGAATTCAAGTACCTGGG -3'
Posted On 2018-06-22