Incidental Mutation 'R6644:Ifi211'
ID 525981
Institutional Source Beutler Lab
Gene Symbol Ifi211
Ensembl Gene ENSMUSG00000026536
Gene Name interferon activated gene 211
Synonyms Ifi205b, Mnda
MMRRC Submission 044765-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R6644 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173723911-173740612 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 173733118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 181 (C181Y)
Ref Sequence ENSEMBL: ENSMUSP00000009340 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009340] [ENSMUST00000111210]
AlphaFold P0DOV1
PDB Structure Solution structures of the PAAD_DAPIN domain of mus musculus interferon-activatable protein 205 [SOLUTION NMR]
Predicted Effect probably benign
Transcript: ENSMUST00000009340
AA Change: C181Y

PolyPhen 2 Score 0.419 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000009340
Gene: ENSMUSG00000026536
AA Change: C181Y

DomainStartEndE-ValueType
PYRIN 6 84 1.94e-14 SMART
low complexity region 120 154 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
Pfam:HIN 225 393 2.2e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111210
SMART Domains Protein: ENSMUSP00000106841
Gene: ENSMUSG00000090272

DomainStartEndE-ValueType
PYRIN 5 83 3.71e-20 SMART
internal_repeat_1 152 166 2.38e-7 PROSPERO
low complexity region 170 200 N/A INTRINSIC
internal_repeat_1 208 222 2.38e-7 PROSPERO
low complexity region 225 249 N/A INTRINSIC
low complexity region 276 292 N/A INTRINSIC
low complexity region 294 305 N/A INTRINSIC
Pfam:HIN 311 479 3.4e-76 PFAM
low complexity region 497 507 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.3%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 C T 10: 79,844,598 (GRCm39) P1461L probably damaging Het
Abhd14a T C 9: 106,321,472 (GRCm39) Y10C probably damaging Het
Adcy2 C T 13: 68,816,671 (GRCm39) V772M possibly damaging Het
Apob A G 12: 8,059,077 (GRCm39) M2487V probably damaging Het
B4galnt1 T C 10: 127,007,662 (GRCm39) probably null Het
Cabp7 C T 11: 4,690,396 (GRCm39) V76I probably benign Het
Cbr3 A G 16: 93,487,399 (GRCm39) Y194C probably damaging Het
Cdk18 G A 1: 132,049,807 (GRCm39) Q58* probably null Het
Cryba4 T C 5: 112,394,628 (GRCm39) D167G probably damaging Het
Czib T G 4: 107,752,119 (GRCm39) I130S probably damaging Het
Dner T C 1: 84,373,428 (GRCm39) N588S probably damaging Het
Dnm1l T C 16: 16,147,737 (GRCm39) I343V probably benign Het
Eif1ad16 A G 12: 87,985,460 (GRCm39) F28L probably benign Het
Fam168b C A 1: 34,875,822 (GRCm39) G21V probably damaging Het
Fbxw17 G A 13: 50,577,255 (GRCm39) R49Q probably damaging Het
Garin2 T A 12: 78,762,060 (GRCm39) D241E probably damaging Het
Gm10332 T A 14: 55,057,616 (GRCm39) F59I probably damaging Het
Gnai3 A G 3: 108,030,852 (GRCm39) probably null Het
Helz T A 11: 107,523,087 (GRCm39) M75K possibly damaging Het
Hnrnph3 C T 10: 62,854,672 (GRCm39) probably benign Het
Immp1l A G 2: 105,767,390 (GRCm39) K83R probably damaging Het
Itga6 G A 2: 71,671,468 (GRCm39) G740R probably damaging Het
Klhl1 T C 14: 96,755,354 (GRCm39) T134A probably benign Het
Klhl7 A G 5: 24,354,244 (GRCm39) D353G probably damaging Het
Map3k1 A G 13: 111,888,983 (GRCm39) S1325P probably benign Het
Map3k4 A G 17: 12,451,297 (GRCm39) probably null Het
Meioc G A 11: 102,559,286 (GRCm39) probably null Het
Mfap5 T C 6: 122,497,555 (GRCm39) F26L probably damaging Het
Myo5a A G 9: 75,054,249 (GRCm39) T386A probably damaging Het
Npc1l1 A T 11: 6,164,013 (GRCm39) L1266Q probably damaging Het
Npc1l1 G T 11: 6,164,014 (GRCm39) L1266M probably damaging Het
Or4c116 A G 2: 88,942,325 (GRCm39) M177T probably benign Het
Or51aa2 C A 7: 103,188,265 (GRCm39) V59F possibly damaging Het
Pbld1 T A 10: 62,910,842 (GRCm39) S233T probably damaging Het
Phf12 A G 11: 77,916,918 (GRCm39) *789W probably null Het
Sf3b2 A T 19: 5,329,992 (GRCm39) probably null Het
Slc23a3 A G 1: 75,105,191 (GRCm39) I459T probably damaging Het
Spata31e4 A G 13: 50,856,071 (GRCm39) T570A possibly damaging Het
Sptbn2 C G 19: 4,799,040 (GRCm39) R2037G probably benign Het
Stard9 A C 2: 120,526,253 (GRCm39) M837L probably benign Het
Stx5a A T 19: 8,732,612 (GRCm39) probably benign Het
Tmc7 A G 7: 118,137,385 (GRCm39) V719A probably benign Het
Trank1 T A 9: 111,193,902 (GRCm39) I642K possibly damaging Het
Trim34a T C 7: 103,910,244 (GRCm39) Y349H probably damaging Het
Uba7 A G 9: 107,858,671 (GRCm39) Y834C possibly damaging Het
Ube2d1 A G 10: 71,092,530 (GRCm39) S105P possibly damaging Het
Vps13a A G 19: 16,722,283 (GRCm39) V343A possibly damaging Het
Zbtb37 G A 1: 160,859,643 (GRCm39) Q221* probably null Het
Zfp119b T C 17: 56,246,148 (GRCm39) N346S probably benign Het
Zfp708 G T 13: 67,218,785 (GRCm39) T358K possibly damaging Het
Other mutations in Ifi211
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03258:Ifi211 APN 1 173,733,098 (GRCm39) missense probably benign 0.40
IGL03304:Ifi211 APN 1 173,735,273 (GRCm39) missense probably damaging 1.00
BB007:Ifi211 UTSW 1 173,733,769 (GRCm39) missense possibly damaging 0.91
BB017:Ifi211 UTSW 1 173,733,769 (GRCm39) missense possibly damaging 0.91
FR4548:Ifi211 UTSW 1 173,733,759 (GRCm39) missense possibly damaging 0.85
R1686:Ifi211 UTSW 1 173,726,969 (GRCm39) missense probably damaging 0.99
R2011:Ifi211 UTSW 1 173,735,169 (GRCm39) missense probably damaging 0.99
R4657:Ifi211 UTSW 1 173,735,226 (GRCm39) missense probably benign 0.03
R5220:Ifi211 UTSW 1 173,735,262 (GRCm39) missense probably damaging 1.00
R5410:Ifi211 UTSW 1 173,733,829 (GRCm39) missense probably benign 0.08
R6953:Ifi211 UTSW 1 173,733,832 (GRCm39) missense probably damaging 1.00
R7451:Ifi211 UTSW 1 173,727,058 (GRCm39) missense probably damaging 1.00
R7567:Ifi211 UTSW 1 173,729,401 (GRCm39) missense probably damaging 1.00
R7667:Ifi211 UTSW 1 173,727,020 (GRCm39) missense probably damaging 1.00
R7930:Ifi211 UTSW 1 173,733,769 (GRCm39) missense possibly damaging 0.91
R8499:Ifi211 UTSW 1 173,733,086 (GRCm39) missense probably benign 0.40
R9002:Ifi211 UTSW 1 173,733,894 (GRCm39) missense possibly damaging 0.68
R9299:Ifi211 UTSW 1 173,735,288 (GRCm39) missense probably damaging 0.96
R9562:Ifi211 UTSW 1 173,733,052 (GRCm39) missense probably benign 0.43
Z1088:Ifi211 UTSW 1 173,735,226 (GRCm39) missense possibly damaging 0.74
Predicted Primers PCR Primer
(F):5'- TTAATTAAACCTCAGGGAGAAGTGG -3'
(R):5'- AGTTTAGACCTGGCCAGAGG -3'

Sequencing Primer
(F):5'- GGGGGACATGGTCAGAATTTC -3'
(R):5'- GTGGGTGCTACTCCTTCAAG -3'
Posted On 2018-06-22