Incidental Mutation 'R6570:Or2m13'
ID 526218
Institutional Source Beutler Lab
Gene Symbol Or2m13
Ensembl Gene ENSMUSG00000050158
Gene Name olfactory receptor family 2 subfamily M member 13
Synonyms Olfr165, MOR279-1, GA_x54KRFPKG5P-15855164-15854223
MMRRC Submission 044694-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R6570 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 19224994-19241884 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19226068 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 233 (S233G)
Ref Sequence ENSEMBL: ENSMUSP00000145668 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052516] [ENSMUST00000206110] [ENSMUST00000206410]
AlphaFold Q8VFA2
Predicted Effect probably benign
Transcript: ENSMUST00000052516
AA Change: S233G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000062079
Gene: ENSMUSG00000050158
AA Change: S233G

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 5.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 36 306 6e-10 PFAM
Pfam:7tm_1 42 291 4e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103984
Predicted Effect probably benign
Transcript: ENSMUST00000206110
AA Change: S233G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000206410
AA Change: S234G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 14 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cdh15 T C 8: 123,584,130 (GRCm39) V77A probably damaging Het
Cfap54 C T 10: 92,651,820 (GRCm39) V3077I unknown Het
Erbb2 T C 11: 98,313,873 (GRCm39) L272P possibly damaging Het
Exd1 T C 2: 119,350,654 (GRCm39) T536A probably benign Het
Hoxc9 A T 15: 102,890,185 (GRCm39) H34L probably benign Het
Kif19a G T 11: 114,675,731 (GRCm39) R401L possibly damaging Het
Mad2l1bp A T 17: 46,463,933 (GRCm39) H30Q probably benign Het
Mettl13 A G 1: 162,371,855 (GRCm39) L26P probably damaging Het
Mmp16 G A 4: 18,011,501 (GRCm39) V110I possibly damaging Het
Plcb4 C T 2: 135,824,906 (GRCm39) A863V probably benign Het
Rnf168 G A 16: 32,108,028 (GRCm39) S219N probably benign Het
Serpine3 T A 14: 62,911,770 (GRCm39) L244Q probably damaging Het
Vmn1r75 T C 7: 11,614,883 (GRCm39) V205A probably damaging Het
Zscan4d A G 7: 10,895,927 (GRCm39) V481A possibly damaging Het
Other mutations in Or2m13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Or2m13 APN 16 19,226,333 (GRCm39) missense probably benign 0.03
IGL01355:Or2m13 APN 16 19,226,333 (GRCm39) missense probably benign 0.03
IGL01363:Or2m13 APN 16 19,226,333 (GRCm39) missense probably benign 0.03
IGL01467:Or2m13 APN 16 19,226,539 (GRCm39) missense probably benign 0.24
IGL02267:Or2m13 APN 16 19,225,914 (GRCm39) missense possibly damaging 0.80
R1194:Or2m13 UTSW 16 19,225,930 (GRCm39) missense possibly damaging 0.75
R1624:Or2m13 UTSW 16 19,226,454 (GRCm39) missense probably benign 0.06
R2248:Or2m13 UTSW 16 19,225,944 (GRCm39) missense probably damaging 0.98
R4865:Or2m13 UTSW 16 19,226,051 (GRCm39) missense probably damaging 0.98
R4988:Or2m13 UTSW 16 19,225,860 (GRCm39) missense probably benign 0.00
R5384:Or2m13 UTSW 16 19,226,547 (GRCm39) missense probably damaging 1.00
R5858:Or2m13 UTSW 16 19,225,975 (GRCm39) missense possibly damaging 0.91
R5997:Or2m13 UTSW 16 19,226,694 (GRCm39) missense probably benign 0.10
R6301:Or2m13 UTSW 16 19,226,167 (GRCm39) missense possibly damaging 0.96
R6703:Or2m13 UTSW 16 19,226,122 (GRCm39) missense probably benign 0.03
R6953:Or2m13 UTSW 16 19,226,278 (GRCm39) missense probably benign 0.04
R7424:Or2m13 UTSW 16 19,225,944 (GRCm39) missense probably damaging 0.98
R7975:Or2m13 UTSW 16 19,226,301 (GRCm39) missense probably damaging 1.00
R8312:Or2m13 UTSW 16 19,225,987 (GRCm39) missense probably benign 0.11
R8880:Or2m13 UTSW 16 19,226,396 (GRCm39) nonsense probably null
R9008:Or2m13 UTSW 16 19,226,173 (GRCm39) missense probably benign 0.00
R9394:Or2m13 UTSW 16 19,226,019 (GRCm39) missense probably benign
R9698:Or2m13 UTSW 16 19,226,342 (GRCm39) nonsense probably null
Z1176:Or2m13 UTSW 16 19,226,485 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTTCATGAATGCCCTGGCTAC -3'
(R):5'- TGTGGTACCAGAGAAATACCTCAC -3'

Sequencing Primer
(F):5'- ATGAATGCCCTGGCTACTTCTTTG -3'
(R):5'- CCAGAGAAATACCTCACTTTTTCTG -3'
Posted On 2018-06-22