Mutagenetix > Incidental Mutation

Incidental Mutation 'R6571:Vmn2r33'

526234

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r33

Ensembl Gene

ENSMUSG00000096691

Gene Name

vomeronasal 2, receptor 33

Synonyms

MMRRC Submission

044695-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R6571 (G1)

Quality Score

142.008

Status

Not validated

Chromosome

Chromosomal Location

7553966-7569785 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 7566668 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 148 (V148A)

Ref Sequence

ENSEMBL: ENSMUSP00000129960 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165921]

AlphaFold

K7N705

Predicted Effect

probably benign
Transcript: ENSMUST00000165921
AA Change: V148A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000129960
Gene: ENSMUSG00000096691
AA Change: V148A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	4.2e-34	PFAM
Pfam:NCD3G	512	565	4.1e-19	PFAM
Pfam:7tm_3	598	833	3.1e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.2%

Validation Efficiency

94% (31/33)

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl6	A	G	11: 54,216,390 (GRCm39)	I161V	possibly damaging	Het
Adamts12	T	C	15: 11,065,187 (GRCm39)	F24S	probably benign	Het
Bche	G	T	3: 73,608,824 (GRCm39)	Q201K	probably benign	Het
Camsap1	A	T	2: 25,829,512 (GRCm39)	D757E	possibly damaging	Het
Crebbp	C	T	16: 3,937,670 (GRCm39)	A698T	possibly damaging	Het
Dab2ip	T	C	2: 35,602,902 (GRCm39)	S399P	probably damaging	Het
Fbxo40	A	T	16: 36,789,668 (GRCm39)	C481S	probably damaging	Het
Fn1	T	A	1: 71,665,349 (GRCm39)	T923S	probably damaging	Het
Gm11437	T	C	11: 84,047,038 (GRCm39)	D147G	probably benign	Het
Gm5592	A	G	7: 40,937,999 (GRCm39)	E427G	probably damaging	Het
Gm6401	T	A	14: 41,787,452 (GRCm39)	I125F	probably damaging	Het
Hmcn1	A	T	1: 150,491,189 (GRCm39)		probably null	Het
Inpp4a	T	C	1: 37,426,839 (GRCm39)	M600T	probably damaging	Het
Itgb6	T	C	2: 60,458,800 (GRCm39)	E374G	probably damaging	Het
Lrba	A	C	3: 86,267,367 (GRCm39)	S1686R	probably damaging	Het
Map3k4	T	C	17: 12,461,579 (GRCm39)	D1200G	possibly damaging	Het
Mmp25	T	C	17: 23,858,870 (GRCm39)	H227R	probably benign	Het
Or6c38	A	C	10: 128,928,990 (GRCm39)	N284K	probably damaging	Het
Papss2	G	A	19: 32,629,342 (GRCm39)		probably null	Het
Rasal2	T	A	1: 156,988,749 (GRCm39)	R718S	possibly damaging	Het
Relch	A	G	1: 105,620,707 (GRCm39)	D394G	probably benign	Het
Rngtt	T	A	4: 33,379,413 (GRCm39)	D438E	probably damaging	Het
S1pr1	A	G	3: 115,505,452 (GRCm39)	S381P	possibly damaging	Het
Septin8	A	G	11: 53,427,990 (GRCm39)	E268G	probably damaging	Het
Slc6a21	A	G	7: 44,930,303 (GRCm39)	K234R	probably damaging	Het
Smg1	A	G	7: 117,783,737 (GRCm39)		probably benign	Het
Sntg1	T	C	1: 8,433,752 (GRCm39)		probably benign	Het
Spag5	G	T	11: 78,212,095 (GRCm39)	R1041I	probably damaging	Het
Spata31d1b	A	T	13: 59,865,269 (GRCm39)	M806L	probably benign	Het
Tnfrsf18	T	A	4: 156,112,776 (GRCm39)	L154*	probably null	Het
Trib2	T	C	12: 15,844,060 (GRCm39)	E194G	probably damaging	Het
Wiz	G	A	17: 32,578,298 (GRCm39)	R405W	probably damaging	Het
Zfp747l1	T	C	7: 126,984,310 (GRCm39)		probably benign	Het

Other mutations in Vmn2r33

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01893:Vmn2r33	APN	7	7,566,776 (GRCm39)	missense	probably benign
R1147:Vmn2r33	UTSW	7	7,557,144 (GRCm39)	missense	probably benign	0.16
R1147:Vmn2r33	UTSW	7	7,557,144 (GRCm39)	missense	probably benign	0.16
R3966:Vmn2r33	UTSW	7	7,557,168 (GRCm39)	missense	probably benign	0.00
R4408:Vmn2r33	UTSW	7	7,554,229 (GRCm39)	missense	probably damaging	1.00
R6783:Vmn2r33	UTSW	7	7,566,797 (GRCm39)	missense	probably benign
R7180:Vmn2r33	UTSW	7	7,566,896 (GRCm39)	missense	probably benign	0.00
R7984:Vmn2r33	UTSW	7	7,566,862 (GRCm39)	missense	probably benign	0.01
R8202:Vmn2r33	UTSW	7	7,557,153 (GRCm39)	missense	possibly damaging	0.87
R8894:Vmn2r33	UTSW	7	7,566,809 (GRCm39)	missense	probably benign	0.00
R8954:Vmn2r33	UTSW	7	7,554,655 (GRCm39)	missense	probably benign	0.02
R8995:Vmn2r33	UTSW	7	7,554,192 (GRCm39)	missense	probably damaging	1.00
R9027:Vmn2r33	UTSW	7	7,554,168 (GRCm39)	missense	probably damaging	1.00
R9564:Vmn2r33	UTSW	7	7,557,081 (GRCm39)	missense	probably benign	0.06
R9608:Vmn2r33	UTSW	7	7,557,153 (GRCm39)	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- AAGTATCCTGGAACAACCTAGATTG -3'
(R):5'- CAAATACGCTTTGGCATTGGC -3'

Sequencing Primer
(F):5'- CCTAGATTGACATAAGCATAAGTCC -3'
(R):5'- GGCCTTTGCAATGGATGAAATC -3'

Posted On

2018-06-22