Incidental Mutation 'R6653:Hephl1'
ID 526512
Institutional Source Beutler Lab
Gene Symbol Hephl1
Ensembl Gene ENSMUSG00000031936
Gene Name hephaestin-like 1
Synonyms zyklopen, thd, cw, Zp, LOC244698
MMRRC Submission 044774-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R6653 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 14963137-15023404 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 14993260 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 525 (V525I)
Ref Sequence ENSEMBL: ENSMUSP00000124518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159985]
AlphaFold Q3V1H3
Predicted Effect probably damaging
Transcript: ENSMUST00000159985
AA Change: V525I

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000124518
Gene: ENSMUSG00000031936
AA Change: V525I

DomainStartEndE-ValueType
low complexity region 7 22 N/A INTRINSIC
Pfam:Cu-oxidase_3 97 209 2.8e-12 PFAM
Pfam:Cu-oxidase_2 289 365 2.4e-9 PFAM
Pfam:Cu-oxidase_3 452 564 1.2e-9 PFAM
Blast:FA58C 604 703 9e-9 BLAST
Pfam:Cu-oxidase_3 805 908 1.6e-7 PFAM
Pfam:Cu-oxidase_2 946 1067 9e-14 PFAM
transmembrane domain 1115 1137 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T G 7: 119,945,229 (GRCm39) L435R probably benign Het
Abcc2 T A 19: 43,800,941 (GRCm39) H627Q probably benign Het
Ankhd1 A T 18: 36,733,836 (GRCm39) probably null Het
Ankrd50 T A 3: 38,511,510 (GRCm39) I286F probably damaging Het
Asb15 A G 6: 24,562,632 (GRCm39) N198S probably benign Het
B4galnt2 T A 11: 95,782,747 (GRCm39) M22L probably benign Het
Bcdin3d T C 15: 99,368,696 (GRCm39) T168A probably damaging Het
Bmp1 A T 14: 70,728,058 (GRCm39) W624R probably damaging Het
Cdh4 C T 2: 179,422,221 (GRCm39) A115V probably benign Het
Cfap53 A G 18: 74,433,280 (GRCm39) T122A probably damaging Het
Chsy1 A G 7: 65,759,941 (GRCm39) K95E probably benign Het
Csde1 C A 3: 102,960,184 (GRCm39) P604T probably damaging Het
Cts7 A T 13: 61,502,817 (GRCm39) L237Q probably damaging Het
Cutal C T 2: 34,775,933 (GRCm39) T88I probably benign Het
Dlg4 G T 11: 69,914,779 (GRCm39) probably benign Het
Dnah7c C A 1: 46,688,500 (GRCm39) T1890K probably benign Het
Dnah7c A G 1: 46,688,511 (GRCm39) S1894G probably benign Het
Eif2b4 C T 5: 31,349,551 (GRCm39) E53K possibly damaging Het
Erp44 T C 4: 48,205,130 (GRCm39) I288V probably null Het
Fcamr A G 1: 130,740,939 (GRCm39) T453A possibly damaging Het
Glb1l3 T C 9: 26,770,884 (GRCm39) T61A probably benign Het
Gpr26 T C 7: 131,585,830 (GRCm39) S267P probably benign Het
Heatr6 A T 11: 83,650,191 (GRCm39) T216S probably benign Het
Jak2 T A 19: 29,266,110 (GRCm39) I517N probably benign Het
Kbtbd4 T A 2: 90,740,113 (GRCm39) Y499* probably null Het
Kif1a A T 1: 93,005,420 (GRCm39) I118N probably damaging Het
Klhdc7b A G 15: 89,271,292 (GRCm39) S725G probably benign Het
Mfsd13a T C 19: 46,356,305 (GRCm39) F137L probably damaging Het
Myo7a T A 7: 97,703,710 (GRCm39) Y1977F probably damaging Het
Naip2 T G 13: 100,298,352 (GRCm39) K561N probably benign Het
Naip2 C T 13: 100,288,644 (GRCm39) V1194I probably benign Het
Nkx2-4 G T 2: 146,925,860 (GRCm39) A334E possibly damaging Het
Nlrp9c T A 7: 26,070,747 (GRCm39) N945Y probably damaging Het
Or2z2 A T 11: 58,346,394 (GRCm39) I127N probably damaging Het
Or4e5 C T 14: 52,728,250 (GRCm39) R57Q probably benign Het
Or8g20 A G 9: 39,396,048 (GRCm39) V164A probably benign Het
Pcdha7 A G 18: 37,107,539 (GRCm39) Q188R probably benign Het
Phf3 A T 1: 30,844,104 (GRCm39) S1618R possibly damaging Het
Phip C A 9: 82,782,794 (GRCm39) E884* probably null Het
Plxnc1 C A 10: 94,779,738 (GRCm39) V235L probably damaging Het
Qser1 A G 2: 104,610,605 (GRCm39) V1226A possibly damaging Het
Ros1 G T 10: 52,018,299 (GRCm39) S786R probably damaging Het
Rps6ka5 A G 12: 100,517,795 (GRCm39) S769P probably damaging Het
Sfxn3 G A 19: 45,038,354 (GRCm39) probably null Het
Specc1 T G 11: 62,037,244 (GRCm39) S813A probably damaging Het
Spry1 T C 3: 37,696,871 (GRCm39) I38T probably damaging Het
Tagap T C 17: 8,152,546 (GRCm39) V577A probably benign Het
Tmem44 T C 16: 30,356,369 (GRCm39) D110G probably damaging Het
Ubn2 A G 6: 38,411,397 (GRCm39) E97G possibly damaging Het
Ubr4 C A 4: 139,200,935 (GRCm39) H4706Q possibly damaging Het
Usp25 T A 16: 76,856,176 (GRCm39) N256K probably benign Het
Vmn2r112 T A 17: 22,820,160 (GRCm39) L11Q probably null Het
Wnt2b C A 3: 104,860,502 (GRCm39) R135L probably damaging Het
Zfp60 T C 7: 27,448,151 (GRCm39) F273S probably benign Het
Other mutations in Hephl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Hephl1 APN 9 14,978,341 (GRCm39) missense probably benign 0.06
IGL01105:Hephl1 APN 9 15,000,320 (GRCm39) missense possibly damaging 0.95
IGL01731:Hephl1 APN 9 14,981,066 (GRCm39) missense probably damaging 1.00
IGL02010:Hephl1 APN 9 15,001,852 (GRCm39) nonsense probably null
IGL02112:Hephl1 APN 9 14,993,111 (GRCm39) splice site probably benign
IGL02227:Hephl1 APN 9 14,981,089 (GRCm39) missense probably damaging 1.00
IGL02490:Hephl1 APN 9 14,964,981 (GRCm39) missense probably benign 0.06
IGL02960:Hephl1 APN 9 14,995,615 (GRCm39) missense probably damaging 1.00
IGL03265:Hephl1 APN 9 14,972,255 (GRCm39) missense probably benign 0.14
R0006:Hephl1 UTSW 9 14,988,060 (GRCm39) missense probably benign 0.16
R0006:Hephl1 UTSW 9 14,988,060 (GRCm39) missense probably benign 0.16
R0007:Hephl1 UTSW 9 14,997,471 (GRCm39) missense possibly damaging 0.58
R0092:Hephl1 UTSW 9 15,001,899 (GRCm39) frame shift probably null
R0421:Hephl1 UTSW 9 14,970,456 (GRCm39) missense probably benign 0.05
R0448:Hephl1 UTSW 9 14,988,222 (GRCm39) missense probably damaging 1.00
R0563:Hephl1 UTSW 9 14,993,241 (GRCm39) missense probably damaging 1.00
R0602:Hephl1 UTSW 9 15,000,347 (GRCm39) missense probably damaging 0.99
R0631:Hephl1 UTSW 9 14,995,820 (GRCm39) missense probably benign 0.04
R0747:Hephl1 UTSW 9 14,965,297 (GRCm39) splice site probably benign
R1123:Hephl1 UTSW 9 14,991,436 (GRCm39) missense probably benign 0.00
R1386:Hephl1 UTSW 9 14,988,050 (GRCm39) missense probably benign
R1711:Hephl1 UTSW 9 14,970,542 (GRCm39) missense probably damaging 1.00
R1743:Hephl1 UTSW 9 15,001,364 (GRCm39) missense probably damaging 0.99
R1833:Hephl1 UTSW 9 14,988,224 (GRCm39) missense probably damaging 0.99
R1908:Hephl1 UTSW 9 14,985,420 (GRCm39) nonsense probably null
R1918:Hephl1 UTSW 9 14,988,114 (GRCm39) missense probably benign 0.16
R1938:Hephl1 UTSW 9 14,965,283 (GRCm39) missense possibly damaging 0.88
R1986:Hephl1 UTSW 9 14,965,848 (GRCm39) missense probably damaging 1.00
R3122:Hephl1 UTSW 9 15,000,265 (GRCm39) missense possibly damaging 0.90
R3832:Hephl1 UTSW 9 14,981,044 (GRCm39) missense probably damaging 1.00
R3833:Hephl1 UTSW 9 14,981,044 (GRCm39) missense probably damaging 1.00
R4280:Hephl1 UTSW 9 15,023,330 (GRCm39) missense probably benign 0.05
R4434:Hephl1 UTSW 9 14,988,092 (GRCm39) missense probably damaging 0.99
R4790:Hephl1 UTSW 9 14,970,467 (GRCm39) missense probably damaging 1.00
R4793:Hephl1 UTSW 9 15,009,286 (GRCm39) missense probably benign 0.34
R4960:Hephl1 UTSW 9 14,997,586 (GRCm39) missense probably damaging 1.00
R5125:Hephl1 UTSW 9 14,997,468 (GRCm39) missense probably damaging 0.98
R5152:Hephl1 UTSW 9 14,991,481 (GRCm39) missense probably damaging 1.00
R5178:Hephl1 UTSW 9 14,997,468 (GRCm39) missense probably damaging 0.98
R5288:Hephl1 UTSW 9 14,988,150 (GRCm39) missense possibly damaging 0.83
R5372:Hephl1 UTSW 9 15,009,195 (GRCm39) nonsense probably null
R5377:Hephl1 UTSW 9 14,981,084 (GRCm39) missense probably damaging 1.00
R5788:Hephl1 UTSW 9 14,995,579 (GRCm39) missense possibly damaging 0.93
R5795:Hephl1 UTSW 9 14,981,056 (GRCm39) missense probably damaging 0.99
R6210:Hephl1 UTSW 9 15,001,860 (GRCm39) missense possibly damaging 0.57
R6303:Hephl1 UTSW 9 15,001,448 (GRCm39) missense possibly damaging 0.69
R6394:Hephl1 UTSW 9 14,985,397 (GRCm39) missense probably benign 0.00
R6764:Hephl1 UTSW 9 15,000,217 (GRCm39) missense possibly damaging 0.88
R7114:Hephl1 UTSW 9 14,981,111 (GRCm39) missense probably damaging 0.96
R7143:Hephl1 UTSW 9 14,972,106 (GRCm39) missense possibly damaging 0.80
R7404:Hephl1 UTSW 9 14,981,047 (GRCm39) missense possibly damaging 0.84
R7446:Hephl1 UTSW 9 15,009,347 (GRCm39) missense probably damaging 1.00
R7447:Hephl1 UTSW 9 15,009,178 (GRCm39) critical splice donor site probably null
R7715:Hephl1 UTSW 9 14,972,081 (GRCm39) missense probably benign 0.36
R8013:Hephl1 UTSW 9 14,965,905 (GRCm39) missense possibly damaging 0.78
R8156:Hephl1 UTSW 9 14,972,210 (GRCm39) missense possibly damaging 0.77
R8755:Hephl1 UTSW 9 15,023,280 (GRCm39) missense probably damaging 1.00
R8755:Hephl1 UTSW 9 14,985,563 (GRCm39) missense probably benign
R8777:Hephl1 UTSW 9 14,972,090 (GRCm39) missense probably benign 0.24
R8777-TAIL:Hephl1 UTSW 9 14,972,090 (GRCm39) missense probably benign 0.24
R9090:Hephl1 UTSW 9 14,988,236 (GRCm39) missense probably damaging 1.00
R9155:Hephl1 UTSW 9 15,000,375 (GRCm39) missense probably damaging 1.00
R9271:Hephl1 UTSW 9 14,988,236 (GRCm39) missense probably damaging 1.00
R9287:Hephl1 UTSW 9 14,995,775 (GRCm39) missense probably benign 0.01
R9487:Hephl1 UTSW 9 14,995,830 (GRCm39) missense possibly damaging 0.84
X0026:Hephl1 UTSW 9 14,995,524 (GRCm39) critical splice donor site probably null
X0066:Hephl1 UTSW 9 14,964,964 (GRCm39) missense probably benign 0.00
Z1088:Hephl1 UTSW 9 14,965,017 (GRCm39) missense probably damaging 1.00
Z1177:Hephl1 UTSW 9 15,001,350 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACAGCCCTGGAAAGAGTGTG -3'
(R):5'- TGAAGCCCAGGGAATCTCTG -3'

Sequencing Primer
(F):5'- TGGTGACATTGGTGGCCCAC -3'
(R):5'- TTTGTGAGGAAAAACGGCCTTC -3'
Posted On 2018-07-23