Mutagenetix > Incidental Mutation

Incidental Mutation 'R6653:Ros1'

526516

Institutional Source

Beutler Lab

Gene Symbol

Ros1

Ensembl Gene

ENSMUSG00000019893

Gene Name

Ros1 proto-oncogene

Synonyms

Ros-1, c-ros

MMRRC Submission

044774-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.142) question?

Stock #

R6653 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

51921817-52071340 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 52018299 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 786 (S786R)

Ref Sequence

ENSEMBL: ENSMUSP00000151720 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020045] [ENSMUST00000218452] [ENSMUST00000219173] [ENSMUST00000219692]

AlphaFold

Q78DX7

Predicted Effect

probably damaging
Transcript: ENSMUST00000020045
AA Change: S807R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000020045
Gene: ENSMUSG00000019893
AA Change: S807R

Domain	Start	End	E-Value	Type
transmembrane domain	7	26	N/A	INTRINSIC
FN3	109	187	1.05e-4	SMART
FN3	205	282	7.45e-10	SMART
LY	369	409	9.17e0	SMART
FN3	568	654	2.24e-4	SMART
LY	734	776	2.28e1	SMART
LY	777	815	4.61e0	SMART
FN3	944	1023	5.53e-4	SMART
FN3	1037	1133	1.07e1	SMART
FN3	1440	1532	1.19e1	SMART
FN3	1551	1637	2.11e0	SMART
FN3	1649	1731	6.8e-4	SMART
FN3	1746	1832	2.7e1	SMART
TyrKc	1938	2208	1.3e-145	SMART
low complexity region	2294	2307	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000218452
AA Change: S786R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000219173
AA Change: S786R

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)

Predicted Effect

probably benign
Transcript: ENSMUST00000219692

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit male infertility due to impaired sperm maturation in the epididymis. Mutant sperm are capable of fertilization in vitro but not in vivo. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca15	T	G	7: 119,945,229 (GRCm39)	L435R	probably benign	Het
Abcc2	T	A	19: 43,800,941 (GRCm39)	H627Q	probably benign	Het
Ankhd1	A	T	18: 36,733,836 (GRCm39)		probably null	Het
Ankrd50	T	A	3: 38,511,510 (GRCm39)	I286F	probably damaging	Het
Asb15	A	G	6: 24,562,632 (GRCm39)	N198S	probably benign	Het
B4galnt2	T	A	11: 95,782,747 (GRCm39)	M22L	probably benign	Het
Bcdin3d	T	C	15: 99,368,696 (GRCm39)	T168A	probably damaging	Het
Bmp1	A	T	14: 70,728,058 (GRCm39)	W624R	probably damaging	Het
Cdh4	C	T	2: 179,422,221 (GRCm39)	A115V	probably benign	Het
Cfap53	A	G	18: 74,433,280 (GRCm39)	T122A	probably damaging	Het
Chsy1	A	G	7: 65,759,941 (GRCm39)	K95E	probably benign	Het
Csde1	C	A	3: 102,960,184 (GRCm39)	P604T	probably damaging	Het
Cts7	A	T	13: 61,502,817 (GRCm39)	L237Q	probably damaging	Het
Cutal	C	T	2: 34,775,933 (GRCm39)	T88I	probably benign	Het
Dlg4	G	T	11: 69,914,779 (GRCm39)		probably benign	Het
Dnah7c	C	A	1: 46,688,500 (GRCm39)	T1890K	probably benign	Het
Dnah7c	A	G	1: 46,688,511 (GRCm39)	S1894G	probably benign	Het
Eif2b4	C	T	5: 31,349,551 (GRCm39)	E53K	possibly damaging	Het
Erp44	T	C	4: 48,205,130 (GRCm39)	I288V	probably null	Het
Fcamr	A	G	1: 130,740,939 (GRCm39)	T453A	possibly damaging	Het
Glb1l3	T	C	9: 26,770,884 (GRCm39)	T61A	probably benign	Het
Gpr26	T	C	7: 131,585,830 (GRCm39)	S267P	probably benign	Het
Heatr6	A	T	11: 83,650,191 (GRCm39)	T216S	probably benign	Het
Hephl1	C	T	9: 14,993,260 (GRCm39)	V525I	probably damaging	Het
Jak2	T	A	19: 29,266,110 (GRCm39)	I517N	probably benign	Het
Kbtbd4	T	A	2: 90,740,113 (GRCm39)	Y499*	probably null	Het
Kif1a	A	T	1: 93,005,420 (GRCm39)	I118N	probably damaging	Het
Klhdc7b	A	G	15: 89,271,292 (GRCm39)	S725G	probably benign	Het
Mfsd13a	T	C	19: 46,356,305 (GRCm39)	F137L	probably damaging	Het
Myo7a	T	A	7: 97,703,710 (GRCm39)	Y1977F	probably damaging	Het
Naip2	T	G	13: 100,298,352 (GRCm39)	K561N	probably benign	Het
Naip2	C	T	13: 100,288,644 (GRCm39)	V1194I	probably benign	Het
Nkx2-4	G	T	2: 146,925,860 (GRCm39)	A334E	possibly damaging	Het
Nlrp9c	T	A	7: 26,070,747 (GRCm39)	N945Y	probably damaging	Het
Or2z2	A	T	11: 58,346,394 (GRCm39)	I127N	probably damaging	Het
Or4e5	C	T	14: 52,728,250 (GRCm39)	R57Q	probably benign	Het
Or8g20	A	G	9: 39,396,048 (GRCm39)	V164A	probably benign	Het
Pcdha7	A	G	18: 37,107,539 (GRCm39)	Q188R	probably benign	Het
Phf3	A	T	1: 30,844,104 (GRCm39)	S1618R	possibly damaging	Het
Phip	C	A	9: 82,782,794 (GRCm39)	E884*	probably null	Het
Plxnc1	C	A	10: 94,779,738 (GRCm39)	V235L	probably damaging	Het
Qser1	A	G	2: 104,610,605 (GRCm39)	V1226A	possibly damaging	Het
Rps6ka5	A	G	12: 100,517,795 (GRCm39)	S769P	probably damaging	Het
Sfxn3	G	A	19: 45,038,354 (GRCm39)		probably null	Het
Specc1	T	G	11: 62,037,244 (GRCm39)	S813A	probably damaging	Het
Spry1	T	C	3: 37,696,871 (GRCm39)	I38T	probably damaging	Het
Tagap	T	C	17: 8,152,546 (GRCm39)	V577A	probably benign	Het
Tmem44	T	C	16: 30,356,369 (GRCm39)	D110G	probably damaging	Het
Ubn2	A	G	6: 38,411,397 (GRCm39)	E97G	possibly damaging	Het
Ubr4	C	A	4: 139,200,935 (GRCm39)	H4706Q	possibly damaging	Het
Usp25	T	A	16: 76,856,176 (GRCm39)	N256K	probably benign	Het
Vmn2r112	T	A	17: 22,820,160 (GRCm39)	L11Q	probably null	Het
Wnt2b	C	A	3: 104,860,502 (GRCm39)	R135L	probably damaging	Het
Zfp60	T	C	7: 27,448,151 (GRCm39)	F273S	probably benign	Het

Other mutations in Ros1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00236:Ros1	APN	10	52,070,986 (GRCm39)	missense	probably benign	0.01
IGL00338:Ros1	APN	10	52,001,907 (GRCm39)	missense	probably benign
IGL00419:Ros1	APN	10	51,967,150 (GRCm39)	missense	probably damaging	0.97
IGL00840:Ros1	APN	10	52,020,969 (GRCm39)	missense	possibly damaging	0.92
IGL00841:Ros1	APN	10	52,020,969 (GRCm39)	missense	possibly damaging	0.92
IGL00951:Ros1	APN	10	52,019,348 (GRCm39)	missense	probably damaging	0.99
IGL01123:Ros1	APN	10	51,996,905 (GRCm39)	missense	probably damaging	1.00
IGL01128:Ros1	APN	10	52,018,424 (GRCm39)	nonsense	probably null
IGL01300:Ros1	APN	10	51,977,809 (GRCm39)	missense	probably benign	0.01
IGL01316:Ros1	APN	10	51,963,975 (GRCm39)	critical splice donor site	probably null
IGL01349:Ros1	APN	10	51,927,122 (GRCm39)	missense	probably damaging	0.99
IGL01363:Ros1	APN	10	52,042,238 (GRCm39)	missense	probably damaging	1.00
IGL01457:Ros1	APN	10	51,922,426 (GRCm39)	splice site	probably benign
IGL01532:Ros1	APN	10	51,967,034 (GRCm39)	splice site	probably benign
IGL01585:Ros1	APN	10	52,031,198 (GRCm39)	missense	probably damaging	1.00
IGL01650:Ros1	APN	10	52,031,075 (GRCm39)	missense	probably damaging	0.99
IGL01672:Ros1	APN	10	51,977,899 (GRCm39)	missense	possibly damaging	0.92
IGL01904:Ros1	APN	10	51,954,007 (GRCm39)	missense	probably damaging	0.97
IGL02040:Ros1	APN	10	51,992,018 (GRCm39)	missense	probably damaging	0.99
IGL02053:Ros1	APN	10	52,038,816 (GRCm39)	missense	probably damaging	1.00
IGL02147:Ros1	APN	10	51,996,991 (GRCm39)	missense	probably damaging	1.00
IGL02169:Ros1	APN	10	51,958,053 (GRCm39)	critical splice donor site	probably null
IGL02247:Ros1	APN	10	52,005,677 (GRCm39)	missense	probably damaging	0.99
IGL02262:Ros1	APN	10	52,055,065 (GRCm39)	missense	probably damaging	0.96
IGL02307:Ros1	APN	10	52,004,534 (GRCm39)	missense	possibly damaging	0.53
IGL02398:Ros1	APN	10	52,020,980 (GRCm39)	splice site	probably benign
IGL02525:Ros1	APN	10	51,992,138 (GRCm39)	missense	possibly damaging	0.66
IGL02718:Ros1	APN	10	51,994,328 (GRCm39)	missense	probably damaging	1.00
IGL02721:Ros1	APN	10	52,048,927 (GRCm39)	splice site	probably benign
IGL02808:Ros1	APN	10	52,001,985 (GRCm39)	missense	probably damaging	1.00
IGL03009:Ros1	APN	10	52,022,003 (GRCm39)	missense	probably benign	0.00
IGL03035:Ros1	APN	10	51,952,080 (GRCm39)	splice site	probably benign
IGL03092:Ros1	APN	10	51,974,902 (GRCm39)	missense	probably damaging	0.99
IGL03309:Ros1	APN	10	51,994,357 (GRCm39)	missense	possibly damaging	0.83
IGL03333:Ros1	APN	10	52,031,267 (GRCm39)	missense	probably damaging	1.00
boss	UTSW	10	51,967,091 (GRCm39)	nonsense	probably null
Chuckwagon	UTSW	10	51,994,299 (GRCm39)	missense	probably damaging	1.00
R1005_Ros1_648	UTSW	10	52,004,501 (GRCm39)	splice site	probably benign
R1220_Ros1_012	UTSW	10	51,974,966 (GRCm39)	missense	probably damaging	0.97
R3423_Ros1_122	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
trail	UTSW	10	52,037,991 (GRCm39)	nonsense	probably null
R0049:Ros1	UTSW	10	51,977,857 (GRCm39)	missense	possibly damaging	0.66
R0049:Ros1	UTSW	10	51,977,857 (GRCm39)	missense	possibly damaging	0.66
R0050:Ros1	UTSW	10	51,977,899 (GRCm39)	missense	probably damaging	0.97
R0050:Ros1	UTSW	10	51,977,899 (GRCm39)	missense	probably damaging	0.97
R0057:Ros1	UTSW	10	52,056,287 (GRCm39)	missense	probably benign	0.00
R0057:Ros1	UTSW	10	52,056,287 (GRCm39)	missense	probably benign	0.00
R0106:Ros1	UTSW	10	52,018,363 (GRCm39)	missense	possibly damaging	0.85
R0106:Ros1	UTSW	10	52,018,363 (GRCm39)	missense	possibly damaging	0.85
R0125:Ros1	UTSW	10	52,001,885 (GRCm39)	missense	probably benign	0.38
R0403:Ros1	UTSW	10	52,019,534 (GRCm39)	splice site	probably benign
R0487:Ros1	UTSW	10	52,031,204 (GRCm39)	missense	possibly damaging	0.69
R0502:Ros1	UTSW	10	52,070,919 (GRCm39)	splice site	probably benign
R0557:Ros1	UTSW	10	51,961,359 (GRCm39)	missense	possibly damaging	0.82
R0599:Ros1	UTSW	10	51,999,396 (GRCm39)	missense	probably damaging	1.00
R0620:Ros1	UTSW	10	51,994,444 (GRCm39)	missense	probably damaging	1.00
R0679:Ros1	UTSW	10	51,942,391 (GRCm39)	missense	possibly damaging	0.95
R1005:Ros1	UTSW	10	52,004,501 (GRCm39)	splice site	probably benign
R1073:Ros1	UTSW	10	51,922,221 (GRCm39)	missense	probably damaging	1.00
R1220:Ros1	UTSW	10	51,974,966 (GRCm39)	missense	probably damaging	0.97
R1279:Ros1	UTSW	10	52,018,262 (GRCm39)	missense	possibly damaging	0.81
R1295:Ros1	UTSW	10	51,964,028 (GRCm39)	missense	possibly damaging	0.92
R1336:Ros1	UTSW	10	52,044,758 (GRCm39)	missense	probably damaging	1.00
R1371:Ros1	UTSW	10	51,964,041 (GRCm39)	missense	probably damaging	0.98
R1447:Ros1	UTSW	10	51,974,954 (GRCm39)	missense	possibly damaging	0.66
R1486:Ros1	UTSW	10	52,048,954 (GRCm39)	missense	probably damaging	1.00
R1499:Ros1	UTSW	10	51,974,773 (GRCm39)	missense	possibly damaging	0.92
R1669:Ros1	UTSW	10	52,037,907 (GRCm39)	missense	probably damaging	1.00
R1744:Ros1	UTSW	10	51,999,475 (GRCm39)	missense	probably damaging	0.99
R1759:Ros1	UTSW	10	51,996,922 (GRCm39)	missense	probably damaging	1.00
R1791:Ros1	UTSW	10	51,976,183 (GRCm39)	missense	probably benign	0.00
R1794:Ros1	UTSW	10	52,000,199 (GRCm39)	nonsense	probably null
R2031:Ros1	UTSW	10	51,943,164 (GRCm39)	missense	possibly damaging	0.88
R2115:Ros1	UTSW	10	52,004,651 (GRCm39)	missense	probably benign	0.00
R2219:Ros1	UTSW	10	52,042,175 (GRCm39)	missense	probably damaging	1.00
R2290:Ros1	UTSW	10	51,994,477 (GRCm39)	missense	probably damaging	0.96
R2329:Ros1	UTSW	10	52,038,983 (GRCm39)	missense	probably damaging	1.00
R2371:Ros1	UTSW	10	52,039,991 (GRCm39)	missense	possibly damaging	0.66
R2879:Ros1	UTSW	10	52,048,936 (GRCm39)	critical splice donor site	probably null
R3154:Ros1	UTSW	10	51,927,077 (GRCm39)	missense	probably benign
R3423:Ros1	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
R3424:Ros1	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
R3425:Ros1	UTSW	10	52,004,512 (GRCm39)	splice site	probably null
R3433:Ros1	UTSW	10	51,967,204 (GRCm39)	missense	probably benign	0.45
R3522:Ros1	UTSW	10	51,967,091 (GRCm39)	nonsense	probably null
R3686:Ros1	UTSW	10	52,021,912 (GRCm39)	missense	probably damaging	1.00
R3710:Ros1	UTSW	10	52,037,991 (GRCm39)	nonsense	probably null
R3771:Ros1	UTSW	10	52,005,087 (GRCm39)	missense	probably damaging	0.97
R3808:Ros1	UTSW	10	51,996,944 (GRCm39)	missense	probably benign	0.08
R3930:Ros1	UTSW	10	52,070,944 (GRCm39)	missense	possibly damaging	0.92
R3950:Ros1	UTSW	10	51,942,484 (GRCm39)	missense	probably damaging	1.00
R3981:Ros1	UTSW	10	51,996,974 (GRCm39)	missense	possibly damaging	0.46
R4007:Ros1	UTSW	10	51,994,328 (GRCm39)	missense	probably damaging	1.00
R4346:Ros1	UTSW	10	52,044,705 (GRCm39)	missense	possibly damaging	0.92
R4382:Ros1	UTSW	10	51,997,055 (GRCm39)	missense	possibly damaging	0.46
R4414:Ros1	UTSW	10	52,038,800 (GRCm39)	critical splice donor site	probably null
R4450:Ros1	UTSW	10	51,954,038 (GRCm39)	missense	probably damaging	0.98
R4468:Ros1	UTSW	10	51,994,452 (GRCm39)	missense	probably damaging	1.00
R4569:Ros1	UTSW	10	52,040,090 (GRCm39)	missense	probably damaging	0.99
R4649:Ros1	UTSW	10	52,005,764 (GRCm39)	missense	possibly damaging	0.66
R4684:Ros1	UTSW	10	52,005,192 (GRCm39)	missense	probably damaging	1.00
R4706:Ros1	UTSW	10	51,977,990 (GRCm39)	missense	possibly damaging	0.95
R4731:Ros1	UTSW	10	52,018,325 (GRCm39)	missense	probably damaging	1.00
R4748:Ros1	UTSW	10	51,992,093 (GRCm39)	missense	probably benign	0.00
R4806:Ros1	UTSW	10	51,972,271 (GRCm39)	missense	probably damaging	0.96
R4865:Ros1	UTSW	10	52,048,966 (GRCm39)	missense	probably damaging	0.99
R4973:Ros1	UTSW	10	52,031,087 (GRCm39)	missense	probably damaging	0.98
R5022:Ros1	UTSW	10	52,000,171 (GRCm39)	missense	possibly damaging	0.46
R5033:Ros1	UTSW	10	52,004,512 (GRCm39)	critical splice donor site	probably null
R5082:Ros1	UTSW	10	52,040,037 (GRCm39)	missense	possibly damaging	0.66
R5083:Ros1	UTSW	10	52,040,037 (GRCm39)	missense	possibly damaging	0.66
R5130:Ros1	UTSW	10	52,040,037 (GRCm39)	missense	possibly damaging	0.66
R5269:Ros1	UTSW	10	51,927,104 (GRCm39)	missense	probably damaging	1.00
R5399:Ros1	UTSW	10	51,967,040 (GRCm39)	critical splice donor site	probably null
R5414:Ros1	UTSW	10	52,031,189 (GRCm39)	missense	probably damaging	1.00
R5659:Ros1	UTSW	10	52,019,482 (GRCm39)	missense	possibly damaging	0.92
R5742:Ros1	UTSW	10	52,018,234 (GRCm39)	critical splice donor site	probably null
R5780:Ros1	UTSW	10	52,070,953 (GRCm39)	missense	probably damaging	1.00
R5805:Ros1	UTSW	10	51,999,385 (GRCm39)	missense	probably damaging	1.00
R5843:Ros1	UTSW	10	52,042,293 (GRCm39)	missense	possibly damaging	0.92
R5881:Ros1	UTSW	10	52,057,894 (GRCm39)	missense	probably benign	0.26
R6027:Ros1	UTSW	10	52,040,064 (GRCm39)	missense	possibly damaging	0.82
R6035:Ros1	UTSW	10	51,954,067 (GRCm39)	missense	probably benign
R6035:Ros1	UTSW	10	51,954,067 (GRCm39)	missense	probably benign
R6052:Ros1	UTSW	10	52,039,999 (GRCm39)	missense	probably benign	0.39
R6175:Ros1	UTSW	10	51,977,881 (GRCm39)	missense	probably benign	0.02
R6315:Ros1	UTSW	10	51,994,306 (GRCm39)	missense	probably benign
R6342:Ros1	UTSW	10	52,031,351 (GRCm39)	missense	probably damaging	1.00
R6470:Ros1	UTSW	10	52,042,140 (GRCm39)	critical splice donor site	probably null
R6527:Ros1	UTSW	10	52,019,473 (GRCm39)	missense	possibly damaging	0.66
R6568:Ros1	UTSW	10	52,038,908 (GRCm39)	missense	probably damaging	1.00
R6573:Ros1	UTSW	10	52,031,106 (GRCm39)	missense	possibly damaging	0.84
R6959:Ros1	UTSW	10	52,040,090 (GRCm39)	missense	probably damaging	0.99
R7011:Ros1	UTSW	10	52,056,272 (GRCm39)	missense	probably damaging	1.00
R7111:Ros1	UTSW	10	52,057,906 (GRCm39)	missense	probably benign	0.02
R7243:Ros1	UTSW	10	51,999,477 (GRCm39)	missense	probably damaging	1.00
R7355:Ros1	UTSW	10	52,042,175 (GRCm39)	missense	probably damaging	1.00
R7385:Ros1	UTSW	10	52,031,222 (GRCm39)	missense	probably benign	0.00
R7460:Ros1	UTSW	10	51,994,299 (GRCm39)	missense	probably damaging	1.00
R7549:Ros1	UTSW	10	52,021,930 (GRCm39)	missense	probably damaging	0.96
R7573:Ros1	UTSW	10	52,046,072 (GRCm39)	missense	probably benign	0.03
R7650:Ros1	UTSW	10	51,922,305 (GRCm39)	missense	probably benign	0.00
R7667:Ros1	UTSW	10	52,040,067 (GRCm39)	missense	probably damaging	1.00
R7696:Ros1	UTSW	10	52,018,379 (GRCm39)	missense	probably damaging	1.00
R7785:Ros1	UTSW	10	52,038,944 (GRCm39)	missense	probably damaging	1.00
R7814:Ros1	UTSW	10	51,972,233 (GRCm39)	missense	probably benign	0.28
R7830:Ros1	UTSW	10	52,031,030 (GRCm39)	missense	probably damaging	0.99
R7832:Ros1	UTSW	10	52,020,957 (GRCm39)	missense	probably damaging	0.99
R7854:Ros1	UTSW	10	52,004,563 (GRCm39)	missense	probably damaging	1.00
R7912:Ros1	UTSW	10	52,044,791 (GRCm39)	missense	probably damaging	1.00
R7972:Ros1	UTSW	10	52,030,926 (GRCm39)	nonsense	probably null
R7993:Ros1	UTSW	10	51,999,443 (GRCm39)	missense	probably benign	0.34
R8036:Ros1	UTSW	10	52,041,439 (GRCm39)	missense	probably benign
R8137:Ros1	UTSW	10	52,001,933 (GRCm39)	missense	possibly damaging	0.87
R8169:Ros1	UTSW	10	51,940,768 (GRCm39)	critical splice donor site	probably null
R8199:Ros1	UTSW	10	51,977,813 (GRCm39)	nonsense	probably null
R8293:Ros1	UTSW	10	51,964,014 (GRCm39)	missense	probably damaging	1.00
R8368:Ros1	UTSW	10	51,940,833 (GRCm39)	missense	probably damaging	1.00
R8406:Ros1	UTSW	10	51,977,941 (GRCm39)	missense	possibly damaging	0.56
R8471:Ros1	UTSW	10	51,997,078 (GRCm39)	missense	probably benign	0.00
R8498:Ros1	UTSW	10	52,055,047 (GRCm39)	missense	probably damaging	0.99
R8532:Ros1	UTSW	10	51,974,852 (GRCm39)	missense	possibly damaging	0.92
R8678:Ros1	UTSW	10	51,963,998 (GRCm39)	missense	probably benign
R8726:Ros1	UTSW	10	51,954,769 (GRCm39)	missense	possibly damaging	0.46
R8789:Ros1	UTSW	10	51,999,328 (GRCm39)	missense	probably damaging	0.99
R8799:Ros1	UTSW	10	51,922,143 (GRCm39)	missense	probably benign	0.08
R8915:Ros1	UTSW	10	51,977,805 (GRCm39)	splice site	probably benign
R8958:Ros1	UTSW	10	51,972,190 (GRCm39)	missense	probably damaging	1.00
R8972:Ros1	UTSW	10	51,999,333 (GRCm39)	missense	probably benign	0.05
R9020:Ros1	UTSW	10	52,031,023 (GRCm39)	missense	probably benign	0.32
R9147:Ros1	UTSW	10	51,927,039 (GRCm39)	missense	probably benign
R9154:Ros1	UTSW	10	51,922,301 (GRCm39)	missense	possibly damaging	0.87
R9189:Ros1	UTSW	10	52,019,502 (GRCm39)	missense	probably damaging	0.99
R9341:Ros1	UTSW	10	51,972,116 (GRCm39)	critical splice donor site	probably null
R9343:Ros1	UTSW	10	51,972,116 (GRCm39)	critical splice donor site	probably null
R9407:Ros1	UTSW	10	51,994,491 (GRCm39)	missense	probably damaging	1.00
R9428:Ros1	UTSW	10	51,958,061 (GRCm39)	missense	probably benign	0.00
R9502:Ros1	UTSW	10	52,000,174 (GRCm39)	missense	probably benign	0.00
R9531:Ros1	UTSW	10	52,007,063 (GRCm39)	missense	probably damaging	1.00
R9546:Ros1	UTSW	10	51,994,215 (GRCm39)	critical splice donor site	probably null
R9562:Ros1	UTSW	10	51,943,170 (GRCm39)	missense	probably damaging	1.00
R9565:Ros1	UTSW	10	51,943,170 (GRCm39)	missense	probably damaging	1.00
R9604:Ros1	UTSW	10	51,994,249 (GRCm39)	missense	probably damaging	1.00
R9645:Ros1	UTSW	10	51,948,148 (GRCm39)	critical splice donor site	probably null
R9658:Ros1	UTSW	10	51,967,069 (GRCm39)	missense	probably damaging	0.99
R9664:Ros1	UTSW	10	51,996,931 (GRCm39)	missense	probably benign	0.18
RF018:Ros1	UTSW	10	52,031,217 (GRCm39)	missense	probably benign
Z1176:Ros1	UTSW	10	51,967,205 (GRCm39)	missense	possibly damaging	0.89
Z1177:Ros1	UTSW	10	52,044,767 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CTGTGATCTTATTCTAACGGTGATC -3'
(R):5'- GATTGACTGGATTTCACCATTCAG -3'

Sequencing Primer
(F):5'- GCAGCACTGTCACAACTAT -3'
(R):5'- CCATTCAGAAGTGATGATGCC -3'

Posted On

2018-07-23