Incidental Mutation 'R6656:Gm21190'
ID 526616
Institutional Source Beutler Lab
Gene Symbol Gm21190
Ensembl Gene ENSMUSG00000106445
Gene Name predicted gene, 21190
Synonyms
MMRRC Submission 044777-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R6656 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 15729454-15734220 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 15730849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 169 (Q169R)
Ref Sequence ENSEMBL: ENSMUSP00000143589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000196384]
AlphaFold A0A0G2JGJ6
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178227
SMART Domains Protein: ENSMUSP00000136079
Gene: ENSMUSG00000094230

DomainStartEndE-ValueType
low complexity region 43 54 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000196384
AA Change: Q169R

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000143589
Gene: ENSMUSG00000106445
AA Change: Q169R

DomainStartEndE-ValueType
Pfam:Takusan 50 134 7.3e-32 PFAM
low complexity region 234 258 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198681
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.8%
Validation Efficiency 97% (35/36)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 T C 1: 179,581,078 (GRCm39) N1708S probably benign Het
Ahnak2 C T 12: 112,748,991 (GRCm39) M285I probably benign Het
Angptl1 A T 1: 156,684,806 (GRCm39) D325V probably damaging Het
Anln A T 9: 22,262,298 (GRCm39) V931E probably damaging Het
Ascc3 C T 10: 50,526,021 (GRCm39) R578* probably null Het
B3galnt2 C T 13: 14,150,161 (GRCm39) A168V probably benign Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Cd22 T C 7: 30,577,182 (GRCm39) I42V probably benign Het
Cyp2b19 C T 7: 26,466,280 (GRCm39) T361I probably benign Het
D930048N14Rik C A 11: 51,544,576 (GRCm39) probably benign Het
Ehf T C 2: 103,113,928 (GRCm39) N23S probably damaging Het
Eif2ak3 T A 6: 70,860,699 (GRCm39) I425N probably damaging Het
Fbxo4 C T 15: 4,005,305 (GRCm39) V192M probably damaging Het
Gngt1 A G 6: 3,994,246 (GRCm39) D8G possibly damaging Het
Ift140 T C 17: 25,251,147 (GRCm39) L31P probably damaging Het
Keg1 C T 19: 12,686,994 (GRCm39) Q8* probably null Het
Lama3 T A 18: 12,682,283 (GRCm39) M1083K possibly damaging Het
Lrp1b A T 2: 40,527,876 (GRCm39) Y68* probably null Het
Lyz3 A G 10: 117,071,534 (GRCm39) V115A probably benign Het
Mctp1 A T 13: 77,178,055 (GRCm39) K947N probably damaging Het
Muc5ac A G 7: 141,357,065 (GRCm39) Y1113C probably damaging Het
Myb C T 10: 21,028,844 (GRCm39) V85M probably damaging Het
Npas2 T G 1: 39,401,029 (GRCm39) S798A unknown Het
Or13a21 G T 7: 139,999,517 (GRCm39) H56Q probably damaging Het
Orc2 A G 1: 58,532,818 (GRCm39) probably null Het
Parpbp T C 10: 87,946,175 (GRCm39) T415A probably benign Het
Pcdha3 T C 18: 37,080,875 (GRCm39) V539A probably benign Het
Piwil4 T C 9: 14,621,230 (GRCm39) E601G probably damaging Het
Pramel51 A T 12: 88,142,763 (GRCm39) L285Q possibly damaging Het
Ptpn3 T A 4: 57,205,905 (GRCm39) I696F probably damaging Het
Sec63 C T 10: 42,692,379 (GRCm39) Q617* probably null Het
Sgip1 C A 4: 102,762,765 (GRCm39) probably benign Het
Sirpd T C 3: 15,385,558 (GRCm39) T115A probably damaging Het
Tktl2 T C 8: 66,965,381 (GRCm39) V313A probably benign Het
Tmem63b C A 17: 45,978,634 (GRCm39) R325L probably benign Het
Ttn C T 2: 76,539,700 (GRCm39) G34429R probably damaging Het
Other mutations in Gm21190
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5992:Gm21190 UTSW 5 15,729,849 (GRCm39) missense probably damaging 0.97
R7345:Gm21190 UTSW 5 15,732,902 (GRCm39) splice site probably null
R7658:Gm21190 UTSW 5 15,732,923 (GRCm39) missense possibly damaging 0.48
R8093:Gm21190 UTSW 5 15,730,814 (GRCm39) missense possibly damaging 0.48
R8368:Gm21190 UTSW 5 15,729,848 (GRCm39) missense possibly damaging 0.94
R8504:Gm21190 UTSW 5 15,730,862 (GRCm39) missense probably benign 0.02
Z1176:Gm21190 UTSW 5 15,731,578 (GRCm39) missense probably benign
Z1176:Gm21190 UTSW 5 15,729,972 (GRCm39) missense not run
Z1176:Gm21190 UTSW 5 15,729,892 (GRCm39) missense probably benign 0.06
Z1177:Gm21190 UTSW 5 15,730,805 (GRCm39) missense probably benign 0.00
Z1177:Gm21190 UTSW 5 15,729,972 (GRCm39) missense not run
Z1177:Gm21190 UTSW 5 15,729,892 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TCTAATGTGCCAATGGTATCAGAC -3'
(R):5'- TGGACTGCAGCCAAAATTTC -3'

Sequencing Primer
(F):5'- TGGTATCAGACAGTCATAGCCTG -3'
(R):5'- GGACTGCAGCCAAAATTTCTTCTTC -3'
Posted On 2018-07-23